Association between tumoral GH-releasing peptide receptor type 1a mRNA expression and in vivo response to GH-releasing peptide-6 in ACTH-dependent Cushing's syndrome patients

European Journal of Endocrinology

Volumn 158, Issue 5, 2008, Pages 605-613

  Machado, Marcio Carlos ^a,b   de Sa, Sandra Valeria ^a   Correa Giannella, Maria Lucia ^a   Giorgi, Ricardo Rodriques ^a   Pereira, Maria Adelaide Albergaria ^a   Cescato, Valter Angelo S ^a   Giannella Neto, Daniel ^a   Salgado, Luis Roberto ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN; DESMOPRESSIN; GROWTH HORMONE SECRETAGOGUE RECEPTOR 1A; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; HYDROCORTISONE; MESSENGER RNA; VASOPRESSIN V1B RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CUSHING SYNDROME; DESMOPRESSIN TEST; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; ECTOPIC CORTICOTROPIN PRODUCTION; ENDOCRINE FUNCTION TEST; FEMALE; HORMONE DETERMINATION; HORMONE RELEASE; HORMONE RESPONSE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; RNA EXTRACTION; TISSUE DIFFERENTIATION;

ACTH SYNDROME, ECTOPIC; ADOLESCENT; ADRENOCORTICOTROPIC HORMONE; ADULT; ANTIDIURETIC AGENTS; CARCINOID TUMOR; CUSHING SYNDROME; DEAMINO ARGININE VASOPRESSIN; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; HYDROCORTISONE; LUNG NEOPLASMS; MALE; MIDDLE AGED; OLIGOPEPTIDES; PROSPECTIVE STUDIES; RECEPTORS, GHRELIN; RECEPTORS, VASOPRESSIN; RNA, MESSENGER; THYMUS NEOPLASMS;

EID: 43149104723     PISSN: 08044643     EISSN: None     Source Type: Journal    
DOI: 10.1530/EJE-07-0659     Document Type: Article

References (35)

