Generation of antiviral major histocompatibility complex class I-restricted T cells in the absence of CD8 coreceptors

Journal of Virology

Volumn 82, Issue 10, 2008, Pages 4697-4705

  Andrews, Nicolas P ^a   Pack, Christopher D ^a   Lukacher, Aron E ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR; CD3 ANTIGEN; CD4 ANTIGEN; GAMMA INTERFERON; HLA ANTIGEN CLASS 1; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL EXPANSION; CONTROLLED STUDY; IN VIVO STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS 1; MOUSE; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; T LYMPHOCYTE; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION; WILD TYPE; ADOPTIVE TRANSFER; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CD8+ T LYMPHOCYTE; CHEMISTRY; CYTOTOXICITY; FLOW CYTOMETRY; IMMUNOLOGY; MICROBIOLOGY; MOUSE MUTANT; T LYMPHOCYTE SUBPOPULATION; TIME;

MUS; POLYOMAVIRUS; VESICULAR STOMATITIS VIRUS;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD3; ANTIGENS, CD4; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS I; INTERFERON TYPE II; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; POLYOMAVIRUS; POLYOMAVIRUS INFECTIONS; RECEPTORS, ANTIGEN, T-CELL; RHABDOVIRIDAE INFECTIONS; T-LYMPHOCYTE SUBSETS; TIME FACTORS; VESICULOVIRUS;

EID: 43249084020     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.02698-07     Document Type: Article

References (43)

