17β-estradiol reduces neuronal apoptosis induced by HIV-1 gp120 in the neocortex of rat

NeuroToxicology

Volumn 26, Issue 5, 2005, Pages 893-903

  Corasaniti, M T ^a   Amantea, D ^b   Russo, R ^a   Piccirilli, S ^c   Leta, A ^b   Corazzari, M ^d   Nappi, G ^e   Bagetta, G ^b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^e C MONDINO NATIONAL NEUROLOGICAL INSTITUTE   (Italy)

Author keywords

17 Estradiol (E 2); gp120; HIV 1 associated dementia (HAD)

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; FULVESTRANT; GLYCOPROTEIN GP 120; INTERLEUKIN 1BETA; TAMOXIFEN; VIRUS GLYCOPROTEIN; INTERLEUKIN 1; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BRAIN; BRAIN INFECTION; BRAIN TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; DEMENTIA; DRUG MECHANISM; ESTROGEN ACTIVITY; HUMAN IMMUNODEFICIENCY VIRUS 1; MALE; MOLECULAR MECHANICS; NEOCORTEX; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; VIRUS INFECTION; ANIMAL; ARTICLE; BRAIN LEVEL; CYTOLOGY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; METABOLISM; NERVE CELL; NICK END LABELING; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WISTAR RAT;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BLOTTING, WESTERN; BRAIN CHEMISTRY; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTRADIOL; HIV ENVELOPE PROTEIN GP120; HUMANS; IN SITU NICK-END LABELING; INTERLEUKIN-1; MALE; NEOCORTEX; NEURONS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 26444598059     PISSN: 0161813X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuro.2005.01.019     Document Type: Conference Paper

References (65)

