메뉴 건너뛰기




Volumn 8, Issue 3, 2004, Pages 715-728

Pharmacologic management of nonalcoholic fatty liver disease

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; ATORVASTATIN; BETAINE; BIGUANIDE; CLOFIBRATE; GEMFIBROZIL; METFORMIN; PIOGLITAZONE; PROBUCOL; ROSIGLITAZONE; TETRAHYDROLIPSTATIN; URSODEOXYCHOLIC ACID;

EID: 4344629342     PISSN: 10893261     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cld.2004.04.011     Document Type: Review
Times cited : (15)

References (75)
  • 1
    • 0033231294 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with insulin resistance
    • Marchesini G., Brizi M., Marsell-Labate A.M., et al. Association of nonalcoholic fatty liver disease with insulin resistance. Am J Med. 107:1999;450-455
    • (1999) Am J Med , vol.107 , pp. 450-455
    • Marchesini, G.1    Brizi, M.2    Marsell-Labate, A.M.3
  • 2
    • 0035084699 scopus 로고    scopus 로고
    • Nonalcohlic steatohepatitis: Association of insulin resistance and mitochondrial abnormalities
    • Sanyal A.J., Campbell-Sangert C., Mirshahi F., et al. Nonalcohlic steatohepatitis: association of insulin resistance and mitochondrial abnormalities. Gastroenterology. 120:2001;1183-1192
    • (2001) Gastroenterology , vol.120 , pp. 1183-1192
    • Sanyal, A.J.1    Campbell-Sangert, C.2    Mirshahi, F.3
  • 3
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman P.G. Obesity as a medical problem. Nature. 404:2000;635-643
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 4
    • 0035516047 scopus 로고    scopus 로고
    • Projection of diabetes burden through 2050: Impact of changing demography and disease prevalence in the US
    • Boyle J.P., Honeycutt A.A., Narayan K.M., et al. Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the US. Diabetes Care. 24:2001;1936-1940
    • (2001) Diabetes Care , vol.24 , pp. 1936-1940
    • Boyle, J.P.1    Honeycutt, A.A.2    Narayan, K.M.3
  • 6
    • 0024336332 scopus 로고
    • Nonalcoholic steatohepatitis: A study of 39 patients
    • Lee R.G. Nonalcoholic steatohepatitis: a study of 39 patients. Hum Pathol. 20:1989;594-598
    • (1989) Hum Pathol , vol.20 , pp. 594-598
    • Lee, R.G.1
  • 7
    • 0025178612 scopus 로고
    • The natural history of nonalcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell E.E., Cooksley W.G., Hanson R., et al. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology. 11:1990;74-80
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3
  • 8
    • 0028070562 scopus 로고
    • Nonalcoholic steatohepatitis: An expanded clinical entity
    • Bacon B.R., Farahvash M.J., Janney C.G., et al. Nonalcoholic steatohepatitis: an expanded clinical entity. Gastroenterology. 107:1994;1103-1109
    • (1994) Gastroenterology , vol.107 , pp. 1103-1109
    • Bacon, B.R.1    Farahvash, M.J.2    Janney, C.G.3
  • 9
    • 0034799113 scopus 로고    scopus 로고
    • Ninety patients with nonalcoholic steatohepatitis: Insulin resistance, familial tendency, and severity of disease
    • Willner I.R., Waters B., Raj Patil S., et al. Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease. Am J Gastroenterol. 96:2001;2957-2961
    • (2001) Am J Gastroenterol , vol.96 , pp. 2957-2961
    • Willner, I.R.1    Waters, B.2    Raj Patil, S.3
  • 10
    • 0036302288 scopus 로고    scopus 로고
    • Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma
    • Bugianesi E., Leone N., Vanni E., et al. Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma. Gastroenterology. 123:2002;134-140
    • (2002) Gastroenterology , vol.123 , pp. 134-140
    • Bugianesi, E.1    Leone, N.2    Vanni, E.3
  • 11
    • 0036307856 scopus 로고    scopus 로고
    • Is hepatocellular carcinoma part of the natural history of nonalcoholic steatohepatitis?
