Polymorphism and linkage disequilibrium of immunoglobulin-like transcript 3 gene

Human Immunology

Volumn 69, Issue 4-5, 2008, Pages 284-290

  Chang, Chih Chao ^a   Silvia, Elaine A ^a   Ho, Eric K ^a   Vlad, George ^a   Suciu Foca, Nicole ^a   Vasilescu, E Rodica ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Genotype; Haplotype; Immunoglobulin like transcript 3; Linkage disequilibrium; Polymorphism

Indexed keywords

IMMUNOGLOBULIN; PROTEIN ILT 3;

ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; DNA SCREENING; EXON; GENE DELETION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE SEQUENCE; GENOMICS; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

BASE SEQUENCE; CHROMOSOME SEGREGATION; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; GENE FREQUENCY; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CELL SURFACE; SEQUENCE ANALYSIS, DNA;

EID: 43449115368     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2008.02.004     Document Type: Article

References (22)

1. Brown D., Trowsdale J., and Allen R. The LILR family: Modulators of innate and adaptive immune pathways in health and disease. Tissue Antigens 64 (2004) 215
2. Nakajima H., Samaridis J., Angman L., and Colonna M. Human myeloid cells express an activating ILT receptor (ILT1) that associates with Fc receptor gamma-chain. J Immunol 162 (1999) 5
3. Banham A.H., Colonna M., Cella M., Micklem K.J., Pulford K., Willis A.C., and Mason D.Y. Identification of the CD85 antigen as ILT2, an inhibitory MHC class I receptor of the immunoglobulin superfamily. J Leukoc Biol 65 (1999) 841
4. Cella M., Dohring C., Samaridis J., Dessing M., Brockhaus M., et al. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med 185 (1997) 1743
5. Colonna M., Nakajima H., and Cella M. A family of inhibitory and activating Ig-like receptors that modulate function of lymphoid and myeloid cells. Semin Immunol 12 (2000) 121
6. Ravetch J.V., and Lanier L.L. Immune inhibitory receptors. Science 290 (2000) 84
7. Kim-Schulze S., Seki T., Vlad G., Scotto L., Fan J., Colombo P.C., et al. Regulation of ILT3 gene expression by processing of precursor transcripts in human endothelial cells. Am J Transplant 6 (2006) 76
8. Kim-Schulze S., Scotto L., Vlad G., Piazza F., Lin H., Liu Z., et al. Recombinant Ig-like transcript 3-Fc modulates T cell responses via induction of Th anergy and differentiation of CD8+ T suppressor cells. J Immunol 176 (2006) 2790
9. Chang C.C., Ciubotariu R., Manavalan J.S., Yuan J., Colovai A.I., Piazza F., et al. Tolerization of dendritic cells by T(S) cells: The crucial role of inhibitory receptors ILT3 and ILT4. Nat Immunol 3 (2002) 237
10. Suciu-Foca N., Feirt N., Zhang Q.Y., Vlad G., Liu Z., Lin H., et al. Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients. J Immunol 178 (2007) 7432
11. Wilson M.J., Torkar M., Haude A., Milne S., Jones T., Sheer D., et al. Plasticity in the organization and sequences of human KIR/ILT gene families. Proc Natl Acad Sci U S A 97 (2000) 4778
12. Young N.T., Canavez F., Uhrberg M., Shum B.P., and Parham P. Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex. Immunogenetics 53 (2001) 270
13. Kuroki K., Tsuchiya N., Shiroishi M., Rasubala L., Yamashita Y., Matsuta K., et al. Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritis. Hum Mol Genet 14 (2005) 2469
14. Torkar M., Haude A., Milne S., Beck S., Trowsdale J., and Wilson M.J. Arrangement of the ILT gene cluster: A common null allele of the ILT6 gene results from a 6.7-kbp deletion. Eur J Immunol 30 (2000) 3655
15. Koch S., Goedde R., Nigmatova V., Epplen J.T., Muller N., de Seze J., et al. Association of multiple sclerosis with ILT6 deficiency. Genes Immun 6 (2005) 445
16. Heinzmann A., Blattmann S., Forster J., Kuehr J., and Deichmann K.A. Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. Eur J Immunogenet 27 (2000) 121
17. Anjos S., Nguyen A., Ounissi-Benkalha H., Tessier M.C., and Polychronakos C. A common autoimmunity predisposing signal peptide variant of the cytotoxic T-lymphocyte antigen 4 results in inefficient glycosylation of the susceptibility allele. J Biol Chem 277 (2002) 46478
18. Xing C., Sestak A.L., Kelly J.A., Nguyen K.L., Bruner G.R., Harley J.B., and Gray-McGuire C. Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: Interaction with 2p11, 12q24 and 19q13 in European Americans. Hum Genet 120 (2007) 623
19. An P., Freedman B.I., Hanis C.L., Chen Y.D., Weder A.B., Schork N.J., et al. Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: Evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. Diabetes 54 (2005) 909
20. Gregory S.G., Schmidt S., Seth P., Oksenberg J.R., Hart J., Prokop A., et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 39 (2007) 1083
21. Lundmark F., Duvefelt K., Iacobaeus E., Kockum I., Wallstrom E., Khademi M., et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 39 (2007) 1108
22. Ueda H., Howson J.M., Esposito L., Heward J., Snook H., and Chamberlain G. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature 423 (2003) 506