Efficacy of the selective extrasynaptic GABAA agonist, gaboxadol, in a model of transient insomnia: A randomized, controlled clinical trial

Sleep Medicine

Volumn 9, Issue 4, 2008, Pages 393-402

  Walsh, James K ^a,b   Mayleben, David ^c   Guico Pabia, Christine ^d   Vandormael, Kristel ^e   Martinez, Rebecca ^d   Deacon, Steve ^f,g  

^a ST LUKE S HOSPITAL   (United States)

^b SAINT LOUIS UNIVERSITY   (United States)

^c Community Research and Sleep Management Institute ^*  (United States)

^d MERCK RESEARCH LABORATORIES   (United States)

^e Merck Sharp and Dohme   (Belgium)

^f H LUNDBECK A S   (Denmark)

^g Lundbeck Ltd   (United Kingdom)

Author keywords

Gaboxadol; Phase advance; SEGA; Selective extrasynaptic GABA agonist; Sleep maintenance; Sleep onset; Slow wave sleep; Transient insomnia

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; GABOXADOL; PLACEBO;

ABSENCE; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COORDINATION DISORDER; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG INDUCED HEADACHE; FEMALE; GAIT DISORDER; HUMAN; HUMAN EXPERIMENT; INSOMNIA; MALE; NAUSEA; NORMAL HUMAN; PARALLEL DESIGN; POLYSOMNOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REM SLEEP; SELF REPORT; SINGLE BLIND PROCEDURE; SKIN IRRITATION; SLEEP DISORDER; SLEEP TIME; SLOW WAVE SLEEP; WAKEFULNESS;

ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; GABA AGONISTS; HUMANS; ISOXAZOLES; MALE; MIDDLE AGED; POLYSOMNOGRAPHY; RECEPTORS, GABA; SLEEP INITIATION AND MAINTENANCE DISORDERS; WAKEFULNESS;

EID: 43449112057     PISSN: 13899457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sleep.2007.06.006     Document Type: Article

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