Post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by hydroxyl radical scavengers and iron chelators

Langenbeck's Archives of Surgery

Volumn 393, Issue 3, 2008, Pages 303-310

  Moussavian, Mohammed R ^a   Slotta, Jan E ^a   Kollmar, Otto ^a   Menger, Michael D ^a   Gronow, Gernot ^b   Schilling, Martin K ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Deferoxamine; Isolated tubular segments; Kidney; Organ preservation; Post hypoxic tissue damage; Scavenger

Indexed keywords

DEFEROXAMINE; GLYCINE; HYDROXYL GROUP; IRON; LIPID; OXYGEN RADICAL; RINGER SOLUTION; SCAVENGER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ATTENUATION; CELL FUNCTION; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; HYPOXIA; ISOLATED KIDNEY; KIDNEY CORTEX; KIDNEY TUBULE; LIPID PEROXIDATION; MALE; NONHUMAN; ORGAN PRESERVATION; PRIORITY JOURNAL; RAT; REOXYGENATION; REPERFUSION INJURY;

EID: 43349091881     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-008-0287-5     Document Type: Article

References (35)

1. 1. G Gronow M Moussavian M Malyusz 1999 Effect of hydroxyl radical scavengers in renal cortical cells Adv Exp Med Biol 471 345 351 10659165 1:CAS:528:DC%2BD3cXksFWktLs%3D Gronow G, Moussavian M, Malyusz M (1999) Effect of hydroxyl radical scavengers in renal cortical cells. Adv Exp Med Biol 471:345–351
2. 2. JL Vinas A Sola G Hotter 2006 Mitochondrial NOS upregulation during renal I/R causes apoptosis in a peroxynitrite-dependent manner Kidney Int 69 1403 1409 16557219 1:CAS:528:DC%2BD28XjsVWrsb8%3D Vinas JL, Sola A, Hotter G (2006) Mitochondrial NOS upregulation during renal I/R causes apoptosis in a peroxynitrite-dependent manner. Kidney Int 69:1403–1409
3. 3. J Jiang I Kurnikov NA Belikova J Xiao Q Zhao AA Amoscato 2007 Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides J Pharmacol Exp Ther 320 1050 1060 17179468 10.1124/jpet.106.114769 1:CAS:528:DC%2BD2sXis1WgtLo%3D Jiang J, Kurnikov I, Belikova NA, Xiao J, Zhao Q, Amoscato AA et al (2007) Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides. J Pharmacol Exp Ther 320:1050–1060
4. 4. JM Weinberg NF Roeser jA Davis MA Venkatachalam 1997 Glycine-protected, hypoxic, proximal tubules develop severely compromised energetic function Kidney Int 52 140 151 9211356 10.1038/ki.1997.313 1:CAS:528:DyaK2sXks1equ7c%3D Weinberg JM, Roeser NF, Davis jA, Venkatachalam MA (1997) Glycine-protected, hypoxic, proximal tubules develop severely compromised energetic function. Kidney Int 52:140–151
5. 5. G Gronow M Malyusz W Niedermayer N Klause 1994 Diminution of histidine-induced reoxygenation damage by glycine in posthypoxic renal cells Adv Exp Med Biol 1345 717 722 Gronow G, Malyusz M, Niedermayer W, Klause N (1994) Diminution of histidine-induced reoxygenation damage by glycine in posthypoxic renal cells. Adv Exp Med Biol 1345:717–722
6. 6. G Gronow N Klause M Malyusz 1994 Restriction of hypoxic membrane defect by glycine improves mitochondrial and cellular function in reoxygenated renal tubules Adv Exp Med Biol 361 585 589 7597986 1:CAS:528:DyaK2MXmslWlsb8%3D Gronow G, Klause N, Malyusz M (1994) Restriction of hypoxic membrane defect by glycine improves mitochondrial and cellular function in reoxygenated renal tubules. Adv Exp Med Biol 361:585–589
7. 7. C Plin JP Tillement A Berdeaux D Morin 2005 Resveratrol protects against cold ischemia–warm reoxygenation-induced damages to mitochondria and cells in rat liver Eur J Pharmacol 528 162 168 16325807 10.1016/j.ejphar.2005.10.044 1:CAS:528:DC%2BD2MXht12rsrrE Plin C, Tillement JP, Berdeaux A, Morin D (2005) Resveratrol protects against cold ischemia–warm reoxygenation-induced damages to mitochondria and cells in rat liver. Eur J Pharmacol 528:162–168
