Neph1 and nephrin interaction in the slit diaphragm is an important determinant of glomerular permeability

Journal of Clinical Investigation

Volumn 112, Issue 2, 2003, Pages 209-221

  Liu, Gang ^a   Kaw, Beenu ^b   Kurfis, Jayson ^a   Rahmanuddin, Syed ^a   Kanwar, Yashpal S ^a   Chugh, Sumant S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b ADVOCATE ILLINOIS MASONIC MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; MESSENGER RNA; NEPHRIN; PROTEIN NEPH1; UNCLASSIFIED DRUG; COMPLEMENTARY DNA; KIRREL1 PROTEIN, MOUSE; MEMBRANE PROTEIN; NEPH1 PROTEIN, RAT; PHOSPHOPROTEIN; PROTEIN; RECOMBINANT PROTEIN; ZONULA OCCLUDENS 1 PROTEIN; ZONULA OCCLUDENS-1 PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GLOMERULUS FILTRATION; IMMUNOGOLD ELECTRON MICROSCOPY; NEPHROTIC SYNDROME; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEINURIA; RAT; AMINO ACID SEQUENCE; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CYTOLOGY; CYTOPLASM; DENSITOMETRY; DIMERIZATION; FLUORESCENCE MICROSCOPY; GLOMERULUS; GLOMERULUS FILTRATION RATE; IMMUNOHISTOCHEMISTRY; KIDNEY; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERODIAGNOSIS; SPRAGUE DAWLEY RAT; TIME; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, WESTERN; CADHERINS; CLONING, MOLECULAR; CYTOPLASM; DENSITOMETRY; DIMERIZATION; DNA, COMPLEMENTARY; GLOMERULAR FILTRATION RATE; IMMUNOHISTOCHEMISTRY; KIDNEY; KIDNEY GLOMERULUS; MEMBRANE PROTEINS; MICE; MICROSCOPY, FLUORESCENCE; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEINS; PRECIPITIN TESTS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS;

EID: 0042242818     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200318242     Document Type: Article

References (37)

