Application and mechanism of inhalation profile improvement of DPI formulations by mechanofusion with magnesium stearate

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 5, 2008, Pages 617-625

  Kumon, Michiko ^a   Machida, Satoshi ^b   Suzuki, Masahiko ^a   Kusai, Akira ^a   Yonemochi, Etsuo ^b   Terada, Katsuhide ^b  

^a DAIICHI SANKYO CO   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

Dry powder inhaler; Lactose; Magnesium stearate; Mechanofusion; Surface property

Indexed keywords

LACTOSE; MAGNESIUM STEARATE;

ARTICLE; DRUG FORMULATION; DRY POWDER; FORCE; MICROSCOPY; PARTICLE SIZE; PHYSICAL CHEMISTRY;

ADHESIVENESS; ADMINISTRATION, INHALATION; ALGORITHMS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUG COMPOUNDING; EXCIPIENTS; LACTOSE; MICROSCOPY, ELECTRON, SCANNING; POWDERS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEARIC ACIDS; SURFACE PROPERTIES;

EID: 43449128875     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.617     Document Type: Article

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