Cigarette smoke-induced pancreatic damage - Experimental data

Langenbeck's Archives of Surgery

Volumn 393, Issue 4, 2008, Pages 581-588

  Wittel, Uwe A ^a   Hopt, Ulrich T ^a   Batra, Surinder K ^b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Carcinogen; Chronic pancreatitis; Cigarette smoking; Nicotine; Pancreatic cancer

Indexed keywords

NICOTINE; PROTEINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIGARETTE SMOKING; ENVIRONMENTAL EXPOSURE; NONHUMAN; PANCREAS INJURY; PANCREATITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 43149113030     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-007-0273-3     Document Type: Article

References (62)

1. 1. W Weiss MA Benarde 1983 The temporal relation between cigarette smoking and pancreatic cancer Am J Public Health 73 1403 1404 6638239 1:STN:280:DyaL2c%2FkvFynsA%3D%3D Weiss W, Benarde MA (1983) The temporal relation between cigarette smoking and pancreatic cancer. Am J Public Health 73:1403–1404
2. 2. F Levi F Lucchini E Negri VC La 2003 Pancreatic cancer mortality in Europe: the leveling of an epidemic Pancreas 27 139 142 12883262 10.1097/00006676-200308000-00006 Levi F, Lucchini F, Negri E, La VC (2003) Pancreatic cancer mortality in Europe: the leveling of an epidemic. Pancreas 27:139–142
3. 3. DM Parkin P Pisani AD Lopez E Masuyer 1994 At least one in seven cases of cancer is caused by smoking. Global estimates for 1985 Int J Cancer 59 494 504 7960219 10.1002/ijc.2910590411 1:STN:280:DyaK2M%2FkvVyrsg%3D%3D Parkin DM, Pisani P, Lopez AD, Masuyer E (1994) At least one in seven cases of cancer is caused by smoking. Global estimates for 1985. Int J Cancer 59:494–504
4. 4. E Fernandez VC La M Porta E Negri F Lucchini F Levi 1994 Trends in pancreatic cancer mortality in Europe, 1955–1989 Int J Cancer 57 786 792 8206673 10.1002/ijc.2910570605 1:STN:280:DyaK2c3ms1Gjtg%3D%3D Fernandez E, La VC, Porta M, Negri E, Lucchini F, Levi F (1994) Trends in pancreatic cancer mortality in Europe, 1955–1989. Int J Cancer 57:786–792
5. 5. I Mulder RT Hoogenveen ML Genugten van PG Lankisch AB Lowenfels AE Hollander de HB Bueno-de-Mesquita 2002 Smoking cessation would substantially reduce the future incidence of pancreatic cancer in the European Union Eur J Gastroenterol Hepatol 14 1343 1353 12468956 10.1097/00042737-200212000-00010 Mulder I, Hoogenveen RT, van Genugten ML, Lankisch PG, Lowenfels AB, de Hollander AE, Bueno-de-Mesquita HB (2002) Smoking cessation would substantially reduce the future incidence of pancreatic cancer in the European Union. Eur J Gastroenterol Hepatol 14:1343–1353
6. 6. B Prokopczyk D Hoffmann M Bologna AJ Cunningham N Trushin S Akerkar T Boyiri S Amin D Desai S Colosimo B Pittman G Leder M Ramadani D Henne-Bruns HG Beger K El-Bayoumy 2002 Identification of tobacco-derived compounds in human pancreatic juice Chem Res Toxicol 15 677 685 12018989 10.1021/tx0101088 1:CAS:528:DC%2BD38Xjt12qsbg%3D Prokopczyk B, Hoffmann D, Bologna M, Cunningham AJ, Trushin N, Akerkar S, Boyiri T, Amin S, Desai D, Colosimo S, Pittman B, Leder G, Ramadani M, Henne-Bruns D, Beger HG, El-Bayoumy K (2002) Identification of tobacco-derived compounds in human pancreatic juice. Chem Res Toxicol 15:677–685
7. 7. IARC (2004) Tobacco smoke and involuntary smoking. IARC monographs on the evaluation of carcinogenic risks to humans, vol 83. WHO International Agency for Research on Cancer, Lyon, France
