-
1
-
-
10644235742
-
Challenges and Opportunities on the Critical Path to New Medical Products
-
Food and Drug Administration. US Department of Health and Human Services
-
Food and Drug Administration. US Department of Health and Human Services (2004) Challenges and Opportunities on the Critical Path to New Medical Products. http://www.fda.gov/oc/initiatives/criticalpath/whitepaper.html.
-
(2004)
-
-
-
2
-
-
0035100888
-
Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
-
Biomarkers Definitions Working Group
-
Biomarkers Definitions Working Group (2001) Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clinical Pharmacology and Therapeutics, 69, 89-95.
-
(2001)
Clinical Pharmacology and Therapeutics
, vol.69
, pp. 89-95
-
-
-
3
-
-
28544446695
-
Biomarkers in cancer staging, prognosis and treatment selection
-
Ludwig, J. A. and Weinstein, J. N. (2005) Biomarkers in cancer staging, prognosis and treatment selection. Nature Reviews Cancer, 5, 845-56.
-
(2005)
Nature Reviews Cancer
, vol.5
, pp. 845-856
-
-
Ludwig, J.A.1
Weinstein, J.N.2
-
4
-
-
33646457229
-
Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies
-
Workman, P., Aboagye, E. O., Chung, Y. L., Griffiths, J. R., Hart, R., Leach, M. O., Maxwell, R. J., McSheehy, P. M., Price, P. M. and Zweit, J. (2006) Minimally invasive pharmacokinetic and pharmacodynamic technologies in hypothesis-testing clinical trials of innovative therapies. Journal of the National Cancer Institute, 98, 580-98.
-
(2006)
Journal of the National Cancer Institute
, vol.98
, pp. 580-598
-
-
Workman, P.1
Aboagye, E.O.2
Chung, Y.L.3
Griffiths, J.R.4
Hart, R.5
Leach, M.O.6
Maxwell, R.J.7
McSheehy, P.M.8
Price, P.M.9
Zweit, J.10
-
5
-
-
32544451155
-
Fitfor-purpose method development and validation for successful biomarker measurement
-
Lee, J. W., Devanarayan, V., Barrett, Y. C., Weiner, R., Allinson, J., Fountain, S., Keller, S., Weinryb, I., Green, M., Duan, L., Rogers, J. A., Millham, R., O'Brien, P. J., Sailstad, J., Khan, M., Ray, C. and Wagner, J. A. (2006) Fitfor-purpose method development and validation for successful biomarker measurement. Pharmaceutical Research, 23, 312-28.
-
(2006)
Pharmaceutical Research
, vol.23
, pp. 312-328
-
-
Lee, J.W.1
Devanarayan, V.2
Barrett, Y.C.3
Weiner, R.4
Allinson, J.5
Fountain, S.6
Keller, S.7
Weinryb, I.8
Green, M.9
Duan, L.10
Rogers, J.A.11
Millham, R.12
O'Brien, P.J.13
Sailstad, J.14
Khan, M.15
Ray, C.16
Wagner, J.A.17
-
6
-
-
33645463194
-
Multiplexed protein measurement: technologies and applications of protein and antibody arrays
-
Kingsmore, S. F. (2006) Multiplexed protein measurement: technologies and applications of protein and antibody arrays. Nature Reviews Drug Discovery, 5, 310-20.
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, pp. 310-320
-
-
Kingsmore, S.F.1
-
7
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
Altomare, D. A. and Testa, J. R. (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene, 24, 7455-64.
-
(2005)
Oncogene
, vol.24
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
8
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco, I. and Sawyers, C. L. (2002) The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nature Reviews Cancer, 2, 489-501.
-
(2002)
Nature Reviews Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
9
-
-
27844432603
-
AKT signaling in normal and malignant cells
-
Testa, J. R. and Tsichlis, P. N. (2005) AKT signaling in normal and malignant cells. Oncogene, 24, 7391-3.
-
(2005)
Oncogene
, vol.24
, pp. 7391-7393
-
-
Testa, J.R.1
Tsichlis, P.N.2
-
10
-
-
0028074316
-
Phosphatidylinositol-3-OH kinase as a direct target of Ras
-
Rodriguez-Viciana, P., Warne, P. H., Dhand, R., Vanhaesebroeck, B., Gout, I., Fry, M. J., Waterfield, M. D. and Downward, J. (1994) Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature, 370, 527-32.
