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Volumn 6, Issue 1, 2008, Pages 15-20

Factors associated with outcome in patients with advanced renal cell carcinoma in the era of antiangiogenic agents

Author keywords

Carbonic anhydrase IX; Hypoxia inducible factor; Sunitinib; Vascular endothelial growth factor; Von Hippel Lindau

Indexed keywords

ALPHA INTERFERON; ALPHA2B INTERFERON; AXITINIB; BEVACIZUMAB; CALCIUM; HEMOGLOBIN; LACTATE DEHYDROGENASE; PHOSPHATASE; PROTEIN KINASE B; PROTEIN S6; SORAFENIB; SUNITINIB; TEMSIROLIMUS; TENSIN; VON HIPPEL LINDAU PROTEIN;

EID: 43249126494     PISSN: 15587673     EISSN: None     Source Type: Journal    
DOI: 10.3816/CGC.2008.n.002     Document Type: Review
Times cited : (7)

References (62)
  • 2
    • 0344442746 scopus 로고    scopus 로고
    • Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease
    • NK Janzen HL Kim RA Figlin Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease Urol Clin North Am 30 2003 843 852
    • (2003) Urol Clin North Am , vol.30 , pp. 843-852
    • Janzen, NK1    Kim, HL2    Figlin, RA3
  • 3
    • 16644373473 scopus 로고    scopus 로고
    • Role of VHL gene mutation in human cancer
    • WY Kim WG Kaelin Role of VHL gene mutation in human cancer J Clin Oncol 22 2004 4991 5004
    • (2004) J Clin Oncol , vol.22 , pp. 4991-5004
    • Kim, WY1    Kaelin, WG2
  • 4
    • 1542344522 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 and oncogenic signalling
    • JI Bardos M Ashcroft Hypoxia-inducible factor-1 and oncogenic signalling Bioessays 26 2004 262 269
    • (2004) Bioessays , vol.26 , pp. 262-269
    • Bardos, JI1    Ashcroft, M2
  • 5
    • 0030834249 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity
    • D Mukhopadhyay B Knebelmann HT Cohen The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity Mol Cell Biol 17 1997 5629 5639
    • (1997) Mol Cell Biol , vol.17 , pp. 5629-5639
    • Mukhopadhyay, D1    Knebelmann, B2    Cohen, HT3
  • 6
    • 21344435054 scopus 로고    scopus 로고
    • Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model
    • L Xu R Tong DM Cochran Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor beta signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model Cancer Res 65 2005 5711 5719
    • (2005) Cancer Res , vol.65 , pp. 5711-5719
    • Xu, L1    Tong, R2    Cochran, DM3
  • 7
    • 0032952010 scopus 로고    scopus 로고
    • Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
    • LE Benjamin D Golijanin A Itin Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal J Clin Invest 103 1999 159 165
    • (1999) J Clin Invest , vol.103 , pp. 159-165
    • Benjamin, LE1    Golijanin, D2    Itin, A3
  • 8
    • 33644833910 scopus 로고    scopus 로고
    • Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
    • RJ Motzer MD Michaelson BG Redman Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma J Clin Oncol 24 2006 16 24
    • (2006) J Clin Oncol , vol.24 , pp. 16-24
    • Motzer, RJ1    Michaelson, MD2    Redman, BG3
  • 9
    • 34548310217 scopus 로고    scopus 로고
    • Sunitinib versus interferonalfa as first-line treatment of metastatic renal cell carcinoma (mRCC): updated results and analysis of prognostic factors
    • RJ Motzer RA Figlin TE Hutson Sunitinib versus interferonalfa as first-line treatment of metastatic renal cell carcinoma (mRCC): updated results and analysis of prognostic factors J Clin Oncol 25 18 suppl 2007 241s (Abstract 5024).
