Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage

Human Genetics

Volumn 115, Issue 3, 2004, Pages 255-262

  Xu, Jianfeng ^a   Langefeld, Carl D ^a   Zheng, S Lilly ^a   Gillanders, Elizabeth M ^b   Chang, Bao Li ^a   Isaacs, Sarah D ^c   Williams, Adrienne H ^a   Wiley, Kathy E ^c   Dimitrov, Latchezar ^a   Meyers, Deborah A ^a   Walsh, Patrick C ^c   Trent, Jeffrey M ^d   Isaacs, William B ^c  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^c DEPARTMENT OF PATHOLOGY   (United States)

^d TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; TUMOR SUPPRESSOR PROTEIN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PHOSPHATASE; PTEN PROTEIN, HUMAN;

ALLELE; ARTICLE; CHROMOSOME 10Q; CHROMOSOME 12P; CHROMOSOME ANALYSIS; CHROMOSOME MAP; CHROMOSOME MARKER; CLINICAL OBSERVATION; CONTROLLED STUDY; EPISTASIS; FAMILY; GENE INTERACTION; GENE TARGETING; GENETIC LINKAGE; GENETIC MODEL; GENETIC RISK; GENETIC SUSCEPTIBILITY; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MEDICAL ASSESSMENT; NONPARAMETRIC TEST; PRIORITY JOURNAL; PROSTATE CANCER; REGRESSION ANALYSIS; TUMOR SUPPRESSOR GENE; AGED; GENETIC EPISTASIS; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MUTATION; PATHOPHYSIOLOGY; PEDIGREE; PROSTATE TUMOR;

AGED; CELL CYCLE PROTEINS; CHROMOSOME MAPPING; CYCLIN-DEPENDENT KINASE INHIBITOR P27; EPISTASIS, GENETIC; GENES, TUMOR SUPPRESSOR; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; MALE; MIDDLE AGED; PEDIGREE; PHOSPHORIC MONOESTER HYDROLASES; PROSTATIC NEOPLASMS; PTEN PHOSPHOHYDROLASE; TUMOR SUPPRESSOR PROTEINS;

