-
1
-
-
2642531001
-
Pemphigus
-
Edition 6, Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI Eds, McGraw-Hill, New York, NY, USA
-
Stanley JR: Pemphigus. In: Fitzpatrick's Dermatology in General Medicine. Edition 6, Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI (Eds), McGraw-Hill, New York, NY, USA (2003):558-567.
-
(2003)
Fitzpatrick's Dermatology in General Medicine
, pp. 558-567
-
-
Stanley, J.R.1
-
2
-
-
11944270639
-
-
Ahmed AR, Yunis EJ, Khatri K, Wagner R, Notani G, Awdeh Z, Alper CA: Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci USA (1990) 87(19):7658-7662.
-
Ahmed AR, Yunis EJ, Khatri K, Wagner R, Notani G, Awdeh Z, Alper CA: Major histocompatibility complex haplotype studies in Ashkenazi Jewish patients with pemphigus vulgaris. Proc Natl Acad Sci USA (1990) 87(19):7658-7662.
-
-
-
-
3
-
-
43549112650
-
-
Bethesda, MD, USA
-
ClinicalTrials.gov: Pemphigus vulgaris. NIH, Bethesda, MD, USA (2008). http://www.clinicaltrials.gov/ct2/results?term=pemphigus+vulgaris
-
(2008)
ClinicalTrials.gov: Pemphigus vulgaris
-
-
-
4
-
-
34548039475
-
Beyond steric hindrance: The role of adhesion signaling pathways in the pathogenesis of pemphigus
-
This review highlights the signaling pathways for which chemical inhibitors have been reported to prevent in vitro and/or in vivo pathology caused by PV IgG, •
-
Sharma P, Mao X, Payne AS: Beyond steric hindrance: The role of adhesion signaling pathways in the pathogenesis of pemphigus. J Dermatol Sci (2007) 48(1):1-14. • This review highlights the signaling pathways for which chemical inhibitors have been reported to prevent in vitro and/or in vivo pathology caused by PV IgG.
-
(2007)
J Dermatol Sci
, vol.48
, Issue.1
, pp. 1-14
-
-
Sharma, P.1
Mao, X.2
Payne, A.S.3
-
5
-
-
33847752201
-
Introducing a novel Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) in pemphigus
-
Pfütze M, Niedermeier A, Hertl M, Eming R: Introducing a novel Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) in pemphigus. Eur J Dermatol (2007) 17(1):4-11.
-
(2007)
Eur J Dermatol
, vol.17
, Issue.1
, pp. 4-11
-
-
Pfütze, M.1
Niedermeier, A.2
Hertl, M.3
Eming, R.4
-
6
-
-
43449130884
-
-
Murrell DF, Dick S, Amagai M, Barnadas MA, Borradori L, Bystryn J-C, Cianchini G, Diaz LA, Fivenson D, Goldsmith LA, Hall R et al: Consensus statement on definitions of disease endpoints and therapeutic response for pemphigus. J Am Acad Dermatol (2008): doi:10.1016/j.jaad.2008.01.012. • This document reports the consensus of international pemphigus experts on definitions of disease endpoints and therapeutic response, an important first step toward standardization of clinical trials in PV.
-
Murrell DF, Dick S, Amagai M, Barnadas MA, Borradori L, Bystryn J-C, Cianchini G, Diaz LA, Fivenson D, Goldsmith LA, Hall R et al: Consensus statement on definitions of disease endpoints and therapeutic response for pemphigus. J Am Acad Dermatol (2008): doi:10.1016/j.jaad.2008.01.012. • This document reports the consensus of international pemphigus experts on definitions of disease endpoints and therapeutic response, an important first step toward standardization of clinical trials in PV.
-
-
-
-
7
-
-
0030796024
-
Treatment of pemphigus vulgaris with mycophenolate mofetil
-
Enk AH, Knop J: Treatment of pemphigus vulgaris with mycophenolate mofetil. Lancet (1997) 350(9076):494.
-
(1997)
Lancet
, vol.350
, Issue.9076
, pp. 494
-
-
Enk, A.H.1
Knop, J.2
-
8
-
-
0344450757
-
Mycophenolate is effective in the treatment of pemphigus vulgaris
-
Enk AH, Knop J: Mycophenolate is effective in the treatment of pemphigus vulgaris. Arch Dermatol (1999) 135(1):54-56.
-
(1999)
Arch Dermatol
, vol.135
, Issue.1
, pp. 54-56
-
-
Enk, A.H.1
Knop, J.2
-
9
-
-
0038797754
-
Treatment of pemphigus vulgaris and pemphigus foliaceus with mycophenolate mofetil
-
Mimouni D, Anhalt GJ, Cummins DL, Kouba DJ, Thorne JE, Nousari HC: Treatment of pemphigus vulgaris and pemphigus foliaceus with mycophenolate mofetil. Arch Dermatol (2003) 139(6):739-742.