8. 8. MS Rao 1987 Animal models of exocrine pancreatic carcinogenesis Cancer Metastasis Rev 6 665 676 3127071 10.1007/BF00047473 1:STN:280:DyaL1c7msFemtg%3D%3D Rao MS (1987) Animal models of exocrine pancreatic carcinogenesis. Cancer Metastasis Rev 6:665–676
9. 9. D Wei HQ Xiong JL Abbruzzese K Xie 2003 Experimental animal models of pancreatic carcinogenesis and metastasis Int J Gastrointest Cancer 33 43 60 12909737 10.1385/IJGC:33:1:43 Wei D, Xiong HQ, Abbruzzese JL, Xie K (2003) Experimental animal models of pancreatic carcinogenesis and metastasis. Int J Gastrointest Cancer 33:43–60
10. 10. P Chowdhury S MacLeod KB Udupa PL Rayford 2002 Pathophysiological effects of nicotine on the pancreas: an update Exp Biol Med (Maywood) 227 445 454 1:CAS:528:DC%2BD38Xlt1WgtrY%3D Chowdhury P, MacLeod S, Udupa KB, Rayford PL (2002) Pathophysiological effects of nicotine on the pancreas: an update. Exp Biol Med (Maywood) 227:445–454
11. 11. HM Schuller 2007 Neurotransmitter receptor-mediated signaling pathways as modulators of carcinogenesis Prog Exp Tumor Res 39 45 63 17314500 10.1159/000100045 1:CAS:528:DC%2BD1MXltFehurs%3D Schuller HM (2007) Neurotransmitter receptor-mediated signaling pathways as modulators of carcinogenesis. Prog Exp Tumor Res 39:45–63
12. 12. D Hoffmann A Rivenson R Abbi EL Wynder 1993 A study of tobacco carcinogenesis: effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats Cancer Res 53 2758 2761 8389244 1:CAS:528:DyaK3sXltFWjs7g%3D Hoffmann D, Rivenson A, Abbi R, Wynder EL (1993) A study of tobacco carcinogenesis: effect of the fat content of the diet on the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats. Cancer Res 53:2758–2761
13. 13. A Rivenson D Hoffmann B Prokopczyk S Amin SS Hecht 1988 Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines Cancer Res 48 6912 6917 3180100 1:CAS:528:DyaL1MXlt1Kqsg%3D%3D Rivenson A, Hoffmann D, Prokopczyk B, Amin S, Hecht SS (1988) Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines. Cancer Res 48:6912–6917
14. 14. J Standop MB Schneider A Ulrich PM Pour 2001 Experimental animal models in pancreatic carcinogenesis: lessons for human pancreatic cancer Dig Dis 19 24 31 11385248 10.1159/000050650 1:STN:280:DC%2BD3MzhtFOjsA%3D%3D Standop J, Schneider MB, Ulrich A, Pour PM (2001) Experimental animal models in pancreatic carcinogenesis: lessons for human pancreatic cancer. Dig Dis 19:24–31
15. 15. DE Bockman J Guo P Buchler MW Muller F Bergmann H Friess 2003 Origin and development of the precursor lesions in experimental pancreatic cancer in rats Lab Invest 83 853 859 12808120 Bockman DE, Guo J, Buchler P, Muller MW, Bergmann F, Friess H (2003) Origin and development of the precursor lesions in experimental pancreatic cancer in rats. Lab Invest 83:853–859
16. 16. P Chowdhury R Doi A Tangoku PL Rayford 1995 Structural and functional changes of rat exocrine pancreas exposed to nicotine Int J Pancreatol 18 257 264 8708398 1:CAS:528:DyaK28Xpt1yksg%3D%3D Chowdhury P, Doi R, Tangoku A, Rayford PL (1995) Structural and functional changes of rat exocrine pancreas exposed to nicotine. Int J Pancreatol 18:257–264