    • Ong J.P., Younossi Z.M. Is hepatocellular carcinoma part of the natural history of nonalcoholic steatohepatitis? Gastroenterology. 123:2002;375-378
    • (2002) Gastroenterology , vol.123 , pp. 375-378
    • Ong, J.P.1    Younossi, Z.M.2
  • 12
    • 0019152816 scopus 로고
    • Nonalcoholic steatohepatitis: Mayo Clinic experience with a hitherto unnamed disease
    • Ludwig J., Viggiano T.R., McGIll D.B., et al. Nonalcoholic steatohepatitis: Mayo Clinic experience with a hitherto unnamed disease. Mayo Clin Proc. 55:1980;434-438
    • (1980) Mayo Clin Proc , vol.55 , pp. 434-438
    • Ludwig, J.1    Viggiano, T.R.2    McGill, D.B.3
  • 13
    • 4243739172 scopus 로고    scopus 로고
    • Clinical factors associated with fibrosis in 102 patients with nonalcoholic steatohepatitis
    • Harrison S.A., Hayashi P. Clinical factors associated with fibrosis in 102 patients with nonalcoholic steatohepatitis. Hepatology. 36:2002;412A
    • (2002) Hepatology , vol.36
    • Harrison, S.A.1    Hayashi, P.2
  • 14
    • 0032695030 scopus 로고    scopus 로고
    • Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis
    • Angulo P., Keach J.C., Batts K.P., et al. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology. 30:1999;1356-1362
    • (1999) Hepatology , vol.30 , pp. 1356-1362
    • Angulo, P.1    Keach, J.C.2    Batts, K.P.3
  • 15
    • 0036291809 scopus 로고    scopus 로고
    • HFE mutations, hepatic iron, and fibrosis: Ethnic-specific association of NASH with C282Y but not with fibrotic severity
    • Chitturi S., Weltman M., Farrell G.C., et al. HFE mutations, hepatic iron, and fibrosis: ethnic-specific association of NASH with C282Y but not with fibrotic severity. Hepatology. 36:2002;142-149
    • (2002) Hepatology , vol.36 , pp. 142-149
    • Chitturi, S.1    Weltman, M.2    Farrell, G.C.3
  • 16
    • 0037990061 scopus 로고    scopus 로고
    • The relationship of obesity to the metabolic syndrome
    • Lebovitz H.E. The relationship of obesity to the metabolic syndrome. Int J Clin Pract. 134:2003;18-27
    • (2003) Int J Clin Pract , vol.134 , pp. 18-27
    • Lebovitz, H.E.1
  • 18
    • 0034994838 scopus 로고    scopus 로고
    • The acute versus the chronic response to exercise
    • Thompson P.D., Crouse S.F., Goodpaster B., et al. The acute versus the chronic response to exercise. Med Sci Sports Exerc. 33(6 Suppl):2001;S438-S445
    • (2001) Med Sci Sports Exerc , vol.33 , Issue.6 SUPPL.
    • Thompson, P.D.1    Crouse, S.F.2    Goodpaster, B.3
  • 20
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G., Myers R., Li Y., et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 108:2001;1167-1174
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 21
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: A tale of two "hits"? [editorial]
    • Day C., James O. Steatohepatitis: a tale of two "hits"? [editorial]. Gastroenterology. 114:1998;842-845
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.1    James, O.2
  • 22
    • 0025186310 scopus 로고
    • Effect of weight reduction on hepatic abnormalities in overweight patients
    • Palmer M., Schaffner F. Effect of weight reduction on hepatic abnormalities in overweight patients. Gastroenterology. 99:1990;1408-1413
    • (1990) Gastroenterology , vol.99 , pp. 1408-1413
    • Palmer, M.1    Schaffner, F.2
  • 23
    • 0030740659 scopus 로고    scopus 로고
    • Therapeutic effects of restricted diet and exercise in obese patients with fatty liver
    • Ueno T., Sagawara H., Sujaka K., et al. Therapeutic effects of restricted diet and exercise in obese patients with fatty liver. J Hepatol. 27:1997;103-107
    • (1997) J Hepatol , vol.27 , pp. 103-107
    • Ueno, T.1    Sagawara, H.2    Sujaka, K.3
  • 24
    • 0014051568 scopus 로고
    • Liver morphology and function tests in obesity and during total starvation
