An integrated study of heart pain and behavior in freely moving rats (using Fos as a marker for neuronal activation)

NeuroSignals

Volumn 13, Issue 5, 2004, Pages 207-226

  Albutaihi, Ibrahim A M ^a   DeJongste, Mike J L ^a   Ter Horst, Gert J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Angina pectoris; Bradykinin; Capsaicin; Pain; Vagus nerve

Indexed keywords

BRADYKININ; CAPSAICIN; PROTEIN FOS;

ANGINA PECTORIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CELL ACTIVATION; CHEMOSENSITIVITY; CONTROLLED STUDY; HEART RATE; MALE; NERVE CELL; NOCICEPTION; NONHUMAN; PAIN; PERICARDIUM; PROTEIN EXPRESSION; RAT; SYMPATHETIC NERVE; VAGUS NERVE;

ANALYSIS OF VARIANCE; ANIMALS; AWARENESS; BEHAVIOR, ANIMAL; BLOOD PRESSURE; BRADYKININ; BRAIN; CAPSAICIN; CELL COUNT; CHEST PAIN; EXPLORATORY BEHAVIOR; HEART RATE; IMMOBILIZATION; IMMUNOHISTOCHEMISTRY; MALE; NEURONS; ONCOGENE PROTEINS V-FOS; PAIN MEASUREMENT; RATS; RATS, WISTAR; SLEEP; SPINAL CORD;

EID: 4344679320     PISSN: 1424862X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000079336     Document Type: Article

References (67)