17. 17. DJ Westerloo van IA Giebelen S Florquin MJ Bruno GJ Larosa L Ulloa KJ Tracey PT der van 2006 The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice Gastroenterology 130 1822 1830 16697744 10.1053/j.gastro.2006.02.022 1:CAS:528:DC%2BD28Xls1Wit7w%3D van Westerloo DJ, Giebelen IA, Florquin S, Bruno MJ, Larosa GJ, Ulloa L, Tracey KJ, van der PT (2006) The vagus nerve and nicotinic receptors modulate experimental pancreatitis severity in mice. Gastroenterology 130:1822–1830
18. 18. P Chowdhury R Hosotani PL Rayford 1989 Inhibition of CCK or carbachol-stimulated amylase release by nicotine Life Sci 45 2163 2168 2481202 10.1016/0024-3205(89)90083-0 1:CAS:528:DyaK3cXjtVGjsg%3D%3D Chowdhury P, Hosotani R, Rayford PL (1989) Inhibition of CCK or carbachol-stimulated amylase release by nicotine. Life Sci 45:2163–2168
19. 19. P Chowdhury PL Rayford LW Chang 1992 Induction of pancreatic acinar pathology via inhalation of nicotine Proc Soc Exp Biol Med 201 159 164 1409731 1:CAS:528:DyaK38XmsVOjsLw%3D Chowdhury P, Rayford PL, Chang LW (1992) Induction of pancreatic acinar pathology via inhalation of nicotine. Proc Soc Exp Biol Med 201:159–164
20. 20. P Chowdhury R Hosotani L Chang PL Rayford 1990 Metabolic and pathologic effects of nicotine on gastrointestinal tract and pancreas of rats Pancreas 5 222 229 1690423 10.1097/00006676-199003000-00016 1:STN:280:DyaK3c7pt1OgtQ%3D%3D Chowdhury P, Hosotani R, Chang L, Rayford PL (1990) Metabolic and pathologic effects of nicotine on gastrointestinal tract and pancreas of rats. Pancreas 5:222–229
21. 21. UA Wittel AP Singh BJ Henley M Andrianifahanana MP Akhter DM Cullen SK Batra 2006 Cigarette smoke-induced differential expression of the genes involved in exocrine function of the rat pancreas Pancreas 33 364 370 17079941 10.1097/01.mpa.0000240601.80570.31 1:CAS:528:DC%2BD28Xht1Cms7nF Wittel UA, Singh AP, Henley BJ, Andrianifahanana M, Akhter MP, Cullen DM, Batra SK (2006) Cigarette smoke-induced differential expression of the genes involved in exocrine function of the rat pancreas. Pancreas 33:364–370
22. 22. UA Wittel KK Pandey M Andrianifahanana SL Johansson DM Cullen MP Akhter RE Brand B Prokopczyk SK Batra 2006 Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats Am J Gastroenterol 101 148 159 16405548 10.1111/j.1572-0241.2006.00405.x 1:CAS:528:DC%2BD28XhsFSrtrY%3D Wittel UA, Pandey KK, Andrianifahanana M, Johansson SL, Cullen DM, Akhter MP, Brand RE, Prokopczyk B, Batra SK (2006) Chronic pancreatic inflammation induced by environmental tobacco smoke inhalation in rats. Am J Gastroenterol 101:148–159
23. 23. MM Shi IW Chong NC Long JA Love JJ Godleski JD Paulauskis 1998 Functional characterization of recombinant rat macrophage inflammatory protein-1 alpha and mRNA expression in pulmonary inflammation Inflammation 22 29 43 9484648 10.1023/A:1022391623063 1:CAS:528:DyaK1cXhtVajtrk%3D Shi MM, Chong IW, Long NC, Love JA, Godleski JJ, Paulauskis JD (1998) Functional characterization of recombinant rat macrophage inflammatory protein-1 alpha and mRNA expression in pulmonary inflammation. Inflammation 22:29–43
24. 24. B Rau A Paszkowski S Lillich K Baumgart P Moller HG Beger 2001 Differential effects of caspase-1/interleukin-1beta-converting enzyme on acinar cell necrosis and apoptosis in severe acute experimental pancreatitis Lab Invest 81 1001 1013 11454989 1:CAS:528:DC%2BD3MXlslamtrs%3D Rau B, Paszkowski A, Lillich S, Baumgart K, Moller P, Beger HG (2001) Differential effects of caspase-1/interleukin-1beta-converting enzyme on acinar cell necrosis and apoptosis in severe acute experimental pancreatitis. Lab Invest 81:1001–1013
