Effects of gamma-secretase inhibitor N-(3,5-difiuorophenacetyi-L-alanyl)- S-phenylglycine t-butyl ester on proliferation and differentiation of neural stem cells

National Medical Journal of China

Volumn 88, Issue 7, 2008, Pages 480-483

  Cai, Liang Zhi ^a   Lin, Ling ^a   Hu, Jian Shi ^a   Zheng, Zhi Hong ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Cell differentiation; Enzyme inhibitors; Proliferation; Stem cells

Indexed keywords

2',3' CYCLIC NUCLEOTIDE 3' PHOSPHODIESTERASE; BETA TUBULIN; CHOLECYSTOKININ OCTAPEPTIDE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GLIAL FIBRILLARY ACIDIC PROTEIN; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; MESSENGER RNA; N (3,5 DIFLUOROPHENACETYLALANYL)PHENYLGLYCINE TERT BUTYL ESTER; NOTCH RECEPTOR; TRANSCRIPTION FACTOR HES 1;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN TISSUE; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GENE EXPRESSION; GROWTH CURVE; IMMUNOFLUORESCENCE; IN VITRO STUDY; NEURAL STEM CELL; NONHUMAN; OLIGODENDROGLIA; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

2',3'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DIPEPTIDES; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN; HOMEODOMAIN PROTEINS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEM CELLS; TIME FACTORS; TUBULIN;

EID: 43749089720     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Gage FH. Mammalian neural stem cells. Science, 2000,287: 1433-1438.
2. Temple S. The development of neural stem cells. Nature, 2001, 414:112-117.
3. Pluchino s, Zanotti L, Deleidi M, et al. Neural stem cells and their use as therapeutic toll in neurological disorders. Brain Res Brain Res Rev, 2005,48:211-219.
4. Hitoshi S, Alexson T, Tropepe V. Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells. Genes Dev, 2002,16:846-858.
5. Gaiano N, Fishell G. The role of Notch in promoting glial and neural stem cell fates. Annu Rev Neurosci, 2002,25:471-490.
6. Chinese source.
7. Ge W, Martinowich K, Wu X, et al. Notch signaling promoted astrogliogenesis via direct CSL-mediated gliol gene activation. J Neurosci Res, 2002,69:848-860.
8. Morrison SJ, Perez SE, Qiao Z, et al. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesisi by neural crest stem cells. Cell, 2000,101:499-510.
9. Morohashi Y, Kan T, Tominari Y, et al. C-terminal fragment of presenilin is the molecular target of a dipeptiic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester). J Biol Chem, 2006,281: 14670-14676.
10. Geling A, Steiner H, Willem M, et al. A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep,2002,3:688-694.
11. Chinese source.
12. Vujovic S, Henderson SR, Flanagan AM, et al. Inhibition of gamma-secretases alters both proliferation and differentiation of mesenchymal stem cells. Cell Prolif, 2007,40:185-195.