Effects of estrogen therapy of postmenopausal women on cytokines measured in peripheral blood

Journal of Bone and Mineral Research

Volumn 13, Issue 10, 1998, Pages 1577-1586

  Rogers, Angela ^a   Eastell, Richard ^a,b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b NORTHERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRACOMBI; ESTROGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYDROCORTISONE; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PREMPAK; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SAMPLING; BONE ATROPHY; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SPECIFICITY; ESTROGEN THERAPY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; OSTEOLYSIS; POSTMENOPAUSE; RECEPTOR BINDING;

ADMINISTRATION, CUTANEOUS; BONE AND BONES; CELLS, CULTURED; CYTOKINES; ESTRADIOL; ESTROGEN REPLACEMENT THERAPY; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-1; INTERLEUKIN-6; LEUKOCYTES; LIPOPOLYSACCHARIDES; MIDDLE AGED; MONOCYTES; NORETHINDRONE; POSTMENOPAUSE; RECEPTORS, INTERLEUKIN-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031667369     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1998.13.10.1577     Document Type: Article

References (42)

1. Ettinger B, Genant HK, Cann CE 1985 Long-term estrogen replacement therapy prevents bone loss and fractures. Ann Intern Med 102:319-324.
2. Nguyen TV, Jones G, Sambrook PN, White CP, Kelly PJ, Eisman JA 1995 Effects of estrogen exposure and reproductive factors on bone mineral density and osteoporotic fractures. J Clin Endocrinol Metab 80:2709-2714.
3. Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL 1988 Evidence of estrogen receptors in normal human osteoblast-like cells. Science 241:84-86.
4. Gray TK, Flynn TC, Gray KM, Nabell LM 1987 17β-estradiol acts directly on the clonal osteoblastic cell line UMR106. Proc Natl Acad Sci USA 84:6267-6271.
5. Ernst M, Heath JK, Schmid C, Froesch ER, Rodan GA 1989 Evidence for a direct effect of estrogen on bone cells in vitro. J Steroid Biochem 34:279-284.
6. Scheven BAA, Damen CA, Hamilton NJ, Vehaar HJJ, Sijmen AD 1992 Stimulatory effects of estrogen and progesterone on proliferation and differentation of normal human osteoblast-like cells in vitro. Biochem Biophys Res Commun 186:54-60.
7. Robinson J, Harriss SA, Riggs BL, Spelsberg TC 1997 Estrogen regulation of human osteoblastic cell proliferation and differentiation. Endocrinology 138:2919-2927.
8. Keeting PE, Scott RE, Colvard DS, Han IK, Spelsberg TC, Riggs BL 1991 Lack of a direct effect of estrogen on proliferation and differentiation of normal human osteoblast-like cells. J Bone Miner Res 6:297-304.
9. Gowen M 1994 Cytokines and cellular interactions in the control of bone remodelling. Bone Miner 8:77-105.
10. Russell RGG 1990 Bone cell biology: The role of cytokines and other mediators. In: Smith R (ed.) Osteoporosis, 2nd Ed. Royal College Physicians, London, U.K., pp. 9-33.
11. Gray TK 1989 Estrogens and the skeleton: Cellular and molecular mechanisms. J Steroid Biochem 34:285-287.
12. Horowitz MC 1993 Cytokines and estrogen in bone: Antiosteoporotic effects. Science 260:626-627.
13. Pacifici R, Rifas L, McCracken R, Vered I, McMurtry C, Avioli LV, Peck WA 1989 Ovarian steroid treatment blocks a postmenopausal increase in blood monocyte interleukin 1 release. Proc Natl Acad Sci USA 86:2398-2402.
14. Pacifici R, Brown C, Puscheck E, Friedrich E, Slatopolsky E, Maggio D, McCracken R, Avioli LV 1991 Effect of surgical menopause and estrogen replacement on cytokine release from human blood mononuclear cells. Proc Natl Acad Sci USA 88:5134-5138.
15. Gowen M, Ralston SH, Russell RGG 1989 Estrogen inhibits the release of tumor necrosis factor by peripheral blood mononuclear cells from women with postmenopausal osteoporosis, but not from men or premenopausal women. J Bone Miner Res 4 (Suppl 1):S255.
16. Ralston SH, Russell RGG, Gowen M 1990 Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women. J Bone Miner Res 5:983-988.
17. Stock JL, Coderse JA, McDonald B, Rosenwasser LJ 1989 Effects of estrogen in vivo and in vitro on spontaneous interleukin-1 release by monocytes from postmenopausal women. J Clin Endocrinol Metab 68:364-368.
18. Gowen M, Wood DD. Ihrie EJ, McGuire MKB, Russell RGG 1983 An interleukin 1 like factor stimulates bone resorption in vitro. Nature 306:378-380.
19. Hannum CH, Wilcox CJ, Arend WP, Joslin FG, Dripps DJ, Heimdal PL, Armes LG, Sommer A, Eisenberg SP, Thompson RC 1990 Interleukin-1 receptor antagonist activity of human interleukin-1 inhibitor. Nature 343:336-340.
