Rapid throughput solubility screening method for BCS class II drugs in animal GI fluids and simulated human GI fluids using a 96-well format

Journal of Pharmaceutical Sciences

Volumn 97, Issue 4, 2008, Pages 1427-1442

  Guo, Jeremy ^a,c   Elzinga, Paul A ^b   Hageman, Michael J ^b   Herron, James N ^a  

^a UNIVERSITY OF UTAH   (United States)

^b BRISTOL MYERS SQUIBB   (United States)

^c NONE   (United States)

Author keywords

BCS; Dissolution; Gastrointestinal; In vitro in vivo correlations (IVIVC); Solubility

Indexed keywords

BETAMETHASONE; BILE SALT; DANAZOL; DIMETHYL SULFOXIDE; GRISEOFULVIN; HALOFANTRINE; MEFENAMIC ACID; PHENYTOIN; PHOSPHATIDYLCHOLINE; SOLVENT; TRIAMCINOLONE; DRUG;

ARTICLE; BODY FLUID; DOG; DRUG ABSORPTION; DRUG CLASSIFICATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG UPTAKE; DUODENUM; FOOD DRUG INTERACTION; FOOD INTAKE; GASTROINTESTINAL TRANSIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METHODOLOGY; NONHUMAN; SCREENING; SMALL INTESTINE; STOMACH EMPTYING; SWINE; ANIMAL; CLASSIFICATION; FILTRATION; GASTROINTESTINAL TRACT; METABOLISM; PHARMACEUTICS; REPRODUCIBILITY; SOLUBILITY;

ANIMALS; BIOPHARMACEUTICS; BODY FLUIDS; FILTRATION; GASTROINTESTINAL TRACT; HUMANS; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; SOLUBILITY;

EID: 43249130982     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21041     Document Type: Article

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