The dg2 (for) gene confers a renal phenotype in Drosophila by modulation of cGMP-specific phosphodiesterase

Journal of Experimental Biology

Volumn 207, Issue 16, 2004, Pages 2769-2776

  MacPherson, Matthew R ^a   Broderick, Kate E ^a   Graham, Shirley ^a   Day, Jonathan P ^a   Houslay, Miles D ^a   Dow, Julian A T ^a   Davies, Shireen A ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

Capa 1; Cyclic nucleotide; dg2 locus; Drosophila melanogaster; Epithelial transport; Malpighian tubule

Indexed keywords

CAPA PROTEIN, DROSOPHILA; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; CYCLIC GMP PHOSPHODIESTERASE; DROSOPHILA PROTEIN; NEUROPEPTIDE;

ALLELE; ANIMAL; ARTICLE; COMPARATIVE STUDY; DROSOPHILA MELANOGASTER; EPITHELIUM; GENETICS; LOCOMOTION; MALPIGHIAN TUBULE; METABOLISM; PHENOTYPE; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSPORT AT THE CELLULAR LEVEL;

3',5'-CYCLIC-GMP PHOSPHODIESTERASE; ALLELES; ANIMALS; BIOLOGICAL TRANSPORT; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EPITHELIUM; LOCOMOTION; MALPIGHIAN TUBULES; NEUROPEPTIDES; PHENOTYPE; SIGNAL TRANSDUCTION;

ANIMALIA; DROSOPHILA MELANOGASTER; MALPIGHIA; MELANOGASTER;

EID: 4344624893     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: 10.1242/jeb.01086     Document Type: Article

References (30)