-
(2003)
Arch Dermatol
, vol.139
, Issue.6
, pp. 739-742
-
-
Mimouni, D.1
Anhalt, G.J.2
Cummins, D.L.3
Kouba, D.J.4
Thorne, J.E.5
Nousari, H.C.6
-
10
-
-
33751248497
-
-
Beissert S, Werfel T, Frieling U, Böhm M, Sticherling M, Stadler R, Zillikens D, Rzany B, Hunzelmann N, Meurer M, Gollnick H et al: A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of pemphigus. Arch Dermatol (2006) 142(11):1447-1454. • This trial in patients with pemphigus (n = 40) investigated the relevant clinical question of the comparable safety and efficacy of azathioprine and MMF, which are widely considered to be first-line adjunctive immunosuppressants in PV.
-
Beissert S, Werfel T, Frieling U, Böhm M, Sticherling M, Stadler R, Zillikens D, Rzany B, Hunzelmann N, Meurer M, Gollnick H et al: A comparison of oral methylprednisolone plus azathioprine or mycophenolate mofetil for the treatment of pemphigus. Arch Dermatol (2006) 142(11):1447-1454. • This trial in patients with pemphigus (n = 40) investigated the relevant clinical question of the comparable safety and efficacy of azathioprine and MMF, which are widely considered to be first-line adjunctive immunosuppressants in PV.
-
-
-
-
12
-
-
43549118038
-
Aspreva and Roche receive orphan drug designation from FDA for evaluation of Cellcept in rare autoimmune disease pemphigus vulgaris
-
Aspreva Pharmaceuticals Corp:, June 06
-
Aspreva Pharmaceuticals Corp: Aspreva and Roche receive orphan drug designation from FDA for evaluation of Cellcept in rare autoimmune disease pemphigus vulgaris. Press Release (2006): June 06.
-
(2006)
Press Release
-
-
-
13
-
-
40149098342
-
-
Roche Pharmaceuticals, Nutley, NJ, USA
-
CellCept prescribing information. Roche Pharmaceuticals, Nutley, NJ, USA (2007). http://www.rocheusa.com/products/cellcept/pi.pdf
-
(2007)
CellCept prescribing information
-
-
-
14
-
-
34548544117
-
-
Chams-Davatchi C, Esmaili N, Daneshpazhooh M, Valikhani M, Balighi K, Hallaji Z, Barzegari M, Akhyani M, Ghodsi SZ, Seirafi H, Nazemi MJ et al: Randomized controlled open-label trial of four treatment regimens for pemphigus vulgaris. J Am Acad Dermatol (2007) 57(4):622-628. • This study was one of the largest clinical trials for PV in which patients (n = 120) were randomized to one of four relevant treatment regimens: prednisolone alone or prednisolone with azathioprine, MMF or pulse intravenous cyclophosphamide.
-
Chams-Davatchi C, Esmaili N, Daneshpazhooh M, Valikhani M, Balighi K, Hallaji Z, Barzegari M, Akhyani M, Ghodsi SZ, Seirafi H, Nazemi MJ et al: Randomized controlled open-label trial of four treatment regimens for pemphigus vulgaris. J Am Acad Dermatol (2007) 57(4):622-628. • This study was one of the largest clinical trials for PV in which patients (n = 120) were randomized to one of four relevant treatment regimens: prednisolone alone or prednisolone with azathioprine, MMF or pulse intravenous cyclophosphamide.
-
-
-
-
16
-
-
1242314812
-
Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity
-
Reuther LO, Vainer B, Sonne J, Larsen N-E: Thiopurine methyltransferase (TPMT) genotype distribution in azathioprine-tolerant and -intolerant patients with various disorders. The impact of TPMT genotyping in predicting toxicity. Eur J Clin Pharmacol (2004) 59(11):797- 801.
-
(2004)
Eur J Clin Pharmacol
, vol.59
, Issue.11
, pp. 797-801
-
-
Reuther, L.O.1
Vainer, B.2
Sonne, J.3
Larsen, N.-E.4
-
18
-
-
34250658145
-
Efficacy and safety of cyclophosphamide, azathioprine, and cyclosporine (ciclosporin) as adjuvant drugs in pemphigus vulgaris
-
Olszewska M, Kolacinska-Strasz Z, Sulej J, Labecka H, Cwikla J, Natorska U, Blaszczyk M: Efficacy and safety of cyclophosphamide, azathioprine, and cyclosporine (ciclosporin) as adjuvant drugs in pemphigus vulgaris. Am J Clin Dermatol (2007) 8(2):85-92.
-
(2007)
Am J Clin Dermatol
, vol.8
, Issue.2
, pp. 85-92
-
-
Olszewska, M.1
Kolacinska-Strasz, Z.2
Sulej, J.3
Labecka, H.4
Cwikla, J.5
Natorska, U.6
Blaszczyk, M.7
-
19
-
-
0041632187
-
Oral cyclophosphamide for treatment of pemphigus vulgaris and foliaceus
-
Cummins DL, Mimouni D, Anhalt GJ, Nousari CH: Oral cyclophosphamide for treatment of pemphigus vulgaris and foliaceus. J Am Acad Dermatol (2003) 49(2):276-280.
-
(2003)
J Am Acad Dermatol
, vol.49
, Issue.2
, pp. 276-280
-
-
Cummins, D.L.1
Mimouni, D.2
Anhalt, G.J.3
Nousari, C.H.4
-
20
-
-
0036282841
-
Long-term efficacy of dexamethasone-cyclophosphamide pulse therapy in pemphigus
-
Kanwar AJ, Kaur S, Thami GP: Long-term efficacy of dexamethasone-cyclophosphamide pulse therapy in pemphigus. Dermatology (2002) 204(3):228-231.
