Obesity; Epiphenomenon or cause of metabolic syndrome?

International Journal of Clinical Practice

Volumn 62, Issue 6, 2008, Pages 932-938

  Lois, K ^a   Young, J ^a   Kumar, S ^a  

^a WALSGRAVE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; FIBRIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; METFORMIN; NICOTINIC ACID; PIOGLITAZONE; ROSIGLITAZONE;

ABDOMINAL OBESITY; BEHAVIOR THERAPY; BLOOD PRESSURE MEASUREMENT; BODY MASS; DIET THERAPY; DYSLIPIDEMIA; ETHNIC DIFFERENCE; GLUCOSE BLOOD LEVEL; HEART FAILURE; HUMAN; HYPERGLYCEMIA; HYPERTENSION; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; METABOLIC SYNDROME X; MONOTHERAPY; OBESITY; PREVALENCE; PRIORITY JOURNAL; REVIEW; SMOKING CESSATION; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADIPOSE TISSUE; DIABETES MELLITUS, TYPE 2; DYSLIPIDEMIAS; FEMALE; HUMANS; HYPERTENSION; INSULIN RESISTANCE; MALE; METABOLIC SYNDROME X; OBESITY; SMOKING CESSATION; WAIST CIRCUMFERENCE;

EID: 43749098556     PISSN: 13685031     EISSN: 17421241     Source Type: Journal    
DOI: 10.1111/j.1742-1241.2008.01773.x     Document Type: Review

References (50)