25. 25. SG Rane JH Lee HM Lin 2006 Transforming growth factor-beta pathway: role in pancreas development and pancreatic disease Cytokine Growth Factor Rev 17 107 119 16257256 10.1016/j.cytogfr.2005.09.003 1:CAS:528:DC%2BD28Xos1Ckug%3D%3D Rane SG, Lee JH, Lin HM (2006) Transforming growth factor-beta pathway: role in pancreas development and pancreatic disease. Cytokine Growth Factor Rev 17:107–119
26. 26. D Closa Y Motoo JL Iovanna 2007 Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine World J Gastroenterol 13 170 174 17226896 1:CAS:528:DC%2BD2sXitlequ7Y%3D Closa D, Motoo Y, Iovanna JL (2007) Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine. World J Gastroenterol 13:170–174
27. 27. M Schiesser D Bimmler TW Frick R Graf 2001 Conformational changes of pancreatitis-associated protein (PAP) activated by trypsin lead to insoluble protein aggregates Pancreas 22 186 192 11249074 10.1097/00006676-200103000-00012 1:STN:280:DC%2BD3Mzit1Onsg%3D%3D Schiesser M, Bimmler D, Frick TW, Graf R (2001) Conformational changes of pancreatitis-associated protein (PAP) activated by trypsin lead to insoluble protein aggregates. Pancreas 22:186–192
28. 28. KJ Carter PL Rutledge ML Steer W Silen 1987 Secretagogue-induced changes in intracellular pH and amylase release in mouse pancreatic acini Am J Physiol 253 G690 G696 2446509 1:CAS:528:DyaL1cXjt1KqtA%3D%3D Carter KJ, Rutledge PL, Steer ML, Silen W (1987) Secretagogue-induced changes in intracellular pH and amylase release in mouse pancreatic acini. Am J Physiol 253:G690–G696
29. 29. J Rosendahl H Bodeker J Mossner N Teich 2007 Hereditary chronic pancreatitis Orphanet J Rare Dis 2 1 17204147 10.1186/1750-1172-2-1 Rosendahl J, Bodeker H, Mossner J, Teich N (2007) Hereditary chronic pancreatitis. Orphanet J Rare Dis 2:1
30. 30. M Sahin-Toth 2006 Biochemical models of hereditary pancreatitis Endocrinol Metab Clin North Am 35 303 312 16632094 10.1016/j.ecl.2006.02.002 1:CAS:528:DC%2BD28XlsFCqurg%3D Sahin-Toth M (2006) Biochemical models of hereditary pancreatitis. Endocrinol Metab Clin North Am 35:303–312
31. 31. N Teich J Rosendahl M Toth J Mossner M Sahin-Toth 2006 Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis Hum Mutat 27 721 730 16791840 10.1002/humu.20343 1:CAS:528:DC%2BD28XptVamsrc%3D Teich N, Rosendahl J, Toth M, Mossner J, Sahin-Toth M (2006) Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis. Hum Mutat 27:721–730
32. 32. H Archer N Jura J Keller M Jacobson D Bar-Sagi 2006 A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen Gastroenterology 131 1844 1855 17087933 10.1053/j.gastro.2006.09.049 1:CAS:528:DC%2BD2sXhtFyltbo%3D Archer H, Jura N, Keller J, Jacobson M, Bar-Sagi D (2006) A mouse model of hereditary pancreatitis generated by transgenic expression of R122H trypsinogen. Gastroenterology 131:1844–1855
33. 33. P Simon FU Weiss M Sahin-Toth M Parry O Nayler B Lenfers J Schnekenburger J Mayerle W Domschke MM Lerch 2002 Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122→Cys) that alters autoactivation and autodegradation of cationic trypsinogen J Biol Chem 277 5404 5410 11719509 10.1074/jbc.M108073200 1:CAS:528:DC%2BD38XhsFCjsbY%3D Simon P, Weiss FU, Sahin-Toth M, Parry M, Nayler O, Lenfers B, Schnekenburger J, Mayerle J, Domschke W, Lerch MM (2002) Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122→Cys) that alters autoactivation and autodegradation of cationic trypsinogen. J Biol Chem 277:5404–5410
