Presentation of a determinant by MHC class II can be prevented through competitive capture by a flanking determinant on a multideterminant peptide

Journal of Autoimmunity

Volumn 31, Issue 1, 2008, Pages 59-65

  Maverakis, Emanual ^b   Beech, Jonathan T ^a   Schneider, Susanne ^b   Sercarz, Eli E ^b  

^a Division of Cellular and Cytokine Immunology   (United Kingdom)

^b TORREY PINES INSTITUTE FOR MOLECULAR STUDIES   (United States)

Author keywords

Antigen processing; Autoimmunity; Golli MBP; MBP; Tolerance

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLERGIC ENCEPHALOMYELITIS; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; HYBRIDOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SEQUENCE ANALYSIS; T LYMPHOCYTE;

ANIMALS; ANTIGEN PRESENTATION; AUTOANTIGENS; BINDING, COMPETITIVE; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; EPITOPES, T-LYMPHOCYTE; HISTOCOMPATIBILITY ANTIGENS CLASS II; HYBRIDOMAS; LYMPHOCYTE ACTIVATION; MICE; MULTIPLE SCLEROSIS; NERVE TISSUE PROTEINS; SELF TOLERANCE; T-LYMPHOCYTES; TRANSCRIPTION FACTORS;

EID: 43649087696     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2008.02.004     Document Type: Article

References (22)

1. Zamvil S.S., Mitchell D.J., Moore A.C., Kitamura K., Steinman L., and Rothbard J.B. T-cell epitope of the autoantigen myelin basic protein that induces encephalomyelitis. Nature 324 (1986) 258-260
2. Klein L., Klugmann M., Nave K.A., Tuohy V.K., and Kyewski B. Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. [see comments]. Nat Med 6 (2000) 56-61
3. Anderson M.S., Venanzi E.S., Klein L., Chen Z., Berzins S.P., Turley S.J., et al. Projection of an immunological self shadow within the thymus by the aire protein. Science 298 (2002) 1395-1401
4. Gammon G., and Sercarz E. How some T cells escape tolerance induction. Nature 342 (1989) 183-185
5. Yoshizawa I., Bronson R., Dorf M.E., and Abromson-Leeman S. T-cell responses to myelin basic protein in normal and MBP-deficient mice. J Neuroimmunol 84 (1998) 131-138
6. Targoni O.S., and Lehmann P.V. Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J Exp Med 187 (1998) 2055-2063
7. Seamons A., Sutton J., Bai D., Baird E., Bonn N., Kafsack B.F., et al. Competition between two MHC binding registers in a single peptide processed from myelin basic protein influences tolerance and susceptibility to autoimmunity. J Exp Med 197 (2003) 1391-1397
8. Maverakis E., Beech J., Stevens D.B., Ametani A., Brossay L., van den Elzen P., et al. Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC. Proc Natl Acad Sci U S A 100 (2003) 5342-5347
9. Pribyl T.M., Campagnoni C.W., Kampf K., Kashima T., Handley V.W., McMahon J., et al. The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems. Proc Natl Acad Sci U S A 90 (1993) 10695-10699
10. Campagnoni A.T., Pribyl T.M., Campagnoni C.W., Kampf K., Amur-Umarjee S., Landry C.F., et al. Structure and developmental regulation of Golli-MBP, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain. J Biol Chem 268 (1993) 4930-4938
11. Fritz R.B., and Kalvakolanu I. Thymic expression of the golli-myelin basic protein gene in the SJL/J mouse. J Neuroimmunol 57 (1995) 93-99
12. Feng J.M., Hu Y.K., Xie L.H., Colwell C.S., Shao X.M., Sun X.P., et al. Golli protein negatively regulates store depletion-induced calcium influx in T cells. Immunity 24 (2006) 717-727
13. Shimonkevitz R., Kappler J., Marrack P., and Grey H. Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing. J Exp Med 158 (1983) 303-316
14. Kumar V., Bhardwaj V., Soares L., Alexander J., Sette A., and Sercarz E. Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon gamma by T cells. Proc Natl Acad Sci U S A 92 (1995) 9510-9514
15. Gautam A.M., Pearson C.I., Smilek D.E., Steinman L., and McDevitt H.O. A polyalanine peptide with only five native myelin basic protein residues induces autoimmune encephalomyelitis. J Exp Med 176 (1992) 605-609
16. Garcia K.C., Radu C.G., Ho J., Ober R.J., and Ward E.S. Kinetics and thermodynamics of T cell receptor-autoantigen interactions in murine experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 98 (2001) 6818-6823
17. Menezes J.S., van den Elzen P., Thornes J., Huffman D., Droin N.M., Maverakis E., et al. A public T cell clonotype within a heterogeneous autoreactive repertoire is dominant in driving EAE. J Clin Invest 117 8 (2007 Aug) 2176-2185
18. Cibotti R., Kanellopoulos J.M., Cabaniols J.P., Halle-Panenko O., Kosmatopoulos K., Sercarz E., et al. Tolerance to a self-protein involves its immunodominant but does not involve its subdominant determinants. Proc Natl Acad Sci U S A 89 (1992) 416-420
19. Harrington C.J., Paez A., Hunkapiller T., Mannikko V., Brabb T., Ahearn M., et al. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity 8 (1998) 571-580
20. Abromson-Leeman S., Alexander J., Bronson R., Carroll J., Southwood S., and Dorf M. Experimental autoimmune encephalomyelitis-resistant mice have highly encephalitogenic myelin basic protein (MBP)-specific T cell clones that recognize a MBP peptide with high affinity for MHC class II. J Immunol 154 (1995) 388-398
21. Manoury B., Mazzeo D., Fugger L., Viner N., Ponsford M., Streeter H., et al. Destructive processing by asparagine endopeptidase limits presentation of a dominant T cell epitope in MBP. Nat Immunol 3 (2002) 169-174
22. Anderton S.M., and Wraith D.C. Selection and fine-tuning of the autoimmune T-cell repertoire. Nat Rev Immunol 2 (2002) 487-498