Sertoli cell morphological alterations in albino rats treated with etoposide during prepubertal phase

Microscopy and Microanalysis

Volumn 14, Issue 3, 2008, Pages 225-235

  Stumpp, Taiza ^a   Freymuller, Edna ^a   Miraglia, Sandra M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Electron microscopy; Etoposide; Sertoli cell; Spermatogenesis; Testis

Indexed keywords

ANTINEOPLASTIC AGENT; ETOPOSIDE;

ANIMAL; ARTICLE; DRUG EFFECT; MALE; PATHOLOGY; RAT; SEMINIFEROUS TUBULE; SERTOLI CELL; SEXUAL MATURATION; SPERMATOGENESIS; TRANSMISSION ELECTRON MICROSCOPY; WISTAR RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ETOPOSIDE; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; RATS; RATS, WISTAR; SEMINIFEROUS TUBULES; SERTOLI CELLS; SEXUAL MATURATION; SPERMATOGENESIS;

RATTUS;

EID: 43949090529     PISSN: 14319276     EISSN: 14358115     Source Type: Journal    
DOI: 10.1017/S1431927608080318     Document Type: Article

References (51)

1. ANDRIEU, M.N., KURTMAN, C., HICSONMEZ, A., OZBILGIN, K., ESER, E. & ERDEMLI, E. (2005). In vivo study to evaluate the protective effects of amifostine on radiation-induced damage of testis tissue. Oncology 69, 44-51.
2. ARNOLD, A.M. (1979). Podophyllotoxin derivative VP 16-213. Cancer Chem Pharmacol 3, 71-80.
3. ATANASSOVA, N.N., WALKER, M., MCK INNELL, C., FISHER, J.S. & SHARPE, R.M. (2005). Evidence that androgens and oestrogens, as well as follicle-stimulating hormone, can alter Sertoli cell number in the neonatal rat. J Endocrinol 184, 107-117.
4. AWAL, M.A., KUROHMARU, M., ANDRIANA, B.B., KANAI, Y. & HAYASHI, Y. (2005). Mono-(2-ethylhexyl) phthalate (MEHP) induces testicular alterations in male guinea pigs at prepubertal stage. Tissue Cell 37, 167-175.
5. BILLIG, H., FURURTA, I., RIVIER, C., TAPANAINEM, J., PARVINEN, M. & HSUEH, A.J. (1995). Apoptosis in testis germ cells: Developmental changes in gonadotropin dependence and localization to selective tubule stages. Endocrinology 136, 5-12.
6. BOEKELHEIDE, K., FLEMING, S.L., ALLIO, T., EMBREE-KU, M.E., HALL, S.J., JOHNSON, K.J., KWON, E.J., PATEL, S.R., RASOULPOUR, R.J., SCHOENFELD, H.A. & THOMPSON, S. (2003). 2,5-hexanedioneinduced testicular injury. Ann Rev Pharmacol Toxicol 43, 125-147.
7. BORDALLO, M.A., GUMARAES, M.M., PESSOA, G.H., CARRICO, M.K., DIMETZ, T., GAZOLLA, H.M., DOBBIN, J. & CASTILHO, I.A. (2004), Decreased serum inhibin B/FSH ratio as a marker of Sertoli cell function in male survivors after chemotherapy in childhood and adolescence. J Pediatr Endocrinol Metab 17, 879-887.
8. CAVIGLIA, D., SCARABELLI, L. & PALMERO, S. (2004). Effects of carnitines on rat sertoli cell protein metabolism. Harm Metab Res 36, 221-225.
9. CESPEDES, R.D., PERETSMAN, S.J., THOMPSON, I.M., JR. & JACKSON, C. (1995). Protection of the germinal epithelium in the rat from the cytotoxic effects of chemotherapy by a luteinizing hormone-releasing hormone agonist and antiandrogen therapy. Urology 46, 688-691.
10. CHAPIN, R.E., GRAY, T.J., PHELPS, J.L. & DUTTON, S.L. (1988). The effects of mono-(2-ethylhexyl)-phthalale on rat Sertoli cell-enriched primary cultures. Toxicol Appl Pharmacol 92, 467-479,
11. CHEN, G.L., YANG, L., ROWE, T.C., HALLIGAN, B.D., TEWEY, K.M. & LIU, L.F. (1984). Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. J Biol Chem 259, 13560-13566.
12. CLEGG, E.J. (1963). Studies on artificial cryptorchidism: Degenerative and regenerative changes in the germinal epithelium of the rat testis, J Endocrinol 27, 241-251.
13. CREAVEN, P.J. & ALLEN, L.M. (1975), EPEG: A new antineoplastic epipodophyllotoxin. Clin Pharmacol Ther 18, 221-226,
14. DALGAARD, M., NELLEMANN, C., LAM, H.R., SORENSEN, I.K. & LADEFOGED, O. (2001). The acute effects of mono(2-ethylhexyl)phthalate (MEHP) on testes of prepubertal Wistar rats. Toxkol Lett 122, 69-79.
