Effects of estrogen on temporal expressions of IL-1β and IL-1ra in rat organotypic hippocampal slices exposed to oxygen-glucose deprivation

Neuroscience Letters

Volumn 438, Issue 2, 2008, Pages 233-237

  Choi, Ji Seung ^a   Kim, Soo Jung ^a   Shin, Jin A ^a   Lee, Kyung Eun ^a   Park, Eun Mi ^a  

^a Ewha Womans University School of Medicine   (South Korea)

Author keywords

Anti inflammation; Estrogen; IL 1 ; IL 1ra; Organotypic hippocampal slice; Oxygen glucose deprivation

Indexed keywords

ESTRADIOL; GLUCOSE; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA; MESSENGER RNA; OXYGEN;

ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN SLICE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; ESTROGEN ACTIVITY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; NERVE CELL NECROSIS; NEUROCHEMISTRY; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; TREATMENT DURATION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL DEATH; CELL SURVIVAL; CYTOPROTECTION; DOWN-REGULATION; ENCEPHALITIS; ESTRADIOL; ESTROGENS; HIPPOCAMPUS; HYPOXIA-ISCHEMIA, BRAIN; INDICATORS AND REAGENTS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; PROPIDIUM; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TIME FACTORS; UP-REGULATION;

EID: 43849112021     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2008.04.026     Document Type: Article

References (32)