1. G. Bagetta, M.T. Corasaniti, L. Aloe, L. Berliocchi, N. Costa, and A. Finazzi-Agrò HIV-1 gp120 produces DNA fragmentation in the cerebral cortex of rat Biochem Biophys Res Commun 211 1995 130 136
2. G. Bagetta, M.T. Corasaniti, L. Aloe, L. Berliocchi, N. Costa, and A. Finazzi-Agrò Intracerebral injection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat Proc Natl Acad Sci USA 93 1996 928 933
3. G. Bagetta, M.T. Corasaniti, W. Malorni, G. Rainaldi, N. Costa, and L. Berliocchi The HIV-1 gp120 causes ultrastructural changes typical of apoptosis in the rat cerebral cortex Neuroreport 7 1996 1722 1724
4. G. Bagetta, M.T. Corasaniti, A.M. Paoletti, L. Berliocchi, R. Nisticò, and A.M. Giammaroli HIV-1 gp120-induced apoptosis in the rat neocortex involves enhanced expression of cyclo-oxygenase type-2 (COX-2) Biochem Biophys Res Commun 244 1998 819 824
5. G. Bagetta, M.T. Corasaniti, L. Berliocchi, R. Nisticò, A.M. Giammaroli, and W. Malorni Involvement of interleukin-1β in the mechanism of human immunodeficiency virus type 1 (HIV-1) recombinant protein gp120-induced apoptosis in the neocortex of rat Neuroscience 89 1999 1051 1066
6. P. Bezzi, G. Carmignoto, L. Pasti, S. Vesce, D. Rossi, and B.L. Rizzino Prostaglandins stimulate calcium-dependent glutamate release in astrocytes Nature 391 1998 281 285
7. S. Brooke, R. Chan, S. Howard, and R. Sapolski Endocrine modulation of the neurotoxicity of gp120: implications for AIDS-related dementia complex Proc Natl Acad Sci USA 94 1997 9457 9462
8. S.M. Brooke, J.R. McLaughlin, K.M. Cortopassi, and R.M. Sapolski Effect of gp120 on glutathione peroxidase activity in cortical cultures and the interaction with steroid hormones J Neurochem 81 2002 277 284
9. H. Budka Neuropathology of human immunodeficiency virus infection Brain Pathol 1 1991 163 175
10. N.G. Carlson, W.A. Wieggel, J. Chen, A. Bacchi, S.W. Rogers, and L.C. Gahring Inflammatory cytokines IL-1α, IL-1β, IL-6 and TNF-α impart neuroprotection to an excitotoxin through distinct pathways J Immunol 163 1999 3963 3968
11. A. Chiesi, S. Vella, L.G. Dally, C. Pedersen, S. Danner, and A.M. Johnson Epidemiology of AIDS dementia complex in Europe. AIDS in Europe study group J Acquir Immune Defic Syndr Hum Retrovirol 11 1996 39 44
12. R.A. Clark, and R. Bessinger Clinical manifestations and predictors of survival in older women infected with HIV J Acquir Immune Defic Syndr Hum Retrovirol 15 1997 341 345
13. A. Coogan, and J.J. O'Connor Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1 beta Neuroreport 8 1997 2107 2110
14. M.T. Corasaniti, M.C. Strongoli, S. Piccirilli, R. Nisticò, A. Costa, and A. Bilotta Apoptosis induced by gp120 in the neocortex of rat involves enhanced expression of cyclooxygenase type 2 (COX-2) and is prevented by NMDA receptor antagonist and by the 21-aminosteroid U-74389G Biochem Biophys Res Commun 274 2000 664 669
15. M.T. Corasaniti, A. Bilotta, M.C. Strongoli, M. Navarra, G. Bagetta, and G. Di Renzo HIV-1 coat protein gp120 stimulates interleukin-1β secretion from human neuroblastoma cells: evidence for a role in the mechanism of cell death Br J Pharmacol 134 2001 1344 1350
16. M.T. Corasaniti, M. Maccarrone, R. Nisticò, W. Malorni, D. Rotiroti, and G. Bagetta Exploitation of the HIV-1 coat glycoprotein, gp120, in neurodegenerative studies in vivo J Neuochem 79 2001 1 8
17. M.T. Corasaniti, S. Piccirilli, A. Paoletti, R. Nisticò, A. Stringaro, and W. Malorni Evidence that the HIV-1 coat protein gp120 causes neuronal apoptosis in the neocortex of rat via a mechanism involving CXCR4 chemokine receptor Neurosci Lett 312 2001 67 70
18. M.T. Corasaniti, P. Turano, A. Bilotta, W. Malorni, A.R. Stringaro, and R. Nisticò Evidence that increases of mitochondrial immunoreactive IL-1β by HIV-1 gp120 implicate in situ cleavage of pro-IL-1β in the neocortex of rat J Neurochem 78 2001 611 618