    • Rozental P., Biava C., Spencer H., et al. Liver morphology and function tests in obesity and during total starvation. Am J Dig Dis. 12:1967;198-208
    • (1967) Am J Dig Dis , vol.12 , pp. 198-208
    • Rozental, P.1    Biava, C.2    Spencer, H.3
  • 25
    • 0025959287 scopus 로고
    • Hepatic effects of dietary weight loss in morbidly obese patients
    • Anderson T., Gluud C., Franzmann M.B., et al. Hepatic effects of dietary weight loss in morbidly obese patients. J Hepatol. 12:1991;224-229
    • (1991) J Hepatol , vol.12 , pp. 224-229
    • Anderson, T.1    Gluud, C.2    Franzmann, M.B.3
  • 26
    • 0033328294 scopus 로고    scopus 로고
    • Parallel reversibility of biological markers of the metabolic syndrome and liver steatosis after gastroplasty-induced weight loss in severe obesity
    • Luyckx F.H., Scheen A.J., Desaive C., Thiry A., Lefebvre P.J. Parallel reversibility of biological markers of the metabolic syndrome and liver steatosis after gastroplasty-induced weight loss in severe obesity. J Clin Endocrinol Metab. 84:1999;4293
    • (1999) J Clin Endocrinol Metab , vol.84 , pp. 4293
    • Luyckx, F.H.1    Scheen, A.J.2    Desaive, C.3    Thiry, A.4    Lefebvre, P.J.5
  • 27
    • 0034048643 scopus 로고    scopus 로고
    • Orlistat, a new lipase inhibitor for the management of obesity
    • Heck A.M., Yanovski J.A., Calis K.A. Orlistat, a new lipase inhibitor for the management of obesity. Pharmacotherapy. 20:2000;270-279
    • (2000) Pharmacotherapy , vol.20 , pp. 270-279
    • Heck, A.M.1    Yanovski, J.A.2    Calis, K.A.3
  • 29
    • 0038471725 scopus 로고    scopus 로고
    • Orlistat treatment in obese, nonalcoholic steatohepatitis patients: A pilot trial
    • Harrison S.A., Fincke C., Helinski D., et al. Orlistat treatment in obese, nonalcoholic steatohepatitis patients: a pilot trial. Hepatology. 36:2002;406A
    • (2002) Hepatology , vol.36
    • Harrison, S.A.1    Fincke, C.2    Helinski, D.3
  • 30
    • 0037382071 scopus 로고    scopus 로고
    • Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis
    • Musso G., Gambino R., De Michieli F., Cassader M., Rizzetto M., Durazzo M., et al. Dietary habits and their relations to insulin resistance and postprandial lipemia in nonalcoholic steatohepatitis. Hepatology. 37:2003;909-916
    • (2003) Hepatology , vol.37 , pp. 909-916
    • Musso, G.1    Gambino, R.2    De Michieli, F.3    Cassader, M.4    Rizzetto, M.5    Durazzo, M.6
  • 31
    • 84933047295 scopus 로고    scopus 로고
    • Ursodeoxycholic acid or clofibrate in the treatment of nonalcohol-induced steatohepatitis: A pilot study
    • Laurin J., Lindor K.D., Crippen J.S., et al. Ursodeoxycholic acid or clofibrate in the treatment of nonalcohol-induced steatohepatitis: a pilot study. Hepatology. 23:1996;1464-1467
    • (1996) Hepatology , vol.23 , pp. 1464-1467
    • Laurin, J.1    Lindor, K.D.2    Crippen, J.S.3
  • 32
    • 0032776856 scopus 로고    scopus 로고
    • A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis
    • Basaranoglu M., Acbay O., Sonsuz A. A controlled trial of gemfibrozil in the treatment of patients with nonalcoholic steatohepatitis. J Hepatol. 31:1999;384
    • (1999) J Hepatol , vol.31 , pp. 384
    • Basaranoglu, M.1    Acbay, O.2    Sonsuz, A.3
  • 35
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann J.M., Moore L.B., Smith-Oliver T.A., et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator- activated receptor gamma (PPAR gamma). J Biol Chem. 270:1995;12953-12956
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3
  • 36
    • 0036310037 scopus 로고    scopus 로고
    • The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes
    • Mayerson A.B., Hundal R.S., Dufour S., et al. The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. Diabetes. 51:2002;797-802