1. Rosen SD, Paulesu E, Frith CD, Frackowiak SJ, Davies GJ, Jones T, Camici PG: Central nervous pathways mediating angina pectoris. Lancet 1994;344:147-150.
2. Sylven C: Angina pectoris. Clinical characteristics, neurophysiological and molecular mechanisms. Pain 1989;36:145-167.
3. Foreman RD: Mechanisms of cardiac pain. Annu Rev Physiol 1999;61:143-167.
4. Malliani A: Link between transient myocardial ischemia and pain; in Sing BS (ed): Silent Myocardial Ischemia and Angina. New York, Pergamon Press, 1988, pp 34-47.
5. Nedrum T, Baker DJ, Coleridge HM, Coleridge JC: Interaction of bradykinin and prostaglandin E1 on cardiac pressor reflex and sympathetic afferents. Am J Physiol 1986;250:815-822.
6. Bolser DC, Chandler MJ, Garrison DW, Foreman RD: Effects of intracardiac bradykinin and capsaicin on spinal and spinoreticular neurons. Am J Physiol 1989;257:1543-1550.
7. De Jongste MJL, Ter Horst GJ: Mediators of inflammation in patients with coronary artery disease; in Ter Horst GJ (ed): The Nervous System and The Heart. Totowa, Humana Press Inc, 2000, pp 467-487.
8. Holzer P: Capsaicin: Cellular targets, mechanisms of action and selectivity for thin sensory neurons. Pharmacol Rev 1991;11:330-343.
9. Szolcsani J: Actions of capsaicin on sensory receptors; in Wood J (ed): Capsaicin in the Study of Pain. London, Academic Press, 1993, pp 1-26.
10. Szolcsani J: Capsaicin-sensitive sensory nerves terminals with local and systemic efferent functions: Facts and scopes of the unorthodox neuroregulatory mechanism. Prog Brain Res 1996;113:343-359.
11. Szolcsanyi J, Oroszi G, Nemeth J, Szilvassy Z, Blasig IE, Tosaki A: Functional and biochemical evidence of capsaicin-induced neural endothelin release in isolated working rat heart. Eur J Pharmacol 2001;419:215-221.
12. Euchner-Wamser I, Meller ST, Gebhart GF: A model of cardiac nociception in chronically instrumented rats: Behavioral and electrophysiological effects of pericardial administration of algogenic substances. Pain 1994;58:117-128.
13. Hunt SP, Pini A, Evans G: Induction of c-fos like protein in spinal cord neurons following sensory stimulation. Nature 1987;328:632-634.
14. Sagar SM, Sharp FR, Curran T: Expression of c-fos protein in brain: Metabolic mapping at the cellular level. Science 1988;240:1328-1331.
15. Dragunow M, Faull R: The use of c-fos as a metabolic marker in neuronal pathway tracing. J Neurosci Methods 1989;29:261-265.
16. Anton F, Herdegen T, Peppel P, Leah JD: c-fos-like immunoreactivity in rat brain stem neurons following noxious chemical stimulation of the nasal mucosa. Neuroscience 1991;41:629-641.
17. Strassman AM, Vos BP: Somatotopic and laminar organization of fos-like immunoreactivity in the medullary and upper cervical dorsal horn induced by noxious fascial stimulation in the rat. J Comp Neurol 1993;331:495-516.
18. Harris JA: Using c-fos as a neural marker of pain. Brain Res Bull 1998;45:1-8.
19. Zimmerman M: Ethical guidelines for investigation of experimental pain in conscious animals. Pain 1983;16:109-110.
20. Kemper RH, Spoelstra MB, Meijler WJ, Ter Horst GJ: Lipopolysaccharide- induced hyperalgesia of intracranial capsaicin sensitive afferents in conscious rats. Pain 1998;78:181-190.
21. Swanson LW: Brain Maps: Computer Graphics Files. Amsterdam, Elsevier, 1992.
22. Pan H, Longhurst JC: Lack of a role of adenosine in activation of ischemically sensitive cardiac sympathetic afferents. Am J Physiol 1995;269:106-113.
23. Dray A, Dickenson A: Capsaicin, nociception and pain; in Wood J (ed): Capsaicin in the Study of Pain. London, Academic Press, 1993, pp 239-253.
24. Coleridge HM, Coleridge JC: Cardiovascular afferents involved in regulation of peripheral vessels. Annu Rev Physiol 1980;42:413-427.
25. Lombardi F, Della Bella P, Casati R, Malliani A: Effects of intracoronary administration of bradykinin on the impulse activity of afferent sympathetic unmyelinated fibers with left ventricular endings in the cat. Circ Res 1981;48:69-75.
26. Clement CI, Keay KA, Owler B, Bandler R: Common patterns of increased and decreased Fos expression in midbrain and pons evoked by noxious deep somatic and noxious visceral manipulations in the rat. J Comp Neurol 1996;366:495-515.
27. Farkas E, Jansen ASP, Loewy AD: Periaqueductal gray matter input to cardiac-related sympathetic premotor neurons. Brain Res 1998;792:179-192.
28. Keay KA, Clement B, Owler B, Depaulis A, Bandler R: Convergence of deep somatic and visceral nociceptive information onto a discrete ventrolateral midbrain periaqueductal gray region. Neuroscience 1994;61:727-732.
29. Lara JP, Parkes MJ, Silvacarvhalo L, Izzo P, Dawidmilner MS, Spyer KM: Cardiovascular and respiratory effects of stimulation of cell bodies of the parabrachial nuclei in anesthetized rat. J Physiol 1994;477:321-329.
30. Ter Horst GJ, Van den Brink A, Homminga SA, Hautvast RV, Rakhorst G, Mettenleiter T, DeJongste MJ, Lie K, and Korf J: Transneuronal viral labelling of rat heart left ventricle controlling pathways. Neuroreport 1993;4:1307-1311.
31. Ter Horst GJ, Hautvast R, DeJongste MJ, Korf J: Neuroanatomy of cardiac activity regulating circuitry: A transneuronal retrograde viral labelling study in the rat. Eur J Neurosci 1996;8:2029-2041.
32. Ter Horst GJ, Postema F: Forebrain parasympathetic control of heart activity: Retrograde transneuronal viral labeling in rats. Am J Physiol 1997;273:2926-2930.
33. Chan RKW, Sawchenko P: Organization and transmitter specificity of medullary neurons activated by sustained hypertension: Implications for understanding baroreceptor reflex circuitry. J Neurosci 1998;18:371-387.
