HMG-CoA reductase inhibitors deplete circulating classical and non-classical monocytes following human heart transplantation

Transplant Immunology

Volumn 19, Issue 2, 2008, Pages 152-157

  Fildes, J E ^a   Shaw, S M ^a   Mitsidou, A ^a   Rogacev, K ^a   Leonard, C T ^a   Williams, S G ^a   Yonan, N ^a  

^a MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Fc RI; Heart transplantation; Immunomodulation; Monocyte; Statin; VLA 4

Indexed keywords

ALPHA4 INTEGRIN; ANTIGEN; ATORVASTATIN; B7 ANTIGEN; CD14 ANTIGEN; CD16 ANTIGEN; CD195 ANTIGEN; CD64 ANTIGEN; FC RECEPTOR; GLYCOPROTEIN P 15095; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; PRAVASTATIN; VERY LATE ACTIVATION ANTIGEN 4;

ADULT; ANTIGEN EXPRESSION; ARTICLE; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; HEART TRANSPLANTATION; HUMAN; IMMUNOPHENOTYPING; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL;

ADULT; AGED; CROSS-SECTIONAL STUDIES; DOWN-REGULATION; FEMALE; HEART TRANSPLANTATION; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTEGRIN ALPHA4; LEUKOCYTE COUNT; MALE; MIDDLE AGED; MONOCYTES; PRAVASTATIN; PYRROLES; RECEPTORS, IGG; UP-REGULATION;

EID: 43949112933     PISSN: 09663274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trim.2008.02.002     Document Type: Article

References (34)