1. Quaggin, S.E., et al. 1999. The basic-helix-loop-helix protein pod1 is critically important for kidney and lung organogenesis. Development. 126:5771-5783.
2. Rohr, C., et al. 2002. The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes. J. Clin. Invest. 109:1073-1082, doi:10.1172/JCI200213961.
3. Miner, J.H., et al. 2002. Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation. J. Clin. Invest. 109:1065-1072. doi:10.1172/JCI200213954.
4. Schnabel, E., Anderson, J.M., and Farquhar, M.G. 1990. The tight junction protein ZO-1 is concentrated along slit diaphragms of the glomerular epithelium. J. Cell. Biol. 111:1255-1263.
5. Orikasa, M., Matsui, K., Oite, T., and Shimizu, F. 1988. Massive proteinuria induced in rats by a single intravenous injection of a monoclonal antibody. J. Immunol. 141:807-814.
6. Kestila, M., et al. 1998. Positionally cloned gene for a normal glomerular protein-nephrin is mutated in congenital nephrotic syndrome. Mol. Cell. 1:575-582.
7. Shih, N.Y., et al. 1999. Congenital nephroric syndrome in mice lacking CD2-associated protein. Science. 286:312-315.
8. Boute, N., et al. 2000. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephroric syndrome. Nat. Genet. 24:349-354.
9. Kaplan, J.M., et al. 2000. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat. Genet. 24:251-256.
10. Reiser, J., Kriz, W., Kretzler, M., and Mundel, P. 2000. The glomerular slit diaphragm is a modified adherens junction. J. Am. Soc. Sec. Nephrol. 11:1-8.
11. Inoue, T., et al. 2001. FAT is a component of glomerular slit diaphragms. Kidney Int. 59:1003-1012.
12. Ihalmo, P., Palmen, T., Ahola, H., Valtonen, E., and Holthofer, H. 2003. Filtrin is a novel member of nephrin-like proteins. Biochem. Biophys. Res. Commun. 300:364-370.
13. Topham, P.S., et al. 1999. Nephritogenic monoclonal antibody 5-1-6 is directed against the extracellular domain of rat nephrin. J. Clin. Invest. 104:1559-1566.
14. Donoviel, D.B., et al. 2001. Proteinuria and perinatal lethality in mice lacking NEPH1, a novel protein with homology to NEPHRIN. Mol. Cell. Biol. 21:4829-4836.
15. Sellin, L., et al., 2003. NEPH1 defines a novel family of podocin interacting proteins. FASEB J. 17:115-117.
16. Mundel, P., and Shankland, S.J. 2002. Podocyte biology and response to injury. J. Am. Soc. Nephrol. 13:3005-3015.
17. BLAST. www.ncbi.nlm.nih.gov/BLAST.
18. Scansite. htrp://scanske.mit.edu/.
19. ExPASy Proteomics tools. http://ca.expasy.org/tools/#primary.
20. SignalP V1.1 World Wide Web Prediction Server. www.cbs.dtu.dk/services/SignalP.
21. DAS - Transmembrane Prediction Server. www.sbc.su.se/~miklos/DAS/.
22. ExPASy ProtScale. http://ca.expasy.org/cgi-bin/protscale.pl.
23. Chugh, S., et al. 2001. Aminopeptidase A: a nephrkogenic target antigen of nephrotoxic serum. Kidney Int. 59:601-613
24. Kawachi, H., et al. 1997. Slit diaphragm-reactive nephritogenic MAb 5-1-6 alters expression of ZO-1 in rat podocytes. Am. J. Physiol. 273:F984-F993.
25. Wada, J., and Kanwar, Y.S. 1998. Characterization of mammalian translocase of inner mitochondrial membrane (Tim44) isolated from diabetic newborn mouse kidney. Proc. Natl. Acad. Sci. U. S. A. 95:144-149.
26. Kanwar, Y.S., et al. 1996. D-glucose-induced dysmorphogenesis of embryonic kidney. J. Clin. Invest. 98:2478-2488.
27. Barletta, G.M., Kovari, J.A., Verma, R.K., Kerjaschki, D., and Holzman, L.B. 2003. Nephrin and Nephl co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers. J. Biol. Chem. 278:19266-19271.
28. Huber, T.B., et al. 2003. The carboxyl terminus of neph family members binds to the PDZ domain protein zonula occludens-1. J. Biol. Chem. 278:13417-13421.
29. Kanwar, Y.S., and Venkatachalam, M.A. 1992. Ultrastructure of the glomerulus and juxta-glomerular apparatus. In Handbook of renal physiology. E.E. Windhager, editor. Oxford University Press. New York, New York, USA. 3-40.
30. Wieslander, J., et al. 1984. Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen. Proc. Natl. Acad. Sci. U. S. A. 81:3838-3842.
31. Abrahamson, D.R., and Caulfield, J.P. 1982. Proteinuria and structural alterations in rat glomerular basement membranes induced by intravenously injected anti-laminin immunoglobulin G. J. Exp. Med. 156:128-145.
32. Hamano, Y., et al. 2002. Determinants of vascular permeability in the kidney glomerulus. J. Biol. Chem. 277:31154-31162.
33. Assmann, K.J.M., van Son, J.P.H.F., Dijkman, H.B.P.M., and Koene, R.A.P. 1992. A nephritogenic rat monoclonal antibody to mouse aminopeptidase A. J. Exp. Med. 175:623-635.
34. Mentzel, S., van Son, J.P., Dijkman, H.B., Wetzels, J.F., and Assmann, K.J. 1999. Induction of albuminuria in mice: synergistic effect of two monoclonal antibodies directed to different domains of aminopeptidase A. Kidney Int. 55:1335-1347.
35. Dworak, H.A., Charles, M.A., Pellerano, L.B., and Sink, H. 2001. Characterization of Drosophila hibris, a gene related to human nephrin. Development. 128:4265-4276.
36. Gerke, P., Huber, T.B., Sellin, L., Benzing, T., and Walz, G. 2003. Homodimerization and heterodimerizarion of the glomerular podocyte proteins nephrin and NEPH1. J. Am. Soc. Nephrol. 14:918-926.
37. Angst, B.D., Marcozzi, C., and Magee, A.I. 2001. The cadherin super-family. J. Cell Sci. 114:625-626.