15. DE OLIVEIRA, R.B., KLAMT, F., CASTRO, M.A., POLYDORO, M., ZANOTTO FILHO, A., GELAIN, D.P., DAL-PIZZOL, F. & NOREIRA, J.C. (2005). Morphological and oxidative alterations on Sertoli cells cytoskeleton due to retinol-induced reactive oxygen species. Mol Cell Biochem 271, 189-196.
16. DESPRAS, E., MICCOLI, L., CREMINON, C., ROUILLARD, D., ANGULO, J.F. & BIARD, D.S. (2003). Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells. Radiat Res 159, 748-758.
17. DJAKIEW, D. & DYM, M. (1988). Pachytene spermatocyte proteins influence Sertoli cell function, Biol Reprod 39, 1193-1205.
18. DYM, M. & RAJ, H.G. (1977), Response of adult rat Sertoli cells and Leydig cells to depletion of luteinizing hormone and testosterone. Biol Reprod 17, 676-696.
19. FREITAS, E.F., CORDEIRO-MORI, R, SASSO-CERRI, E., LUCAS, S.R. & MIRAGLIA, S.M. (2002). Alterations of spermatogenesis in etoposide-trealed rats: A stereological study, Interciencia 27, 227-235.
20. GUITTON, N., TOUZALIN, A.M., SHARPE, R.M., CHENG, C.Y., PINON-LATAILLADE, G., MERITTE, H., CHENAL, C. & JEGOU, B. (2000). Regulatory influence of germ cells on Sertoli cell function in pre-pubertal rat after acute irradiation of the testis. Int J Androl 23, 332-339.
21. HAKOVIRTA, H., PARVINEN, M. & LAHDETIE, J. (1993). Effects of etoposide on stage-specific DNA synthesis during rat spermatogenesis, Mutat Res 301, 189-193.
22. HANDE, K.R. (1998). Etoposide: Four decades of development of a topoisomerase II inhibitor. Eur J Cancer 34, 1514-1520.
23. HUCKINS, C. (1965). The duration of spermatogenesis in pre- and postpuberal Wistar rats. Anat Rec 151, 365 (abstract).
24. JAHNUKAINEN, K., JAHNUKAINEN, T., SALMI, T.T., SVECHNIKOV, K., EKSBORG, S, & SÖDER, O. (2001), Amifostine protects against early but not late toxic effects of doxorubicin in infant rats. Cancer Res 61, 6423-6427.
25. JOHNSTON, H., BAKER, P.J., ABEL, M., CHARLTON, H.M., JACKSON, G., FLEMING, L., KUMAR, T.R. & O'SAUGHNESSY, P.J. (2004). Regulation of Sertoli cell number and activity by folliclestimulating hormone and androgen during postnatal development in the mouse. Endocrinology 145, 318-329.
26. KAMISCHKE, A., KUHLMANN, M., WEINBAUER, G.F., LUETJENS, M., YEUNG, C.H., KRONHOLZ, H.L. & NIESCHLAG, E. (2003), Gonadal protection from radiation by GnRH antagonist or recombinant human FSH: A controlled trial in a male nonhuman primate (Macaco fascicularis). J Endocrinol 179, 183-194.
27. KOBAYASHI, D., GOTO, A., MAEDA, T., NEZU, J., TSUJI, A. & TAMAI, I. (2005). OCTN2-mediated transport of carnitine in isolated Sertoli cells. Reproduction 129, 729-736.
28. LEE, J., RICHBURG, J.H., SHIPP, E.B., MEISTRICH, M.L. & BOEKELHEIDE, K. (1999). The FAS system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology 140, 852-858.
29. MAEDA, T., GOTO, A., KOBAYASHI, D. & TAMAI, I. (2007). Transport of organic cations across the blood-testis barrier. Mol Pharm 4, 600-607.
30. MANTOVANI, A. & MARANGHI, F. (2005), Risk assessment of chemicals potentially affecting male fertility. Contraception 72, 308-313.
31. MARKELEWICZ, R.J., JR., HALL, S.J. & BOEKELHEIDE, K. (2004). 2,5-hexanedione and carbendazim coexposure synergistically disrupts rat spermatogenesis despite opposing molecular effects on microtubules. Toxkol Sc 80, 92-100.
32. MEISTRICH, M.L., WILSON, G., YE, W.S., THRASH, C. & HUHTANIEMI, I. (1996), Relationship among hormonal treatments, suppression of spermatogenesis, and testicular protection from chemotherapy-induced damage. Endocrinology 137, 3823-3831.
33. MOFFIT, J.S., BRYANT, B.H., HALL, S.J. & BOEKELHEIDE, K. (2007). Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis, Toxicol Pathol 35, 719-727.