34. Kuo DC, Oravitz JJ, de Groat WC: Tracing of afferent and efferent pathways in the left inferior cardiac nerve of the cat using retrograde and transport of horseradish peroxidase. Brain Res 1984;321:111-118.
35. Vance WH, Bowker RC: Spinal origins of cardiac afferents from the region of the left anterior descending artery. Brain Res 1983;258:96-100.
36. Apkarian AV, Hodge CJ: Primate spinothalamic pathways. 2. The cells of origin of the dorsolateral and ventral spinothalamic pathways. J Comp Neurol 1989;288:474-492.
37. Hopkins DA, Armour JA: Ganglionic distribution of afferent neurons innervating the canine heart and cardiopulmonary nerves. J Auton Nerv Syst 1989;26:213-222.
38. 5 spinothalamic neurons. J Neurophysiol 1984;51:592-603.
39. 5 medial spinothalamic cells. Am J Physiol 1985;249:147-152.
40. Lenz FA, Gracely RH, Hope EJ, Baker F, Rowland LH, Dougherty PM, Richardson RT: The sensation of angina can be evoked by stimulation of the human thalamus. Pain 1994;59:119-125.
41. Oppenheimer SM, Kulshreshtha N, Lenz FA, Zhang Z, Rowland LH, Dougherty P: Distribution of cardiovascular related cells in the human thalamus. Clin Auton Res 1989;8:173-179.
42. Allen GV, Saper CB, Hurley KM, Cechetto D: Organization of visceral and limbic connections in the insular cortex of the rat. J Comp Neurol 1991;311:1-16.
43. Cechetto DF, Saper CB: Evidence for a viscerotopic sensory representation in the cortex and thalamus in the rat. J Comp Neurol 1987;262:27-45.
44. Takada M: Widespread dopaminergic projections of the subparafascicular thalamic nucleus in the rat. Brain Res Bull 1993;32:301-309.
45. Yasui Y, Nakano K, Mizuno N: Descending projections from the subparafascicular thalamic nucleus to the brainstem in the rat. Exp Brain Res 1992;90:508-518.
46. Su HS, Bentivoglio M: Thalamic midline cell populations projecting to the nucleus accumbens, amygdala, and hippocampus in the rat. J Comp Neurol 1990;297:582-593.
47. Cameron A, Khan IA, Westlund KN, Cliffer KD, Willis W: The efferent projections of the periaqueductal gray in the rat: A Phaseolus vulgaris-leucoagglutinin study. 1. Ascending projections. J Comp Neurol 1995;351:568-584.
48. Otake K, Nakamura Y: Single neurons in Barrington's nucleus projecting to both the paraventricular thalamic nucleus and the spinal cord by way of axon collaterals: A double labeling study in the rat. Neurosci Lett 1996;209:97-100.
49. Davis KD, Taylor S, Crawley AP, Wood M, Mikulis D: Functional MRI of pain- and attention-related activations in the human cingulate cortex. J Neurophysiol 1997;77:3370-3380.
50. Sullivan RM, Gratton A: Lateralized effects of medial prefrontal cortex lesions on neuroendocrine and autonomic stress responses in rats. J Neurosci 1999;19:2834-2840.
51. Devinsky O, Morrell MJ, Vogt BA: Contributions of anterior cingulate cortex to behaviour. Brain 1995;118:279-306.
52. Takagishi M, Chiba T: Efferent projections of the infralimbic (area 25) region of the medial prefrontal cortex in the rat: An anterograde PHA-L study. Brain Res 1991;566:26-39.
53. Luiten PG, Ter Horst GJ, Steffens AB: The hypothalamus, intrinsic connections and outflow pathways to the endocrine system in relation to the control of feeding and metabolism. Prog Neurobiol 1987;28:1-54.
54. Saper CB: Central autonomic nervous system; in Paxinos G (ed): The Rat Nervous System, ed 2. San Diego, Academic Press, 1995, pp 107-135.
55. Sawchenko PE, Swanson LW: Organization of CRF immunoreactive cells and fibers in the rat brain: Immunohistochemical studies; in Souza EB, Nemeroff CB (eds): Corticotropin-Releasing Factor: Basic and Clinical Studies of a Neuropeptide. Boca Raton, CRC Press Inc, 1990, pp 29-52.
56. Ter Horst GJ: Emotions and heart-activity control; in Ter Horst GJ (ed): The Nervous System and The Heart. Totowa, Humana Press Inc, 2000, pp 55-116.
57. Rosen SD, Paulesu E, Nihoyannopoulos P, Tousoulis D, Frackowiak RS, Frith CD, Jones T, Camici PG: Silent ischemia as a central problem: Regional brain activation compared in silent and painful myocardial ischemia. Ann Intern Med 1996;124:939-949.
58. Albutaihi IAM, DeJongste MJL, Ter Horst GJ: Cardiac nociception in rats; Neuronal pathways and the influence of dermal neurostimulation on conveyance to the central nervous system. J Mol Neurosci 2003;20:43-52.
59. Stamford JA: Descending control of pain. Br J Anaesth 1995;75:217-227.
60. Besson JM, Chaouch A: Peripheral and spinal mechanisms of nociception. Physiol Rev 1987;67:67-186.
61. Gerhart KD, Yeziersky RP, Wilcox TK, Willis WD: Inhibition of primate spinothalamic tract neurons by stimulation of the periaqueductal gray or adjacent midbrain reticular formation. J Neurophysiol 1984;51:450-466.
62. Bandler R, Shipley MT: Columnar organization of the midbrain periaqueductal gray: Modules for emotional expression? Trends Neurosci 1994;17:379-384.
63. Leung CG, Mason P: Physiological survey of medullary raphe and magnocellular reticular neurons in the anesthetized rat. J Neurophysiol 1998;80:1630-1646.
64. Aston-Jones G, Shipley MT, Grzanna R: The locus coeruleus, A5 and A7 noradrenergic cell groups; in Paxinos G (ed): The Rat Nervous System, ed 2. San Diego, Academic Press, 1995, pp 183-213.
65. Sim LJ, Joseph SA: Efferent projections of the nucleus raphe magnus. Brain Res Bull 1992;28:679-682.
66. Martinez M, Phillips P, Herbert J: Adaptation in patterns of c-fos expression in the brain associated with exposure to either single or repeated social stress in male rats. Eur J Neurosci 1998;10:20-33.
67. Ishida Y, Hashiguchi H, Takeda R, Ishizuka Y, Mitsuyama Y, Kannan H, Nishimori T, Nakahara D: Conditioned-fear stress increases Fos expression in monoaminergic and GABAergic neurons of the locus coeruleus and dorsal raphe nuclei. Synapse 2002;45:46-51.