1. Ghigo E, Arvat E, Ramunni J, Colao A, Gianotti L, Deghenghi R, Lombardi G & Camanni F. Adrenocorticotropin- and cortisol-releasing effect of hexarelin, a synthetic growth hormone-releasing peptide, in normal subjects and patients with Cushing's syndrome. Journal of Clinical Endocrinology and Metabolism 1997 82 2439-2444.
2. Arvat E, Giordano R, Ramunni J, Arnaldi G, Colao A, Deghenghi R, Lombardi G, Mantero F, Camanni F & Ghigo E. Adrenocorticotropin and cortisol hyperresponsiveness to hexarelin in patients with Cushing's disease bearing a pituitary microadenoma, but not in those with macroadenoma. Journal of Clinical Endocrinology and Metabolism 1998 83 4207-4211.
3. Grottoli S, Arvat E, Gauna C, Maccagno B, Ramunni J, Giordano R, Maccario M, Deghenghi R & Ghigo E. Effects of alprazolam, a benzodiazepine, on the ACTH-, GH- and PRL-releasing activity of hexarelin, a synthetic peptidyl GH secretagogue (GHS), in patients with simple obesity and in patients with Cushing's disease. Pituitary 1999 2 197-204.
4. Arvat E, Ramunni J, Giordano R, Maccagno B, Broglio F, Benso A, Deghenghi R & Ghigo E. Effects of the combined administration of hexarelin, a synthetic peptidyl GH secretagogue, and hCRH on ACTH, cortisol and GH secretion in patients with Cushing's disease. Journal of Endocrinological Investigation 1999 22 23-28.
5. Coiro V, Volpi R, Capretti L, Caffarri G & Chiodera P. Desmopressin and hexarelin tests in alcohol-induced pseudo-Cushing's syndrome. Journal of Internal Medicine 2000 247 667-673.
6. Leal-Cerro A, Torres E, Soto A, Dios E, Deghenghi R, Arvat E, Ghigo E, Dieguez C & Casanueva FF. Ghrelin is no longer able to stimulate growth hormone secretion in patients with Cushing's syndrome but instead induces exaggerated corticotrophin and cortisol responses. Neuroendocrinology 2002 76 390-396.
7. Oliveira JH, Vieira JG, Abucham J & Lengyel AM. GHRP-6 is able to stimulate cortisol and ACTH release in patients with Cushing's disease: comparison with DDAVP. Journal of Endocrinological Investigation 2003 26 230-235.
8. Correa-Silva SR, Nascif SO & Lengyel AM. Decreased GH secretion and enhanced ACTH and cortisol release after ghrelin administration in Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6) and GHRH. Pituitary 2006 91 101-107.
9. de Keyzer Y, Lenne F & Bertagna X. Widespread transcription of the growth hormone-releasing peptide receptor gene in neuroendocrine human tumors. European Journal of Endocrinology 1997 137 715-718.
10. Korbonits M, Bustin SA, Kojima M, Jordan S, Adams EF, Lowe DG, Kangawa K & Grossman AB. The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors. Journal of Clinical Endocrinology and Metabolism 2001 86 881-887.
11. Arnaldi G, Mancini T, Kola B, Appolloni G, Freddi S, Concettoni C, Bearzi I, Masini A, Boscaro M & Mantero F. Cyclical Cushing's syndrome in a patient with a bronchial neuroendocrine tumor (typical carcinoid) expressing ghrelin and growth hormone secretagogue receptors. Journal of Clinical Endocrinology and Metabolism 2003 88 5834-5840.
12. Malerbi DA, Mendonca BB, Liberman B, Toledo SP, Corradini MC, Cunha-Neto MB, Fragoso MC & Wajchenberg BL. The desmopressin stimulation test in the differential diagnosis of Cushing's syndrome. Clinical Endocrinology 1993 38 463-472.
13. de Keyzer Y, Lenne F, Auzan C, Jegou S, Rene P, Vaudry H, Kuhn JM, Luton JP, Clauser E & Bertagna X. The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome. Journal of Clinical Investigation 1996 97 1311-1318.
14. Dahia PL, Ahmed-Shuaib A, Jacobs RA, Chew SL, Honegger J, Fahlbusch R, Besser GM & Grossman AB. Vasopressin receptor expression and mutation analysis in corticotrophin-secreting tumors. Journal of Clinical Endocrinology and Metabolism 1996 81 1768-1771.
15. de Keyzer Y, Rene P, Beldjord C, Lenne F & Bertagna X. Overexpression of vasopressin (V3) and corticotrophin-releasing hormone receptor genes in corticotroph tumours. Clinical Endocrinology 1998 49 475-482.
16. Newell-Price J, Trainer P, Besser M & Grossman A. The diagnosis and differential diagnosis of Cushing's syndrome and pseudo-Cushing's states. Endocrine Reviews 1998 19 647-672.
17. Salgado LR, Fragoso MCBV, Knoepfelmacher M, Machado MC, Domenice S, Pereira MAA & Mendonça BB. Ectopic ACTH syndrome: our experience with 25 cases. European Journal of Endocrinology 2006 155 725-733.
