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Volumn 19, Issue 3, 2008, Pages 324-325

Genetics and molecular biology: A cholesterol-lowering drug with antibacterial properties

Author keywords

[No Author keywords available]

Indexed keywords

BPH 652; DEHYDROSQUALENE SYNTHASE; HYPOCHOLESTEROLEMIC AGENT; SQUALENE SYNTHASE; SQUALENE SYNTHASE INHIBITOR;

EID: 43249128651     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e3282ff8630     Document Type: Note
Times cited : (1)

References (11)
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    • Liu CI, Liu GY, Song Y, et al. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science 2008; 14 Feb [Epub ahead of print]. This groundbreaking article describes a novel approach to combat Staphylococcus aureus infections, through a surprising link to cholesterol biosynthesis. Blocking the synthesis of the bacterial virulence factor staphyloxanthin by a cholesterol biosynthesis inhibitor increases the susceptibility of S. aureus to the innate immune system. Although S. aureus does not synthesize cholesterol, the enzymatic steps responsible for staphyloxanthin production are remarkably similar to the early steps of cholesterol biosynthesis. Hence, inhibitors of human SQS, proposed as cholesterol-lowering drugs, also block the synthesis of the S. aureus virulence factor. Since SQS inhibitors have already undergone trials in humans, this new strategy might see rapid implementation in the clinics.
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* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.