19. M. Curran, and L. Wiseman Fulvestrant Drugs 61 2001 807 813
20. D.B. Dubal, P.J. Shughrue, M.E. Wilson, I. Merchenthaler, and P.M. Wise Estradiol modulates bcl-2 in cerebral ischemia: a potential role for estrogen receptors J Neurosci 19 1999 6385 6393
21. M.J. Evans, K. Lai, L.J. Shaw, D.C. Harnish, and C.C. Chadwick Estrogen receptor α inhibits IL-1β induction of gene expression in the mouse liver Endocrinology 143 2002 2559 2570
22. I.P. Everall, P.J. Luthert, and P.L. Lantos Neuronal loss in the frontal cortex in HIV infection Lancet 337 1991 1119 1121
23. R. Galien, and T. Garcia Estrogen receptor impairs interleukin-6 expression by preventing protein binding on the NF-κB site Nucleic Acid Res 25 1997 2424 2429
24. L.M. Garcia-Segura, I. Azcoitia, and L.L. Don Carlos Neuroprotection by estradiol Prog Neurobiol 63 2001 29 60
25. L.M. Garcia-Segura, F. Cardona-Gomez, F. Naftolin, and J.A. Chowen Estradiol upregulates Bcl-2 expression in adult brain neurons NeuroReport 9 1998 593 597
26. Y. Gavrieli, Y. Sherman, and S.A. Ben-Sasson Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation J Cell Biol 119 1992 493 501
27. P. Hagan, S. Poole, A.F. Bristow, F. Tilders, and F.S. Silverstein Intracerebral NMDA injection stimulates production of interleukin-1β in perinatal rat brain J Neurochem 67 1996 2215 2218
28. J. Hesselgesser, D. Taub, P. Baskar, M. Greenberg, J. Hoxie, and D.L. Kolson Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4 Curr Biol 8 1998 595 598
29. S. Howard, S. Brooke, and R. Sapolski Mechanisms of estrogenic protection against gp120-induced neurotoxicity Exp Neurol 168 2001 385 391
30. R.L. Jilka, G. Hangoc, G. Girasole, G. Passeri, D.C. Williams, and J.S. Abrams Increased osteoclast development after estrogen loss: mediation by interleukin-6 Science 257 1992 88 91
31. H. Kan, Z. Xie, and M.S. Finkel HIV gp120 enhances NO production by cardiac myocytes through p38 MAP kinase-mediated NF-kB activation Am J Physiol Heart Circ Physiol 279 2000 3138 3143
32. S.A. Lipton, and H.E. Gendelman Dementia associated with the acquired immunodeficiency syndrome New Engl J Med 332 1995 934 940
33. M. Maccarrone, M. Bari, M.T. Corasaniti, R. Nisticò, G. Bagetta, and A. Finazzi-Agrò HIV-1 coat glycoprotein gp120 induces apoptosis in rat brain neocortex by deranging the arachidonate cascade in favour of prostanoids J Neurochem 75 2000 196 203
34. S.E. McKenna, N.G. Simon, and A. Cologer-Clifford An assessment of agonist/antagonist effects of tamoxifen in the female mouse brain Horm Behav 26 1992 536 544
35. A. Maggi, P. Ciana, S. Belcredito, and E. Vegeto Estrogens in the nervous sytem: mechanisms and nonreproductive functions Annu Rev Physiol 66 2004 291 313
36. A. Matejuk, K. Adlard, A. Zamora, M. Silverman, A.A. Vandenbark, and H. Offner 17 beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis J Neurosci Res 65 2001 529 542
37. L.G. Miller, and J.M. Fahey Interleukin-1 modulates GABAergic and glutamatergic function in brain Ann NY Acad Sci 739 1994 292
38. C.A. Murray, B. Mcgahon, S. Mcbennett, and M.A. Lynch Interleukin-1β inhibits glutamate release in hippocampus of young, but not aged, rats Neurobiol Aging 18 1997 343 348
39. J. Nilsen, and R.D. Brinton Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression Proc Natl Acad Sci USA 100 2003 2842 2847
40. S. Ogawa, D.B. Lubahn, K.S. Korach, and D.W. Pfaff Behavioral effects of estrogen receptor gene disruption in male mice Proc Natl Acad Sci USA 94 1997 1476 1481
41. S. Ogawa, J. Chan, A.E. Chester, J.A. Gustafsson, K.S. Korach, and D.W. Pfaff Survival of reproductive behaviours in estrogen receptor beta gene-deficient (βERKO) male and female mice Proc Natl Acad Sci USA 96 1999 12887 12892
42. T. Ohtsuki, C.A. Ruetzler, K. Tasaki, and J.M. Hallenbeck Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampus CA1 neurons J Cereb Blood Flow Metab 16 1996 1137 1142