34. 34. H Witt W Luck HC Hennies M Classen A Kage U Lass O Landt M Becker 2000 Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis Nat Genet 25 213 216 10835640 10.1038/76088 1:CAS:528:DC%2BD3cXjvFOgtLk%3D Witt H, Luck W, Hennies HC, Classen M, Kage A, Lass U, Landt O, Becker M (2000) Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Nat Genet 25:213–216
35. 35. K Kuwata M Hirota H Shimizu M Nakae S Nishihara A Takimoto K Mitsushima N Kikuchi K Endo M Inoue M Ogawa 2002 Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution J Gastroenterol 37 928 934 12483248 10.1007/s005350200156 1:CAS:528:DC%2BD38XptFGisLo%3D Kuwata K, Hirota M, Shimizu H, Nakae M, Nishihara S, Takimoto A, Mitsushima K, Kikuchi N, Endo K, Inoue M, Ogawa M (2002) Functional analysis of recombinant pancreatic secretory trypsin inhibitor protein with amino-acid substitution. J Gastroenterol 37:928–934
36. 36. O Kiraly A Boulling H Witt MC Le JM Chen J Rosendahl C Battaggia T Wartmann M Sahin-Toth C Ferec 2007 Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis Hum Mutat 28 469 476 17274009 10.1002/humu.20471 1:CAS:528:DC%2BD2sXlsVyqurY%3D Kiraly O, Boulling A, Witt H, Le MC, Chen JM, Rosendahl J, Battaggia C, Wartmann T, Sahin-Toth M, Ferec C (2007) Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis. Hum Mutat 28:469–476
37. 37. A Boulling MC Le P Trouve O Raguenes JM Chen C Ferec 2007 Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene Eur J Hum Genet 15 936 942 17568390 10.1038/sj.ejhg.5201873 1:CAS:528:DC%2BD2sXpsVaqs7g%3D Boulling A, Le MC, Trouve P, Raguenes O, Chen JM, Ferec C (2007) Functional analysis of pancreatitis-associated missense mutations in the pancreatic secretory trypsin inhibitor (SPINK1) gene. Eur J Hum Genet 15:936–942
38. 38. O Kiraly T Wartmann M Sahin-Toth 2007 Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation Gut 56 1434 1439 10.1136/gut.2006.115725 1:CAS:528:DC%2BD2sXht1SrsbvE Kiraly O, Wartmann T, Sahin-Toth M (2007) Missense mutations in pancreatic secretory trypsin inhibitor (SPINK1) cause intracellular retention and degradation. Gut 56:1434–1439
39. 39. A Masamune K Kume Y Takagi K Kikuta K Satoh A Satoh T Shimosegawa 2007 N34S mutation in the SPINK1 gene is not associated with alternative splicing Pancreas 34 423 428 17446841 10.1097/mpa.0b013e3180335fd0 1:CAS:528:DC%2BD2sXls1Gltbw%3D Masamune A, Kume K, Takagi Y, Kikuta K, Satoh K, Satoh A, Shimosegawa T (2007) N34S mutation in the SPINK1 gene is not associated with alternative splicing. Pancreas 34:423–428
40. 40. H Witt M Sahin-Toth O Landt JM Chen T Kahne JP Drenth Z Kukor E Szepessy W Halangk S Dahm K Rohde HU Schulz MC Le N Akar RW Ammann K Truninger M Bargetzi E Bhatia C Castellani GM Cavestro M Cerny G stro-Bisol G Spedini H Eiberg JB Jansen M Koudova E Rausova M Macek Jr. N Malats FX Real HJ Menzel P Moral R Galavotti PF Pignatti O Rickards J Spicak NO Zarnescu W Bock TM Gress H Friess J Ockenga H Schmidt R Pfutzer M Lohr P Simon FU Weiss MM Lerch N Teich V Keim T Berg B Wiedenmann W Luck DA Groneberg M Becker T Keil A Kage J Bernardova M Braun C Guldner J Halangk J Rosendahl U Witt M Treiber R Nickel C Ferec 2006 A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis Nat Genet 38 668 673 16699518 10.1038/ng1797 1:CAS:528:DC%2BD28XltVOhtbc%3D Witt H, Sahin-Toth M, Landt O, Chen