-
(2002)
Dermatology
, vol.204
, Issue.3
, pp. 228-231
-
-
Kanwar, A.J.1
Kaur, S.2
Thami, G.P.3
-
21
-
-
0033670052
-
Immunoablative high-dose cyclophosphamide without stem cell rescue in a patient with pemphigus vulgaris
-
Hayag MV, Cohen JA, Kerdel FA: Immunoablative high-dose cyclophosphamide without stem cell rescue in a patient with pemphigus vulgaris. J Am Acad Dermatol (2000) 43(6):1065-1069.
-
(2000)
J Am Acad Dermatol
, vol.43
, Issue.6
, pp. 1065-1069
-
-
Hayag, M.V.1
Cohen, J.A.2
Kerdel, F.A.3
-
22
-
-
0038723740
-
Evaluating the role of immunoablative high-dose cyclophosphamide therapy in pemphigus vulgaris
-
Nousari CH, Brodsky R, Anhalt GJ: Evaluating the role of immunoablative high-dose cyclophosphamide therapy in pemphigus vulgaris. J Am Acad Dermatol (2003) 49(1):148-150.
-
(2003)
J Am Acad Dermatol
, vol.49
, Issue.1
, pp. 148-150
-
-
Nousari, C.H.1
Brodsky, R.2
Anhalt, G.J.3
-
23
-
-
0029585375
-
High-dose intravenous immunoglobulins for immediate control of severe pemphigus vulgaris
-
Messer G, Sizmann N, Feucht H, Meurer M: High-dose intravenous immunoglobulins for immediate control of severe pemphigus vulgaris. Br J Dermatol (1995) 133(6):1014-1016.
-
(1995)
Br J Dermatol
, vol.133
, Issue.6
, pp. 1014-1016
-
-
Messer, G.1
Sizmann, N.2
Feucht, H.3
Meurer, M.4
-
24
-
-
0036715291
-
Corticosteroid-sparing effect of intravenous immunoglobulin therapy in patients with pemphigus vulgaris
-
Sami N, Qureshi A, Ruocco E, Ahmed AR: Corticosteroid-sparing effect of intravenous immunoglobulin therapy in patients with pemphigus vulgaris. Arch Dermatol (2002) 138(9):1158-1162.
-
(2002)
Arch Dermatol
, vol.138
, Issue.9
, pp. 1158-1162
-
-
Sami, N.1
Qureshi, A.2
Ruocco, E.3
Ahmed, A.R.4
-
25
-
-
28244492845
-
Novel mechanisms of target cell death and survival and of therapeutic action of IVIg in pemphigus
-
Arredondo J, Chernyavsky AI, Karaouni A, Grando SA: Novel mechanisms of target cell death and survival and of therapeutic action of IVIg in pemphigus. Am J Pathol (2005) 167(6):1531-1544.
-
(2005)
Am J Pathol
, vol.167
, Issue.6
, pp. 1531-1544
-
-
Arredondo, J.1
Chernyavsky, A.I.2
Karaouni, A.3
Grando, S.A.4
-
26
-
-
33751106428
-
IVIg selectively and rapidly decreases circulating pathogenic autoantibodies in pemphigus vulgaris
-
Bystryn JC, Jiao D: IVIg selectively and rapidly decreases circulating pathogenic autoantibodies in pemphigus vulgaris. Autoimmunity (2006) 39(7):601-607.
-
(2006)
Autoimmunity
, vol.39
, Issue.7
, pp. 601-607
-
-
Bystryn, J.C.1
Jiao, D.2
-
27
-
-
31044440897
-
-
Li N, Zhao M, Hilario-Vargas J, Prisayanh P, Warren S, Diaz LA, Roopernian DC, Liu Z: Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J Clin Invest (2005) 115(12):3440-3450. • This study demonstrated that mice deficient for the neonatal Fc receptor are resistant to the protective effects of IVIg in mouse passive transfer models of autoimmune blistering disease, suggesting a potential mechanism for the clinical benefit of IVIg in autoantibody-mediated diseases.
-
Li N, Zhao M, Hilario-Vargas J, Prisayanh P, Warren S, Diaz LA, Roopernian DC, Liu Z: Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases. J Clin Invest (2005) 115(12):3440-3450. • This study demonstrated that mice deficient for the neonatal Fc receptor are resistant to the protective effects of IVIg in mouse passive transfer models of autoimmune blistering disease, suggesting a potential mechanism for the clinical benefit of IVIg in autoantibody-mediated diseases.
-
-
-
-
28
-
-
0042522722
-
Stroke and deep venous thrombosis complicating intravenous immunoglobulin infusions
-
Katz KA, Hivnor CM, Geist DE, Shapiro M, Ming ME, Werth VP: Stroke and deep venous thrombosis complicating intravenous immunoglobulin infusions. Arch Dermatol (2003) 139(8):991-993.
