Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 4,4′-butylidenebis(2-tert-butyl-5-methylphenol) and 3-(dibutylamino) phenol, based on the OECD draft protocols

Archives of Toxicology

Volumn 82, Issue 5, 2008, Pages 301-311

  Yamasaki, Kanji ^a   Miyata, Katusi ^a   Shiraishi, Keiji ^a   Muroi, Takako ^a   Higashihara, Nobuhiko ^a   Oshima, Hiroshi ^a   Minobe, Yasushi ^a  

^a CHEMICALS EVALUATION AND RESEARCH INSTITUTE   (Japan)

Author keywords

3 (Dibutylamino) phenol; 4,4 Butylidenebis(2 tert butyl 5 methylphenol); Endocrine effects; Enhanced Test Guideline 407; Hershberger assay; Rat; Uterotrophic assay

Indexed keywords

3 (DIBUTYLAMINO)PHENOL; 4,4' BUTYLIDENEBIS(2 TERT BUTYL 5 METHYLPHENOL); LIOTHYRONINE; PHENOL DERIVATIVE; THYROTROPIN; THYROXINE;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CASTRATION; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; HERSHBERGER ASSAY; HORMONE DETERMINATION; LIOTHYRONINE BLOOD LEVEL; LIVER FUNCTION; LIVER WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEMEN ANALYSIS; SPRAGUE DAWLEY RAT; THYROID FOLLICLE CELL; THYROID HYPERPLASIA; THYROID WEIGHT; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; UTEROTROPHIC ASSAY; UTERUS WEIGHT;

ADMINISTRATION, ORAL; ANIMALS; ENDOCRINE DISRUPTORS; FEMALE; GENITALIA, MALE; GUIDELINES AS TOPIC; HEMOSIDERIN; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; ORGAN SIZE; PHENOLS; RATS; RATS, SPRAGUE-DAWLEY; SPLEEN; STOMACH; THYROID GLAND; THYROID HORMONES; UTERUS;

RATTUS;

EID: 43749101882     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-007-0250-1     Document Type: Article

References (32)

