Molecular modeling and docking analysis of Entamoeba histolytica glyceraldehyde-3 phosphate dehydrogenase, a potential target enzyme for anti-protozoal drug development

Chemical Biology and Drug Design

Volumn 71, Issue 6, 2008, Pages 554-562

  Singh, Shailza ^a   Malik, Balwant Kishen ^b   Sharma, Durlabh Kumar ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY DELHI   (India)

^b CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

Author keywords

Docking; Energy minimization; Entamoeba histolytica; Glyceraldehyde 3 phosphate dehydrogenase; Glycolytic pathway; Molecular modeling

Indexed keywords

3 (1,3 BENZODIOXOL 5 YL) 6 [(1H INDOL 3 YLMETHYLENE)AMINO] 2H CHROMEN 2 ONE; 3 (1,3 BENZODIOXOL 5 YL) 6 [(2 FURYLMETHYLENE)AMINO] 2H CHROMEN 2 ONE; 3 (1,3 BENZODIOXOL 5 YL) 6 [(H PYRROL 2 YLMETHYLENE)AMINO] 2H CHROMEN 2 ONE; 3 (1,3 BENZODIOXOL 5 YL) 6 [(THIEN 2 YLMETHYLENE)AMINO] 2H CHROMEN 2 ONE; ANTIPROTOZOAL AGENT; ARGININE; COUMARIN DERIVATIVE; DEXTRO GLYCERATE 1,3 BISPHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHATE; SERINE; THREONINE;

ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG TARGETING; ENTAMOEBA HISTOLYTICA; ENZYME MECHANISM; GLYCOLYSIS; LEISHMANIA MEXICANA; MOLECULAR DOCKING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL;

ANIMALS; ANTIPROTOZOAL AGENTS; COMPUTER SIMULATION; COUMARINS; ENTAMOEBA HISTOLYTICA; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; LEISHMANIA MEXICANA; MODELS, MOLECULAR; PROTEIN BINDING; PROTOZOAN PROTEINS;

ENTAMOEBA; ENTAMOEBA HISTOLYTICA; LEISHMANIA MEXICANA;

EID: 43949120770     PISSN: 17470277     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2008.00666.x     Document Type: Article

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