Gonadal protection from radiation by GnRH antagonist or recombinant human FSH: A controlled trial in a male nonhuman primate (Macaca fascicularis)

Journal of Endocrinology

Volumn 179, Issue 2, 2003, Pages 183-194

  Kamischke, A ^b   Kuhlmann, M ^b   Weinbauer, G F ^b,c   Luetjens, M ^b   Yeung, C H ^b   Kronholz, H L ^a   Nieschlag, E ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b INST OF REPRO MED OF THE UNIV   (Germany)

^c Department of Veterinary Services and Colony Management   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CETRORELIX; GONADORELIN ANTAGONIST; INHIBIN B; PLACEBO; RECOMBINANT FOLLITROPIN; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG SCREENING; EJACULATION; GONAD FUNCTION; HORMONE DETERMINATION; MACACA; MALE; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION PROTECTION; RANDOMIZATION; SEMEN ANALYSIS; SPERMATOGENESIS; TESTIS BIOPSY; TESTIS SIZE;

ANALYSIS OF VARIANCE; ANIMALS; CELL COUNT; FOLLICLE STIMULATING HORMONE, HUMAN; GONADOTROPIN-RELEASING HORMONE; INHIBINS; MACACA FASCICULARIS; MALE; MODELS, ANIMAL; RADIATION INJURIES, EXPERIMENTAL; RADIOTHERAPY; RANDOM ALLOCATION; SPERM COUNT; TESTIS; TESTOSTERONE; TREATMENT FAILURE;

EID: 0344898853     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.0.1790183     Document Type: Article

References (53)