1. Broderick, K. E., Kean, L., Dow, J. A. T., Pyne, N. J. and Davies, S. A. (2004). Ectopic expression of bovine type 5 phosphodiesterase confers a renal phenotype in Drosophila. J. Biol. Chem. 279, 8159-8168.
2. Broderick, K. E., MacPherson, M. R., Regulski, M., Tully, T., Dow, J. A. T. and Davies, S. A. (2003). Interactions between epithelial nitric oxide signaling and phosphodiesterase activity in Drosophila. Am. J. Physiol. 285, C1207-C1218.
3. Cabrero, P., Radford, J. C., Broderick, K. E., Veenstra, J., Spana, E., Davies, S. and Dow, J. A. T. (2002). The CRF gene of Drosophila melanogaster encodes a diuretic peptide that activates cAMP signalling. J. Exp. Biol. 205, 3799-3807.
4. Davies, S.-A. (2000). Nitric oxide signalling in insects. Insect Biochem. Mol. Biol. 30, 1123-1138.
5. 2b, a cardioacceleratory peptide, is present in Drosophila and stimulates tubule fluid secretion via cGMP. Am. J. Physiol. 269, R1321-R1326.
6. Davies, S. A., Stewart, E. J., Huesmann, G. R., Skaer, N. J. V., Maddrell, S. H. P., Tublitz, N. J. and Dow, J. A. T. (1997). Neuropeptide stimulation of the nitric oxide signaling pathway in Drosophila melanogaster Malpighian tubules. Am. J. Physiol. 42, R823-R827.
7. Day, J. P., Houslay, M. D. and Davies, S. A. (2003). Cloning and characterisation of a novel cGMP-specific phosphodiesterase from Drosophila melanogaster. BMC Meeting Abstracts: 1st International Conference on cGMP: NO/sGC Interaction and its Therapeutic Implications 1, p: 0014.
8. de Belle, J. S., Hilliker, A. J. and Sokolowski, M. B. (1989). Genetic localization of foraging (for): a major gene for larval behavior in Drosophila melanogaster. Genetics 123, 157-163.
9. de Belle, J. S., Sokolowski, M. B. and Hilliker, A. J. (1993). Genetic analysis of the foraging microregion of Drosophila melanogaster. Genome 36, 94-101.
10. Dousa, T. P. (1999). Cyclic-3′,5′-nucleotide phosphodiesterase isozymes in cell biology and pathophysiology of the kidney. Kidney Int. 55, 29-62.
11. Dow, J. A. T. (1999). The multifunctional Drosophila melanogaster V-ATPase is encoded by a multigene family. J. Bioenerget. Biomembr. 31, 75-83.
12. Dow, J. A. T. and Davies, S. A. (2001). The Drosophila melanogaster Malpighian tubule. Adv. Insect Physiol. 28, 1-83.
13. Dow, J. A. T. and Davies, S. A. (2003). Integrative physiology, functional genomics and epithelial function in a genetic model organism. Physiol. Rev. 83, 687-729.
14. Dow, J. A. T., Maddrell, S. H., Davies, S. A., Skaer, N. J. and Kaiser, K. (1994b). A novel role for the nitric oxide-cGMP signaling pathway: the control of epithelial function in Drosophila. Am. J. Physiol. 266, R1716-1719.
15. Dow, J. A. T., Maddrell, S. H., Gortz, A., Skaer, N. J., Brogan, S. and Kaiser, K. (1994a). The malpighian tubules of Drosophila melanogaster: a novel phenotype for studies of fluid secretion and its control. J. Exp. Biol. 197, 421-428.
16. Edwards, A. S. and Scott, J. D. (2000). A-kinase anchoring proteins: protein kinase A and beyond. Curr. Opin. Cell Biol. 12, 217-221.
17. Foster, J. L., Higgins, G. C. and Jackson, F. R. (1996). Biochemical properties and cellular localization of the Drosophila DG1 cGMP-dependent protein kinase. J. Biol. Chem. 271, 23322-23328.
18. Francis, S. H., Turko, I. V. and Corbin, J. D. (2001). Cyclic nucleotide phosphodiesterases: relating structure and function. Prog. Nucl. Acid Res. Mol. Biol. 65, 1-52.
19. French, P. J., Bijman, J., Edixhoven, M., Vaandrager, A. B., Scholte, B. J., Lohmann, S. M., Nairn, A. C. and de Jonge, H. R. (1995). Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II. J. Biol. Chem. 270, 26626-26631.
20. Gambaryan, S., Hausler, C., Markert, T., Pohler, D., Jarchau, T., Walter, U., Haase, W., Kurtz, A. and Lohmann, S. M. (1996). Expression of type II cGMP-dependent protein kinase in rat kidney is regulated by dehydration and correlated with renin gene expression. J. Clin. Invest. 98, 662-670.
21. Hall, K. U., Collins, S. P., Gamm, D. M., Massa, E., DePaoli-Roach, A. A. and Uhler, M. D. (1999). Phosphorylation-dependent inhibition of protein phosphatase-1 by G-substrate. A Purkinje cell substrate of the cyclic GMP-dependent protein kinase. J. Biol. Chem. 274, 3485-3495.
22. Kalderon, D. and Rubin, G. M. (1989). cGMP-dependent protein kinase genes in Drosophila. J. Biol. Chem. 264, 10738-10748.
23. Kean, L., Cazenave, W., Costes, L., Broderick, K. E., Graham, S., Pollock, V. P., Davies, S. A., Veenstra, J. A. and Dow, J. A. T. (2002). Two nitridergic peptides are encoded by the gene capability in Drosophila melanogaster. Am. J. Physiol. 282, R1297-R1307.
24. Osborne, K. A., Robichon, A., Burgess, E., Butland, S., Shaw, R. A., Coulthard, A., Pereira, H. S., Greenspan, R. J. and Sokolowski, M. B. (1997). Natural behaviour polymorphism due to a cGMP-dependent protein kinase of Drosophila. Science 277, 834-836.
25. Oster, H., Werner, C., Magnone, M. C., Mayser, H., Feil, R., Seeliger, M. W., Hofmann, F. and Albrecht, U. (2003). cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock. Curr. Biol. 13, 725-733.
26. Pereira, H. S. and Sokolowski, M. B. (1993). Mutations in the larval foraging gene affect adult locomotory behavior after feeding in Drosophila melanogaster. Proc. Natl. Acad. Sci. USA 90, 5044-5046.
27. Pfeifer, A., Aszodi, A., Seidler, U., Ruth, P., Hofmann, F. and Fassler, R. (1996). Intestinal secretory defects and dwarfism in mice lacking cGMP-dependent protein kinase II. Science 274, 2082-2086.
28. Schlossmann, J., Ammendola, A., Ashman, K., Zong, X., Huber, A., Neubauer, G., Wang, G. X., Allescher, H. D., Korth, M., Wilm, M. et al. (2000). Regulation of intracellular calcium by a signalling complex of IRAG, IP3 receptor and cGMP kinase Ibeta. Nature 404, 197-201.
29. Sokolowski, M. B. and Hansell, K. P. (1992). The foraging locus: behavioral tests for normal muscle movement in rover and sitter Drosophila melanogaster larvae. Genetica 85, 205-209.
30. Vaandrager, A. B. and de Jonge, H. R. (1996). Signalling by cGMP-dependent protein kinases. Mol. Cell. Biochem. 157, 23-30.