    • (2007) J Clin Oncol , vol.25 , Issue.18 suppl , pp. 241s
    • Motzer, RJ1    Figlin, RA2    Hutson, TE3
  • 10
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clear-cell renal-cell carcinoma
    • B Escudier T Eisen WM Stadler Sorafenib in advanced clear-cell renal-cell carcinoma N Engl J Med 356 2007 125 134
    • (2007) N Engl J Med , vol.356 , pp. 125-134
    • Escudier, B1    Eisen, T2    Stadler, WM3
  • 11
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • RJ Motzer TE Hutson P Tomczak Sunitinib versus interferon alfa in metastatic renal-cell carcinoma N Engl J Med 356 2007 115 124
    • (2007) N Engl J Med , vol.356 , pp. 115-124
    • Motzer, RJ1    Hutson, TE2    Tomczak, P3
  • 12
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • JC Yang L Haworth RM Sherry A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer N Engl J Med 349 2003 427 434
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, JC1    Haworth, L2    Sherry, RM3
  • 13
    • 35549007093 scopus 로고    scopus 로고
    • Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib
    • BI Rini GT Wilding G Hudes Axitinib (AG-013736; AG) in patients (pts) with metastatic renal cell cancer (RCC) refractory to sorafenib J Clin Oncol 25 2007 242s (Abstract 5032).
    • (2007) J Clin Oncol , vol.25 , pp. 242s
    • Rini, BI1    Wilding, GT2    Hudes, G3
  • 14
    • 35549006672 scopus 로고    scopus 로고
    • A randomized, controlled, double-blind phase III study (AVOREN) of bevacizumab/interferon-α2a vs placebo/interferon-α2a as first-line therapy in metastatic renal cell carcinoma
    • B Escudier P Koralewski A Pluzanska A randomized, controlled, double-blind phase III study (AVOREN) of bevacizumab/interferon-α2a vs placebo/interferon-α2a as first-line therapy in metastatic renal cell carcinoma J Clin Oncol 25 18 suppl 2007 2s (Abstract 3).
    • (2007) J Clin Oncol , vol.25 , Issue.18 suppl , pp. 2s
    • Escudier, B1    Koralewski, P2    Pluzanska, A3
  • 15
    • 0024247135 scopus 로고
    • Prognostic factors for survival in patients with recurrent or metastatic renal cell carcinoma
    • PJ Elson RS Witte DL Trump Prognostic factors for survival in patients with recurrent or metastatic renal cell carcinoma Cancer Res 48 1988 7310 7313
    • (1988) Cancer Res , vol.48 , pp. 7310-7313
    • Elson, PJ1    Witte, RS2    Trump, DL3
  • 16
    • 0023727132 scopus 로고
    • Prognostic factors of adult metastatic renal carcinoma: a multivariate analysis
    • A de Forges A Rey M Klink Prognostic factors of adult metastatic renal carcinoma: a multivariate analysis Semin Surg Oncol 4 1988 149 154
    • (1988) Semin Surg Oncol , vol.4 , pp. 149-154
    • de Forges, A1    Rey, A2    Klink, M3
  • 17
    • 0026725212 scopus 로고
    • Prognostic factors for survival in patients with advanced renal cell carcinoma treated with recombinant interleukin-2
    • PA Palmer J Vinke T Philip Prognostic factors for survival in patients with advanced renal cell carcinoma treated with recombinant interleukin-2 Ann Oncol 3 1992 475 480
    • (1992) Ann Oncol , vol.3 , pp. 475-480
    • Palmer, PA1    Vinke, J2    Philip, T3
  • 18
    • 0027985315 scopus 로고
    • Prognostic factors and survival in patients with metastatic renal cell carcinoma treated with chemotherapy or interferon-alpha
    • SD Fossa A Kramar JP Droz Prognostic factors and survival in patients with metastatic renal cell carcinoma treated with chemotherapy or interferon-alpha Eur J Cancer 30A 1994 1310 1314
    • (1994) Eur J Cancer , vol.30A , pp. 1310-1314
    • Fossa, SD1    Kramar, A2    Droz, JP3
  • 19
    • 0032772880 scopus 로고    scopus 로고
    • Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma
    • RJ Motzer M Mazumdar J Bacik Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma J Clin Oncol 17 1999 2530 2540
    • (1999) J Clin Oncol , vol.17 , pp. 2530-2540
    • Motzer, RJ1    Mazumdar, M2    Bacik, J3
  • 20
    • 0036138580 scopus 로고    scopus 로고
    • Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma
    • RJ Motzer J Bacik BA Murphy Interferon-alfa as a comparative treatment for clinical trials of new therapies against advanced renal cell carcinoma J Clin Oncol 20 2002 289 296
    • (2002) J Clin Oncol , vol.20 , pp. 289-296
    • Motzer, RJ1    Bacik, J2    Murphy, BA3
  • 21
    • 4644268358 scopus 로고    scopus 로고
    • Prognostic factors in patients with advanced renal cell carcinoma: development of an international kidney cancer working group
    • RM Bukowski S Negrier P Elson Prognostic factors in patients with advanced renal cell carcinoma: development of an international kidney cancer working group Clin Cancer Res 10 2004 6310S 6314S
    • (2004) Clin Cancer Res , vol.10 , pp. 6310S-6314S
    • Bukowski, RM1    Negrier, S2    Elson, P3
  • 22
    • 33750081436 scopus 로고    scopus 로고
    • Thrombocytosis as a prognostic factor for survival in patients with metastatic renal cell carcinoma
    • R Suppiah PE Shaheen P Elson Thrombocytosis as a prognostic factor for survival in patients with metastatic renal cell carcinoma Cancer 107 2006 1793 1800
    • (2006) Cancer , vol.107 , pp. 1793-1800
    • Suppiah, R1    Shaheen, PE2    Elson, P3
  • 23
    • 33847284868 scopus 로고    scopus 로고
    • Prognostic factors associated with long-term survival in previously untreated metastatic renal cell carcinoma
    • TK Choueiri B Rini JA Garcia Prognostic factors associated with long-term survival in previously untreated metastatic renal cell carcinoma Ann Oncol 18 2007 249 255
    • (2007) Ann Oncol , vol.18 , pp. 249-255
    • Choueiri, TK1    Rini, B2    Garcia, JA3
  • 24
    • 14144252047 scopus 로고    scopus 로고
    • Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma
    • TM Mekhail RM Abou-Jawde G Boumerhi Validation and extension of the Memorial Sloan-Kettering prognostic factors model for survival in patients with previously untreated metastatic renal cell carcinoma J Clin Oncol 23 2005 832 841
    • (2005) J Clin Oncol , vol.23 , pp. 832-841
    • Mekhail, TM1    Abou-Jawde, RM2    Boumerhi, G3
  • 25
    • 0037428774 scopus 로고    scopus 로고
    • Metastatic renal carcinoma comprehensive prognostic system
    • J Atzpodien P Royston T Wandert Metastatic renal carcinoma comprehensive prognostic system Br J Cancer 88 2003 348 353
    • (2003) Br J Cancer , vol.88 , pp. 348-353
    • Atzpodien, J1    Royston, P2    Wandert, T3
  • 26
    • 34548315347 scopus 로고    scopus 로고
    • Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis
    • RM Bukowski T Eisen C Szczylik Final results of the randomized phase III trial of sorafenib in advanced renal cell carcinoma: survival and biomarker analysis J Clin Oncol 25 18 suppl 2007 240s (Abstract 5023).
    • (2007) J Clin Oncol , vol.25 , Issue.18 suppl , pp. 240s
    • Bukowski, RM1    Eisen, T2    Szczylik, C3
  • 27
    • 35549005750 scopus 로고    scopus 로고
    • Sunitinib therapy for patients (pts) with metastatic renal cell carcinoma (mRCC): updated results of two phase II trials and prognostic factor analysis for survival
    • JE Rosenberg RJ Motzer MD Michaelson Sunitinib therapy for patients (pts) with metastatic renal cell carcinoma (mRCC): updated results of two phase II trials and prognostic factor analysis for survival J Clin Oncol 25 18 suppl 2007 258s (Abstract 5095).