-
(2003)
Arch Dermatol
, vol.139
, Issue.8
, pp. 991-993
-
-
Katz, K.A.1
Hivnor, C.M.2
Geist, D.E.3
Shapiro, M.4
Ming, M.E.5
Werth, V.P.6
-
29
-
-
21844478520
-
Dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgaris
-
Heaphy MR, Albrecht J, Werth VP: Dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgaris. Arch Dermatol (2005) 141(6):699-702.
-
(2005)
Arch Dermatol
, vol.141
, Issue.6
, pp. 699-702
-
-
Heaphy, M.R.1
Albrecht, J.2
Werth, V.P.3
-
31
-
-
38549139173
-
Multicenter randomized, double-blind, placebo-controlled, clinical trial of dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgaris
-
Werth VP, Fivenson D, Pandya AG, Chen D, Rico MJ, Albrecht J, Jacobus D: Multicenter randomized, double-blind, placebo-controlled, clinical trial of dapsone as a glucocorticoid-sparing agent in maintenance-phase pemphigus vulgaris. Arch Dermatol (2008) 144(1):25-32.
-
(2008)
Arch Dermatol
, vol.144
, Issue.1
, pp. 25-32
-
-
Werth, V.P.1
Fivenson, D.2
Pandya, A.G.3
Chen, D.4
Rico, M.J.5
Albrecht, J.6
Jacobus, D.7
-
32
-
-
33750291236
-
-
Ahmed AR, Spigelman Z, Cavacini LA, Posner MR: Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin. N Engl J Med (2006) 355(17):1772-1779. •• This trial combined the use of rituximab with IVIg in patients with PV (n = 11), of whom nine achieved clinical remission without adverse effects. The researchers suggested that IVIg serves to replace humoral immunity otherwise depleted by rituximab, thereby avoiding infectious complications.
-
Ahmed AR, Spigelman Z, Cavacini LA, Posner MR: Treatment of pemphigus vulgaris with rituximab and intravenous immune globulin. N Engl J Med (2006) 355(17):1772-1779. •• This trial combined the use of rituximab with IVIg in patients with PV (n = 11), of whom nine achieved clinical remission without adverse effects. The researchers suggested that IVIg serves to replace humoral immunity otherwise depleted by rituximab, thereby avoiding infectious complications.
-
-
-
-
33
-
-
34547761274
-
-
Joly P, Mouquet H, Roujeau JC, D'Incan M, Gilbert D, Jacquot S, Gougeon ML, Bedane C, Muller R, Dreno B, Doutre MS et al: A single cycle of rituximab for the treatment of severe pemphigus. N Engl J Med (2007) 357(6):545-552. •• This trial demonstrated that a single cycle of rituximab is effective in patients with PV (n = 21), although two patients had serious infectious complications, including fatal septicemia.
-
Joly P, Mouquet H, Roujeau JC, D'Incan M, Gilbert D, Jacquot S, Gougeon ML, Bedane C, Muller R, Dreno B, Doutre MS et al: A single cycle of rituximab for the treatment of severe pemphigus. N Engl J Med (2007) 357(6):545-552. •• This trial demonstrated that a single cycle of rituximab is effective in patients with PV (n = 21), although two patients had serious infectious complications, including fatal septicemia.
-
-
-
-
34
-
-
34247368924
-
Rituximab in the adjuvant treatment of pemphigus vulgaris: A prospective open-label pilot study in five patients
-
Goh MS, McCormack C, Dinh HV, Welsh B, Foley P, Prince HM: Rituximab in the adjuvant treatment of pemphigus vulgaris: A prospective open-label pilot study in five patients. Br J Dermatol (2007) 156(5):990-996.
-
(2007)
Br J Dermatol
, vol.156
, Issue.5
, pp. 990-996
-
-
Goh, M.S.1
McCormack, C.2
Dinh, H.V.3
Welsh, B.4
Foley, P.5
Prince, H.M.6
-
35
-
-
27744448035
-
Extremely high titer of anti-human chimeric antibody following re-treatment with rituximab in a patient with active systemic lupus erythematosus
-
Saito K, Nawata M, Iwata S, Tokunaga M, Tanaka Y: Extremely high titer of anti-human chimeric antibody following re-treatment with rituximab in a patient with active systemic lupus erythematosus. Rheumatology (2005) 44(11):1462-1464.
-
(2005)
Rheumatology
, vol.44
, Issue.11
, pp. 1462-1464
-
-
Saito, K.1
Nawata, M.2
Iwata, S.3
Tokunaga, M.4
Tanaka, Y.5
-
36
-
-
0037379757
-
Preventing antibodies to infliximab in patients with Crohn's disease: Optimize not immunize
-
Sandborn WJ: Preventing antibodies to infliximab in patients with Crohn's disease: Optimize not immunize. Gastroenterology (2003) 124(4):1140-1145.
-
(2003)
Gastroenterology
, vol.124
, Issue.4
, pp. 1140-1145
-
-
Sandborn, W.J.1
-
37
-
-
0024370845
-
Mediators of inflammation in blister fluids from patients with pemphigus vulgaris and bullous pemphigoid
-
Grando SA, Glukhenky BT, Drannik GN, Epshtein EV, Kostromin AP, Korostash TA: Mediators of inflammation in blister fluids from patients with pemphigus vulgaris and bullous pemphigoid. Arch Dermatol (1989) 125(7):925-930.