-
(1994)
Nature
, vol.370
, pp. 527-532
-
-
Rodriguez-Viciana, P.1
Warne, P.H.2
Dhand, R.3
Vanhaesebroeck, B.4
Gout, I.5
Fry, M.J.6
Waterfield, M.D.7
Downward, J.8
-
11
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson, K. M. and Anderson, N. G. (2002) The protein kinase B/Akt signalling pathway in human malignancy. Cellular Signalling, 14, 381-95.
-
(2002)
Cellular Signalling
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
12
-
-
27844461512
-
Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 30 kinase/AKT pathways
-
Larue, L. and Bellacosa, A. (2005) Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 30 kinase/AKT pathways. Oncogene, 24, 7443-54.
-
(2005)
Oncogene
, vol.24
, pp. 7443-7454
-
-
Larue, L.1
Bellacosa, A.2
-
13
-
-
0037728809
-
The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
-
Grille, S. J., Bellacosa, A., Upson, J., Klein-Szanto, A. J., van Roy, F., Lee-Kwon, W., Donowitz, M., Tsichlis, P. N. and Larue, L. (2003) The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines. Cancer Research, 63, 2172-8.
-
(2003)
Cancer Research
, vol.63
, pp. 2172-2178
-
-
Grille, S.J.1
Bellacosa, A.2
Upson, J.3
Klein-Szanto, A.J.4
Van Roy, F.5
Lee-Kwon, W.6
Donowitz, M.7
Tsichlis, P.N.8
Larue, L.9
-
14
-
-
21144457217
-
Functional analysis of PIK3CA gene mutations in human colorectal cancer
-
Ikenoue, T., Kanai, F., Hikiba, Y., Obata, T., Tanaka, Y., Imamura, J., Ohta, M., Jazag, A., Guleng, B., Tateishi, K., Asaoka, Y., Matsumura, M., Kawabe, T. and Omata, M. (2005) Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Research, 65, 4562-7.
-
(2005)
Cancer Research
, vol.65
, pp. 4562-4567
-
-
Ikenoue, T.1
Kanai, F.2
Hikiba, Y.3
Obata, T.4
Tanaka, Y.5
Imamura, J.6
Ohta, M.7
Jazag, A.8
Guleng, B.9
Tateishi, K.10
Asaoka, Y.11
Matsumura, M.12
Kawabe, T.13
Omata, M.14
-
15
-
-
22144491262
-
Mutations of PIK3CA in gastric adenocarcinoma
-
Li, V. S., Wong, C. W., Chan, T. L., Chan, A. S., Zhao, W., Chu, K. M., So, S., Chen, X., Yuen, S. T. and Leung, S. Y. (2005) Mutations of PIK3CA in gastric adenocarcinoma. BMC Cancer, 5, 29.
-
(2005)
BMC Cancer
, vol.5
, pp. 29
-
-
Li, V.S.1
Wong, C.W.2
Chan, T.L.3
Chan, A.S.4
Zhao, W.5
Chu, K.M.6
So, S.7
Chen, X.8
Yuen, S.T.9
Leung, S.Y.10
-
16
-
-
33645717035
-
Human tumor mutants in the p110alpha subunit of PI3K
-
Liu, Z. and Roberts, T. M. (2006) Human tumor mutants in the p110alpha subunit of PI3K. Cell Cycle, 5, 675-7.
-
(2006)
Cell Cycle
, vol.5
, pp. 675-677
-
-
Liu, Z.1
Roberts, T.M.2
-
17
-
-
29144433991
-
Phosphoinositide 3-kinase: from viral oncoprotein to drug target
-
Vogt, P. K., Bader, A. G. and Kang, S. (2006) Phosphoinositide 3-kinase: from viral oncoprotein to drug target. Virology, 344, 131-8.
-
(2006)
Virology
, vol.344
, pp. 131-138
-
-
Vogt, P.K.1
Bader, A.G.2
Kang, S.3
-
18
-
-
30144437253
-
Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB
-
Costa, L. F., Balcells, M., Edelman, E. R., Nadler, L. M. and Cardoso, A. A. (2006) Proangiogenic stimulation of bone marrow endothelium engages mTOR and is inhibited by simultaneous blockade of mTOR and NF-kappaB. Blood, 107, 285-92.
-
(2006)
Blood
, vol.107
, pp. 285-292
-
-
Costa, L.F.1
Balcells, M.2
Edelman, E.R.3
Nadler, L.M.4
Cardoso, A.A.5
-
19
-
-
2942735384
-
Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer
-
Raymond, E., Alexandre, J., Faivre, S., Vera, K., Materman, E., Boni, J., Leister, C., Korth-Bradley, J., Hanauske, A. and Armand, J. P. (2004) Safety and pharmacokinetics of escalated doses of weekly intravenous infusion of CCI-779, a novel mTOR inhibitor, in patients with cancer. Journal of Clinical Oncology, 22, 2336-47.