    • (2007) J Clin Oncol , vol.25 , Issue.18 suppl , pp. 258s
    • Rosenberg, JE1    Motzer, RJ2    Michaelson, MD3
  • 28
    • 34548229506 scopus 로고    scopus 로고
    • Sorafenib With Interferon Alfa-2b As First-Line Treatment of Advanced Renal Carcinoma: A Phase II Study of the Southwest Oncology Group
    • CW Ryan BH Goldman PN Lara Sorafenib With Interferon Alfa-2b As First-Line Treatment of Advanced Renal Carcinoma: A Phase II Study of the Southwest Oncology Group J Clin Oncol 25 2007 3296 3301
    • (2007) J Clin Oncol , vol.25 , pp. 3296-3301
    • Ryan, CW1    Goldman, BH2    Lara, PN3
  • 29
    • 34648873387 scopus 로고    scopus 로고
    • Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of toxicity in an expanded access trial with subpopulation analysis
    • ME Gore C Porta S Oudard Sunitinib in metastatic renal cell carcinoma (mRCC): preliminary assessment of toxicity in an expanded access trial with subpopulation analysis J Clin Oncol 25 18 suppl 2007 237s (Abstract 5010).
    • (2007) J Clin Oncol , vol.25 , Issue.18 suppl , pp. 237s
    • Gore, ME1    Porta, C2    Oudard, S3
  • 30
    • 34547108341 scopus 로고    scopus 로고
    • Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy
    • TK Choueiri JA Garcia P Elson Clinical factors associated with outcome in patients with metastatic clear-cell renal cell carcinoma treated with vascular endothelial growth factor-targeted therapy Cancer 110 2007 543 550
    • (2007) Cancer , vol.110 , pp. 543-550
    • Choueiri, TK1    Garcia, JA2    Elson, P3
  • 31
    • 33646441904 scopus 로고    scopus 로고
    • Impact of immune parameters on longterm survival in metastatic renal cell carcinoma
    • F Donskov H von der Maase Impact of immune parameters on longterm survival in metastatic renal cell carcinoma J Clin Oncol 24 2006 1997 2005
    • (2006) J Clin Oncol , vol.24 , pp. 1997-2005
    • Donskov, F1    von der Maase, H2
  • 32
    • 84988414788 scopus 로고    scopus 로고
    • WBC changes as a pharmacodynamic marker of outcome in metastatic renal cell carcinoma (mRCC) patients (Pts) receiving sunitinib
    • S George A Richmond P Elson WBC changes as a pharmacodynamic marker of outcome in metastatic renal cell carcinoma (mRCC) patients (Pts) receiving sunitinib J Clin Oncol 25 28 suppl 2007 245s (Abstract 5043).
    • (2007) J Clin Oncol , vol.25 , Issue.28 suppl , pp. 245s
    • George, S1    Richmond, A2    Elson, P3
  • 33
    • 4644262523 scopus 로고    scopus 로고
    • Gene expression profiling of renal cell carcinoma
    • MH Tan CG Rogers JT Cooper Gene expression profiling of renal cell carcinoma Clin Cancer Res 10 2004 6315S 6321S
    • (2004) Clin Cancer Res , vol.10 , pp. 6315S-6321S
    • Tan, MH1    Rogers, CG2    Cooper, JT3
  • 34
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • N Ferrara HP Gerber J LeCouter The biology of VEGF and its receptors Nat Med 9 2003 669 676
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N1    Gerber, HP2    LeCouter, J3
  • 35
    • 2942756034 scopus 로고    scopus 로고
    • Interleukin-6, interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: prognostic value of interleukin-6–from the Groupe Francais d'Immunotherapie
    • S Negrier D Perol C Menetrier-Caux Interleukin-6, interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: prognostic value of interleukin-6–from the Groupe Francais d'Immunotherapie J Clin Oncol 22 2004 2371 2378
    • (2004) J Clin Oncol , vol.22 , pp. 2371-2378
    • Negrier, S1    Perol, D2    Menetrier-Caux, C3
  • 36
    • 39149121748 scopus 로고    scopus 로고
    • Serum level of vascular endothelial growth factor (VEGF) as an independent prognostic factor in metastatic renal cell carcinoma (MRCC)
    • S Negrier S Chabaud B Escudier Serum level of vascular endothelial growth factor (VEGF) as an independent prognostic factor in metastatic renal cell carcinoma (MRCC) J Clin Oncol 25 18 suppl 2007 245s (Abstract 5044).