1. Awoniyi CA, Zirkin BR, Chandrashekar V & Schlaff WD 1992 Exogenously administered testosterone maintains spermatogenesis quantitatively in adult rats actively immunized against gonadotropin-releasing hormone. Endocrinology 130 3283-3288.
2. Behre HM, Nashan D, Hubert W & Nieschlag E 1992 Depot gonadotropin-releasing hormone agonist blunts the androgen-induced suppression of spermatogenesis in a clinical trial of male contraception. Journal of Clinical Endocrinology and Metabolism 74 84-90.
3. Brennemann W, Brensing KA, Leipner N, Boldt I & Klingmuller D 1994 Attempted protection of spermatogenesis from irradiation in patients with seminoma by D-tryptophan-6 luteinizing hormone releasing hormone. Journal of Clinical Investigation 72 838-842.
4. Chandolia RK, Weinbauer GF, Simoni M, Behre HM & Nieschlag E 1991 Comparative effects of chronic administration of the non-steroidal antiandrogens flutamide and Casodex on the reproductive system of the adult male rat. Acta Endocrinologica 125 547-555.
5. Clifton DK & Bremner WJ 1983 The effect of testicular X-irradiation on spermatogenesis in man. A comparison with the mouse. Journal of Andrology 4 387-392.
6. Delic JI, Bush C & Peckham MJ 1986 Protection from procarbazine-induced damage of spermatogenesis in the rat by androgen. Cancer Research 46 1909-1914.
7. Foresta C, Bettella A, Ferlin A, Garolla A & Rossato M 1998 Evidence for a stimulatory role of follicle-stimulating hormone on the spermatogonial population in adult males. Fertility and Sterility 69 636-642.
8. Fossa SD, Klepp O & Norman N 1988 Lack of gonadal protection by medroxyprogesterone acetate-induced transient medical castration during chemotherapy for testicular cancer. British Journal of Urology 62 449-453.
9. Greiner R 1982 Die Erholung der Spermatogenese nach fraktionierter, niedrig dosierter Bestrahlung der männlichen Gonaden. Strahlentherapie 158 342-355.
10. Huhtaniemi I, Nikula H, Parvinen M & Rannikko S 1987 Pituitary-testicular function of prostatic cancer patients during treatment with a gonadotropin-releasing hormone agonist analog. II. Endocrinology and histology of the testis. Journal of Andrology 8 363-373.
11. Johnson DH, Linde R, Hainsworth JD, Vale W, Rivier J, Stein R, Flexner J, Van Welch R & Greco FA 1985 Effect of a luteinizing hormone releasing hormone agonist given during combination chemotherapy on postherapy fertility in male patients with lymphoma: preliminary observations. Blood 65 832-836.
12. Kangasniemi M, Wilson G, Huhtaniemi I & Meistrich ML 1995a Protection against procarbazine-induced testicular damage by GnRH-agonist and antiandrogen treatment in the rat. Endocrinology 136 3677-3680.
13. Kangasniemi M, Wilson G, Parchuri N, Huhtaniemi I & Meistrich ML 1995b Rapid protection of rat spermatogenic stem cells against procarbazine by treatment with a gonadotropin-releasing hormone antagonist (Nal-Glu) and an antiandrogen (flutamide). Endocrinology 136 2881-2888.
14. Kliesch S, Kamischke A & Nieschlag E 2000 Cryopreservation of sperm. In Andrology: Male Reproductive Health and Dysfunction, edn 2, pp 349-356. Eds E Nieschlag & HM Behre. Heidelberg: Springer.
15. Krause W & Pfluger KH 1989 Treatment with the gonadotropin-releasing hormone agonist buserelin to protect spermatogenesis against cytotoxic treatment in young men. Andrologia 21 265-270.
16. Krishnamurthy H, Weinbauer GF, Aslam H, Yeung CH & Nieschlag E 1998 Quantification of apoptotic testicular germ cells in normal and methoxyacetic acid-treated mice as determined by flow cytometry. Journal of Andrology 19 710-717.
17. Lewis RW, Dowling KJ & Schally AV 1985 D-Tryptophan-6 analog of luteinizing hormone-releasing hormone as a protective agent against testicular damage caused by cyclophosphamide in baboons. PNAS 82 2975-2979.
18. McLachlan RI, O'Donnell L, Stanton PG, Balourdos G, Frydenberg M, de Kretser DM & Robertson DM 2002 Effects of testosterone plus medroxyprogesterone acetate on semen quality, reproductive hormones, and germ cell populations in normal young men. Journal of Clinical Endocrinology and Metabolism 87 546-556.
19. Meirow D & Schenker JG 1995 Cancer and male infertility. Human Reproduction 10 2017-2022.
20. Meistrich ML 1998 Hormonal stimulation of the recovery of spermatogenesis following chemo- or radiotherapy. Acta Pathologica, Microbiologica, et Immunologica Scandinavica 106 37-46.
21. Meistrich ML & Kangasniemi M 1997 Hormone treatment after irradiation stimulates recovery of rat spermatogenesis from surviving spermatogonia. Journal of Andrology 18 80-87.
22. Meistrich ML, Hunter NR, Suzuki N, Trostle PK & Withers HR 1978 Gradual regeneration of mouse testicular stem cells after exposure to ionizing radiation. Radiation Research 74 349-362.
23. Meistrich ML, Wilson G, Ye WS, Thrash C & Huhtaniemi I 1996 Relationship among hormonal treatments, suppression of spermatogenesis, and testicular protection from chemotherapy-induced damage. Endocrinology 137 3823-3831.
24. Meistrich ML, Wilson G, Zhang Y, Kurdoglu B & Terry NH 1997 Protection from procarbazine-induced testicular damage by hormonal pretreatment does not involve arrest of spermatogonial proliferation. Cancer Research 57 1091-1097.
25. Meistrich ML, Wilson G & Huhtaniemi I 1999 Hormonal treatment after cytotoxic therapy stimulates recovery of spermatogenesis. Cancer Research 59 3557-3560.
26. Meistrich ML, Wilson G, Kangasniemi M & Huhtaniemi I 2000 Mechanism of protection of rat spermatogenesis by hormonal pretreatment: stimulation of spermatogonial differentiation after irradiation. Journal of Andrology 21 464-469.
27. Morse HC, Horike N, Rowley MJ & Heller CG 1973 Testosterone concentrations in testes of normal men: effects of testosterone propionate administration. Journal of Clinical Endocrinology and Metabolism 37 882-886.