-
(2004)
Journal of Clinical Oncology
, vol.22
, pp. 2336-2347
-
-
Raymond, E.1
Alexandre, J.2
Faivre, S.3
Vera, K.4
Materman, E.5
Boni, J.6
Leister, C.7
Korth-Bradley, J.8
Hanauske, A.9
Armand, J.P.10
-
20
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre, S., Kroemer, G. and Raymond, E. (2006) Current development of mTOR inhibitors as anticancer agents. Nature Reviews Drug Discovery, 5, 671-88.
-
(2006)
Nature Reviews Drug Discovery
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
21
-
-
0041662261
-
Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients
-
Peralba, J. M., DeGraffenried, L., Friedrichs, W., Fulcher, L., Grunwald, V., Weiss, G. and Hidalgo, M. (2003) Pharmacodynamic evaluation of CCI-779, an inhibitor of mTOR, in cancer patients. Clinical Cancer Research, 9, 2887-92.
-
(2003)
Clinical Cancer Research
, vol.9
, pp. 2887-2892
-
-
Peralba, J.M.1
DeGraffenried, L.2
Friedrichs, W.3
Fulcher, L.4
Grunwald, V.5
Weiss, G.6
Hidalgo, M.7
-
22
-
-
12444259660
-
Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients
-
Malik, S. N., Siu, L. L., Rowinsky, E. K., deGraffenried, L., Hammond, L. A., Rizzo, J., Bacus, S., Brattain, M. G., Kreisberg, J. I. and Hidalgo, M. (2003) Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients. Clinical Cancer Research, 9, 2478-86.
-
(2003)
Clinical Cancer Research
, vol.9
, pp. 2478-2486
-
-
Malik, S.N.1
Siu, L.L.2
Rowinsky, E.K.3
deGraffenried, L.4
Hammond, L.A.5
Rizzo, J.6
Bacus, S.7
Brattain, M.G.8
Kreisberg, J.I.9
Hidalgo, M.10
-
23
-
-
78649519766
-
Monitoring Signal Transduction in Whole Blood by Flow Cytometry
-
AAI
-
Covey, T., Mu, S., Middleton, S. and Saris, C. J. M. (2005) Monitoring Signal Transduction in Whole Blood by Flow Cytometry, AAI.
-
(2005)
-
-
Covey, T.1
Mu, S.2
Middleton, S.3
Saris, C.J.M.4
-
24
-
-
1642463417
-
Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications
-
Krutzik, P. O., Irish, J. M., Nolan, G. P. and Perez, O. D. (2004) Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications. Clinical Immunology, 110, 206-21.
-
(2004)
Clinical Immunology
, vol.110
, pp. 206-221
-
-
Krutzik, P.O.1
Irish, J.M.2
Nolan, G.P.3
Perez, O.D.4
-
25
-
-
0346244001
-
Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events
-
Krutzik, P. O. and Nolan, G. P. (2003) Intracellular phospho-protein staining techniques for flow cytometry: monitoring single cell signaling events. Cytometry A, 55, 61-70.
-
(2003)
Cytometry A
, vol.55
, pp. 61-70
-
-
Krutzik, P.O.1
Nolan, G.P.2
-
26
-
-
0032128447
-
Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update
-
Trepanier, D. J., Gallant, H., Legatt, D. F. and Yatscoff, R. W. (1998) Rapamycin: distribution, pharmacokinetics and therapeutic range investigations: an update. Clinical Biochemistry, 31, 345-51.
-
(1998)
Clinical Biochemistry
, vol.31
, pp. 345-351
-
-
Trepanier, D.J.1
Gallant, H.2
Legatt, D.F.3
Yatscoff, R.W.4
-
27
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group study
-
Galanis, E., Buckner, J. C., Maurer, M. J., Kreisberg, J. I., Ballman, K., Boni, J., Peralba, J. M., Jenkins, R. B., Dakhil, S. R., Morton, R. F., Jaeckle, K. A., Scheithauer, B. W., Dancey, J., Hidalgo, M. and Walsh, D. J. (2005) Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group study. Journal of Clinical Oncology, 23, 5294-304.
-
(2005)
Journal of Clinical Oncology
, vol.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Maurer, M.J.3
Kreisberg, J.I.4
Ballman, K.5
Boni, J.6
Peralba, J.M.7
Jenkins, R.B.8
Dakhil, S.R.9
Morton, R.F.10
Jaeckle, K.A.11
Scheithauer, B.W.12
Dancey, J.13
Hidalgo, M.14
Walsh, D.J.15
|