    • (2007) J Clin Oncol , vol.25 , Issue.18 suppl , pp. 245s
    • Negrier, S1    Chabaud, S2    Escudier, B3
  • 37
    • 34547779489 scopus 로고    scopus 로고
    • Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins
    • SE Deprimo CL Bello J Smeraglia Circulating protein biomarkers of pharmacodynamic activity of sunitinib in patients with metastatic renal cell carcinoma: modulation of VEGF and VEGF-related proteins J Transl Med 5 2007 32
    • (2007) J Transl Med , vol.5 , pp. 32
    • Deprimo, SE1    Bello, CL2    Smeraglia, J3
  • 38
    • 35548990498 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in bevacizumab-refractory metastatic renal cell carcinoma (mRCC): Updated results and analysis of circulating biomarkers
    • DJ George MD Michaelson JE Rosenberg Phase II trial of sunitinib in bevacizumab-refractory metastatic renal cell carcinoma (mRCC): Updated results and analysis of circulating biomarkers J Clin Oncol 25 18 suppl 2007 243s (Abstract 5035).
    • (2007) J Clin Oncol , vol.25 , Issue.18 suppl , pp. 243s
    • George, DJ1    Michaelson, MD2    Rosenberg, JE3
  • 39
    • 33748302779 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1-alpha, hypoxia-inducible factor-2alpha and vascular endothelial growth factor in sporadic clear cell renal cell renal cell carcinoma and their significance in the pathogenesis thereof [in Chinese]
    • N Zhang K Gong XY Yang Expression of hypoxia-inducible factor-1-alpha, hypoxia-inducible factor-2alpha and vascular endothelial growth factor in sporadic clear cell renal cell renal cell carcinoma and their significance in the pathogenesis thereof [in Chinese] Zhonghua Yi Xue Za Zhi 86 2006 1526 1529
    • (2006) Zhonghua Yi Xue Za Zhi , vol.86 , pp. 1526-1529
    • Zhang, N1    Gong, K2    Yang, XY3
  • 40
    • 0035394516 scopus 로고    scopus 로고
    • Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxiainducible factor-1alpha in clear cell renal carcinomas
    • MS Wiesener PM Munchenhagen I Berger Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxiainducible factor-1alpha in clear cell renal carcinomas Cancer Res 61 2001 5215 5222
    • (2001) Cancer Res , vol.61 , pp. 5215-5222
    • Wiesener, MS1    Munchenhagen, PM2    Berger, I3
  • 41
    • 12944266844 scopus 로고    scopus 로고
    • The expression of hypoxiainducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma
    • A Lidgren Y Hedberg K Grankvist The expression of hypoxiainducible factor 1alpha is a favorable independent prognostic factor in renal cell carcinoma Clin Cancer Res 11 2005 1129 1135
    • (2005) Clin Cancer Res , vol.11 , pp. 1129-1135
    • Lidgren, A1    Hedberg, Y2    Grankvist, K3
  • 42
    • 0037314709 scopus 로고    scopus 로고
    • Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy
    • MH Bui D Seligson KR Han Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy Clin Cancer Res 9 2003 802 811
    • (2003) Clin Cancer Res , vol.9 , pp. 802-811
    • Bui, MH1    Seligson, D2    Han, KR3
  • 43
    • 85119756435 scopus 로고    scopus 로고
    • Bui MH, Visapaa H, Seligson D, et al. Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma. J Urol 171:2461-6.
  • 44
    • 85119741218 scopus 로고    scopus 로고
    • Use of carbonic anhydrase IX (CAIX) expression and Von Hippel Lindau (VHL) gene mutation status to predict survival in renal cell carcinoma
    • AJ Pantuck Q Trinh PI Karakiewicz Use of carbonic anhydrase IX (CAIX) expression and Von Hippel Lindau (VHL) gene mutation status to predict survival in renal cell carcinoma J Clin Oncol 25 18 suppl 2007 245s (Abstract 5042).
