Selective PrP-like protein, doppel immunoreactivity in dystrophic neurites of senile plaques in Alzheimer's disease

Neuropathology and Applied Neurobiology

Volumn 30, Issue 4, 2004, Pages 329-337

  Ferrer, I ^a,b   Freixas, M ^a   Blanco, R ^a   Carmona, M ^a   Puig, B ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

Author keywords

Alzheimer; Amyloid; Creutzfeldt Jakob; Doppel; Parkinson; PrP

Indexed keywords

AMYLOID BETA PROTEIN; METHIONINE; PRION PROTEIN; PROTEIN DOPPEL; UNCLASSIFIED DRUG; VALINE;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN CORTEX; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DIFFUSE LEWY BODY DISEASE; DYSTROPHY; FATAL FAMILIAL INSOMNIA; FEMALE; GLIA CELL; GRANULE CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; KURU; MALE; NEURITE; NEUROFIBRILLARY TANGLE; OXIDATIVE STRESS; PARKINSON DISEASE; PICK PRESENILE DEMENTIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENILE PLAQUE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; ASTROCYTES; BRAIN; BRAIN CHEMISTRY; CREUTZFELDT-JAKOB SYNDROME; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LEWY BODY DISEASE; MALE; MIDDLE AGED; NEURITES; NEUROFIBRILLARY TANGLES; PARKINSON DISEASE; PICK DISEASE OF THE BRAIN; PRIONS; SENILE PLAQUES; TESTIS;

EID: 4344661358     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2003.00534.x     Document Type: Article

References (40)