JM, Kahne T, Drenth JP, Kukor Z, Szepessy E, Halangk W, Dahm S, Rohde K, Schulz HU, Le MC, Akar N, Ammann RW, Truninger K, Bargetzi M, Bhatia E, Castellani C, Cavestro GM, Cerny M, stro-Bisol G, Spedini G, Eiberg H, Jansen JB, Koudova M, Rausova E, Macek M Jr., Malats N, Real FX, Menzel HJ, Moral P, Galavotti R, Pignatti PF, Rickards O, Spicak J, Zarnescu NO, Bock W, Gress TM, Friess H, Ockenga J, Schmidt H, Pfutzer R, Lohr M, Simon P, Weiss FU, Lerch MM, Teich N, Keim V, Berg T, Wiedenmann B, Luck W, Groneberg DA, Becker M, Keil T, Kage A, Bernardova J, Braun M, Guldner C, Halangk J, Rosendahl J, Witt U, Treiber M, Nickel R, Ferec C (2006) A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis. Nat Genet 38:668–673
41. 41. GJ Morosco GC Goeringer 1979 Pancreatic elastase and serum alpha 1-antitrypsin levels in beagle dogs smoking high-and low-nicotine cigarettes: possible mechanism of pancreatic cancer in cigarette smokers J Toxicol Environ Health 5 879 890 316012 1:CAS:528:DyaL3cXhs12isg%3D%3D 10.1080/15287397909529797 Morosco GJ, Goeringer GC (1979) Pancreatic elastase and serum alpha 1-antitrypsin levels in beagle dogs smoking high-and low-nicotine cigarettes: possible mechanism of pancreatic cancer in cigarette smokers. J Toxicol Environ Health 5:879–890
42. 42. A Janoff H Carp DK Lee RT Drew 1979 Cigarette smoke inhalation decreases alpha 1-antitrypsin activity in rat lung Science 206 1313 1314 316187 10.1126/science.316187 1:CAS:528:DyaL3cXltlaisQ%3D%3D Janoff A, Carp H, Lee DK, Drew RT (1979) Cigarette smoke inhalation decreases alpha 1-antitrypsin activity in rat lung. Science 206:1313–1314
43. 43. MD Evans DF Church WA Pryor 1991 Aqueous cigarette tar extracts damage human alpha-1-proteinase inhibitor Chem Biol Interact 79 151 164 1884428 10.1016/0009-2797(91)90079-M 1:CAS:528:DyaK3MXmtVSqtbg%3D Evans MD, Church DF, Pryor WA (1991) Aqueous cigarette tar extracts damage human alpha-1-proteinase inhibitor. Chem Biol Interact 79:151–164
44. 44. A Aubertin 1991 Vitamin C: how it may protect against cancer is unclear J Natl Cancer Inst 83 396 397 1999846 10.1093/jnci/83.6.396 1:STN:280:DyaK3M7lsFWhug%3D%3D Aubertin A (1991) Vitamin C: how it may protect against cancer is unclear. J Natl Cancer Inst 83:396–397
45. 45. WA Pryor MM Dooley DF Church 1986 The inactivation of alpha-1-proteinase inhibitor by gas-phase cigarette smoke: protection by antioxidants and reducing species Chem Biol Interact 57 271 283 3486047 10.1016/0009-2797(86)90002-5 1:CAS:528:DyaL28Xkt1Sgs70%3D Pryor WA, Dooley MM, Church DF (1986) The inactivation of alpha-1-proteinase inhibitor by gas-phase cigarette smoke: protection by antioxidants and reducing species. Chem Biol Interact 57:271–283
46. 46. RA Stockley SC Afford 1983 The interaction of cigarette smoke solution with alpha 1-antitrypsin: effect on inhibitory capacity, electrophoretic mobility and immunological measurement Clin Sci (Lond) 64 223 230 1:CAS:528:DyaL3sXhtVantb0%3D Stockley RA, Afford SC (1983) The interaction of cigarette smoke solution with alpha 1-antitrypsin: effect on inhibitory capacity, electrophoretic mobility and immunological measurement. Clin Sci (Lond) 64:223–230
47. 47. A Janoff R Dearing 1982 Alpha 1-proteinase inhibitor is more sensitive to inactivation by cigarette smoke than is leukocyte elastase Am Rev Respir Dis 126 691 694 6982012 1:CAS:528:DyaL38XmtFShsbg%3D Janoff A, Dearing R (1982) Alpha 1-proteinase inhibitor is more sensitive to inactivation by cigarette smoke than is leukocyte elastase. Am Rev Respir Dis 126:691–694
