Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 10, 2008, Pages 3060-3063

  Shen, Gang ^a   Zhu, Jinge ^a   Simpson, Anthony M ^a   Pei, Dehua ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Antibacterial; Hydroxamate; Inhibition; Macrocycle; Peptide deformylase

Indexed keywords

HYDROXAMIC ACID DERIVATIVE; PEPTIDE DEFORMYLASE INHIBITOR;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN;

AMIDOHYDROLASES; ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BINDING, COMPETITIVE; DRUG DESIGN; HEXANOIC ACIDS; HYDROXAMIC ACIDS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; STRUCTURE-ACTIVITY RELATIONSHIP;

BACILLUS SUBTILIS; ESCHERICHIA COLI; POSIBACTERIA;

EID: 43549104003     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.12.011     Document Type: Article

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