1. Grundy SM. Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. J Am Coll Cardiol 2006 47 : 1093 100.
2. Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO consultation. Diabet Med 1998 15 : 539 53.
3. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA 2001 285 : 2486 97.
4. International Diabetes Federation. The IDF Worldwide Definition of the Metabolic Syndrome. http://www.idf.org (accessed April 2005).
5. Alberti KG, Zimmet P, Shaw J. IDF Epidemiology Task Force Consensus Group. The metabolic syndrome - a new worldwide definition. Lancet 2005 366 : 1059 62.
6. Zimmet P, Alberti G, Shaw J. A new IDF worldwide definition of the metabolic syndrome: the rationale and the results. Diabetes Voice 2005 50 : 32. http://www.diabetesvoice.org (accessed September 2005).
7. Greenspan FS, Gardner DG. Basic & Clinical Endocrinology. Columbus, OH : Lange Medical Books/McGraw-Hill, 2007.
8. Evans JL, Goldfine ID, Maddux BA et al. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes 2003 52 : 1 8. http://www.medscape.com (accessed January 2003).
9. Lelliott C, Vidal-Puig AJ. Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes 2004 28 : S22 8.
10. DeFronzo RA, Mandarino LJ. Pathogenesis of Type 2 Diabetes Mellitus, Chapter 9. http://Endotext.com (accessed January 2003).
11. de Jongh RT, Clark ADH, Stehouwer CDA et al. Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers. Diabetologia 2004 47 : 978 86. http://www.springerlink.com
12. Ross R, Kolka C, Rattigan S, Clark M. Acute blockade by endothelin-1 of haemodynamic insulin action in rats. Diabetologia 2007 50 : 443 51. http://www.ingentaconnect.com/
13. Audrey Nguyen MT, Satoh H, Olefsky JM et al. JNK and TNF-a mediated free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J Biol Chem. http://www.jbc.org (accessed October 2005).
14. Solinas G, Naugler W, Karin M et al. Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates. Proceedings of the National Academy of Sciences of the USA. http://www.pubmedcentral.nih.gov/ (accessed October 2006).
15. Sbarbati A, Osculati F, Maffeis C et al. Obesity and inflammation: evidence for an elementary lesion. Pediatrics 2006 117 : 220 3. http://pediatrics.aappublications.org
16. Ferrant AW. Role of Adipose Tissue Macrophages in Obesity-Induced Insulin Resistance: from Serendipity to Paradigm Shift. http://www.the-aps.org/ (accessed 1 May 2007).
17. Jager J, Grémeaux T, Tanti J-F et al. Interleukin-1β-induced insulin resistance in adipocytes through down regulation of insulin receptor substrate-1 expression. Endocrinology 2007 148 : 241 51. http://endo. endojournals.org/
18. Dandona P. Obesity Causes Inflammation which Accelerates Aging. http://www.futurepundit.com (accessed September 2004).
19. Yeh ETH, Willerson JT, Calabro P, Chang D. First Link Found between Obesity, Inflammation and Vascular Disease. http://www.eurekalert.org (accessed 19 September 2005).
20. Unger RH. The physiology of cellular liporegulation. Annu Rev Physiol 2003 65 : 333 47.
21. Ren J. Lessons from the leptin paradox in cardiac regulation - too much versus too little. J Physiol 2005 565 : 347. http://www.pubmedcentral.nih.gov/
22. Haynes WG. Neural mechanisms in obesity-related hypertension: role of leptin in obesity-related hypertension Internet website of experimental physiology. http://ep.physoc.org/ (accessed September 2005).
23. Ehtesham NZ. Does resistin resist insulin? Curr Sci 2002 83 : 1190. http://www.ias.ac.in/.
24. Kopp H-P, Krzyzanowska K, Schernthaner G et al. Effects of marked weight loss on plasma levels of adiponectin, markers of chronic subclinical inflammation and insulin resistance in morbidly obese women. Int J Obes 2005 29 : 766 71. http://www.nature.com
25. Sharma AM, Janke J, Luft FC et al. Angiotensin blockade prevents type 2 diabetes by formation of fat cells. American Heart Association. Hypertension. http://www.jhypertension.com (accessed October 2002).
26. Zucker M. Sleep-disordered breathing, insulin resistance linked. Pulm Rev, 7. http://www.pulmonaryreviews.com/ (accessed July 2002).
27. Sharma AM, Bramlage P, Kirch W. Antihypertensive Effect of Irbesartan and Predictors of Response in Obesity-Associated Hypertension, Medscape Diabetes and Endocrinology. http://www.medscape.com (accessed September 2006).
28. Wolk R, Shamsuzzaman ASM, Somers VK. Obesity, Sleep Apnea, and Hypertension. American Heart Association. http://hyper.ahajournals.org (accessed November 2003).
29. Hypertension PV. Single sugars and fatty acids. J Hum Hypertens 2005 19 : S5 9.
30. Emdin M, Gastaldelli A, Ferrannini E et al. Hyperinsulinemia and Autonomic Nervous System Dysfunction in Obesity. Circulation publication. American Heart Association. http://hyper.ahajournals.org (accessed January 2001).
31. Frontoni S, Bracaglia D, Gigli F. Relationship between autonomic dysfunction, insulin resistance and hypertension, in diabetes. NCBI. http://www.ncbi.nlm.nih.gov (accessed December 2005).
32. DeFronzo RA. The effect of insulin on renal sodium metabolism. Diabetologia 1981 21 : 165 71.
33. Narkiewicz K. Obesity and hypertension - the issue is more complex than we thought. Oxford journals. Nephrol Dial Transplant 2006 21 : 264 7. http://ndt.oxfordjournals.org (accessed February 2006).
34. Hall JE, Kuo JJ, Tallam L et al. Obesity-associated hypertension and kidney disease. Medscape Diabetes Endocrinol. http://www.medscape.com (accessed March 2003).
35. Hall JE. Pathophysiology of Obesity Hypertension. NCBI. http://www.ncbi.nlm.nih.gov (accessed 2 April 2000).
36. Praga M. Obesity - a neglected culprit in renal disease. Obesity-related glomerulopathies - clinical features and epidemiology. Oxford journals. Nephrol Dial Transplant 2002 17 : 1157 9. http://ndt.oxfordjournals.org (accessed July 2002).
37. Wolf G, Ziyadeh FN. Leptin and Renal Fibrosis. Contrib Nephrol 2006 151 : 175 83.
38. Moreau P, Lamarche L, Laflamme AK, Calderone A et al. Chronic hyperinsulinaemia and hypertension: the role of the sympathetic nervous system. NCBI. http://www.ncbi.nlm.nih.gov (accessed March 1995).
39. Hausberg M, Morgan DA, Haynes WG et al. Leptin potentiates thermogenic sympathetic responses to hypothermia. A receptor-mediated effect. Diabetes 2002 51 : 2434 40. http://diabetes.diabetesjournals.org/
40. Enriori PJ, Evans AE, Cowley MA et al. Leptin resistance and obesity. Obesity 2006. http://www.obesityresearch.org/
41. Furukawa S, Fujita T, Shimomura I et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 2004 114 : 1752 61. http://www.jci.org
42. Bao YCX, Wang AL, Chen S et al. Studies of the association between angiotensinogen gene regulation and cytokines in essential hypertension. http://www.medscape.com (accessed October 2003).
43. Sesso HD, Wang L, Buring JE, Ridker PM, Gaziano JM. Comparison of interleukin-6 and C-reactive protein for the risk of developing hypertension in women. JAMA 2003 290 : 2945 51.
44. Jeng JR, Wang JH, Lin SZ et al. Association of interleukin-6 gene G-174C polymorphism and plasma plasminogen activator inhibitor-1 level in Chinese patients with and without hypertension. http://www.medscape.com (accessed April 2005).
45. Urban M. Selected Cytokines (Il-6, Il-8, Il-10, MCP-1, TNF-Alpha) in Children and Adolescents with Atherosclerosis Risk Factors: Obesity, Hypertension, Diabetes. http://www.medscape.com (accessed January 2003).
46. Huang AL, Vita JA. Effects of Systemic Inflammation on Endothelium-Dependent Vasodilation. http://www.medscape.com (accessed January 2006).
47. Lonnqvist F, Thome A, Arner P et al. Pathogenic Role of Visceral Fat Beta 3-Adrenoceptors in Obesity. http://www.ncbi.nlm.nih.gov (accessed March 1995).
48. Hoffstedt J, Arner P, Hellers G, Lonnqvist F. Variation in Adrenergic Regulation of Lipolysis between Omental and Subcutaneous Adipocytes from Obese and Non-Obese Men. http://www.ncbi.nlm.nih.gov (accessed April 1997).
49. Stewart PM, Boulton A, Kumar S, Clark PMS, Shackleton CHL. Cortisol metabolism in human obesity: impaired cortisone-cortisol conversion in subjects with central adiposity. J Clin Endocrinol Metab 1999 84 : 1022 7.
50. Bays HE, Chapman RH, Grandy S. The relationship of body mass index to diabetes mellitus, hypertension and dyslipidaemia: comparison of data from two national surveys. Int J Clin Pract 2007 61 : 737 47.