-
(1989)
Arch Dermatol
, vol.125
, Issue.7
, pp. 925-930
-
-
Grando, S.A.1
Glukhenky, B.T.2
Drannik, G.N.3
Epshtein, E.V.4
Kostromin, A.P.5
Korostash, T.A.6
-
38
-
-
0034040593
-
In vitro and in vivo expression of interleukin-1 α and tumor necrosis factor-α mRNA in pemphigus vulgaris: Interleukin-1 α and tumor necrosis factor-α are involved in acantholysis
-
Feliciani C, Toto P, Amerio P, Pour SM, Coscione G, Amerio P, Shivji G, Wang BH, Sauder DN: In vitro and in vivo expression of interleukin-1 α and tumor necrosis factor-α mRNA in pemphigus vulgaris: Interleukin-1 α and tumor necrosis factor-α are involved in acantholysis. J Invest Dermatol (2000) 114(1):71-77.
-
(2000)
J Invest Dermatol
, vol.114
, Issue.1
, pp. 71-77
-
-
Feliciani, C.1
Toto, P.2
Amerio, P.3
Pour, S.M.4
Coscione, G.5
Amerio, P.6
Shivji, G.7
Wang, B.H.8
Sauder, D.N.9
-
39
-
-
22944467520
-
Infliximab in the management of severe pemphigus vulgaris
-
Pardo J, Mercader P, Mahiques L, Sanchez-Carazo JL, Oliver V, Fortea JM: Infliximab in the management of severe pemphigus vulgaris. Br J Dermatol (2005) 153(1):222-223.
-
(2005)
Br J Dermatol
, vol.153
, Issue.1
, pp. 222-223
-
-
Pardo, J.1
Mercader, P.2
Mahiques, L.3
Sanchez-Carazo, J.L.4
Oliver, V.5
Fortea, J.M.6
-
40
-
-
24144491556
-
Rapid control of therapy-refractory pemphigus vulgaris by treatment with the tumour necrosis factor-α inhibitor infliximab
-
Jacobi A, Schuler G, Hertl M: Rapid control of therapy-refractory pemphigus vulgaris by treatment with the tumour necrosis factor-α inhibitor infliximab. Br J Dermatol (2005) 153(2):448-449.
-
(2005)
Br J Dermatol
, vol.153
, Issue.2
, pp. 448-449
-
-
Jacobi, A.1
Schuler, G.2
Hertl, M.3
-
41
-
-
21844437632
-
Successful treatment of recalcitrant pemphigus vulgaris and pemphigus vegetans with etanercept and carbon dioxide laser
-
Lin MH, Hsu CK, Lee JY: Successful treatment of recalcitrant pemphigus vulgaris and pemphigus vegetans with etanercept and carbon dioxide laser. Arch Dermatol (2005) 141(6):680-682.
-
(2005)
Arch Dermatol
, vol.141
, Issue.6
, pp. 680-682
-
-
Lin, M.H.1
Hsu, C.K.2
Lee, J.Y.3
-
44
-
-
0029589932
-
-
Wucherpfennig KW, Yu B, Bhol K, Monos DS, Argyris E, Karr RW, Ahmed AR, Strominger JL: Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: Charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Proc Natl Acad Sci USA (1995) 92(25):11935-11939. • The researchers compared PV- and rheumatoid arthritis (RA)-linked alleles of HLA-DR4 and demonstrated that basic residues within a Dsg3 peptide confer specific binding to acidic residues in the peptide binding pocket of PV- but not RA-associated HLA haplotypes.
-
Wucherpfennig KW, Yu B, Bhol K, Monos DS, Argyris E, Karr RW, Ahmed AR, Strominger JL: Structural basis for major histocompatibility complex (MHC)-linked susceptibility to autoimmunity: Charged residues of a single MHC binding pocket confer selective presentation of self-peptides in pemphigus vulgaris. Proc Natl Acad Sci USA (1995) 92(25):11935-11939. • The researchers compared PV- and rheumatoid arthritis (RA)-linked alleles of HLA-DR4 and demonstrated that basic residues within a Dsg3 peptide confer specific binding to acidic residues in the peptide binding pocket of PV- but not RA-associated HLA haplotypes.
-
-
-
-
46
-
-
33644806004
-
An open-label phase I clinical study to assess the safety of PI-0824 in patients with pemphigus vulgaris
-
Anhalt G, Werth V, Strober B, Connolly M, Korman N, Greenstein D, Fantasia J, Kalish R: An open-label phase I clinical study to assess the safety of PI-0824 in patients with pemphigus vulgaris. J Invest Dermatol (2005) 125: Abs023.
-
(2005)
J Invest Dermatol
, vol.125
-
-
Anhalt, G.1
Werth, V.2
Strober, B.3
Connolly, M.4
Korman, N.5
Greenstein, D.6
Fantasia, J.7
Kalish, R.8
-
47
-
-
21244476854
-
Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization
-
Berkowitz P, Hu P, Liu Z, Diaz LA, Enghild JJ, Chua MP, Rubenstein DS: Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J Biol Chem (2005) 280(25):23778-23784.