18. Arlt W, Dahia PL, Callies F, Nordmeyer JP, Allolic, B, Grossman AB & Reincke M. Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro. Clinical Endocrinology 1997 47 623-627.
19. Tsagarakis S, Tsigos C, Vasiliou V, Tsiotra P, Kaskarelis J, Sotiropoulou C, Raptis SA & Thalassinos N. The desmopressin and combined CRH-desmopressin tests in the differential diagnosis of ACTH-dependent Cushing's syndrome: constraints imposed by the expression of V2 vasopressin receptors in tumors with ectopic ACTH secretion. Journal of Clinical Endocrinology and Metabolism 2002 87 1646-1653.
20. Oldfield EH, Doppman JL, Nieman LK, Chrousos GP, Miller DL, Katz DA, Cutler GB, Jr & Loriaux DL. Petrosal sinus sampling with and without corticotrophin-releasing hormone for the differential diagnosis of Cushing's syndrome. New England Journal of Medicine 1991 325 897-905.
21. Machado MC, Sa SV, Domenice S, Fragoso MCB, Puglia P Jr, Pereira MAA, Mendonca BB & Salgado LR. The role of desmopressin in bilateral and simultaneous inferior petrosal sinus sampling for differential diagnosis of ACTH-dependent Cushing's syndrome. Clinical Endocrinology 2007 66 136-142.
22. Kaye TB & Crapo L. The Cushing syndrome: an update on diagnostic tests. Annals of Internal Medicine 1990 112 434-444.
23. Invitti C, Giraldi FP, de Martin M & Cavagnini F. Diagnosis and management of Cushing's syndrome: results of an Italian multicentre study. Study Group of the Italian Society of Endocrinology on the pathophysiology of the hypothalamic-pituitary-adrenal axis. Journal of Clinical Endocrinology and Metabolism 1999 84 440-448.
24. Pecori Giraldi F, Invitti C & Cavagnini F. Study Group of the Italian Society of Endocrinology on the pathophysiology of the hypothalamic-pituitary-adrenal axis. The corticotrophin-releasing hormone test in the diagnosis of ACTH-dependent Cushing's syndrome: a reappraisal. Clinical Endocrinology 2001 54 601-607.
25. Watzinger F & Lion T. Multiplex PCR for quality control of template RNA/ cDNA in RT-PCR assays. Leukemia 1998 12 1984-1986.
26. Livak KJ & Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001 25 402-408.
27. Pfaffl MW. A new mathematical model for relative quantification in real time RT-PCR. Nucleic Acids Research 2001 29 2002-2007.
28. Lania A, Ballare E, Corbetta S, Filopanti M, Persani L & Spada A. Growth hormone-releasing hexapeptide (GHRP-6) increases intracellular calcium concentrations in cultured cells from human pituitary adenomas of different types. European Journal of Endocrinology 1998 139 343-348.
29. Martinez-Fuentes AJ, Moreno-Fernandez J, Vazquez-Martinez R, Duran-Prado M, de la Riva A, Tena-Sempere M, Dieguez C, Jimenez-Reina L, Webb SM, Pumar A, Leal-Cerro A, Benito-Lopez P, Malagon MM & Castano IP. Ghrelin is produced by and directly activates corticotrope cells from adrenocorticotropin-secreting adenomas. Journal of Clinical Endocrinology and Metabolism 2006 91 2225-2231.
30. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG & Van der Ploeg LH. A receptor in pituitary and hypothalamus that functions in growth hormone release, Science 1996 273 974-977.
31. Korbonits M, Jacobs RA, Aylwin SJ, Burrin JM, Dahia PL, Monson JP, Honegger J, Fahlbush R, Trainer PJ, Chew SL, Besser GM & Grossman AB. Expression of the growth hormone secretagogue receptor in pituitary adenomas and other neuroendocrine tumors. Journal of Clinical Endocrinology and Metabolism 1998 83 3624-3630.
32. Tamura H, Kamegai J, Sugihara H, Kineman RD, Frohman LA & Wakabayashi I. Glucocorticoids regulate pituitary growth hormone secretagogue receptor gene expression. Journal of Neuroendocrinology 2000 12 481-485.
33. Petersenn S, Rasch AC, Penshorn M, Beil FU & Schulte HM. Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor. Endocrinology 2001 142 2649-2659.
34. Chabot V, de Keyzer Y, Gebhard S, Uske A, Bischof-Delaloye A, Rey F, Dusmet M & Gomez P. Ectopic ACTH Cushing's syndrome: V3 vasopressin receptor but not CRH receptor gene expression in a pulmonary carcinoid tumor. Hormone Research 1998 50 226-231.
35. Pecori Giraldi F, Marini E, Torchiana E, Mortini P, Dubini A & Cavagnini F. Corticotrophin-releasing activity of desmopressin in Cushing's disease: lack of correlation between in vivo and in vitro responsiveness. Journal of Endocrinology 2003 177 373-379.