EID: 4344572615     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Cairns P, Okami K, Halachmi S, Halachmi N, Esteller M, Herman JG, Jen J, Isaacs WB, Bova GS, Sidransky D (1997) Frequent inactivation of PTEN/MMAC1 in primary prostate cancer. Cancer Res 57:4997-5000
2. Chang BL, Zheng SL, Isaacs SD, Wiley KE, Turner A, Li G, Walsh PC, Meyers DA, Isaacs WB II, Xu J (2004) The polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer. Cancer Res 64:1997-1999
3. Cordon-Cardo C, Koff A, Drobnjak M, Capodieci P, Osman I, Millard SS, Gaudin PB, Fazzari M, Zhang ZF, Massague J, Scher HI (1998) Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma. J Natl Cancer Inst 90:1284-1291
4. Davis CC, Brown WM, Lange EM, Rich SS, Langefeld CD (2001) Nonparametric linkage regression. II. Identification of influential pedigrees in tests for linkage. Genet Epidemiol 21(Suppl 1): S123-S129
5. Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP (1998) Pten is essential for embryonic development and tumour suppression. Nat Genet 19:348-355
6. Di Cristofano A, De Acetis M, Koff A, Cordon-Cardo C, Pandolfi PP (2001) Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nat Genet 27:222-224
7. Hauser ER, Watanabe RM, Duren WL, Bass MP, Langefeld CD, Boehnke M (2004) Ordered subset analysis in genetic linkage mapping of complex traits. Genet Epidemiol 10.1002/ gepi.2000
8. Hermans KG, Van Alewijk DC, Veltman JA, Van Weerden W, Van Kessel AG, Trapman J (2004) Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines. Genes Chromosomes Cancer 39:171-184
9. Isaacs WB, Xu J, Walsh PC (2001) Hereditary prostate cancer. In: Chung LWK, Isaacs WB, Simons JW (eds) Prostate cancer, biology, genetics, and the new therapeutics. Humana, New Jersey, pp 13-28
10. Jemal A, Murray T, Samuels A, Ghafoor A, Ward E, Thun MJ (2003) Cancer statistics, 2003. CA Cancer J Clin 53:5-26
11. Kibel AS, Schutte M, Kern SE, Isaacs WB, Bova GS (1998) Identification of 12p as a region of frequent deletion in advanced prostate cancer. Cancer Res 58:5652-5655
12. Komiya A, Suzuki H, Ueda T, Yatani R, Emi M, Ito H, Shimazaki J (1996) Allelic losses at loci on chromosome 10 are associated with metastasis and progression of human prostate cancer. Genes Chromosomes Cancer 17:245-253
13. Kong A, Cox NJ (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet 61:1179-1188
14. Langefeld CD (1999) The application of statistical methods for highly stratified data to linkage and association analyses of complex genetic traits. PhD Thesis, University of Michigan
15. Langefeld CD, Davis CC, Brown WM (2001) Nonparametric linkage regression I: combined Caucasian CSGA and German genome scans for asthma. Genet Epidemiol 21:S136-S141
16. Liang J, Zubovitz J, Petrocelli T, Kotchetkov R, Connor MK, Han K, Lee JH, Ciarallo S, Catzavelos C, Beniston R, Franssen E, Slingerland JM (2002) PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med 8:1153-1160
17. Lu Y, Lin YZ, LaPushin R, Cuevas B, Fang X, Yu SX, Davies MA, Khan H, Furui T, Mao M, Zinner R, Hung MC, Steck P, Siminovitch K, Mills GB (1999) The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene 18:7034-7045
18. Medema RH, Kops GJ, Bos JL, Burgering BM (2000) AFX-like forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 404:782-787
19. Paramio JM, Navarro M, Segrelles C, Gomez-Casero E, Jorcano JL (1999) PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein. Oncogene 18:7462-7468
20. Parsons R, Simpson L (2003) PTEN and cancer. Methods Mol Biol 222:147-166
21. Philipp-Staheli J, Payne SR, Kemp CJ (2001) p27(Kip1): regulation and function of a haploinsufficient tumor suppressor and its misregulation in cancer. Cell Res 264:148-168
22. Podsypanina K, Ellenson LH, Nemes A, Gu J, Tamura M, Yamada KM, Cordon-Cardo C, Catoretti G, Fisher PE, Parsons R (1999) Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci USA 96:1563-1568
23. Shin I, Yakes FM, Rojo F, Shin NY, Bakin AV, Baselga J, Arteaga CL (2002) PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8:1145-1152
24. Suzuki A, Pompa JL de la, Stambolic V, Elia AJ, Sasaki T, Barco Barrantes I del, Ho A, Wakeham A, Itie A, Khoo W, Fukumoto M, Mak TW (1999) High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 8:1169-1178
25. Suzuki H, Freije D, Nusskern DR, Okami K, Cairns P, Sidransky D, Isaacs WB, Bova GS (1998) Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues. Cancer Res 58:204-209
26. Vanhaesebroeck B, Alessi DR (2000) The PI3 K-PDK1 connection: more than just a road to PKB. Biochem J 346:561-576
27. Whittemore A, Halpern J (1994) A class of tests for linkage using affected pedigree members. Biometrics 50:118-127
28. Wu X, Senechal K, Neshat MS, Whang YE, Sawyers CL (1998) The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway. Proc Natl Acad Sci USA 95:15587-15591
29. Xu J, Gillanders EM, Isaacs SD, Chang BL, Wiley KE, Zheng SL, Jones M, Gildea D, Riedesel E, Albertus J, Freas-Lutz D, Markey C, Meyers DA, Walsh PC, Trent JM, Isaacs WB (2003) Genome-wide scan for prostate cancer susceptibility genes in the Johns Hopkins hereditary prostate cancer families. Prostate 57:320-325