28. Plant TM & Marshall GR 2001 The functional significance of FSH in spermatogenesis and the control of its secretion in male primates. Endocrine Reviews 22 764-786.
29. Rolf C & Nieschlag E 2000 The aging male In Andrology: Male Reproductive Health and Dysfunction, edn 2, pp 419-432. Eds E Nieschlag & HM Behre. Heidelberg: Springer.
30. Rowley MJ, Leach DR, Warner GA & Heller CG 1974 Effect of graded doses of ionizing radiation on the human testis. Radiation Research 59 665-678.
31. Schlatt S 1999 Prospects and problems for germ cell transplantation in the male. International Journal of Andrology 22 13-18.
32. Schlatt S, Foppiani L, Rolf C, Weinbauer GF & Nieschlag E 2002 Germ cell transplantation into X-irradiated monkey testes. Human Reproduction 17 55-62.
33. Shetty G, Wilson G, Huhtaniemi I, Shuttlesworth GA, Reissmann T & Meistrich ML 2000 Gonadotropin-releasing hormone analogs stimulate and testosterone inhibits the recovery of spermatogenesis in irradiated rats. Endocrinology 141 1735-1745.
34. Shuttlesworth GA, de Rooij DG, Huhtaniemi I, Reissmann T, Russell LD, Shetty G, Wilson G & Meistrich ML 2000 Enhancement of A spermatogonial proliferation and differentiation in irradiated rats by gonadotropin-releasing hormone antagonist administration. Endocrinology 141 37-49.
35. van Alphen MM, van de Kant HJ & de Rooij DG 1988a Depletion of the spermatogonia from the seminiferous epithelium of the rhesus monkey after X irradiation. Radiation Research 113 473-486.
36. van Alphen MM, van de Kant HJ & de Rooij DG 1988b Repopulation of the seminiferous epithelium of the rhesus monkey after X irradiation. Radiation Research 113 487-500.
37. van Alphen MM, van de Kant HJ & de Rooij DG 1988c Follicle-stimulating hormone stimulates spermatogenesis in the adult monkey. Endocrinology 123 1449-1455.
38. van Alphen MM, van de Kant HJ, Davids JA, Warmer CJ, Bootsma AL & de Rooij DG 1989a Dose-response studies on the spermatogonial stem cells of the rhesus monkey (Macaca mulatta) after X irradiation. Radiation Research 119 443-451.
39. van Alphen MM, van de Kant HJ & de Rooij DG 1989b Protection from radiation-induced damage of spermatogenesis in the rhesus monkey (Macaca mulatta) by follicle-stimulating hormone. Cancer Research 49 533-536.
40. Waxman JH, Ahmed R, Smith D, Wrigley PF, Gregory W, Shalet S, Crowther D, Rees LH, Besser GM & Malpas JS 1987 Failure to preserve fertility in patients with Hodgkin's disease. Cancer Chemotherapy and Pharmacology 19 159-162.
41. Weinbauer GF & Nieschlag E 1998 The role of testosterone in spermatogenesis. In Testosterone: Action, Deficiency, Substitution, edn 2, pp 143-168. Eds E Nieschlag & HM Behre. Heidelberg: Springer.
42. Weinbauer GF, Gockeler E & Nieschlag E 1988 Testosterone prevents complete suppression of spermatogenesis in the gonadotropin-releasing hormone antagonist-treated nonhuman primate (Macaca fascicularis). Journal of Clinical Endocrinology and Metabolism 67 284-290.
43. Weinbauer GF, Behre HM & Nieschlag E 1992 Human FSH transiently stimulates size and spermatogenesis in the adult non-human primate. Acta Endocrinologica 126 (Suppl 4) 97.
44. Weinbauer GF, Limberger A, Behre HM & Nieschlag E 1994 Can testosterone alone maintain the gonadotrophin-releasing hormone antagonist-induced suppression of spermatogenesis in the non-human primate? Journal of Endocrinology 142 485-495.
45. Weinbauer GF, Schubert J, Yeung CH, Rosiepen G & Nieschlag E 1998 Gonadotrophin-releasing hormone antagonist arrests premeiotic germ cell proliferation but does not inhibit meiosis in the male monkey: a quantitative analysis using 5-bromodeoxyuridine and dual parameter flow cytometry. Journal of Endocrinology 156 23-34.
46. Weinbauer GF, Gromoll J, Simoni S & Nieschlag E 2000 Physiology of testicular function. In Andrology: Male Reproductive Health and Dysfunction, edn 2, pp. 23-61. Eds E Nieschlag & HM Behre. Heidelberg: Springer.
47. Weinbauer GF, Aslam H, Krishnamurthy H, Brinkworth MH, Einspanier A & Hodges JK 2001a Quantitative analysis of spermatogenesis and apoptosis in the common marmoset (Callithrix jacchus reveals high rates of spermatogonial turnover and high spermatogenic efficiency. Biology of Reproduction 64 120-126.
48. Weinbauer GF, Schlatt S, Walter V & Nieschlag E 2001b Testosterone-induced inhibition of spermatogenesis is more closely related to suppression of FSH than to testicular androgen levels in the cynomolgus monkey model (Macaca fascicularis). Journal of Endocrinology 168 25-38.
49. World Health Organization 1999 WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction, edn 4. Cambridge: Cambridge University Press.
50. Yeung CH, Morrell JM, Cooper TG, Weinbauer GF, Hodges JK & Nieschlag E 1996 Maturation of sperm motility in the epididymis of the common marmoset (Callithrix jacchus) and the cynomolgus monkey (Macaca fascicularis). International Journal of Andrology 19 113-121.
51. Zhengwei Y, Wreford NG, Royce P, de Kretser DM & McLachlan RI 1998a Stereological evaluation of human spermatogenesis after suppression by testosterone treatment: heterogeneous pattern of spermatogenic impairment. Journal of Clinical Endocrinology and Metabolism 83 1284-1291.
52. Zhengwei Y, Wreford NG, Schlatt S, Weinbauer GF, Nieschlag E & McLachlan RI 1998b Acute and specific impairment of spermatogonial development by GnRH antagonist-induced gonadotrophin withdrawal in the adult macaque (Macaca fascicularis). Journal of Reproduction and Fertility 112 139-147.
53. Zirkin BR 1993 Regulation of spermatogenesis in the adult mammal: gonadotropins and androgens. In Cell and Molecular Biology of the Testis, pp 166-188. Eds C Desjardins & LL Ewing. Oxford: Oxford University Press.