-
(2005)
J Biol Chem
, vol.280
, Issue.25
, pp. 23778-23784
-
-
Berkowitz, P.1
Hu, P.2
Liu, Z.3
Diaz, L.A.4
Enghild, J.J.5
Chua, M.P.6
Rubenstein, D.S.7
-
48
-
-
39149110925
-
Induction of p38MAPK and Hsp27 phosphorylation in pemphigus patient skin
-
Berkowitz P, Diaz LA, Hall RP, Rubenstein DS: Induction of p38MAPK and Hsp27 phosphorylation in pemphigus patient skin. J Invest Dermatol (2007) 128(3):738-740.
-
(2007)
J Invest Dermatol
, vol.128
, Issue.3
, pp. 738-740
-
-
Berkowitz, P.1
Diaz, L.A.2
Hall, R.P.3
Rubenstein, D.S.4
-
49
-
-
33748069469
-
p38MAPK inhibition prevents disease in pemphigus vulgaris mice
-
This study was the first to demonstrate that inhibition of the p38 MAPK pathway prevents PV in the murine passive transfer model, an in vivo follow up to an earlier study demonstrating that PV IgG causes activation of p38 MAPK in human keratinocytes, ••
-
Berkowitz P, Hu P, Warren S, Liu Z, Diaz LA, Rubenstein DS: p38MAPK inhibition prevents disease in pemphigus vulgaris mice. Proc Natl Acad Sci USA (2006) 103(34):12855-12860. •• This study was the first to demonstrate that inhibition of the p38 MAPK pathway prevents PV in the murine passive transfer model, an in vivo follow up to an earlier study demonstrating that PV IgG causes activation of p38 MAPK in human keratinocytes.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.34
, pp. 12855-12860
-
-
Berkowitz, P.1
Hu, P.2
Warren, S.3
Liu, Z.4
Diaz, L.A.5
Rubenstein, D.S.6
-
50
-
-
34249331264
-
Novel strategies for inhibition of the p38 MAPK pathway
-
Given the toxicities associated with first and second generation p38 MAPK inhibitors, this review examines other potential targets for inhibition within the p38 signaling pathway, •
-
Zhang J, Shen B, Lin A: Novel strategies for inhibition of the p38 MAPK pathway. Trends Pharmacol Sci (2007) 28(6):286-295. • Given the toxicities associated with first and second generation p38 MAPK inhibitors, this review examines other potential targets for inhibition within the p38 signaling pathway.
-
(2007)
Trends Pharmacol Sci
, vol.28
, Issue.6
, pp. 286-295
-
-
Zhang, J.1
Shen, B.2
Lin, A.3
-
51
-
-
33745679123
-
Targeting signal transduction as a strategy to treat inflammatory diseases
-
O'Neill LAJ: Targeting signal transduction as a strategy to treat inflammatory diseases. Nat Rev Drug Discov (2006) 5(7):549-563.
-
(2006)
Nat Rev Drug Discov
, vol.5
, Issue.7
, pp. 549-563
-
-
O'Neill, L.A.J.1
-
52
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian MA, Biggs WH 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM et al: A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol (2005) 23(3):329-336.
-
(2005)
Nat Biotechnol
, vol.23
, Issue.3
, pp. 329-336
-
-
Fabian, M.A.1
Biggs 3rd, W.H.2
Treiber, D.K.3
Atteridge, C.E.4
Azimioara, M.D.5
Benedetti, M.G.6
Carter, T.A.7
Ciceri, P.8
Edeen, P.T.9
Floyd, M.10
Ford, J.M.11
-
54
-
-
33644756634
-
Inhibition of pemphigus vulgaris by targeting of the CD40-CD154 co-stimulatory pathway: A step toward antigen-specific therapy?
-
Liu Z, Li N, Diaz LA: Inhibition of pemphigus vulgaris by targeting of the CD40-CD154 co-stimulatory pathway: A step toward antigen-specific therapy? J Invest Dermatol (2006) 126(1):11-13.
-
(2006)
J Invest Dermatol
, vol.126
, Issue.1
, pp. 11-13
-
-
Liu, Z.1
Li, N.2
Diaz, L.A.3
-
55
-
-
0037333857
-
A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis
-
Boumpas DT, Furie R, Manzi S, Illei GG, Wallace DJ, Balow JE, Vaishnaw A: A short course of BG9588 (anti-CD40 ligand antibody) improves serologic activity and decreases hematuria in patients with proliferative lupus glomerulonephritis. Arthritis Rheum (2003) 48(3):719-727.
-
(2003)
Arthritis Rheum
, vol.48
, Issue.3
, pp. 719-727
-
-
Boumpas, D.T.1
Furie, R.2
Manzi, S.3
Illei, G.G.4
Wallace, D.J.5
Balow, J.E.6
Vaishnaw, A.7
-
56
-
-
33644770230
-
-
Aoki-Ota M, Kinoshita M, Ota T, Tsunoda K, Iwasaki T, Tanaka S, Koyasu S, Nishikawa T, Amagai M: Tolerance induction by the blockade of CD40/CD154 interaction in pemphigus vulgaris mouse model. J Invest Dermatol (2006) 126(1):105-113. • This was the first demonstration that CD40/CD154 blockade prevents disease onset in an active immune mouse model of PV, although it did not ameliorate established disease in the same model.