8. 8. RA Zager K Burkhart 1997 Myoglobin toxicity in proximal human kidney cells: roles of Fe, Ca 2+, H 2 O 2, and terminal mitochondrial electron transport Kidney Int 51 728 738 9067905 10.1038/ki.1997.104 1:CAS:528:DyaK2sXitFalsr0%3D Zager RA, Burkhart K (1997) Myoglobin toxicity in proximal human kidney cells: roles of Fe, Ca 2+, H 2 O 2, and terminal mitochondrial electron transport. Kidney Int 51:728–738
9. 9. T Hashimoto M Hirata T Itoh Y Kanmura H Kuriyama 1986 Inositol 1,4,5-trisphosphate activates pharmacomechanical coupling in smooth muscle of the rabbit mesenteric artery J Physiol 370 605 618 3007748 1:CAS:528:DyaL28Xls1Glsbo%3D Hashimoto T, Hirata M, Itoh T, Kanmura Y, Kuriyama H (1986) Inositol 1,4,5-trisphosphate activates pharmacomechanical coupling in smooth muscle of the rabbit mesenteric artery. J Physiol 370:605–618
10. 10. GH Gronow JJ Cohen 1984 Substrate support for renal functions during hypoxia in the perfused rat kidney Am J Physiol 247 618 631 Gronow GH, Cohen JJ (1984) Substrate support for renal functions during hypoxia in the perfused rat kidney. Am J Physiol 247:618–631
11. 11. H Bertermann G Gronow C Weiss 1975 An improved technique for metabolic studies on isolated cortical cells and tubules of the rat kidney Curr Probl Clin Biochem 4 76 78 1192780 1:CAS:528:DyaE28XhtVWksL4%3D Bertermann H, Gronow G, Weiss C (1975) An improved technique for metabolic studies on isolated cortical cells and tubules of the rat kidney. Curr Probl Clin Biochem 4:76–78
12. 12. CD Knox JM Pierce IB Nicoud AE Belous CM Jones CD Anderson 2006 Inhibition of phospholipase C attenuates liver mitochondrial calcium overload following cold ischemia Transplantation 81 567 572 16495805 10.1097/01.tp.0000199267.98971.77 1:CAS:528:DC%2BD28XhslWgtbw%3D Knox CD, Pierce JM, Nicoud IB, Belous AE, Jones CM, Anderson CD et al (2006) Inhibition of phospholipase C attenuates liver mitochondrial calcium overload following cold ischemia. Transplantation 81:567–572
13. 13. PD Cherry HA Omar KA Farrell JS Stuart MS Wolin 1990 Superoxide anion inhibits cGMP-associated bovine pulmonary arterial relaxation Am J Physiol 259 1056 1062 Cherry PD, Omar HA, Farrell KA, Stuart JS, Wolin MS (1990) Superoxide anion inhibits cGMP-associated bovine pulmonary arterial relaxation. Am J Physiol 259:1056–1062
14. 14. D Salvemini TM Doyle S Cuzzocrea 2006 Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation Biochem Soc Trans 34 965 970 17052238 10.1042/BST0340965 1:CAS:528:DC%2BD28XhtFWnsb3K Salvemini D, Doyle TM, Cuzzocrea S (2006) Superoxide, peroxynitrite and oxidative/nitrative stress in inflammation. Biochem Soc Trans 34:965–970
15. 15. MA Khalid M Ashraf 1992 Maximal OH production is seen upon reoxygenation of viable anoxic cultured cardiomyocytes but not of compromised cells Am J Cardiovasc Pathol 4 245 255 1338485 1:STN:280:ByyB387otlw%3D Khalid MA, Ashraf M (1992) Maximal OH production is seen upon reoxygenation of viable anoxic cultured cardiomyocytes but not of compromised cells. Am J Cardiovasc Pathol 4:245–255
16. 16. PB Kopnin LS Agapova BP Kopnin PM Chumakov 2007 Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species upregulation and genetic instability Cancer Res 67 4671 4678 17510393 10.1158/0008-5472.CAN-06-2466 1:CAS:528:DC%2BD2sXltl2gsro%3D Kopnin PB, Agapova LS, Kopnin BP, Chumakov PM (2007) Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species upregulation and genetic instability. Cancer Res 67:4671–4678