34. PINON-LATAILLADE, G., MASSON, C., BERNARDINO-SGHERRI, J., HENRIOT, V., MAUFFREY, P., FROBERT, Y., ARANEDA, S. & ANGULO, J.F. (2004). KIN17 encodes an RNA-binding protein and is expressed during mouse spermatogenesis. J Cell Sci 117, 3691-3702.
35. PINON-LATAILLADE, G., VELEZ DE AL CALLE, J.F., VIGUIER-MARTINEZ, M.C., GARNIER, D.H., FOLLIOT, R., MAAS, S. & JEGOU, B. (1988), Influence of germ cells upon Sertoli cells during continuous low-dose rate gamma-irradiation of adult rats, Mol Cell Endocrinol 58, 51-63.
36. PINON-LATAILLADE, G., VIGUIER-M ARTINEZ, M.C., TOUZALIN, A.M., MAAS, S. & JEGOU, B. (1991). Effect of an acute exposure of rat testes to gamma rays on germ cells and on Sertoli and Leydig cell functions. Reprod Nutr Dev 31, 617-629.
37. RICHBURG, J.H. & BOEKELHEIDE, K. (1996). Mono-(2-ethylhexyl) phthalate rapidly alters both Sertoli cell vimentin filaments and germ cell apoptosis in young rat testes. Toxicol Appl Pharmacol 137, 42-50.
38. RICHBURG, J.H., JOHNSON, K.J., SCHOENFELD, H.A., MEISTRICH, M.L. & DIX, D.J. (2002). Defining the cellular and molecular mechanisms of toxicant action in the testis. Toxicol Lett 135, 167-183,
39. RICHBURG, J.H., NANEZ, A. & GAO, H. (1999). Participation of the Fas-signaling system in the initiation of germ cell apoptosis in young rat testes after exposure to mono-(2-ethylhexyl) phthalate. Toxicol Appl Pharmacol 160, 271-278.
40. RUSSELL, L.D. (1993). Form, dimensions, and cytology of mammalian Sertoli cells. In The Sertoli Cell, Russell, L.D. & Griswold, M.D. (Eds.), pp. 1-37. Clearwater, FL: Cache River Press.
41. SASSO-CERRI, E. & MIRAGLIA, S.M. (2002). In situ demonstration of both TUNEL-labeled germ cell and Sertoli cell in die cimetidine-treated rats. Histol Histopathol 17, 411-417.
42. SINHA, B.K., HAIM, N., DUSRE, L., KERRIGAN, D. & POMMIER, Y. (1988). DNA strand breaks produced by etoposide (VP-16,213) in sensitive and resistant human breast tumor cells: Implications for the mechanism of action. Cancer Res 48, 5096-5100.
43. STALLARD, B.J. & GRISWOLD, M.D. (1990). Germ cell regulation of Sertoli cell transferrin mRNA levels, Mol Endocrinol 4, 393-401.
44. STUMPP, T., FREYMULLER, E. & MIRAGLIA, S.M. (2006). Sertoli cell function in albino rats treated with etoposide during prepubertal phase. Histochem Cell Biol 126, 353-361.
45. STUMPP, T, SASSO-CERRI, E., FREYMÜLLER, E. & MIRAGLIA, S.M. (2004). Apotosis and testicular altertions in albino rats treated with etoposide during prepubertal phase. Anat Rec 279, 611-622.
46. TAN, K.A., DE GENDT, K., ATANASSOVA, N., WALKER, M., SHARPE, R.M., SAUNDERS, P.T., DENOLET, E. & VERHOEVEN, G. (2005), The role of androgens in sertoli cell proliferation and functional maturation: Studies in mice with total or Sertoli cell-selective ablation of the androgen receptor. Endocrinology 146, 2674-2683.
47. THYSEN, B., MORRIS, P.L., GATZ, M. & BLOCH, E. (1990). The effect of mono(2-ethylhexyl) phthalate on Sertoli cell transferrin secretion in vitro. Toxicol Appl Pharmcol 106, 154-157.
48. TREINEN, K.A., DODSON, C. & HEINDEL, J.J. (1990). Inhibition of FSH-stimuialed cAMP accumulation and progesterone production by mono(2-ethylhexyl) phthalate in rat granulosa cell cultures. Toxicol Appl Pharmacol 106, 334-340.
49. WANG, R., CHANG, J.S., ZHOU, X.M. & CHEN, D.Y. (1991). Varicocele in the rat: A new experimental model. Effect on histology, ultrastructure and temperature of the testis and the epididymis. Urol Res 19, 319-322.
50. WANG, Z.Q., WATANANBE, Y., TOKI, A. & ITANO, T. (2002). Altered distribution of Sertoli cell vimentin and increased apoptosis in cryplorchid rats. J Pediatr Surg 37, 648-652.
51. ZHU, O., VAN THIEL, D.H. & GAVALIER, J.S. (1997), Effects of ethanol on rat Sertoli cell function: Studies in vitro and in vivo. Alcohol Clin Exp Res 21, 1409-1417.