Preparation of piperazine derivatives as 5-HT7 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 10, 2008, Pages 5405-5412

  Yoon, Juhee ^a   Yoo, Eun A ^a   Kim, Ji Yeon ^a   Pae, Ae Nim ^b   Rhim, Hyewhon ^b   Park, Woo Kyu ^c   Kong, Jae Yang ^c   Park Choo, Hea Young ^a  

^a Ewha Womans University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

^c Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

5 HT2c receptor antagonists; 5 HT7 receptor antagonists; Piperazine; Sulfonamide

Indexed keywords

3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 3,N DIMETHYL N [1 METHYL 3 (4 METHYL 1 PIPERIDINYL)PROPYL]BENZENESULFONAMIDE; 4 METHOXY N [3 [4 (2 METHOXYPHENYLPIPERAZIN 1 YL)PROPYL]BENZENESULFONAMIDE; DR 4004; PIPERAZINE DERIVATIVE; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 6 RECEPTOR; SEROTONIN 7 ANTAGONIST; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST;

ANIMAL CELL; ARTICLE; BINDING ASSAY; CHO CELL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; NONHUMAN;

ANIMALS; BINDING SITES; CHO CELLS; CRICETINAE; CRICETULUS; DRUG EVALUATION, PRECLINICAL; HUMANS; MOLECULAR CONFORMATION; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 43749091957     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.023     Document Type: Article

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