1. Abrahamsen B., Shalhoub V., Larson E.K., Eriksen E.F., Beck-Nielsen H., and Marks Jr. S.C. Cytokine RNA levels in transiliac bone biopsies from healthy early postmenopausal women. Bone 26 (2000) 137-145
2. Arend W.P. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 13 (2002) 323-340
3. Betz A.L., Yang G.Y., and Davidson B.L. Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain. J. Cereb. Blood Flow Metab. 15 (1995) 547-551
4. Chiappetta O., Gliozzi M., Siviglia E., Amantea D., Morrone L.A., Berliocchi L., Bagetta G., and Corasaniti M.T. Evidence to implicate early modulation of interleukin-1beta expression in the neuroprotection afforded by 17beta-estradiol in male rats undergone transient middle cerebral artery occlusion. Int. Rev. Neurobiol. 82 (2007) 357-372
5. Corasaniti M.T., Amantea D., Russo R., Piccirilli S., Leta A., Corazzari M., Nappi G., and Bagetta G. 17beta-estradiol reduces neuronal apoptosis induced by HIV-1 gp120 in the neocortex of rat. Neurotoxicology 26 (2005) 893-903
6. Dirnagl U., Iadecola C., and Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci. 22 (1999) 391-397
7. Gahwiler B.H. Organotypic cultures of neural tissue. Trends Neurosci. 11 (1988) 484-489
8. Hallenbeck J.M. Significance of the inflammatory response in brain ischemia. Acta Neurochir. Suppl. 66 (1996) 27-31
9. Johnson A.B., Bake S., Lewis D.K., and Sohrabji F. Temporal expression of IL-1beta protein and mRNA in the brain after systemic LPS injection is affected by age and estrogen. J. Neuroimmunol. 174 (2006) 82-91
10. Jung Y.J., Park S.J., Park J.S., and Lee K.E. Glucose/oxygen deprivation induces the alteration of synapsin I and phosphosynapsin. Brain Res. 996 (2004) 47-54
11. Laake J.H., Haug F.M., Wieloch T., and Ottersen O.P. A simple in vitro model of ischemia based on hippocampal slice cultures and propidium iodide fluorescence. Brain Res. Brain Res. Protoc. 4 (1999) 173-184
12. Liao S.L., Chen W.Y., and Chen C.J. Estrogen attenuates tumor necrosis factor-alpha expression to provide ischemic neuroprotection in female rats. Neurosci. Lett. 330 (2002) 159-162
13. Lindberg M.K., Moverare S., Eriksson A.L., Skrtic S., Gao H., Dahlman-Wright K., Gustafsson J.A., and Ohlsson C. Identification of estrogen-regulated genes of potential importance for the regulation of trabecular bone mineral density. J. Bone Miner. Res. 17 (2002) 2183-2195
14. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
15. Loddick S.A., and Rothwell N.J. Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J. Cereb. Blood Flow Metab. 16 (1996) 932-940
16. Loddick S.A., Wong M.L., Bongiorno P.B., Gold P.W., Licinio J., and Rothwell N.J. Endogenous interleukin-1 receptor antagonist is neuroprotective. Biochem. Biophys. Res. Commun. 234 (1997) 211-215
17. Nordell V.L., Scarborough M.M., Buchanan A.K., and Sohrabji F. Differential effects of estrogen in the injured forebrain of young adult and reproductive senescent animals. Neurobiol. Aging 24 (2003) 733-743
18. Park E.M., Cho S., Frys K.A., Glickstein S.B., Zhou P., Anrather J., Ross M.E., and Iadecola C. Inducible nitric oxide synthase contributes to gender differences in ischemic brain injury. J. Cereb. Blood Flow Metab. 26 (2006) 392-401
19. Park E.M., Hong S., and Lee K.E. Estrogen pretreatment of organotypic hippocampal slices protects neurons against oxygen-glucose deprivation with Akt activation. Korean J. Physiol. Pharmacol. 10 (2006) 123-130
20. Relton J.K., and Rothwell N.J. Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat. Brain Res. Bull. 29 (1992) 243-246
21. Rogers A., and Eastell R. Effects of estrogen therapy of postmenopausal women on cytokines measured in peripheral blood. J. Bone Miner. Res. 13 (1998) 1577-1586
22. Santizo R.A., Anderson S., Ye S., Koenig H.M., and Pelligrino D.A. Effects of estrogen on leukocyte adhesion after transient forebrain ischemia. Stroke 31 (2000) 2231-2235
23. Strasser U., and Fischer G. Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation. J. Neurosci. Methods 57 (1995) 177-186
24. Suzuki S., Brown C.M., Dela Cruz C.D., Yang E., Bridwell D.A., and Wise P.M. Timing of estrogen therapy after ovariectomy dictates the efficacy of its neuroprotective and antiinflammatory actions. Proc. Natl. Acad. Sci. U.S.A. 104 (2007) 6013-6018
25. Tarkowski E., Liljeroth A.M., Minthon L., Tarkowski A., Wallin A., and Blennow K. Cerebral pattern of pro- and anti-inflammatory cytokines in dementias. Brain Res. Bull. 61 (2003) 255-260
26. Touzani O., Boutin H., Chuquet J., and Rothwell N. Potential mechanisms of interleukin-1 involvement in cerebral ischaemia. J. Neuroimmunol. 100 (1999) 203-215
27. Vezzani A., Moneta D., Richichi C., Aliprandi M., Burrows S.J., Ravizza T., Perego C., and De Simoni M.G. Functional role of inflammatory cytokines and antiinflammatory molecules in seizures and epileptogenesis. Epilepsia 43 Suppl. 5 (2002) 30-35
28. Wang Q., Tang X.N., and Yenari M.A. The inflammatory response in stroke. J. Neuroimmunol. 184 (2007) 53-68
29. Wang X., Li X., Currie R.W., Willette R.N., Barone F.C., and Feuerstein G.Z. Application of real-time polymerase chain reaction to quantitate induced expression of interleukin-1beta mRNA in ischemic brain tolerance. J. Neurosci. Res. 59 (2000) 238-246
30. Wei R., Listwak S.J., and Sternberg E.M. Lewis hypothalamic cells constitutively and upon stimulation express higher levels of mRNA for pro-inflammatory cytokines and related molecules: comparison with inflammatory resistant Fischer rat hypothalamic cells. J. Neuroimmunol. 135 (2003) 10-28
31. Wood P.L. Microglia as a unique cellular target in the treatment of stroke: potential neurotoxic mediators produced by activated microglia. Neurol. Res. 17 (1995) 242-248
32. Yamasaki Y., Matsuura N., Shozuhara H., Onodera H., Itoyama Y., and Kogure K. Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats. Stroke 26 (1995) 676-680 discussion 681