    • (2002) Diabetes , vol.51 , pp. 797-802
    • Mayerson, A.B.1    Hundal, R.S.2    Dufour, S.3
  • 37
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • Fryer L.G.D., Parbu-Patel A., Carling D. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem. 277:2002;25226-25232
    • (2002) J Biol Chem , vol.277 , pp. 25226-25232
    • Fryer, L.G.D.1    Parbu-Patel, A.2    Carling, D.3
  • 38
    • 0036068327 scopus 로고    scopus 로고
    • Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110β protein levels in skeletal muscle of type 2 diabetic subjects
    • Kim Y.-B., Ciaraldi T.P., Kong A., et al. Troglitazone but not metformin restores insulin-stimulated phosphoinositide 3-kinase activity and increases p110β protein levels in skeletal muscle of type 2 diabetic subjects. Diabetes. 51:2002;443-448
    • (2002) Diabetes , vol.51 , pp. 443-448
    • Kim, Y.-B.1    Ciaraldi, T.P.2    Kong, A.3
  • 39
    • 0036082703 scopus 로고    scopus 로고
    • Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
    • Galli A., Crabb D.W., Cerri E., et al. Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro. Gastroenterology. 122:2002;1924-1940
    • (2002) Gastroenterology , vol.122 , pp. 1924-1940
    • Galli, A.1    Crabb, D.W.2    Cerri, E.3
  • 41
    • 0342502229 scopus 로고    scopus 로고
    • Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus
    • Menon K.V.N., Angulo P., Lindor K.D. Severe cholestatic hepatitis from troglitazone in a patient with nonalcoholic steatohepatitis and diabetes mellitus. Am J Gastroenterol. 96:2001;1631-1634
    • (2001) Am J Gastroenterol , vol.96 , pp. 1631-1634
    • Menon, K.V.N.1    Angulo, P.2    Lindor, K.D.3
  • 43
    • 0141996322 scopus 로고    scopus 로고
    • Effect of pioglitazone on biochemical indices of nonalcoholic fatty liver disease in upper body obesity
    • Shadid S., Jensen M.D. Effect of pioglitazone on biochemical indices of nonalcoholic fatty liver disease in upper body obesity. Clin Gastro Hepatol. 1:2003;384-387
    • (2003) Clin Gastro Hepatol , vol.1 , pp. 384-387
    • Shadid, S.1    Jensen, M.D.2
  • 45
    • 0037794933 scopus 로고    scopus 로고
    • A randomized controlled pilot study of pioglitazone and vitamin e versus vitamin e for nonalcoholic steatohepatitis [abstract]
    • Sanyal A.J., Contos M.J., Sargeant C., Stravitz R.T., Luketic V.A., Sterling R.K., et al. A randomized controlled pilot study of pioglitazone and vitamin E versus vitamin E for nonalcoholic steatohepatitis [abstract]. Hepatology. 36(Suppl):2002;382A
    • (2002) Hepatology , vol.36 , Issue.SUPPL.
    • Sanyal, A.J.1    Contos, M.J.2    Sargeant, C.3    Stravitz, R.T.4    Luketic, V.A.5    Sterling, R.K.6
  • 47
    • 0141532275 scopus 로고    scopus 로고
    • Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone
    • Neuschwander-Tetri B.A., Brunt E.M., Wehmeiher K.R., Oliver D., Bacon B.R. Improved nonalcoholic steatohepatitis after 48 weeks of treatment with the PPAR-γ ligand rosiglitazone. Hepatology. 38:2003;1008-1017
    • (2003) Hepatology , vol.38 , pp. 1008-1017
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeiher, K.R.3    Oliver, D.4    Bacon, B.R.5
  • 48
    • 0037385387 scopus 로고    scopus 로고
    • Interim results of a pilot study demonstrating the early effects of the PPAR-γ ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis
    • Neuschwander-Tetri B.A., Brunt E.M., Wehmeiher K.R., Sponseller C., Hampton K., Bacon B.R. Interim results of a pilot study demonstrating the early effects of the PPAR-γ ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with non-alcoholic steatohepatitis. J Hepatol. 38:2003;434-440
    • (2003) J Hepatol , vol.38 , pp. 434-440
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeiher, K.R.3    Sponseller, C.4    Hampton, K.5    Bacon, B.R.6