1. Li A, Sakaguchi S, Shigematsu K, Atarashi R, Roy BC, Nakaoke R, Arima K, Okimura N, Kopacek J, Katamine S. Physiological expression of the gene for PrP-like protein, PrPLP/Dpl, by brain endothelial cells and its ectopic expression in neurons of PrP-deficient mice ataxic due to Purkinje cell degeneration. Am J Pathol 2000; 157: 1447-52
2. Moore RC, Lee IY, Silverman GL, Harrison PM, Strome R, Heirich C, Karunaratne A, Pasternak SH, Chrishti MA, Liang Y, Mastrangelo P, Wang K, Smit AF, Katamine S, Carlson GA, Cohen FE, Prusiner SB, Melton DW, Tremblay P, Hood LE, Westaway D. Ataxia in prion protein (PrP)-deficient mice is associated with up-regulation of the novel PrP-like protein doppel. J Mol Biol 1999; 292: 797-817
3. Silverman GL, Qin K, Morre RC, Yang Y, Mastrangelo P, Tremblay P, Prusiner SB, Cohen FE, Westaway D. Doppel is an N-glycosylated, glycosylphosphophatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss. J Biol Chem 2000; 275: 26834-41
4. Tranulis MA, Espenes A, Comincini S, Stkretting G, Harbitz I. The PrP-like protein Doppel gene in sheep and cattle: cDNA sequence and expression. Mamm Genome 2001; 12: 376-9
5. Peoc'h K, Serres C, Frobert Y, Martin C, Lehmann S, Chasseigneaux S, Sazdovitch V, Grassi J, Jouannet P, Launay JM, Laplanche JL. The human 'prion-like' protein Doppel is expressed in both Sertoli cells and spermatozoa. J Biol Chem 2002; 277: 43071-8
6. Behrens A, Genoud N, Naumann H, Rulicke T, Janett F, Heppner FL, Ledermann B, Aguzzi A. Absence of the prion protein homologue Doppel causes male sterility. EMBO J 2002; 21: 3652-8
7. Legname G, Nelken P, Guan Z, Kanyo ZF, DeArmond SJ, Prusiner SB. Prion and doppel proteins bind to granule cells of the cerebellum. Proc Natl Acad Sci USA 2002; 99: 16285-90
8. Moore RC, Mastrangelo P, Bouzamondo E, Heirich C, Legname G, Prusiner SB, Hood L, Westaway D, DeArmond SJ, Tremblay P. Doppel-induced cerebellar degeneration in transgenic mice. Proc Natl Acad Sci USA 2001; 98: 15288-93
9. Rossi D, Cozzio A, Flechsing E, Klein MA, Rulicke T, Aguzzi A, Weissmann C. Onset of ataxia and Purkinje cell loss in PrP null mice inversely correlated with Dpl level in brain. EMBO J 2001; 20: 694-702
10. Behrens A, Aguzzi A. Small is not beautiful: antagonizing functions for the prion protein PrP (C) and its homologue Dpl. Trends Neurosci 2002; 25: 150-4
11. Nishida N, Tremblay P, Sugimoto T, Shigematsu K, Shirabe S, Petron C, Erpel SP, Nakaoke R, Atarashi R, Houtani T, Torchia M, Sakageno M, DeArmond SJ, Prusiner SB, Katamine S. A mouse prion protein transgene rescues mice deficient for the prion protein gene from Purkinje cell degeneration and demyelination. Lab Invest 1999; 79: 689-97
12. Mo H, Moore RC, Cohen FE, Westaway D, Prusiner SB, Wright PE, Dysson HJ. Two different neurodegenerative diseases caused by proteins with similar structures. Proc Natl Acad Sci USA 2001; 98: 2352-7
13. Tuzi NL, Gall E, Melton D, Manson JC. Expression of doppel in the CNS of mice does not modulate transmissible spongiform encephalopathy disease. J Gen Virol 2002; 83: 705-11
14. Comincini S, Foti MG, Tranulis MA, Hills D, Di Guardo G, Vaccari G, Williams JL, Harbitz I, Ferretti L. Genomic organization, comparative analysis, and genetic polymorphisms of the bovine and ovine prion Doppel genes (PRND). Mamm Genome 2001; 12: 729-33
15. Mead S, Beck J, Dickinson A, Fisher EM, Collinge J. Examination of the human prion protein-like gene doppel for genetic susceptibility to sporadic and variant Creutzfeldt-Jakob disease. Neurosci Lett 2000; 290: 117-20
16. Peoc'h K, Guerin C, Brandel JP, Launay JM, Laplanche JL. First report of polymorphism in the prion-like protein gene (PRND): implications for human prion diseases. Neurosci Lett 2000; 286: 144-8
17. Schroeder B, Franz B, Hempfling P, Selbert M, Jurgens T, Kretzschmar HA, Bodemer M, Poser S, Zerr I. Polymorphism within the prion-like protein gene (Prnd) and their implications in human prion diseases, Alzheimer's disease and other neurological disorders. Hum Genet 2001; 109: 319-25
18. Infante J, Llorca J, Rodero L, Palacio E, Berciano J, Combarros O. Polymorphism at codon 174 of the prion-like protein gene is not associated with sporadic Alzheimer's disease. Neurosci Lett 2002; 332: 213-15