48. 48. P Chowdhury RC Bone DB Louria PL Rayford 1982 Effect of cigarette smoke on human serum trypsin inhibitory capacity and antitrypsin concentration Am Rev Respir Dis 126 177 179 6979962 1:CAS:528:DyaL38XltVGntro%3D Chowdhury P, Bone RC, Louria DB, Rayford PL (1982) Effect of cigarette smoke on human serum trypsin inhibitory capacity and antitrypsin concentration. Am Rev Respir Dis 126:177–179
49. 49. H Ito T Watanabe SR Shore DM Aviado 1976 Functional and biochemical effects on the lung following inhalation of cigarette smoke and its constituents. III. Serum antitrypsin and bronchomotor responses in rats Toxicol Appl Pharmacol 35 403 412 1265756 10.1016/0041-008X(76)90063-6 1:CAS:528:DyaE28Xhs1ShtbY%3D Ito H, Watanabe T, Shore SR, Aviado DM (1976) Functional and biochemical effects on the lung following inhalation of cigarette smoke and its constituents. III. Serum antitrypsin and bronchomotor responses in rats. Toxicol Appl Pharmacol 35:403–412
50. 50. AP Majumdar GA Davis MA Dubick MC Geokas 1985 Nicotine stimulation of protein secretion from isolated rat pancreatic acini Am J Physiol 248 G158 G163 2578743 1:CAS:528:DyaL2MXhsVClt74%3D Majumdar AP, Davis GA, Dubick MA, Geokas MC (1985) Nicotine stimulation of protein secretion from isolated rat pancreatic acini. Am J Physiol 248:G158–G163
51. 51. K Baskaran S Laconi MK Reddy 1994 Transformation of hamster pancreatic duct cells by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in vitro Carcinogenesis 15 2461 2466 7955092 10.1093/carcin/15.11.2461 1:CAS:528:DyaK2MXitFyktLY%3D Baskaran K, Laconi S, Reddy MK (1994) Transformation of hamster pancreatic duct cells by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), in vitro. Carcinogenesis 15:2461–2466
52. 52. YS Ho CH Chen YJ Wang RG Pestell C Albanese RJ Chen MC Chang JH Jeng SY Lin YC Liang H Tseng WS Lee JK Lin JS Chu LC Chen CH Lee WL Tso YC Lai CH Wu 2005 Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation Toxicol Appl Pharmacol 205 133 148 15893541 10.1016/j.taap.2004.09.019 1:CAS:528:DC%2BD2MXktVGks7c%3D Ho YS, Chen CH, Wang YJ, Pestell RG, Albanese C, Chen RJ, Chang MC, Jeng JH, Lin SY, Liang YC, Tseng H, Lee WS, Lin JK, Chu JS, Chen LC, Lee CH, Tso WL, Lai YC, Wu CH (2005) Tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) induces cell proliferation in normal human bronchial epithelial cells through NFkappaB activation and cyclin D1 up-regulation. Toxicol Appl Pharmacol 205:133–148
53. 53. HM Schuller L Zhang DL Weddle A Castonguay K Walker MS Miller 2002 The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK J Cancer Res Clin Oncol 128 525 532 12384795 10.1007/s00432-002-0365-y 1:CAS:528:DC%2BD3sXksVykug%3D%3D Schuller HM, Zhang L, Weddle DL, Castonguay A, Walker K, Miller MS (2002) The cyclooxygenase inhibitor ibuprofen and the FLAP inhibitor MK886 inhibit pancreatic carcinogenesis induced in hamsters by transplacental exposure to ethanol and the tobacco carcinogen NNK. J Cancer Res Clin Oncol 128:525–532
54. 54. HM Schuller 2007 Nitrosamines as nicotinic receptor ligands Life Sci 80 2274 2280 17459420 10.1016/j.lfs.2007.03.006 1:CAS:528:DC%2BD2sXmtVeht70%3D Schuller HM (2007) Nitrosamines as nicotinic receptor ligands. Life Sci 80:2274–2280