  • 49
    • 0012785395 scopus 로고    scopus 로고
    • Metformin reverses fatty liver disease in obese, leptin-deficient mice
    • Lin H.Z., Yang S., Chuckaree C., et al. Metformin reverses fatty liver disease in obese, leptin-deficient mice. Nat Med. 6:2000;998-1003
    • (2000) Nat Med , vol.6 , pp. 998-1003
    • Lin, H.Z.1    Yang, S.2    Chuckaree, C.3
  • 50
    • 0035883890 scopus 로고    scopus 로고
    • Metformin in non-alcoholic steatohepatitis
    • Marchesini G., Brizi M., Blanchi G., et al. Metformin in non-alcoholic steatohepatitis. Lancet. 358:2001;893-894
    • (2001) Lancet , vol.358 , pp. 893-894
    • Marchesini, G.1    Brizi, M.2    Blanchi, G.3
  • 51
    • 0038826548 scopus 로고    scopus 로고
    • Metformin in non alcoholic steatohepatitis (NASH): Efficacy and safety: A preliminary report
    • Nair S., Diehl A.M., Perrillo R. Metformin in non alcoholic steatohepatitis (NASH): efficacy and safety: a preliminary report. Gastroenterology. 1222:2002;A621
    • (2002) Gastroenterology , vol.1222 , pp. 621
    • Nair, S.1    Diehl, A.M.2    Perrillo, R.3
  • 52
    • 0037772442 scopus 로고    scopus 로고
    • Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II
    • Bataller R., Sancho-Bru P., Gines P., Lora J.M., Al-Garawi A., Sole M., et al. Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II. Gastroenterology. 125:2003;117-125
    • (2003) Gastroenterology , vol.125 , pp. 117-125
    • Bataller, R.1    Sancho-Bru, P.2    Gines, P.3    Lora, J.M.4    Al-Garawi, A.5    Sole, M.6
  • 53
    • 0037963091 scopus 로고    scopus 로고
    • Angiotensin-I-converting enzyme inhibitors may be an alternative anti-angiogenic strategy in the treatment of liver fibrosis and hepatocellular carcinoma. Possible role of vascular endothelial growth factor
    • Yoshiji H., Kuriyama S., Fukui H. Angiotensin-I-converting enzyme inhibitors may be an alternative anti-angiogenic strategy in the treatment of liver fibrosis and hepatocellular carcinoma. Possible role of vascular endothelial growth factor. Tumour Biol. 23:2002;348-356
    • (2002) Tumour Biol , vol.23 , pp. 348-356
    • Yoshiji, H.1    Kuriyama, S.2    Fukui, H.3
  • 54
    • 0034968140 scopus 로고    scopus 로고
    • The expression of AT1 receptor on hepatic stellate cells in rat fibrosis induced by CCl4
    • Wei H., Lu H., Li D., Zhan Y., Wang Z., Huang X. The expression of AT1 receptor on hepatic stellate cells in rat fibrosis induced by CCl4. Chinese Med J. 114:2001;583-587
    • (2001) Chinese Med J , vol.114 , pp. 583-587
    • Wei, H.1    Lu, H.2    Li, D.3    Zhan, Y.4    Wang, Z.5    Huang, X.6
  • 55
    • 0242524659 scopus 로고    scopus 로고
    • Advances in the understanding and treatment of nonalcoholic fatty liver disease
    • Harrison S.A., DiBisceglie A.M. Advances in the understanding and treatment of nonalcoholic fatty liver disease. Drugs. 63:2003;1-17
    • (2003) Drugs , vol.63 , pp. 1-17
    • Harrison, S.A.1    Dibisceglie, A.M.2
  • 56
    • 0345186310 scopus 로고    scopus 로고
    • Vitamin e but not glutathione precursors inhibits hepatic fibrosis in experimental NASH exhibiting oxidative stress and mitochondrial abnormalities
    • Phung N., Farrell G., Robertson G. Vitamin E but not glutathione precursors inhibits hepatic fibrosis in experimental NASH exhibiting oxidative stress and mitochondrial abnormalities. Hepatology. 34:2001;361A
    • (2001) Hepatology , vol.34
    • Phung, N.1    Farrell, G.2    Robertson, G.3
  • 57
    • 0026670128 scopus 로고
    • Vitamin e dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis
    • Parola M., Leonarduzzi G., Biasi F., et al. Vitamin E dietary supplementation protects against carbon tetrachloride-induced chronic liver damage and cirrhosis. Hepatology. 16(4):1992;1014-1021