1. Allison, A. C., and L. W. Law. 1968. Effects of antilymphocyte serum on virus oncogenesis. Proc. Soc. Exp. Biol. Med. 127:207-212.
2. Andrews, N. P., C. D. Pack, V. Vezys, G. N. Barber, and A. E. Lukacher. 2007. Early virus-associated bystander events affect the fitness of the CD8 T cell response to persistent virus infection. J. Immunol. 178:7267-7275.
3. -/- mice. Thymic positive selection is biased toward the helper phenotype. J. Immunol. 155:3727-3733.
4. Bendig, M. M., T. Thomas, and W. R. Folk. 1980. Viable deletion mutant in the medium and large T-antigen-coding sequences of the polyoma virus genome. J. Virol. 33:1215-1220.
5. -/- double knockout mice. Int. J. Cancer 67:405-408.
6. Busch, D. H., and E. G. Pamer. 1999. T cell affinity maturation by selective expansion during infection. J. Exp. Med. 189:701-710.
7. + T cells. J. Immunol. 171:17-21.
8. Dalloul, A. H., K. Ngo, and W. P. Fung-Leung. 1996. CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice. Eur. J. Immunol. 26:213-218.
9. Daniels, M. A., and S. C. Jameson. 2000. Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers. J. Exp. Med. 191:335-346.
10. de la Calle-Martin, O., M. Hernandez, J. Ordi, N. Casamitjana, J. I. Arostegui, I. Caragol, M. Ferrando, M. Labrador, J. L. Rodriguez-Sanchez, and T. Espanol. 2001. Familial CD8 deficiency due to a mutation in the CD8α gene. J. Clin. Investig. 108:117-123.
11. Derby, M., M. Alexander-Miller, R. Tse, and J. Berzofsky. 2001. High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL. J. Immunol. 166:1690-1697.
12. + T cells. J. Immunol. 166:7009-7013.
13. 2- microglobulin knockout mice are highly susceptible to polyoma virus tumorigenesis. Virology 252:275-284.
14. Fung-Leung, W. P., T. M. Kundig, R. M. Zinkernagel, and T. W. Mak. 1991. Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J. Exp. Med. 174:1425-1429.
15. Fung-Leung, W. P., M. W. Schilham, A. Rahemtulla, T. M. Kundig, M. Vollenweider, J. Potter, W. van Ewijk, and T. W. Mak. 1991. CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell 65:443-449.
16. + T lymphocytes in healthy seropositive donors. J. Virol. 74:8140-8150.
17. Goepfert, P. A., A. Bansal, B. H. Edwards, G. D. Ritter, Jr., I. Tellez, S. A. McPherson, S. Sabbaj, and M. J. Mulligan. 2000. A significant number of human immunodeficiency virus epitope-specific cytotoxic T lymphocytes detected by tetramer binding do not produce gamma interferon. J. Virol. 74:10249-10255.
18. Goldrath, A. W., K. A. Hogquist, and M. J. Bevan. 1997. CD8 lineage commitment in the absence of CD8. Immunity 6:633-642.
19. Harper, J. S., III, C. J. Dawe, B. D. Trapp, P. E. McKeever, M. Collins, J. L. Woyciechowska, D. L. Madden, and J. L. Sever. 1983. Paralysis in nude mice caused by polyomavirus-induced vertebral tumors. Prog. Clin. Biol. Res. 105:359-367.
20. Holler, P. D., and D. M. Kranz. 2003. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity 18: 255-264.
21. + T cell responses during a persistent virus infection. J. Immunol. 174:7950-7960.
22. + T cell help over the course of persistent infection. J. Immunol. 179:1113-1121.
23. Kerry, S. E., J. Buslepp, L. A. Cramer, R. Maile, L. L. Hensley, A. I. Nielsen, P. Kavathas, B. J. Vilen, E. J. Collins, and J. A. Frelinger. 2003. Interplay between TCR affinity and necessity of coreceptor ligation: high-affinity peptide-MHC/TCR interaction overcomes lack of CD8 engagement. J. Immunol. 171:4493-4503.
24. Laugel, B., D. A. Price, A. Milicic, and A. K. Sewell. 2007. CD8 exerts differential effects on the deployment of cytotoxic T lymphocyte effector functions. Eur. J. Immunol. 37:905-913.
25. Lee, P. P., C. Yee, P. A. Savage, L. Fong, D. Brockstedt, J. S. Weber, D. Johnson, S. Swetter, J. Thompson, P. D. Greenberg, M. Roederer, and M. M. Davis. 1999. Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat. Med. 5:677-685.
26. Liunggren, G., H. G. Liunggren, and T. Dalianis. 1994. T cell subsets involved in immunity against polyoma virus-induced tumors. Virology 198: 714-716.
27. s: a dominantly acting gene in C3H/BiDa mice conferring susceptibility to tumor induction by polyoma virus. Virology 196:241-248.
28. k-restricted epitope in the middle T protein. J. Immunol. 160:1724-1734.
29. Martínez, C., M. A. Marcos, I. M. de Alboran, J. M. Alonso, R. de Cid, G. Kroemer, and A. Coutinho. 1993. Functional double-negative T cells in the periphery express T cell receptor Vβ gene products that cause deletion of single-positive T cells. Eur. J. Immunol. 23:250-254.
30. + T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity 27:203-213.
31. Murali-Krishna, K., J. D. Altman, M. Suresh, D. J. Sourdive, A. J. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8:177-187.
32. Purbhoo, M. A., J. M. Boulter, D. A. Price, A. L. Vuidepot, C. S. Hourigan, P. R. Dunbar, K. Olson, S. J. Dawson, R. E. Phillips, B. K. Jakobsen, J. I. Bell, and A. K. Sewell. 2001. The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor ζ chain. J. Biol. Chem. 276:32786-32792.
33. Sebzda, E., M. Choi, W. P. Fung-Leung, T. W. Mak, and P. S. Ohashi. 1997. Peptide-induced positive selection of TCR transgenic thymocytes in a coreceptor-independent manner. Immunity 6:643-653.
34. + T cells without selection of higher affinity TCR. Nat. Immunol. 2:711-717.
35. + T cells. Immunology 103:270-280.
36. + cells. J. Immunol. 145:3209-3215.
37. Szomolanyi-Tsuda, E., and R. M. Welsh. 1996. T cell-independent antibody-mediated clearance of polyoma virus in T cell-deficient mice. J. Exp. Med. 183:403-411.
38. Vandeputte, M. 1968. The effect of heterologous antilymphocytic serum on the oncogenic activity of polyoma virus. Life Sci. 7:855-865.
39. Vezys, V., D. Masopust, C. C. Kemball, D. L. Barber, L. A. O'Mara, C. P. Larsen, T. C. Pearson, R. Ahmed, and A. E. Lukacher. 2006. Continuous recruitment of naive T cells contributes to heterogeneity of antiviral CD8 T cells during persistent infection. J. Exp. Med. 203:2263-2269.
40. Wherry, E. J., J. N. Blattman, K. Murali-Krishna, R. van der Most, and R. Ahmed. 2003. Viral persistence alters CD8 T-cell immunodominance and tissue distribution and results in distinct stages of functional impairment. J. Virol. 77:4911-4927.
41. Wirth, J. J., A. Amalfitano, R. Gross, M. B. Oldstone, and M. M. Fluck. 1992. Organ- and age-specific replication of polyomavirus in mice. J. Virol. 66: 3278-3286.
42. Xiao, Z., M. F. Mescher, and S. C. Jameson. 2007. Detuning CD8 T cells: down-regulation of CD8 expression, tetramer binding, and response during CTL activation. J. Exp. Med. 204:2667-2677.
43. Yee, C., P. A. Savage, P. P. Lee, M. M. Davis, and P. D. Greenberg. 1999. Isolation of high avidity melanoma-reactive CTL from heterogeneous populations using peptide-MHC tetramers. J. Immunol. 162:2227-2234.