17. 17. MK Ozer H Parlakpinar Y Cigremis M Ucar N Vardi A Acet 2005 Ischemia-reperfusion leads to depletion of glutathione content and augmentation of malondialdehyde production in the rat heart from overproduction of oxidants: can caffeic acid phenethyl ester (CAPE) protect the heart? Mol Cell Biochem 273 169 175 16013452 10.1007/s11010-005-0551-8 1:CAS:528:DC%2BD2MXkt1Kqt78%3D Ozer MK, Parlakpinar H, Cigremis Y, Ucar M, Vardi N, Acet A (2005) Ischemia-reperfusion leads to depletion of glutathione content and augmentation of malondialdehyde production in the rat heart from overproduction of oxidants: can caffeic acid phenethyl ester (CAPE) protect the heart? Mol Cell Biochem 273:169–175
18. 18. LJ Martin K Chen Z Liu 2005 Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation J Neurosci 25 6449 6459 16000635 10.1523/JNEUROSCI.0911-05.2005 1:CAS:528:DC%2BD2MXmtF2ktrw%3D Martin LJ, Chen K, Liu Z (2005) Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation. J Neurosci 25:6449–6459
19. 19. L Chen HM Lee GH Greeley Jr EW Englander 2007 Accumulation of oxidatively generated DNA damage in the brain: a mechanism of neurotoxicity Free Radic Biol Med 42 385 393 17210451 10.1016/j.freeradbiomed.2006.11.009 1:CAS:528:DC%2BD2sXis1ehuw%3D%3D Chen L, Lee HM, Greeley GH Jr, Englander EW (2007) Accumulation of oxidatively generated DNA damage in the brain: a mechanism of neurotoxicity. Free Radic Biol Med 42:385–393
20. 20. DP Barondeau CJ Kassmann JA Tainer ED Getzoff 2006 Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation J Am Chem Soc 128 4685 4693 16594705 10.1021/ja056635l 1:CAS:528:DC%2BD28Xis1Kisbk%3D Barondeau DP, Kassmann CJ, Tainer JA, Getzoff ED (2006) Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation. J Am Chem Soc 128:4685–4693
21. 21. A Zecchina M Rivallan G Berlier C Lamberti G Ricchiardi 2007 Structure and nuclearity of active sites in Fe-zeolites: comparison with iron sites in enzymes and homogeneous catalysts Phys Chem Chem Phys 9 3483 3499 17612716 10.1039/b703445h 1:CAS:528:DC%2BD2sXntlWqtbw%3D Zecchina A, Rivallan M, Berlier G, Lamberti C, Ricchiardi G (2007) Structure and nuclearity of active sites in Fe-zeolites: comparison with iron sites in enzymes and homogeneous catalysts. Phys Chem Chem Phys 9:3483–3499
22. 22. D Maiti AA Sarjeant KD Karlin 2007 Copper(II)-hydroperoxo complex induced oxidative N-dealkylation chemistry J Am Chem Soc 129 6720 6721 17474748 10.1021/ja0719024 1:CAS:528:DC%2BD2sXksl2rt7c%3D Maiti D, Sarjeant AA, Karlin KD (2007) Copper(II)-hydroperoxo complex induced oxidative N-dealkylation chemistry. J Am Chem Soc 129:6720–6721
23. 23. W Droge HM Schipper 2007 Oxidative stress and aberrant signaling in aging and cognitive decline Aging Cell 6 361 370 17517043 10.1111/j.1474-9726.2007.00294.x 1:CAS:528:DC%2BD2sXntVOjsrw%3D Droge W, Schipper HM (2007) Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell 6:361–370
24. 24. B Vries de SJ Walter L Bonsdorff von TG Wolfs LW Heurn van J Parkkinen 2004 Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injury Transplantation 77 669 675 15021827 10.1097/01.TP.0000115002.28575.E7 de Vries B, Walter SJ, von Bonsdorff L, Wolfs TG, van Heurn LW, Parkkinen J et al (2004) Reduction of circulating redox-active iron by apotransferrin protects against renal ischemia-reperfusion injury. Transplantation 77:669–675
25. 25. XH Wang K Wang F Zhang XC Li J Li W De 2005 Heme oxygenase-1 alleviates ischemia-reperfusion injury in aged liver World J Gastroenterol 11 690 694 15655823 1:CAS:528:DC%2BD2MXisVKjsLc%3D Wang XH, Wang K, Zhang F, Li XC, Li J, De W et al (2005) Heme oxygenase-1 alleviates ischemia-reperfusion injury in aged liver. World J Gastroenterol 11:690–694
