Alleviating effects of active fraction of Euonymus alatus abundant in flavonoids on diabetic mice

American Journal of Chinese Medicine

Volumn 36, Issue 1, 2008, Pages 125-140

  Fang, Xian Kang ^a   Gao, Yuan ^a   Yang, Hai Yan ^a   Lang, Su Mei ^a   Wang, Qiu Juan ^a   Yu, Bo Yang ^a   Zhu, Dan Ni ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Diabetes; Euonymus alatus; Flavonoids; Oxidative Stress; Phenolic Acid

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ACETIC ACID ETHYL ESTER; ALLOXAN; ANTIDIABETIC AGENT; CHOLESTEROL; EUONYMOUS ALATUS EXTRACT; FLAVANOID; GLUCOSE; MALONALDEHYDE; METFORMIN; PHENOL; PLANT EXTRACT; PLASMA PROTEIN; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; EUONYMUS; EUONYMUS ALATUS; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCEMIC CONTROL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOPATHOLOGY; IN VITRO STUDY; INSULIN RELEASE; MALE; MOUSE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET; PROTEIN GLYCOSYLATION; SCAVENGING SYSTEM;

ANIMAL FEED; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DIETARY FATS; EUONYMUS; FLAVONOIDS; GLUCOSE TOLERANCE TEST; MALE; MICE; MICE, INBRED STRAINS; PLANT PREPARATIONS;

EID: 44049087119     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X08005643     Document Type: Article

References (30)