    • (1992) Hepatology , vol.16 , Issue.4 , pp. 1014-1021
    • Parola, M.1    Leonarduzzi, G.2    Biasi, F.3
  • 58
    • 0026638458 scopus 로고
    • Vitamin e dietary supplementation inhibits tissue growth factor beta-1 gene expression in the rat liver
    • Parola M., Muraca R., Dianzani I., et al. Vitamin E dietary supplementation inhibits tissue growth factor beta-1 gene expression in the rat liver. FEBS Lett. 308:1992;267-270
    • (1992) FEBS Lett , vol.308 , pp. 267-270
    • Parola, M.1    Muraca, R.2    Dianzani, I.3
  • 59
    • 0034126755 scopus 로고    scopus 로고
    • Vitamin e treatment of nonalcoholic steatohepatitis in children: A pilot study
    • Lavine J.E. Vitamin E treatment of nonalcoholic steatohepatitis in children: a pilot study. J Pediatr. 136:2000;734-738
    • (2000) J Pediatr , vol.136 , pp. 734-738
    • Lavine, J.E.1
  • 60
    • 0034799895 scopus 로고    scopus 로고
    • Plasma transforming growth factor-1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis: A pilot study
    • Hasegawa T., Yoneda M., Nakamura K., et al. Plasma transforming growth factor-1 level and efficacy of α-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Aliment Pharmacol Ther. 15:2001;1667-1672
    • (2001) Aliment Pharmacol Ther , vol.15 , pp. 1667-1672
    • Hasegawa, T.1    Yoneda, M.2    Nakamura, K.3
  • 61
    • 0344742265 scopus 로고    scopus 로고
    • Vitamin e and vitamin C in the treatment of nonalcoholic steatohepatitis
    • Harrison S.A., Torgerson S., Hayashi P., et al. Vitamin E and vitamin C in the treatment of nonalcoholic steatohepatitis. Am J Gastroenterol. 98:2003;2485-2490
    • (2003) Am J Gastroenterol , vol.98 , pp. 2485-2490
    • Harrison, S.A.1    Torgerson, S.2    Hayashi, P.3
  • 62
    • 0034174474 scopus 로고    scopus 로고
    • S-adenosylmethionine
    • Lu S.C. S-adenosylmethionine. Int J Biochem Cell Bio. 32:2000;391-395
    • (2000) Int J Biochem Cell Bio , vol.32 , pp. 391-395
    • Lu, S.C.1
  • 63
    • 0344867846 scopus 로고    scopus 로고
    • Spanish collaborative group for the study of alcoholic liver cirrhosis. S-adenosylmethionine in the treatment of alcoholic liver cirrhosis: A randomized, placebo-controlled, double-blind multicenter clinical trial
    • Mato J.M., Camara J., Ortiz P., et al. Spanish collaborative group for the study of alcoholic liver cirrhosis. S-adenosylmethionine in the treatment of alcoholic liver cirrhosis: a randomized, placebo-controlled, double-blind multicenter clinical trial. J Hepatol. 30:1999;1081-1089
    • (1999) J Hepatol , vol.30 , pp. 1081-1089
    • Mato, J.M.1    Camara, J.2    Ortiz, P.3
  • 64
    • 0034834208 scopus 로고    scopus 로고
    • Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: Results of a pilot study
    • Abdelmalek M.F., Angulo P., Jorgensen R.A., et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol. 96:2001;2711-2717
    • (2001) Am J Gastroenterol , vol.96 , pp. 2711-2717
    • Abdelmalek, M.F.1    Angulo, P.2    Jorgensen, R.A.3
  • 65
    • 0033884107 scopus 로고    scopus 로고
    • Eficacy and safety of oral betaine glucuronate in nonalcoholic steatohepatitis
    • Miglio F., Rovati L.C., Santoro A., Setkikar I. Eficacy and safety of oral betaine glucuronate in nonalcoholic steatohepatitis. Arzneim-Forsch./Drug Res. 50:2000;722-727
    • (2000) Arzneim-Forsch./Drug Res , vol.50 , pp. 722-727
    • Miglio, F.1    Rovati, L.C.2    Santoro, A.3    Setkikar, I.4
  • 66
    • 0037812264 scopus 로고    scopus 로고
    • Phlebotomy reduces transaminase levels in patients with chronic non-viral non-alcoholic steatohepatitis
    • Desai T.K. Phlebotomy reduces transaminase levels in patients with chronic non-viral non-alcoholic steatohepatitis. Hepatology. 24(Suppl):1996;1498A
    • (1996) Hepatology , vol.24 , Issue.SUPPL.