    • (2007) J Clin Oncol , vol.25 , Issue.18 suppl , pp. 245s
    • Pantuck, AJ1    Trinh, Q2    Karakiewicz, PI3
  • 45
    • 21044442672 scopus 로고    scopus 로고
    • Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer
    • M Atkins M Regan D McDermott Carbonic anhydrase IX expression predicts outcome of interleukin 2 therapy for renal cancer Clin Cancer Res 11 2005 3714 3721
    • (2005) Clin Cancer Res , vol.11 , pp. 3714-3721
    • Atkins, M1    Regan, M2    McDermott, D3
  • 46
    • 37549043546 scopus 로고    scopus 로고
    • Hypoxia-Inducible Factor 1{alpha} in Clear Cell Renal Cell Carcinoma
    • T Klatte DB Seligson SB Riggs Hypoxia-Inducible Factor 1{alpha} in Clear Cell Renal Cell Carcinoma Clin Cancer Res 13 2007 7388 7393
    • (2007) Clin Cancer Res , vol.13 , pp. 7388-7393
    • Klatte, T1    Seligson, DB2    Riggs, SB3
  • 47
    • 0036154040 scopus 로고    scopus 로고
    • VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma
    • P Schraml K Struckmann F Hatz VHL mutations and their correlation with tumour cell proliferation, microvessel density, and patient prognosis in clear cell renal cell carcinoma J Pathol 196 2002 186 193
    • (2002) J Pathol , vol.196 , pp. 186-193
    • Schraml, P1    Struckmann, K2    Hatz, F3
  • 48
    • 25144503984 scopus 로고    scopus 로고
    • Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma
    • JH Kim CW Jung YH Cho Somatic VHL alteration and its impact on prognosis in patients with clear cell renal cell carcinoma Oncol Rep 13 2005 859 864
    • (2005) Oncol Rep , vol.13 , pp. 859-864
    • Kim, JH1    Jung, CW2    Cho, YH3
  • 49
    • 16744366213 scopus 로고    scopus 로고
    • VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation
    • H Brauch G Weirich J Brieger VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation Cancer Res 60 2000 1942 1948
    • (2000) Cancer Res , vol.60 , pp. 1942-1948
    • Brauch, H1    Weirich, G2    Brieger, J3
  • 50
    • 0037120977 scopus 로고    scopus 로고
    • VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma
    • M Yao M Yoshida T Kishida VHL tumor suppressor gene alterations associated with good prognosis in sporadic clear-cell renal carcinoma J Natl Cancer Inst 94 2002 1569 1575
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1569-1575
    • Yao, M1    Yoshida, M2    Kishida, T3
  • 51
    • 44549084875 scopus 로고    scopus 로고
    • Use of Von-Hippel Lindau (VHL) mutation status to predict objective response to vascular endothelial growth factor (VEGF)-targeted therapy in metastatic renal cell carcinoma (RCC)
    • TK Choueiri SA Vaziri BI Rini Use of Von-Hippel Lindau (VHL) mutation status to predict objective response to vascular endothelial growth factor (VEGF)-targeted therapy in metastatic renal cell carcinoma (RCC) J Clin Oncol 25 18 suppl 2007 238s (Abstract 5012).