-
Aoki-Ota M, Kinoshita M, Ota T, Tsunoda K, Iwasaki T, Tanaka S, Koyasu S, Nishikawa T, Amagai M: Tolerance induction by the blockade of CD40/CD154 interaction in pemphigus vulgaris mouse model. J Invest Dermatol (2006) 126(1):105-113. • This was the first demonstration that CD40/CD154 blockade prevents disease onset in an active immune mouse model of PV, although it did not ameliorate established disease in the same model.
-
-
-
-
57
-
-
0034612560
-
The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. Cooperative Group on Fogo Selvagem Research
-
Warren SJ, Lin MS, Giudice GJ, Hoffmann RG, Hans-Filho G, Aoki V, Rivitti EA, Santos V, Diaz LA: The prevalence of antibodies against desmoglein 1 in endemic pemphigus foliaceus in Brazil. Cooperative Group on Fogo Selvagem Research. N Engl J Med (2000) 343(1):23-30.
-
(2000)
N Engl J Med
, vol.343
, Issue.1
, pp. 23-30
-
-
Warren, S.J.1
Lin, M.S.2
Giudice, G.J.3
Hoffmann, R.G.4
Hans-Filho, G.5
Aoki, V.6
Rivitti, E.A.7
Santos, V.8
Diaz, L.A.9
-
58
-
-
0033958306
-
A case of pemphigus vulgaris improved by cigarette smoking
-
Mehta JN, Martin AG: A case of pemphigus vulgaris improved by cigarette smoking. Arch Dermatol (2000) 136(1):15-17.
-
(2000)
Arch Dermatol
, vol.136
, Issue.1
, pp. 15-17
-
-
Mehta, J.N.1
Martin, A.G.2
-
59
-
-
1542336471
-
Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists
-
An intriguing study that offered in vivo and biochemical evidence that cholinergic agonists may ameliorate disease in PV, potentially through upregulation of classical cadherin-based cell adhesion, •
-
Nguyen VT, Arredondo J, Chernyavsky AI, Pittelkow MR, Kitajima Y, Grando SA: Pemphigus vulgaris acantholysis ameliorated by cholinergic agonists. Arch Dermatol (2004) 140(3):327-334. • An intriguing study that offered in vivo and biochemical evidence that cholinergic agonists may ameliorate disease in PV, potentially through upregulation of classical cadherin-based cell adhesion.
-
(2004)
Arch Dermatol
, vol.140
, Issue.3
, pp. 327-334
-
-
Nguyen, V.T.1
Arredondo, J.2
Chernyavsky, A.I.3
Pittelkow, M.R.4
Kitajima, Y.5
Grando, S.A.6
-
60
-
-
33745952031
-
Healing effect of pilocarpine gel 4% on skin lesions of pemphigus vulgaris
-
Iraji F, Yoosefi A: Healing effect of pilocarpine gel 4% on skin lesions of pemphigus vulgaris. Int J Dermatol (2006) 45(6):743-746.
-
(2006)
Int J Dermatol
, vol.45
, Issue.6
, pp. 743-746
-
-
Iraji, F.1
Yoosefi, A.2
-
61
-
-
41249092968
-
Differential coupling of M1 muscarinic and α 7 nicotinic receptors to inhibition of pemphigus acantholysis
-
Chernyavsky AI, Arredondo J, Piser T, Karlsson E, Grando SA: Differential coupling of M1 muscarinic and α 7 nicotinic receptors to inhibition of pemphigus acantholysis. J Biol Chem (2008) 283(6):3401-3408.
-
(2008)
J Biol Chem
, vol.283
, Issue.6
, pp. 3401-3408
-
-
Chernyavsky, A.I.1
Arredondo, J.2
Piser, T.3
Karlsson, E.4
Grando, S.A.5
-
62
-
-
0028203927
-
Transdermal nicotine for active ulcerative colitis
-
Pullan RD, Rhodes J, Ganesh S, Mani V, Morris JS, Williams GT, Newcombe RG, Russell MA, Feyerabend C, Thomas GA, Sawe U: Transdermal nicotine for active ulcerative colitis. N Engl J Med (1994) 330(12):811- 815.
-
(1994)
N Engl J Med
, vol.330
, Issue.12
, pp. 811-815
-
-
Pullan, R.D.1
Rhodes, J.2
Ganesh, S.3
Mani, V.4
Morris, J.S.5
Williams, G.T.6
Newcombe, R.G.7
Russell, M.A.8
Feyerabend, C.9
Thomas, G.A.10
Sawe, U.11
-
63
-
-
0034116198
-
Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus
-
Amagai M, Tsunoda K, Suzuki H, Nishifuji K, Koyasu S, Nishikawa T: Use of autoantigen-knockout mice in developing an active autoimmune disease model for pemphigus. J Clin Invest (2000) 105(5):625-631.