    • Desai, T.K.1
  • 67
    • 0000679912 scopus 로고    scopus 로고
    • Phlebotomy reduces transaminase levels in patients with non-alcoholic steatohepatitis [abstract]
    • Desai T.K. Phlebotomy reduces transaminase levels in patients with non-alcoholic steatohepatitis [abstract]. Gastroenterology. 118:2000;A1071
    • (2000) Gastroenterology , vol.118 , pp. 1071
    • Desai, T.K.1
  • 68
    • 0000439294 scopus 로고    scopus 로고
    • Effect of phlebotomy on non-alcoholic steatohepatitis (NASH) [abstract]
    • Nitecki J., Jackson F.W., Allen M.L., et al. Effect of phlebotomy on non-alcoholic steatohepatitis (NASH) [abstract]. Gastroenterology. 118:2000;A6679
    • (2000) Gastroenterology , vol.118 , pp. 6679
    • Nitecki, J.1    Jackson, F.W.2    Allen, M.L.3
  • 69
    • 0036211032 scopus 로고    scopus 로고
    • Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease
    • Facchini F.S., Hua N.W., Stoohs R.A. Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease. Gastroenterology. 122:2002;931-939
    • (2002) Gastroenterology , vol.122 , pp. 931-939
    • Facchini, F.S.1    Hua, N.W.2    Stoohs, R.A.3
  • 70
    • 0000953246 scopus 로고    scopus 로고
    • Treatment of non-alcoholic steatohepatitis with N-acetylcysteine
    • Gulbahar O., Karasu Z.A., Ersoz G., Akarca U.S., Musoglu A. Treatment of non-alcoholic steatohepatitis with N-acetylcysteine. Gastroenterology. 118(Suppl):2000;A6550
    • (2000) Gastroenterology , vol.118 , Issue.SUPPL. , pp. 6550
    • Gulbahar, O.1    Karasu, Z.A.2    Ersoz, G.3    Akarca, U.S.4    Musoglu, A.5
  • 71
    • 0035085858 scopus 로고    scopus 로고
    • Treatment of nonalcoholic fatty liver: Present and emerging therapies
    • Angulo P., Lindor K.D. Treatment of nonalcoholic fatty liver: present and emerging therapies. Semin Liver Dis. 21:2001;81-88
    • (2001) Semin Liver Dis , vol.21 , pp. 81-88
    • Angulo, P.1    Lindor, K.D.2
  • 72
    • 84933047295 scopus 로고    scopus 로고
    • Ursodeoxycholic acid or clofibrate in the treatment of nonalcohol-induced steatohepatitis: A pilot study
    • Laurin J., Lindor K.D., Crippen J.S., et al. Ursodeoxycholic acid or clofibrate in the treatment of nonalcohol-induced steatohepatitis: a pilot study. Hepatology. 23:1996;1464-1467
    • (1996) Hepatology , vol.23 , pp. 1464-1467
    • Laurin, J.1    Lindor, K.D.2    Crippen, J.S.3
  • 73
    • 0000685882 scopus 로고    scopus 로고
    • Effect of ursodeoxycholic acid plus diet in patients with non-alcoholic steatohepatitis
    • Ceriani R., Bunati S., Morini L., et al. Effect of ursodeoxycholic acid plus diet in patients with non-alcoholic steatohepatitis. Hepatology. 28:1998;386A
    • (1998) Hepatology , vol.28
    • Ceriani, R.1    Bunati, S.2    Morini, L.3
  • 74
    • 0001083778 scopus 로고    scopus 로고
    • Ursodeoxycholic acid in the treatment of nonalcoholic steatohepatitis:results of a prospective clinical controlled trial
    • Guma G., Viola L., Thome M., et al. Ursodeoxycholic acid in the treatment of nonalcoholic steatohepatitis:results of a prospective clinical controlled trial. Hepatology. 26:1997;387A
    • (1997) Hepatology , vol.26
    • Guma, G.1    Viola, L.2    Thome, M.3
  • 75
    • 1542515099 scopus 로고    scopus 로고
    • Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis: results of a randomized, placebo-controlled trial
    • Lindor K.D. Ursodeoxycholic acid for treatment of nonalcoholic steatohepatitis:results of a randomized, placebo-controlled trial. Hepatology. 39:2004;770-778
    • (2004) Hepatology , vol.39 , pp. 770-778
    • Lindor, K.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.