43. J.A. Ospina, H.N. Brevig, D.N. Krause, and S.P. Duckles Estrogen suppresses IL-1beta-mediated induction of COX-2 pathway in rat cerebral blood vessels Am J Physiol Heart Circ Physiol 286 2004 H2010 H2019
44. G. Paxinos, and C. Watson The rat brain in stereotaxic coordinates 1998 Academic Press San Diego (CA)
45. C.R. Plata-Salaman, and J.M. Ffrench-Mullen Interleukin-1β depresses calcium currents in CA1 hippocampal neurons at pathophysiological concentrations Brain Res Bull 29 1992 221 223
46. A.K. Pringle, N. Niyadurupola, P. Johns, D.C. Anthony, and F. Iannotti Interleukin-1beta exacerbates hypoxia-induced neuronal damage, but attenuates toxicity produced by simulated ischemia and excitotoxicity in rat organotypic hippocampal slice cultures Neurosci Lett 305 2001 29 32
47. R.W. Price, B. Brew, J. Sidtis, M. Rosenblum, A.C. Scheck, and P. Cleary The brain and AIDS: central nervous system HIV-1 infection and AIDS dementia complex Science 239 1988 586 592
48. A. Ray, K.E. Prefontaine, and P. Rau Down-modulation of interleukin-6 gene expression by 17β-estradiol in the absence of high affinity DNA binding by the estrogen receptor J Biol Chem 269 1994 12940 12946
49. E.F. Rissman, A.H. Early, J.A. Taylor, K.S. Korach, and D.B. Lubahn Estrogen receptors are essential for female sexual receptivity Endocrinology 138 1997 507 510
50. Robertson K, Vaughn B, Kapoor C, Robertson W, Kalkowski J, Fiscus S, et al. Gender and neurological functioning in HIV infection. Conference on Human Retroviruses and Related Infections; 2000. Abs. # 297.
51. N.J. Rothwell Cytokines-killers in the brain? J Physiol 514 1999 3 17
52. N.J. Rothwell, and P.J. Strijbos Cytokines in neurodegeneration and repair Int J Dev Neurosci 13 1995 179 185
53. B. Stein, and M.X. Yang Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPδ Mol Cell Biol 15 1995 4971 4979
54. M.F. Stins, D. Pearce, F. Di Cello, A. Erdreich-Epstein, C.A. Pardo, and K. Sik Kim Induction of intercellular adhesion molecule-1 on human brain endothelial cells by HIV-1 gp120: role of CD4 and chemokine coreceptors Lab Invest 83 2003 1787 1798
55. P.J. Strijbos, and N.J. Rothwell Interleukin-1β attenuates the excitatory amino aid-induced neurodegeneration in vitro: involvement of nerve growth factor J Neurosci 15 1995 3468 3474
56. W.H. Sun, E.T. Keller, B.S. Stebler, and W.B. Ershler Estrogen inhibits phorbol ester-induced IκBα transcription and protein degradation Biochem Biophys Res Commun 244 1998 691 695
57. J. Turchan, C. Anderson, K.F. Hauser, Q. Sun, J. Zhang, and Y. Liu Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine BMC Neurosci 2 2001 3
58. B. Viviani, S. Bartesaghi, F. Gardoni, A. Mezzani, M.M. Behrens, and T. Bartfai Interleukin 1-β enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases J Neurosci 23 2003 8692 8700
59. X. Wang, X. Li, R.W. Currie, R.N. Willette, F.C. Barone, and G.Z. Feuerstein Application of real-time polymerase chain reaction to quantitate induced expression of interleukin-1β mRNA in ischemic brain tolerance J Neurosci Res 59 2000 238 246
60. C.A. Wiley, E. Masliah, M. Morey, C. Lemere, R. DeTeresa, and M. Grafe Neocortical damage during HIV infection Ann Neurol 29 1991 651 657
61. P.M. Wise Estrogens and neuroprotection Trends Endocrinol Met 13 2002 229 230
62. Y. Yamasaki, N. Matsuura, H. Shozuhara, H. Onodera, Y. Itoyama, and K. Kogure Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats Stroke 26 1995 676 680
63. M.L. Zeise, S. Madamba, and G.R. Siggins Interleukin-1β increases synaptic inhibition in rat hippocampal pyramidal neurons in vitro Regul Pept 39 1992 1 7
64. I. Zemlyak, S.M. Brooke, and R.M. Sapolski Protection against gp120-induced neurotoxicity by an array of estrogenic steroids Brain Res 958 2002 272 276
65. L. Zhao, T. Wu, and D.R. Brinton Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Brain Res 1010 2004 22 34