-
(2000)
J Clin Invest
, vol.105
, Issue.5
, pp. 625-631
-
-
Amagai, M.1
Tsunoda, K.2
Suzuki, H.3
Nishifuji, K.4
Koyasu, S.5
Nishikawa, T.6
-
64
-
-
33746709482
-
Pathogenic human monoclonal antibody against desmoglein 3
-
Yeh SW, Cavacini LA, Bhol KC, Lin MS, Kumar M, Duval M, Posner MR, Ahmed AR: Pathogenic human monoclonal antibody against desmoglein 3. Clin Immunol (2006) 120(1):68-75.
-
(2006)
Clin Immunol
, vol.120
, Issue.1
, pp. 68-75
-
-
Yeh, S.W.1
Cavacini, L.A.2
Bhol, K.C.3
Lin, M.S.4
Kumar, M.5
Duval, M.6
Posner, M.R.7
Ahmed, A.R.8
-
65
-
-
20144387052
-
Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display
-
Payne AS, Ishii K, Kacir S, Lin C, Li H, Hanakawa Y, Tsunoda K, Amagai M, Stanley JR, Siegel DL: Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J Clin Invest (2005) 115(4):888-899.
-
(2005)
J Clin Invest
, vol.115
, Issue.4
, pp. 888-899
-
-
Payne, A.S.1
Ishii, K.2
Kacir, S.3
Lin, C.4
Li, H.5
Hanakawa, Y.6
Tsunoda, K.7
Amagai, M.8
Stanley, J.R.9
Siegel, D.L.10
-
66
-
-
34250659705
-
Targeting pemphigus autoantibodies by their heavy chain variable region genes
-
This study investigated restricted variable region gene usage by PV autoantibodies cloned by phage display and demonstrated that specific anti-idiotypic reagents can be used to adsorb or directly block disease-causing antibodies from the PV patient serum from whom the antibodies were cloned, •
-
Payne AS, Siegel DL, Stanley JR: Targeting pemphigus autoantibodies by their heavy chain variable region genes. J Invest Dermatol (2007) 127(7):1681-1691. • This study investigated restricted variable region gene usage by PV autoantibodies cloned by phage display and demonstrated that specific anti-idiotypic reagents can be used to adsorb or directly block disease-causing antibodies from the PV patient serum from whom the antibodies were cloned.
-
(2007)
J Invest Dermatol
, vol.127
, Issue.7
, pp. 1681-1691
-
-
Payne, A.S.1
Siegel, D.L.2
Stanley, J.R.3
-
67
-
-
0030955675
-
H gene segments in human Rh(D) red cell antibodies
-
H gene segments in human Rh(D) red cell antibodies. Blood (1997) 89(9):3277-3286.
-
(1997)
Blood
, vol.89
, Issue.9
, pp. 3277-3286
-
-
Boucher, G.1
Broly, H.2
Lemieux, R.3
-
68
-
-
0022408976
-
Azathioprine suppresses the mixed lymphocyte reaction of patients with Lesch-Nyhan syndrome
-
Szawlowski PW, Al-Safi SA, Dooley T, Maddocks JL: Azathioprine suppresses the mixed lymphocyte reaction of patients with Lesch-Nyhan syndrome. Br J Clin Pharmacol (1985) 20(5):489-491.
-
(1985)
Br J Clin Pharmacol
, vol.20
, Issue.5
, pp. 489-491
-
-
Szawlowski, P.W.1
Al-Safi, S.A.2
Dooley, T.3
Maddocks, J.L.4
-
69
-
-
0028867899
-
Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis
-
Auphan N, DiDonato JA, Rosette C, Helmberg A, Karin M: Immunosuppression by glucocorticoids: Inhibition of NF-κB activity through induction of IκB synthesis. Science (1995) 270(5234):286-290.
-
(1995)
Science
, vol.270
, Issue.5234
, pp. 286-290
-
-
Auphan, N.1
DiDonato, J.A.2
Rosette, C.3
Helmberg, A.4
Karin, M.5
-
70
-
-
0347087440
-
Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes
-
Nguyen VT, Arredondo J, Chernyavsky AI, Kitajima Y, Pittelkow M, Grando SA: Pemphigus vulgaris IgG and methylprednisolone exhibit reciprocal effects on keratinocytes. J Biol Chem (2004) 279(3):2135-2146.
-
(2004)
J Biol Chem
, vol.279
, Issue.3
, pp. 2135-2146
-
-
Nguyen, V.T.1
Arredondo, J.2
Chernyavsky, A.I.3
Kitajima, Y.4
Pittelkow, M.5
Grando, S.A.6
-
71
-
-
0030213253
-
The history of the oxazaphosphorine cytostatics
-
Brock N: The history of the oxazaphosphorine cytostatics. Cancer (1996) 78(3):542-547.
-
(1996)
Cancer
, vol.78
, Issue.3
, pp. 542-547
-
-
Brock, N.1
-
72
-
-
0033963648
-
Dapsone: Unapproved uses or indications
-
Wolf R, Tüzün B, Tüzün Y: Dapsone: Unapproved uses or indications. Clin Dermatol (2000) 18(1):37-53.
-
(2000)
Clin Dermatol
, vol.18
, Issue.1
, pp. 37-53
-
-
Wolf, R.1
Tüzün, B.2
Tüzün, Y.3
|