    • (2007) J Clin Oncol , vol.25 , Issue.18 suppl , pp. 238s
    • Choueiri, TK1    Vaziri, SA2    Rini, BI3
  • 52
    • 0032584108 scopus 로고    scopus 로고
    • Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells
    • F Okada JW Rak BS Croix Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells Proc Natl Acad Sci U S A 95 1998 3609 3614
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 3609-3614
    • Okada, F1    Rak, JW2    Croix, BS3
  • 53
    • 0031985127 scopus 로고    scopus 로고
    • Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src
    • LM Ellis CA Staley W Liu Down-regulation of vascular endothelial growth factor in a human colon carcinoma cell line transfected with an antisense expression vector specific for c-src J Biol Chem 273 1998 1052 1057
    • (1998) J Biol Chem , vol.273 , pp. 1052-1057
    • Ellis, LM1    Staley, CA2    Liu, W3
  • 54
    • 0041920901 scopus 로고    scopus 로고
    • TSC2 regulates VEGF through mTOR-dependent and -independent pathways
    • JB Brugarolas F Vazquez A Reddy TSC2 regulates VEGF through mTOR-dependent and -independent pathways Cancer Cell 4 2003 147 158
    • (2003) Cancer Cell , vol.4 , pp. 147-158
    • Brugarolas, JB1    Vazquez, F2    Reddy, A3
  • 55
    • 31544455868 scopus 로고    scopus 로고
    • Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma
    • BI Rini V Weinberg S Dunlap Maximal COX-2 immunostaining and clinical response to celecoxib and interferon alpha therapy in metastatic renal cell carcinoma Cancer 106 2006 566 575
    • (2006) Cancer , vol.106 , pp. 566-575
    • Rini, BI1    Weinberg, V2    Dunlap, S3
  • 56
    • 33846866035 scopus 로고    scopus 로고
    • The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer
    • D Cho S Signoretti M Regan The role of mammalian target of rapamycin inhibitors in the treatment of advanced renal cancer Clin Cancer Res 13 2007 758s 763s
    • (2007) Clin Cancer Res , vol.13 , pp. 758s-763s
    • Cho, D1    Signoretti, S2    Regan, M3
  • 57
    • 0036848820 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice
    • D Kedar CH Baker JJ Killion Blockade of the epidermal growth factor receptor signaling inhibits angiogenesis leading to regression of human renal cell carcinoma growing orthotopically in nude mice Clin Cancer Res 8 2002 3592 3600
    • (2002) Clin Cancer Res , vol.8 , pp. 3592-3600
    • Kedar, D1    Baker, CH2    Killion, JJ3
  • 58
    • 33750209892 scopus 로고    scopus 로고
    • IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells
    • AH Rosendahl G Forsberg IGF-I and IGFBP-3 augment transforming growth factor-beta actions in human renal carcinoma cells Kidney Int 70 2006 1584 1590
    • (2006) Kidney Int , vol.70 , pp. 1584-1590
    • Rosendahl, AH1    Forsberg, G2
  • 59
    • 33846164401 scopus 로고    scopus 로고
    • Somatic von Hippel-Lindau (VHL) gene analysis and clinical outcome under antiangiogenic treatment in metastatic renal cell carcinoma: preliminary results
    • S Gad V Sultan-Amar J Meric Somatic von Hippel-Lindau (VHL) gene analysis and clinical outcome under antiangiogenic treatment in metastatic renal cell carcinoma: preliminary results Targeted Oncology 2 2007 3 6
    • (2007) Targeted Oncology , vol.2 , pp. 3-6
    • Gad, S1    Sultan-Amar, V2    Meric, J3
  • 60
    • 1542398693 scopus 로고    scopus 로고
    • Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma
    • MB Atkins M Hidalgo WM Stadler Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinoma J Clin Oncol 22 2004 909 918
    • (2004) J Clin Oncol , vol.22 , pp. 909-918
    • Atkins, MB1    Hidalgo, M2    Stadler, WM3
  • 61
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • G Hudes M Carducci P Tomczak Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma N Engl J Med 356 2007 2271 2281
    • (2007) N Engl J Med , vol.356 , pp. 2271-2281
    • Hudes, G1    Carducci, M2    Tomczak, P3
  • 62
    • 35348858663 scopus 로고    scopus 로고
    • Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma
    • D Cho S Signoretti S Dabora Potential histologic and molecular predictors of response to temsirolimus in patients with advanced renal cell carcinoma Clin Genitourin Cancer 5 2007 379 385
    • (2007) Clin Genitourin Cancer , vol.5 , pp. 379-385
    • Cho, D1    Signoretti, S2    Dabora, S3


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