Intravenous subhypnotic propofol in central pain: A double-blind, placebo-controlled, crossover study

Clinical Neuropharmacology

Volumn 27, Issue 4, 2004, Pages 182-186

  Canavero, S ^a,b   Bonicalzi, V ^a  

^a Turin Advanced Neuromodulation Group   (Italy)

^b NONE   (Italy)

Author keywords

Central pain; Propofol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; INTRALIPID; PLACEBO; PROPOFOL;

ADULT; AGED; ALERTNESS; ALLODYNIA; ARTICLE; BOLUS INJECTION; BURNING SENSATION; CHRONIC PAIN; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FEMALE; HUMAN; MALE; PAIN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SPINAL CORD INJURY; STATISTICAL ANALYSIS; STROKE; VISUAL ANALOG SCALE;

ADULT; AGED; ANESTHETICS, INTRAVENOUS; CHI-SQUARE DISTRIBUTION; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; GABA AGONISTS; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; PAIN; PAIN MEASUREMENT; PROPOFOL;

EID: 4344694845     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wnf.0000138635.42121.9e     Document Type: Article

References (43)

1. Tasker RR. Central pain states. In: Loeser JD, ed. Bonica's Management of Pain. Philadelphia: Lippincott Williams & Wilkins;2001:433-457.
2. Mailis A, Bennett GJ. Painful neurological disorders: clinical aspects. In: Aronoff GM, ed. Evaluation and Treatment of Chronic Pain. Baltimore: Williams & Wilkins;1999:93-114.
3. Canavero S, Bonicalzi V. The neurochemistry of central pain: evidence from clinical studies, hypothesis and therapeutic implications. Pain. 1998;74:109-114. Review article.
4. Finnerup NB, Yezierski RP, Sang CN, et al. Treatment of spinal cord injury pain. Pain Clin Updates. 2001;9:1-6.
5. Canavero S, Bonicalzi V. Lamotrigine control of central pain. Pain. 1996;68:179-181. Clinical note.
6. Vestergaard K, Andersen G, Gottrup H, et al. Lamotrigine for central poststroke pain: a randomized controlled trial. Neurology. 2000;56:184-190.
7. Attal N, Brasseur B, Parker F, et al. Effects of the anticonvulsant gabapentin on neuropathic peripheral and central pain: a pilot study. Eur Neurol. 1998;40:191-200.
8. Awerbuch GI, Sandyk R. Mexiletine for thalamic pain syndrome. Int J Neurosci. 1990;55:129-133.
9. Canavero S, Bonicalzi V, Paolotti R. Lack of effect of topiramate for central pain. Neurology. 2002;58:831-832.
10. Canavero S, Bonicalzi V, Paolotti R. Reboxetine for central pain: a single-blind prospective study. Clin Neuropharmacol. 2002;25:238-239.
11. Canavero S, Bonicalzi V, Pagni CA, et al. Propofol analgesia in central pain: preliminary clinical observations. J Neurol. 1995;242:561-567.
12. Canavero S, Bonicalzi V, Dotta M, et al. Low-rate repetitive TMS allays central pain. Neurol Res. 2003;25:151-152.
13. Anker-Moller E, Spangsberg N, Arendt-Nielsen L, et al. Subhypnotic doses of thiopentone and propofol cause analgesia to experimentally induced acute pain. Br J Anaesth. 1991;66:185-188.
14. Hand R Jr, Riley GP, Nick ML, et al. The analgesic effects of subhypnotic doses of propofol in human volunteers with experimentally induced tourniquet pain. AANA J. 2001;69:466-470.
15. Zacny JP, Coalson DW, Young CJ, et al. Propofol at conscious sedation doses produces mild analgesia to cold pressor-induced pain in healthy volunteers. J Clin Anesth. 1996;8:469-474.
16. Gilron I, Coderre TJ. Preemptive analgesic effects of steroid anesthesia with alphaxolone in the rat formalin test: evidence for differential GABA(A) receptor modulation in persistent nociception. Anesthesiology. 1996;84:572-579.
17. Anwar MM, Abdel-Rahman MS. Effect of propofol on perception of pain in mice: mechanism of action. Comp Biochem Physiol A Mol Integr Physiol. 1998;120:249-253.
18. Krusz JC, Scott V, Belanger J. Intravenous propofol: unique effectiveness in treating intractable migraine. Headache. 2000;40:224-230.
19. Attal N, Gaudè V, Brasseur L, et al. Intravenous lidocaine in central pain: a double-blind, placebo-controlled, psychophysical study. Neurology. 2000;54:564-574.
20. Attal N, Guirimand F, Brasseur L, et al. Effects of IV morphine in central pain. A randomized placebo-controlled study. Neurology. 2002;58:554-563.