55. 55. JM Cancela CF Van A Galione AV Tepikin OH Petersen 2002 Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers EMBO J 21 909 919 11867519 10.1093/emboj/21.5.909 1:CAS:528:DC%2BD38XitFylsLg%3D Cancela JM, Van CF, Galione A, Tepikin AV, Petersen OH (2002) Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers. EMBO J 21:909–919
56. 56. MJ Bragado LJ Garcia A Montero JI San Roman JJ Calvo MA Lopez 1993 Nicotinic cholinergic influences in pancreatic secretion induced by intraduodenal alkaline and acid solutions in the rabbit Gen Pharmacol 24 687 692 8365651 1:CAS:528:DyaK3sXltV2ltL0%3D Bragado MJ, Garcia LJ, Montero A, San Roman JI, Calvo JJ, Lopez MA (1993) Nicotinic cholinergic influences in pancreatic secretion induced by intraduodenal alkaline and acid solutions in the rabbit. Gen Pharmacol 24:687–692
57. 57. B Prokopczyk G Leder N Trushin AJ Cunningham S Akerkar B Pittman M Ramadani J Straeter HG Beger D Henne-Bruns K El-Bayoumy 2005 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue Cancer Epidemiol Biomarkers Prev 14 540 541 15734986 10.1158/1055-9965.EPI-04-0626 1:CAS:528:DC%2BD2MXhs1Ghsbo%3D Prokopczyk B, Leder G, Trushin N, Cunningham AJ, Akerkar S, Pittman B, Ramadani M, Straeter J, Beger HG, Henne-Bruns D, El-Bayoumy K (2005) 4-Hydroxy-1-(3-pyridyl)-1-butanone, an indicator for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced DNA damage, is not detected in human pancreatic tissue. Cancer Epidemiol Biomarkers Prev 14:540–541
58. 58. SN Murthy VP Dinoso Jr. HR Clearfield WY Chey 1977 Simultaneous measurement of basal pancreatic, gastric acid secretion, plasma gastrin, and secretin during smoking Gastroenterology 73 758 761 892379 1:CAS:528:DyaE2sXls1amtrg%3D Murthy SN, Dinoso VP Jr., Clearfield HR, Chey WY (1977) Simultaneous measurement of basal pancreatic, gastric acid secretion, plasma gastrin, and secretin during smoking. Gastroenterology 73:758–761
59. 59. P Brown 1976 The influence of smoking on pancreatic function in man Med J Aust 2 290 293 995000 1:STN:280:DyaE2s%2FlsFylsQ%3D%3D Brown P (1976) The influence of smoking on pancreatic function in man. Med J Aust 2:290–293
60. 60. TE Bynum TE Solomon LR Johnson ED Jacobson 1972 Inhibition of pancreatic secretion in man by cigarette smoking Gut 13 361 365 5036091 10.1136/gut.13.5.361 1:STN:280:DyaE383ht1WrtA%3D%3D Bynum TE, Solomon TE, Johnson LR, Jacobson ED (1972) Inhibition of pancreatic secretion in man by cigarette smoking. Gut 13:361–365
61. 61. MD Askari MS Tsao HM Schuller 2005 The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors J Cancer Res Clin Oncol 131 639 648 16091975 10.1007/s00432-005-0002-7 1:CAS:528:DC%2BD2MXhtFartL%2FN Askari MD, Tsao MS, Schuller HM (2005) The tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone stimulates proliferation of immortalized human pancreatic duct epithelia through beta-adrenergic transactivation of EGF receptors. J Cancer Res Clin Oncol 131:639–648
62. 62. MH Tai BL Upham LK Olson MS Tsao DN Reed Jr JE Trosko 2007 Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells Int J Cancer 120 1855 1862 17266035 10.1002/ijc.22530 1:CAS:528:DC%2BD2sXjsVCqs7k%3D Tai MH, Upham BL, Olson LK, Tsao MS, Reed Jr DN, Trosko JE (2007) Cigarette smoke components inhibited intercellular communication and differentiation in human pancreatic ductal epithelial cells. Int J Cancer 120:1855–1862