1. Carrier M., Rivard M., Kostuk W., Latter D., Daly P., Davies R., et al. The Canadian Study of Cardiac Transplantation. Atherosclerosis. Investigators of the CASCADE Study. Can J Cardiol 15 12 (1999) 1337-1344
2. van Nieuw Amerongen G.P., Vermeer M.A., Negre-Aminou P., Lankelma J., Emeis J.J., and van Hinsbergh V.W. Simvastatin improves disturbed endothelial barrier function. Circulation 102 23 (2000) 2803-2809
3. Szczeklik A., Undas A., Musial J., Gajewski P., Swadzba J., and Jankowski M. Antithrombotic actions of statins. Med Sci Monit 7 6 (2001) 1381-1385
4. Greenwood J., and Mason J.C. Statins and the vascular endothelial inflammatory response. Trends Immunol 28 2 (2007) 88-98
5. Rice J.B., Stoll L.L., Li W.G., Denning G.M., Weydert J., Charipar E., et al. Low-level endotoxin induces potent inflammatory activation of human blood vessels: inhibition by statins. Arterioscler Thromb Vasc Biol 23 9 (2003) 1576-1582
6. Kurakata S., Kada M., Shimada Y., Komai T., and Nomoto K. Effects of different inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, pravastatin sodium and simvastatin, on sterol synthesis and immunological functions in human lymphocytes in vitro. Immunopharmacology 34 1 (1996) 51-61
7. Katznelson S., Wang X.M., Chia D., Ozawa M., Zhong H.P., Hirata M., et al. The inhibitory effects of pravastatin on natural killer cell activity in vivo and on cytotoxic T lymphocyte activity in vitro. J Heart Lung Transplant 17 4 (1998) 335-340
8. Bellosta S., and Bernini F. Modulation of macrophage function and metabolism. Handb Exp Pharmacol 170 (2005) 665-695
9. Methe H., Kim J.O., Kofler S., Nabauer M., and Weis M. Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes. Arterioscler Thromb Vasc Biol 25 7 (2005) 1439-1445
10. Takahashi H.K., Mori S., Iwagaki H., Yoshino T., Tanaka N., Weitz-Schmidt G., et al. Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. J Leukoc Biol 77 3 (2005) 400-407
11. Djaldetti M., Salman H., Bergman M., and Bessler H. Effect of pravastatin, simvastatin and atorvastatin on the phagocytic activity of mouse peritoneal macrophages. Exp Mol Pathol 80 2 (2006) 160-164
12. Llaverias G., Rebollo A., Pou J., Vazquez-Carrera M., Sanchez R.M., Laguna J.C., et al. Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes. Biochem Pharmacol 71 5 (2006) 605-614
13. Tacke F., and Randolph G.J. Migratory fate and differentiation of blood monocyte subsets. Immunobiology 211 6-8 (2006) 609-618
14. Blocher S., Wilker S., Sucke J., Pfeil U., Dietrich H., Weimer R., et al. Acute rejection of experimental lung allografts: characterization of intravascular mononuclear leukocytes. Clin Immunol 124 1 (2007) 98-108
15. Passlick B., Flieger D., and Ziegler-Heitbrock H.W. Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 74 7 (1989) 2527-2534
16. Akhlaghi F., McLachlan A.J., Keogh A.M., and Brown K.F. Effect of simvastatin on cyclosporine unbound fraction and apparent blood clearance in heart transplant recipients. Br J Clin Pharmacol 44 6 (1997) 537-542
17. Ballantyne C.M., Corsini A., Davidson M.H., Holdaas H., Jacobson T.A., Leitersdorf E., et al. Risk for myopathy with statin therapy in high-risk patients. Arch Intern Med 163 5 (2003) 553-564
18. Baumgarth N., and Roederer M. A practical approach to multicolor flow cytometry for immunophenotyping. J Immunol Methods 243 1-2 (2000) 77-97
19. Steppich B., Dayyani F., Gruber R., Lorenz R., Mack M., and Ziegler-Heitbrock H.W. Selective mobilization of CD14(+)CD16(+) monocytes by exercise. Am J Physiol Cell Physiol 279 3 (2000) C578-C586
20. Barcova M., Kacani L., Speth C., and Dierich M.P. gp41 envelope protein of human immunodeficiency virus induces interleukin (IL)-10 in monocytes, but not in B, T, or NK cells, leading to reduced IL-2 and interferon-gamma production. J Infect Dis 177 4 (1998) 905-913
21. Andersson U., Wang H., Palmblad K., Aveberger A.C., Bloom O., Erlandsson-Harris H., et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes. J Exp Med 192 4 (2000) 565-570
22. Bar-Or A., Nuttall R.K., Duddy M., Alter A., Kim H.J., Ifergan I., et al. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain 126 Pt 12 (2003) 2738-2749
23. Chaitidis P., O'Donnell V., Kuban R.J., Bermudez-Fajardo A., Ungethuem U., and Kuhn H. Gene expression alterations of human peripheral blood monocytes induced by medium-term treatment with the TH2-cytokines interleukin-4 and -13. Cytokine 30 6 (2005) 366-377
24. Game D.S., and Lechler R.I. Pathways of allorecognition: implications for transplantation tolerance. Transpl Immunol 10 2-3 (2002) 101-108
25. Nuutila J., Hohenthal U., Laitinen I., Kotilainen P., Rajamaki A., Nikoskelainen J., et al. Simultaneous quantitative analysis of FcgammaRI (CD64) expression on neutrophils and monocytes: a new, improved way to detect infections. J Immunol Methods 328 1-2 (2007) 189-200
26. Fanger N.A., Voigtlaender D., Liu C., Swink S., Wardwell K., Fisher J., et al. Characterization of expression, cytokine regulation, and effector function of the high affinity IgG receptor Fc gamma RI (CD64) expressed on human blood dendritic cells. J Immunol 158 7 (1997) 3090-3098
27. Connor R.I., Shen L., and Fanger M.W. Evaluation of the antibody-dependent cytotoxic capabilities of individual human monocytes. Role of Fc gamma RI and Fc gamma RII and the effects of cytokines at the single cell level. J Immunol 145 5 (1990) 1483-1489
28. Gosselin E.J., Wardwell K., Gosselin D.R., Alter N., Fisher J.L., and Guyre P.M. Enhanced antigen presentation using human Fc gamma receptor (monocyte/macrophage)-specific immunogens. J Immunol 149 11 (1992) 3477-3481
29. Weber C., Erl W., Weber K.S., and Weber P.C. HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia. J Am Coll Cardiol 30 5 (1997) 1212-1217
30. Niwa S., Totsuka T., and Hayashi S. Inhibitory effect of fluvastatin, an HMG-CoA reductase inhibitor, on the expression of adhesion molecules on human monocyte cell line. Int J Immunopharmacol 18 11 (1996) 669-675
31. Kwak B., Mulhaupt F., Myit S., and Mach F. Statins as a newly recognized type of immunomodulator. Nat Med 6 12 (2000) 1399-1402
32. Tousoulis D., Antoniades C., Vassiliadou C., Toutouza M., Pitsavos C., Tentolouris C., et al. Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure. Eur J Heart Fail 7 7 (2005) 1126-1132
33. Sallusto F., and Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179 4 (1994) 1109-1118
34. Randolph G.J., Sanchez-Schmitz G., Liebman R.M., and Schakel K. The CD16(+) (FcgammaRIII(+)) subset of human monocytes preferentially becomes migratory dendritic cells in a model tissue setting. J Exp Med 196 4 (2002) 517-527