20. Guise TA, Garrett IR, Bonewald LF, Mundy GR 1993 Interleukin-1 receptor antagonist inhibits the hypercalcemia mediated by interleukin-1. J Bone Miner Res 8:583-587.
21. Mundy GR 1993 Cytokines and growth factors in the regulation of bone remodeling. J Bone Miner Res 8:S505-S510.
22. Kimble RB, Kitazawa R, Vannice JL, Pacifici R 1994 Persistent bone-sparing effect of interleukin-1 receptor antagonist: A hypothesis on the role of IL-1 in ovariectomy-induced bone loss. Calcif Tissue Int 55:260-265.
23. Khosla S, Peterson JM, Egan K, Jones JD, Riggs BL 1994 Circulating cytokine levels in osteoporotic and normal women. J Clin Endocrinol Metab 79:707-711.
24. Pacifici R 1992 Is there a causal role for IL-1 in postmenopausal bone loss? Calcif Tissue Int 50:295-299.
25. Pacifici R, Vannice JL, Rifas L, Kimble RB 1993 Monocytic secretion of interleukin-1 receptor antagonist in normal and osteoporotic women: Effects of menopause and estrogen/progesterone therapy. J Clin Endocrinol Metab 77:1135-1141.
26. Cohen-Solal ME, Graulef AM, Denne MA, Gueris J, Baylink D, Devernejoul MC 1993 Peripheral monocyte culture supernatants of menopausal women can induce bone resorption: Involvement of cytokines. J Clin Endocrinol Metab 77:1648-1653.
27. Pacifici R, Avioli LV 1993 The effect of natural and surgical menopause on the secretion of cytokines from human blood monocytes. Osteoporos Int Suppl 1:S106-S107.
28. De Groote D, Zangerle PF, Gevaert Y, Fassotte MF, Beguin Y, Noizat-Pirenne F, Pirenne J, Gathy R, Lopez M, Dehart I, et al. 1992 Direct stimulation of cytokines (IL-1-beta, TNF-alpha-IL-6, IL-2, IFN-gamma and GM-CSF) in whole blood. I. Comparison with isolated PBMC stimulation. Cytokine 4:239-248.
29. Zheng X, Vrindts Y, De Groote D, Franchimont F 1998 Direct stimulation of cytokines (IL-1beta, IL-2, IL-6, TNF-alpha, IFN-gamma, GM-CSF, LIF) in whole blood: Differences between normal and osteoporotic women. J Bone Miner Res 9:S332 (abstract).
30. Rickard DJ, Russell RGG, Gowen M 1992 Oestradiol inhibits the release of tumor necrosis factor but not IL-6 from adult human osteoblasts in vitro. Osteoporos Int 2:94-102.
31. Girasole G, Jilka RL, Passeri G, Boswell S, Boder G, Williams DC, Manolagas SC 1992 17β estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: A potential mechanisim for the antiosteoporotic effect of estrogens. J Clin Invest 89:883-891.
32. Manolagas SC, Bellido T, Jilka RL 1995 Sex steroids, cytokines and the bone marrow: New concepts on the pathogenesis of osteoporosis. Ciba Found Symp 191:187-196; discussion 197-2.
33. Manolagas SC, Jilka RL 1995 Bone marrow, cytokines, and bone remodeling: Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332:305-311.
34. Manolagas SC, Bellido T, Jilka RL 1995 New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: Roles of il-6 and gp130. Int J Immunopharmacol 17:109-116.
35. Jilka RL, Hangoc G, Girasole G, Passeri G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC 1992 Increased osteoclast development after estrogen loss - Mediation by interleukin-6. Science 257:88-91.
36. Maruo N, Chen JT, Ogata E, Shiraki M, Morita I 1996 Serum level of soluble interleukin-6 receptor is correlated with the change of bone density during estrogen therapy. J Bone Miner Res 11 (Suppl. 1):S118 (abstract 94).
37. Heaney M, Golde D 1996 Soluble cytokine Receptors. Blood 87:847-857.
38. Cohen-Solal ME, Graulet AM, Gueris J, Denne MA, Bergot C, Morieux C, Sedel L, Kuntz D, de Vernejoul MC 1995 Bone resorption at the femoral neck is dependent on local factors in nonosteoporotic late postmenopausal women: An in vitro-in vivo study. J Bone Miner Res 10:307-314.
39. De Groote D, Gevaert Y, Lopez M, Gathy R, Fauchet F, Dehart I, Jadoul M, Radoux D, Franchimont P 1993 Novel method for the measurement of cytokine production by a one stage procedure. J Immunol Meth 163:259-267.
40. Elasser-Beile U, von Kleist S, Stahle W, Schurhammer-Fuhrmann C, Monting JS, Gallati H 1993 Cytokine levels in whole blood cultures as parameters of the cellular immunologic activity in patients with malignant melanoma and basal cell carcinoma. Cancer 71:231-236.
41. Nerad JL, Griffiths JK, Van der Meer JWM, Endres S, Poutsiaka DD, Keutsch GT, Bennish M, Salam MA, Dinarello CA, Cannon JG 1992 Interleukin-1β, interleukin-1 receptor antagonist and TNFα production in whole blood. J Leukocyte Biol 52:687-692.
42. Kassem M, Khosla S, Spelsberg TC, Riggs BL 1996 Cytokine production in the bone marrow microenvironment: Failure to demonstrate estrogen regulation in early postmenopausal women. J Clin Endocrinol Metab 81:513-518.