26. 26. JM Weinberg JA Davis M Abarzua R Kunkel 1990 Protection by glycine of proximal tubules from injury due to inhibitors of mitochondrial ATP production Am J Physiol 258 1127 1140 Weinberg JM, Davis JA, Abarzua M, Kunkel R (1990) Protection by glycine of proximal tubules from injury due to inhibitors of mitochondrial ATP production. Am J Physiol 258:1127–1140
27. 27. MS Paller M Patten 1992 Protective effects of glutathione, glycine, or alanine in an in vitro model of renal anoxia J Am Soc Nephrol 2 1338 1344 1627758 1:CAS:528:DyaK38XitVOktbw%3D Paller MS, Patten M (1992) Protective effects of glutathione, glycine, or alanine in an in vitro model of renal anoxia. J Am Soc Nephrol 2:1338–1344
28. 28. MR Moussavian JE Slotta O Kollmar MD Menger MK Schilling G Gronow 2007 Hemoglobin induces cytotoxic damage of glycine-preserved renal tubules Transpl Int 20 884 894 17854446 10.1111/j.1432-2277.2007.00538.x 1:CAS:528:DC%2BD2sXht1ehsrrJ Moussavian MR, Slotta JE, Kollmar O, Menger MD, Schilling MK, Gronow G (2007) Hemoglobin induces cytotoxic damage of glycine-preserved renal tubules. Transpl Int 20:884–894
29. 29. J Nakamura ER Purvis JA Swenberg 2003 Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells Nucleic Acids Res 31 1790 1795 12626721 10.1093/nar/gkg263 1:CAS:528:DC%2BD3sXit1yksLc%3D Nakamura J, Purvis ER, Swenberg JA (2003) Micromolar concentrations of hydrogen peroxide induce oxidative DNA lesions more efficiently than millimolar concentrations in mammalian cells. Nucleic Acids Res 31:1790–1795
30. 30. E Grassmann AM Reichlmayr-Lais M Kirchgessner JJ Kim 1983 Iron concentration in various organs of rats following administration of various iron and protein loads Z Ernahrungswiss 22 195 204 6649713 10.1007/BF02024694 1:CAS:528:DyaL3sXmtFWnsLs%3D Grassmann E, Reichlmayr-Lais AM, Kirchgessner M, Kim JJ (1983) Iron concentration in various organs of rats following administration of various iron and protein loads. Z Ernahrungswiss 22:195–204
31. 31. MS Paller 1994 The cell biology of reperfusion injury in the kidney J Investig Med 42 632 639 8521026 1:STN:280:BymD2crpslc%3D Paller MS (1994) The cell biology of reperfusion injury in the kidney. J Investig Med 42:632–639
32. 32. M Liu S Okada 1994 Induction of free radicals and tumors in the kidneys of Wistar rats by ferric ethylenediamine-N, N ′-diacetate Carcinogenesis 15 2817 2821 8001240 10.1093/carcin/15.12.2817 1:CAS:528:DyaK2MXivVGhtbw%3D Liu M, Okada S (1994) Induction of free radicals and tumors in the kidneys of Wistar rats by ferric ethylenediamine-N, N ′-diacetate. Carcinogenesis 15:2817–2821
33. 33. G Zhao IS Ayene AB Fisher 1997 Role of iron in ischemia-reperfusion oxidative injury of rat lungs Am J Respir Cell Mol Biol 16 293 299 9070614 1:CAS:528:DyaK2sXitV2iurg%3D Zhao G, Ayene IS, Fisher AB (1997) Role of iron in ischemia-reperfusion oxidative injury of rat lungs. Am J Respir Cell Mol Biol 16:293–299
34. 34. M Shadid F Bel Van P Steendijk CA Dorrepaal R Moison ET Velde Van Der J Baan 1999 Effect of deferoxamine on post-hypoxic-ischemic reperfusion injury of the newborn lamb heart Biol Neonate 75 239 249 10026372 10.1159/000014101 1:CAS:528:DyaK1MXhvFKqtL8%3D Shadid M, Van Bel F, Steendijk P, Dorrepaal CA, Moison R, Van Der Velde ET, Baan J (1999) Effect of deferoxamine on post-hypoxic-ischemic reperfusion injury of the newborn lamb heart. Biol Neonate 75:239–249
35. 35. C Bauer I Marzi R Larsen 1997 Deferoxamine-conjugated hydroxyethyl starch reduces reperfusion injury to the liver following hemorrhagic shock Anaesthesist 46 53 56 9082870 10.1007/s001010050372 1:STN:280:ByiB3c7itFU%3D Bauer C, Marzi I, Larsen R (1997) Deferoxamine-conjugated hydroxyethyl starch reduces reperfusion injury to the liver following hemorrhagic shock. Anaesthesist 46:53–56