1. Andrews P, Freyberger A, Hartmann E, Eiben R, Loof I, Schmidt U, Temerowski M, Becka M (2001) Feasibility and potential gains of enhancing the subacute rat study protocol (OECD test guideline no. 407) by additional parameters selected to determine endocrine modulation. A pre-validation study to determine endocrine-mediated effects of the antiandrogenic drug flutamide. Arch Toxicol 75:65-73
2. Cosmetic Industry Review (1988) Final report on the safety assessment of p-aminophenol, m-aminophenol, and o-aminophenol. J Am Coll Toxicol 7:279-333
3. Fowler LM, Foster JR, Lock EA (1993) Effect of ascorbic acid, acivicin and probenecid on the nephrotoxicity of 4-aminophenol in the Fischer 344 rats. Arch Toxicol 67:613-621
4. Gelbke HP, Hofmann A, Owens JW, Freyberger A (2007) The enhancement of the subacute repeat dose toxicity test OECD TG 407 for the detection of endocrine active chemicals: comparison with toxicity tests of longer duration. Arch Toxicol 81:227-250
5. Kennel P, Pallen C, Barale-Thomas E, Espuna G, Bars R (2003) Tamoxifen: 28-day oral toxicity study in the rat based on the enhanced OECD test guideline 407 to detect endocrine effects. Arch Toxicol 77:487-489
6. Koizumi M, Nishimura N, Enami T, Sunaga M, Horikawa H, Kamata E, Hasegawa R (2002) Comparative toxicity study of 3-animophenol in newborn and young rats. J Toxicol Sci 28:59-70
7. Kunimatsu T, Yamada T, Miyata K, Yabushita S, Seki T, Okuno Y, Matsuo M (2004) Evaluation for reliability and feasibility of the draft protocol for the enhanced rat 28-day subacute study (OECD guideline 407) using androgen antagonist flutamide. Toxicology 2000:77-89
8. Mellert W, Deckardt K, Walter J, Gfatter S, van Ravenzwaay B (2003) Detection of endocrine-modulating effects of the antithyroid acting drug 6-propyl-2-thiouracil in rats, based on the "enhanced OECD test guideline 407". Regul Toxicol Pharmacol 38:368-377
9. Miyata K, Shiraishi S, Houshuyama S, Imatanaka N, Umano T, Minobe Y, Yamasaki K (2006) Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the "Enhanced OECD Test Guideline no. 407". Arch Toxicol 80:181-186
10. OECD (1999) EMSG OECD draft proposal for testing of adequacy of an enhanced OECD protocol, Repeated dose (28 days) toxicity (oral) study, based on OECD 407. OECD, Paris
11. OECD (2000) OECD protocol for investigating the efficacy of the enhanced TG407 test guideline (phase 2), rationale for the investigation, and description of the protocol. OECD, Paris
12. OECD (2001) Third meeting of the validation management group for the screening and testing of endocrine disrupters (mammalian effects). OECD, Paris
13. OECD (2006) OECD 5th meeting of the validation management group for mammalian effects testing (VMG-Mammalian) of the task force on endocrine disrupters testing and assessment. OECD, Washington
14. OECD (2007) OECD 6th meeting of the validation management group for mammalian effects testing (VMG-Mammalian) of the task force on endocrine disrupters testing and assessment. OECD, Ljubljana
15. Okazaki K, Okazaki S, Nishimura S, Nakamura H, Kitamura Y, Hatayama K, Nakamura A, Tsuda T, Katsumata T, Nishikawa A, Hirose M (2001) A repeated 28-day oral dose toxicity study of methoxychlor in rats, based on the 'enhanced OECD test guideline 407' for screening endocrine-disrupting chemicals. Arch Toxicol 75:513-521
16. Okazaki K, Imazawa T, Nakamura H, Furukawa F, Nishikawa A, Hirose M (2002a) A repeated 28-day oral dose toxicity study of 17α- methyltestosterone in rats, based on the 'enhanced OECD test guideline 407' for screening endocrine-disrupting chemicals. Arch Toxicol 75:635-642
17. Okazaki K, Okazaki S, Nakamura H, Kitamura Y, Hatayama K, Wakabayashi S, Tsuda T, Katsumata T, Nishikawa A, Hirose M (2002b) A repeated 28-day oral dose toxicity study of genisein in rats, based on the 'enhanced OECD test guideline 407' for screening endocrine-disrupting chemicals. Arch Toxicol 76:553-559
18. Rankin GO, Beers KW, Nicoll DW, Anestis DK, Hong SK, Hubbard JL, Ball JG, Valentovic MA, Brown PI (1996) Nephrotoxic potential of 2-amino-5-chlorophenol and 4-amino-3-chlorophenol in Fischer 344 rats: comparisons with 2- and 4-chloroaniline and 2- and 4-aminophenol. Toxicology 108:109-123
19. Re TA, Loehr RF, Rodriguez SC, Rodwell DE, Burnett CM (1984) Results of teratogenicity testing of m-aminophenol in Sprague-Dawley rats. Fundam Appl Toxicol 4:98-104
20. Shin JH, Moon HJ, Kim TS, Kang IH, Kim HY, Choi KS, Han SY (2006a) Repeated 28-day oral toxicity study of vinclozolin in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects. Arch Toxicol 80:547-554
21. Shin JH, Moon HJ, Kang IH, Kim TS, Kim IY, Park IS, Kim HS, Jeung EB, Han SY (2006b) Repeated 28-day oral toxicity study of ketoconazole in rats based on the draft protocol for the "Enhanced OECD Test Guideline No. 407" to detect endocrine effects. Arch Toxicol 80:797-803
22. Shiraishi K, Miyata K, Houshuyama S, Imatanaka N, Umano T, Minobe Y, Yamasaki K (2006) Subacute oral toxicity study of diethylphthalate based on the draft protocol for "Enhanced OECD Test Guideline no. 407". Arch Toxicol 80:10-16
23. Takagi A, Momma J, Aida Y, Takada K, Suzuki S, Naitoh K, Tobe M, Hasegawa R, Kurokawa Y (1992) Toxicity studies of a synthetic antioxidant, 2,2′-methylenebis(4-ethyl-6-tert-butylphenol) in rats. 1. Acute and subchronic toxicity. J Toxicol Sci 17:135-153
24. Takagi A, Kawasaki N, Momma J, Aida Y, Ohno Y, Hasegawa R, Kurokawa Y (1993) Toxicity studies of a synthetic antioxidant, 2,2′-methylenebis(4- ethyl-6-tert-butylphenol) in rats. 2. Uncoupling effects on oxidative phosphorylation of liver mitochondoria. J Toxicol Sci 18:49-55
25. Takagi A, Sekita K, Saitoh M, Kanno J (2005) Acute, subchronic and chronic toxicity studies of a synthetic antioxidant, 2,2′- isobutylidenebis(4,6-dimethylphenol) in rats. J Toxicol Sci 30:275-285
26. Takahashi O, Hiraga K (1981) Effects of four bisphenolic antioxidants on lipid contents of rat liver. Toxicol Lett 8:77-86
27. Takahashi O, Oishi S (2006) Male reproductive toxicity of four bisphenol antioxidants in mice and rats and their estrogenic effects. Arch Toxicol 80:225-241
28. Toyoda K, Shibuntani M, Tamaru T, Koujitani T, Uneyama C, Hirose M (2000) Repeated dose (28 days) oral toxicity study of flutamide in rats, based on the draft protocol for the 'enhanced OECD test guideline 407' for screening for endocrine-disrupting chemicals. Arch Toxicol 74:127-132
29. Wason S, Pohlmeyer-Esch G, Pallen C, Palazzi X, Espina G, Bars R (2003) 17α-methyltestosterone: 28-day oral toxicity study in the rat based on the "enhanced OECD test guideline 407" to detect endocrine effects. Toxicology 192:119-137
30. Woo GH, Shibutani M, Ichiki T, Hamamura M, Lee KY, Inoue K, Hirose MA (2007) Repeated 28-day oral dose toxicity study of nonylphenol in rats, based on the 'Enhanced OECD Test Guideline 407' for screening of endocrine-disrupting chemicals. Arch Toxicol 81:77-88
31. Yamasaki K, Tago Y, Nagai K, Sawaki M, Noda S, Takatsuki M (2002a) Comparison of toxicity studies based on the draft protocol for the "enhanced OECD test guideline no. 407" and the research protocol of "pubertal development and thyroid function in immature male rats" with 6-n-propyl-2-thiouracil. Arch Toxicol 76:495-501
32. Yamasaki K, Sawaki M, Noda S, Imatanaka M, Takatsuki M (2002b) Subacute oral toxicity study of ethynyl estradiol and bisphenol A based on the draft protocol for the "enhanced OECD test guideline no. 407". Arch Toxicol 76:65-74