Bofutsushosan, a traditional Chinese formulation, inhibits pancreatic lipase activity in vitro and suppresses the elevation of plasma triacylglycerols after oral administration of lipid emulsion

Journal of Traditional Medicines

Volumn 22, Issue 6, 2005, Pages 308-313

  Saito, Masataka ^a   Hamazaki, Tomohito ^a   Tani, Tadato ^b   Watanabe, Shiro ^a,b  

^a Department of Clinical Sciences ^*

^b UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Bofutsushosan; Kampo formulation; lipid emulsion; pancreatic lipase; plasma triacylglycerols

Indexed keywords

EID: 43549106759     PISSN: 18801447     EISSN: 18813747     Source Type: Journal    
DOI: 10.11339/jtm.22.308     Document Type: Article

References (15)

1. Hioki, C., Yoshimoto, K. and Yoshida, T.: Efficacy of bofu-tsusho-san, an oriental herbal medicine, in obese Japanese women with impaired glucose tolerance. Clin. Exp. Pharmacol. Physiol. 31, 614-619, 2004.
2. Morimoto, Y., Sakata, M., Ohno, A., Maegawa, T. and Tajima, S.: Effects of bofu-tsusho-san, a traditional Chinese medicine, on body fat accumulation in fructose-loaded rats. Nippon Yakurigaku Zasshi 117, 77-86, 2001.
3. Yoshida, T., Sakane, N., Wakabayashi, Y., Umekawa, T., and Kondo, M.: Thermogenic, anti-obesity effects of bofu-tsusho-san in MSG-obese mice. Int. J. Obes. Relat. Metab. Disord. 19, 717-722, 1995.
4. Ohno, K., Chung, H-J., Maruyama, I. and Tani, T.: Bofutsusyosan, a traditional Chinese medicine, prevents intimal thickening and vascular smooth muscle cell proliferation induced by balloon endothelial denudation in rats. Biol. Pharm. Bull. In press.
5. Staels, B., Dallongeville, J., Auwerx, J., Schoonjans, K., Leitersdorf, E. and Fruchart, J. C.: Mechanism of action of fibrates on lipid and lipoprotein metabolism. Circulation 98, 2088-2093, 1998.
6. Ooi, T. C., Cousins, M., Ooi, D. S., Nakajima, K. and Edwards, A. L.: Effect of fibrates on postprandial remnant-like particles in patients with combined hyperlipidemia. Atherosclerosis 172, 375-382, 2004.
7. Hauptman, J., Lucas, C., Boldrin, M. N., Collins, H. and Segal, K. R.: Orlistat in the long-term treatment of obesity in primary care settings. Arch. Fam. Med. 9, 160-167, 2000.
8. Han, L. K., Zheng, Y. N., Xu, B. J., Okuda, H. and Kimura, Y.: Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. J. Nutr. 132, 2241-2245, 2000.
9. Han, L. K., Gong, X. J., Kawano, S., Saito, M., Kimura, Y. and Okuda, H.: Antiobesity actions of Zingiber officinale Roscoe. Yakugaku Zasshi. 125, 213-217, 2005.
10. Han, L. K., Gong, X. J., Kawano, S., Saito, M., Kimura, Y. and Okuda, H.: New biologically active triterpenoid saponins from Scabiosa tschiliensis. J. Nat. Prod., 67, 604-613, 2004.
11. Tsujita, T., Sumiyoshi, M., Han, L. K., Fujiwara, T., Tsujita, J., Okuda, H.: Saponins from platycodi radix ameliorate high fat diet-induced obesity in mice. J. Nutr. 132, 2241-2245, 2002.
12. Han, L. K., Zheng, Y. N., Xu, B. J., Okuda, H. and Kimura, Y.: Platycodi radix affects lipid metabolism in mice with high fat diet-induced obesity. J. Nutr., 130, 2760-2764, 2000.
13. Bligh, E. G. and Dyer, W. J.: A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol., 37, 911-917, 1959.
14. Duncombe, W. G.: The Colorimetric micro-determination of non-esterified fatty acids in plasma. Clin. Chim. Acta, 10, 122-125, 1964.
15. Matsuda, H., Li, Y., Yamahara, J. and Yoshikawa, M.: Inhibition of gastric emptying by triterpene saponin, momordin Ic, in mice: roles of blood glucose, capsaicin-sensitive sensory nerves, and central nervous system. J Pharmacol. Exp. Ther., 289, 729-734, 1999.