21. Trapani G, Altomare C, Liso G, et al. Propofol in anesthesia: mechanism of action, structure-activity relationships, and drug delivery. Curr Med Chem. 2000;7:249-271.
22. Bai D, Pennefather PS, MacDonald JF, et al. The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors. J Neurosci. 1999;19:10635-10646.
23. Mohammadi B, Haeseler G, Leuwer M, et al. Structural requirements of phenol derivatives for direct activation of chloride currents via GABA(A) receptors. Eur J Pharmacol. 2001;421:85-91.
24. Concas A, Santoro G, Serra M, et al. Neurochemical action of the general anesthetic propofol on the chloride ion channel coupled with GABA-a receptors. Brain Res. 1991;542:225-232.
25. Wafford KA, Thompson SA, Thomas D, et al. Functional characterization of human gamma-aminobutyric acid A receptors containing the alpha 4 subunit. Mol Pharmacol. 1996;50:670-678.
26. Fan SZ, Liu CC, Yu HY, et al. Lack of effect of flumazenil on the reversal of propofol anaesthesia. Acta Anaesthesiol Scand. 1995;39:299-301.
27. O'Shea SM, Wong LC, Harrison NL. Propofol increases agonist efficacy at the GABA(A) receptor. Brain Res. 2000;852:344-348.
28. Ghiani CA, Tuligi G, Maciocco E, et al. Biochemical evaluations of the effects of lorecrezole and propofol on the GABAA receptor in rat brain. Biochem Pharmacol. 1996;51:1527-1534.
29. Sanna E, Mascia MP, Klein RL, et al. Actions of the general anesthetic propofol on recombinant human GABAA receptors: influence of receptor subunits. J Pharmacol Exp Ther. 1995;274:353-360.
30. Murugaiah KD, Hemmings HC Jr. Effects of intravenous general anesthetics on [3H]GABA release from rat cortical synaptosomes. Anesthesiology. 1998;89:919-928.
31. Shyr MH, Tsai TH, Yang CH, et al. Propofol anesthesia increases dopamine and serotonin activities at the somatosensory cortex in rats: a microdialysis study. Anesth Analg. 1997;84:1344-1348.
32. Borgeat A. Subhypnotic doses of propofol do not possess antidopaminergic properties. Anesth Analg. 1997;84:196-198.
33. Meuret P, Backman SB, Bonhomme V, et al. Physostigmine reverses propofol-induced unconsciousness and attenuation of the auditory steady state response and bispectral index in human volunteers. Anesthesiology. 2000;93:708-717.
34. Lingamaneni R, Birch ML, Hemmings HC Jr. Widespread inhibition of sodium channel-dependent glutamate release from isolated nerve terminals by isoflurane and propofol. Anesthesiology. 2001;95:1460-1466.
35. Ratnakumari L, Hemmings HC Jr. Effects of propofol on sodium channel-dependent sodium influx and glutamate release in rat cerebrocortical synaptosomes. Anesthesiology. 1997;86:428-439.
36. Rehberg B, Duch DS. Suppression of central nervous system sodium channels by propofol. Anesthesiology. 1999;91:512-520.
37. Inoue Y, Shibuya I, Kabashima N, et al. The mechanism of inhibitory actions of propofol on rat supraoptic neurons. Anesthesiology. 1999;91:167-178.
38. Alkire MT, Haier RJ. Correlating in vivo anaesthetic effects with ex vivo receptor density data supports a GABAergic mechanism of action for propofol, but not for isoflurane. Br J Anaesth. 2001;86:618-626.
39. Buggy DJ, Nicol B, Rowbotham DJ, et al. Effects of intravenous anesthetic agents on glutamate release: a role for GABAA receptor-mediated inhibition. Anesthesiology. 2000;92:1067-1073.
40. Bonhomme V, Fiset P, Meuret P, et al. Propofol anesthesia and cerebral blood flow changes elicited by vibrotactile stimulation: a positron emission tomography study. J Neurophysiol. 2001;85:1299-1308.
41. Alkire MT, Pomfrett CJ, Haier RJ, et al. Functional brain imaging during anesthesia in humans: effects of halothane on global and regional cerebral glucose metabolism. Anesthesiology. 1999;90:701-709.
42. Fiset P, Paus T, Dalozet, et al. Brain mechanisms of propofol-induced loss of consciousness in humans: a positron emission tomographic study. J Neurosci. 1999;19:5506-5513.
43. Angel A, LeBeau F. A comparison of the effects of propofol with other anaesthetic agents on the centripetal transmission of sensory information. Gen Pharmacol. 1992;23:945-963.