19. Mastrangelo P, Serpell L, Dafforn T, Lesk A, Fraser P, Westaway D. A cluster of familial Creutzfeldt-Jakob disease mutations recapitulate conserved residues in Doppel: a case of molecular mimicry? FEBS Lett 2002; 532: 21-6
20. Peoc'h K, Volland H, De Gassart A, Beaudry P, Sazdovitch V, Sorgat MC, Creminon C, Laplanche JL, Lehmann S. Prion-like protein Doppel expression is not modified in scrapie infected cells and in the brains of patients with Creutzfeldt-Jakob disease. FEBS Lett 2003; 536: 61-5
21. Esiri MM, Carter J, Ironside JW. Prion protein immunoreactivity in brain samples from an unselected autopsy population: findings in 200 consecutive cases. Neuropathol Appl Neurobiol 2000; 26: 273-84
22. Kovacs GG, Zerbi P, Voigtlander T, Strohschneider M, Trabattoni G, Hainfellner JA, Budka H. The prion protein in human neurodegenerative disorders. Neurosci Lett 2002; 329: 269-72
23. Ferrer I, Blanco R, Carmona M, Puig B, Ribera R, Rey MJ, Ribalta T. Prion protein expression in senile plaques in Alzheimer's disease. Acta Neuropathol 2001; 101: 49-56
24. Braak H, Braak E. Temporal sequence of Alzheimer's disease-related pathology. In Cerebral Cortex, Vol 14, Neurodegenerative, Age-related Changes in Structure, Function of Cerebral Cortex. Eds A Peters, JH Morrison. New York, Boston, Dordrecht, London, Moscow: Kluwer Academic/Plenum Publishers, 1999; 475-512
25. Ferrer I. The neuropathology spectrum of Lewy body disorders. In Neurodegenerative Disorders Associated with α-Synuclein Pathology. Eds E Tolosa, JB Schulz, IG McKeith, I Ferrer. Barcelona: Ars Medica, 2002; 83-98
26. Ferrer I, Puig B, Blanco R, Martí E. Prion protein deposition and abnormal synaptic protein expression in the cerebellum in Creutzfeldt-Jakob disease. Neuroscience 2000; 97: 715-26
27. Ferrer I, Martí E, Tortosa A, Blasi J. Dystrophic neurites of senile plaques are defective in proteins involved in exocytosis and neurotransmission. J Neuropathol Exp Neurol 1998; 57: 218-25
28. Brion JP, Couck AM, Bruce M, Anderton B, Flament-Durand J. Synaptophysin and chromogranin A immunoreactivities in senile plaques of Alzheimer's disease. Brain Res 1991; 539: 143-50
29. Lassmann H, Weiler R, Fisher P, Bancher C, Jellinger K, Floor E, Danielcyck W. Synaptic pathology in Alzheimer's disease: immunological data for markers of synaptic and large dense-core vesicles. Neuroscience 1992; 46: 1-8
30. Muñoz D. Chromogranin A-like immunoreactive neurons are major constituents of senile plaques. Lab Invest 1991; 64: 826-32
31. Ferrer I, Aymamí A, Rovira A, Grau-Veciana JM. Growth of abnormal neurites in atypical Alzheimer's disease. A study with the Golgi method. Acta Neuropathol 1983; 59: 167-70
32. Ferrer I, Guionnet N, Cruz-Sanchez F, Tuñon T. Neuronal alterations in patients with dementia: a Golgi study on biopsy samples. Neurosci Lett 1990; 114: 11-16
33. Paula-Barbosa MM, Cardoso RM, Guimaraes ML, Cruz C. Dendritic degeneration and regrowth in the cerebral cortex of patients with Alzheimer's disease. J Neurol Sci 1980; 45: 129-34
34. Probst A, Basler V, Bron B, Ulrich J. Neuritic plaques in senile dementia of Alzheimer's type: a Golgi analysis in the hippocampal region. Brain Res 1983; 268: 249-54
35. Scheibel A, Tomiyasu U. Dendritic sprouting in Alzheimer's presenile dementia. Exp Neurol 1978; 60: 1-8
36. Masliah E, Mallory K, Hansen L, Alford M, DeTeresa R, Terry R, Baudier J, Saitoh T. Localization of amyloid precursor protein in GAP-43-immunoreactive aberrant sprouting neurites in Alzheimer's disease. Brain Res 1992; 574: 312-16
37. Masliah E, Mallory K, Hansen L, Alford M, Albright T, DeTeresa R, Terry R, Baudier J, Saitoh T. Patterns of aberrant sprouting in Alzheimer's disease. Neuron 1991; 6: 729-39
38. Wong BS, Liu T, Paisley D, Li R, Pan T, Chen SG, Perry G, Petersen RB, Smith MA, Melton DW, Gambetti P, Brown DR, Sy MS. Induction of HO-1 and NOS in doppel-expressive mice devoid of PrP: implications for doppel function. Mol Cell Neurosci 2001; 17: 768-75
39. Qin K, Coomaraswamy J, Mastrangelo P, Yang Y, Lugowski S, Petromilli C, Prusiner SB, Fraser PE, Goldberg JM, Chakrabartty A, Westaway D. The PrP-like protein Doppel binds copper. J Biol Chem 2003; 278: 888-96
40. Atarashi R, Sakaguchi S, Shigematsu K, Arima K, Okimura N, Yamaguchi N, Li A, Kopacecek J, Katamine S. Abnormal activation of glial cells in the brains of prion protein deficient mice ectopically expressing prion protein-like protein PrPLP/Dpl. Mol Med 2001; 7: 803-9