1. Ahmad, F., P. Khalid, M.M. Khan, A.K. Rastogi and J.R. Kidwai. Insulin like activity in (-)-epicatechin. Acta Diabetol. Lat. 26: 291-300, 1989.
2. Braca, A., N.D. Tommasi, L.D. Bari, C. Pizza, M. Politi and I. Morelli. Antioxidant principles from Bauhinia terapotensis. J. Nat. Prod. 64: 892-895, 2001.
3. Ceriello, A. Oxidative stress and glycemic regulation. Metabolism 49: 27-29, 2000.
4. Ceriello, A. and E. Motz. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscl. Throm. Vas. Biol. 24: 816-823, 2004.
5. Cha, B.Y., C.J. Park, D.G. Lee, Y.C. Lee, D.W. Kim, J.D. Kim, W.G. Seo and C.H. Kim. Inhibitory effect of methanol extract of Euonymus alatus on matrix metalloproteinase-9. J. Ethnopharmacol. 85: 163-167, 2003.
6. Chung, H.S., H.J. Jeong, J.S. Kim, S.I. Jeong, K.S. Kim, K.S. Kim, B.K. Kang, J.W. Ahn, S.H. Baek and H.M. Kim. Activation of inducible nitric oxide synthase by Euonymus alatus in mouse peritoneal macrophages. Clin. Chim. Acta 318: 113-120, 2002.
7. DeFronzo, R.A. Pharmacologic therapy for type 2 diabetes mellitus. Ann. Int. Med. 17: 281-303, 1999.
8. Evans, J.L., I.D. Gold.ne, B.A. Maddux and G.M. Grodsky. Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction? Diabetes 52: 1-8, 2003.
9. Groop, L.C. and T. Toumi. Non-insulin-dependent diabetes mellitus - a collision between thrifty genes and an affluent society. Ann. Med. 29: 37-53, 1997.
10. Hii, C.S. and S.L. Hovell. Effects of epicatechin on rat islets of Langerhans. Diabetes 33: 291-296, 1984.
11. Jorge, A.P., H. Horst, E. de Sousa, M.G. Pizzolatti and F.R. Silva. Insulinomimetic effects of kaempferitrin on glycaemia and on 14C-glucose uptake in rat soleus muscle. Chem. Biol. Interact. 149: 89-96, 2004.
12. Kim, J.D., S.M. Kang, B.I. Seo, H.Y. Choi, H.S. Choi and S.K. Ku. Anti-diabetic activity of SMK001, a poly herbal formula in streptozotocin induced diabetic rats: Therapeutic study. Bio. Pharm. Bull. 29: 477-482, 2006.
13. Lebowitz, H.E. α-Glucosidase inhibitors as agents in the treatment of diabetes. Diabetes Rev. 6: 132-145, 1998.
14. Lee, T.K., D.I. Kim, J.Y. Han and C.H. Kim. Inhibitory effects of Scutellaria barbata D. Don. and Euonymus alatus Sieb. on aromatase activity of human leiomyomal cells. Immunopharmacol. Immunotoxicol. 26: 315-327, 2004.
15. Manonmani, G., V. Bhavapriya, S. Kalpana, S. Govindasamy and T. Apparanantham. Antioxidant activity of Cassia fistula (Linn.) flowers in alloxan induced diabetic rats. J. Ethnopharmacol. 97: 39-42, 2005.
16. Maritim, A.C., R.A. Sanders and J.B. Watkins III. Diabetes, oxidative stress, and antioxidants: A review. J. Biochem. Mol. Toxic. 17: 24-38, 2003.
17. Moller, D.E. New drug targets for type 2 diabetes and the metabolic syndrome. Nature 414: 821-827, 2001.
18. Nijveldt, R.J., E. van Nood, D.E. van Hoorn, P.G. Boelens, K. van Norren and P.A. van Leeuwen. Flavonoids: A review of probable mechanism of action and potential applications. Am. J. Clin. Nutr. 74: 418-425, 2001.
19. Paollisso, G. and D. Giugliano. Oxidative stress and insulin action. Is there a relationship? Diabetologia 39: 357-363, 1996.
20. Park, S.H., S.K. Ko and S.H. Chung. Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice. J. Ethnopharmacol. 102: 326-335, 2005a.
21. Park, S.H., S.K. Ko and S.H. Chung. Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice. J. Ethnopharmacol. 102: 326-335, 2005b.
22. Sabu, M.C., K. Smitha and R. Kuttan. Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. J. Ethnopharmacol. 83: 109-116, 2002.
23. Sheehan, M.T. Current therapeutic options in type 2 diabetes mellitus: A practical approach. Clin. Med. Res. 1: 189-200, 2003.
24. Shen, P., M.H. Liu, T.Y. Ng, Y.H. Chan and E.L. Yong. Differential effects of isoflavones, from astragalus membranaceus and pueraria thomsonii, on the activation of PPARα, PPARγ, and adipocyte differentiation in vitro. J. Nutr. 136: 899-905, 2006.
25. Shetty, A.K., R. Rashmi, M.G.R. Rajan, K. Sambaiah and P.V. Salimath. Antidiabetic influence of quercetin in streptozocin-induced diabetic rats. Nutr. Res. 24: 373-381, 2004.
26. Silva, F.R., B. Szpoqanicz, M.G. Pizzolatti, M.A. Willrich and E. de Sousa. Acute effect of Bauhinia forficata on serum glucose levels in normal and alloxan-induced diabetic rats. J. Ethnopharmacol. 83: 33-37, 2002.
27. Wang, W.X., Q.X. Zhou, M. Guand and Z.L. Gu. Effects of different control samples on content determination of total phenolic acid in Xiongshao capsules. Chin. Tradit. Pat. Med. 23: 536-537, 2001.
28. Xing, S.L., W.Z. Huang and J.Y. Zheng. The research advance of clinic and experiment of Euonymus alatus. Jilin J. Tradit. Chin. Med. 25: 62-63, 2005.
29. Zhang, B.B. and D.E. Moller. New approaches in the treatment of type 2 diabetes. Curr. Opin. Chem. Biol. 4: 464-467, 2000.
30. Zhang, L.F. and J.X. Zhao. The recent research situation of Euonymus alatus. China J. Chin. Mat. Med. 30: 1895-1898, 2005.