Regulation of the human mitotic centromere-associated kinesin (MCAK) promoter by the transcription factors Sp1 and E2F1

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

Volumn 1779, Issue 5, 2008, Pages 356-361

  Jun, Do Youn ^a,b   Park, Hae Sun ^a   Lee, Ji Young ^a   Kim, Young Ho ^a  

^a Kyungpook National University   (South Korea)

^b Kyungpook National University   (South Korea)

Author keywords

Activator Sp1; HEK 293 cells; Human MCAK promoter; Repressor E2F1; Transcriptional regulation

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CCAAT ENHANCER BINDING PROTEIN BETA; E BOX FACTOR; NF 1 PROTEIN; PROTEIN C MYB; PROTEIN P300; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR SP1;

ARTICLE; BINDING SITE; BIOINFORMATICS; CELL CLONING; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYO; GENE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MITOTIC CENTROMERE ASSOCIATED KINESIN GENE; NUCLEOTIDE SEQUENCE; PLASMID; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN MOTIF; TRANSCRIPTION REGULATION;

BASE SEQUENCE; BINDING SITES; CELL LINE; E2F1 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; JURKAT CELLS; KINESIN; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; SP1 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS);

EID: 43149088952     PISSN: 18749399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagrm.2008.03.013     Document Type: Article

References (25)

1. Hirokawa N., and Takemura R. Kinesin superfamily proteins and their various functions and dynamics. Exp. Cell Res. 301 (2004) 50-59
2. Lawrence C.J., et al. A standardized kinesin nomenclature. J. Cell Biol. 167 (2004) 19-22
3. Manning A.L., Ganem N.J., Bakhoum S.F., Wagenbach M., Wordeman L., and Copmton D.A. The kinesin-13 proteins kif2a, kif2b, and kif2c/MCAK have distinct roles during mitosis in human cells. Mol. Biol. Cell 18 (2007) 2970-2979
4. Ganem N.J., and Compton D.A. The KinI kinesin kif2a is required for bipolar spindle assembly through a functional relationship with MCAK. J. Cell Biol. 166 (2004) 473-478
5. Helenius J., Brouhard G., Kalaidzidis Y., Diez S., and Howard J. The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends. Nature 441 (2006) 115-119
6. Ems-McClung S., Hertzer K.M., Zhang X., Miller M.W., and Walczak C.E. The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly. Mol. Biol. Cell 18 (2007) 282-294
7. Wordeman L., and Mitchison T.J. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J. Cell Biol. 128 (1995) 95-104
8. Wordeman L., Wagenbach M., and Maney T. Mutations in the ATP-binding domain affect the subcellular distribution of mitotic centromere-associated kinesin (MCAK). Cell Biol. Int. 23 (1999) 275-286
9. Ohi R., Coughlin M.L., Lane W.S., and Mitchison T.J. An inner centromere protein that stimulates the microtubule depolymerizing activity of a Kin I kinesin. Dev. Cell 5 (2003) 309-321
10. Andrews P.D., Ovechkina Y., Morrice N., Wagenbach M., Duncan K., Wordeman L., and Swedlow J.R. Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6 (2004) 253-268
11. Lan W., Zhang X., Kline-Smith S.L., Rosasco S.E., Barrett-Wilt G.A., Shabanowitz J., Hunt D.F., Walczak C.E., and Stukenberg P.T. Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity. Curr. Biol. 14 (2004) 273-286
12. Kim I.G., Jun D.Y., Sohn U., and Kim Y.H. Cloning and expression of human mitotic centromere-associated kinesin gene. Biochim. Biophys. Acta. 1359 (1997) 181-186
13. Nakamura Y., Tanaka F., Haraguchi N., Mimori K., Matsumoto T., Inoue H., Yanaga K., and Mori M. Clinicopathological and biological significance of mitotic centromere-associated kinesin overexpression in human gastric cancer. Br. J. Cancer 97 (2007) 543-549
14. Kline-Smith S.L., and Walczak C.E. The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells. Mol. Biol. Cell 13 (2002) 2718-2731
15. Lania L., Majello B., and De Luca P. Transcriptional regulation by the Sp family proteins. Int. J. Biochem. Cell Biol. 29 (1997) 1313-1323
16. Suske G. The Sp-family of transcription factors. Gene 238 (1999) 291-300
17. Rayman J.B., Takahashi Y., Indjeian V.B., Dannenberg J.H., Catchpole S., Watson R.J., te Riele H., and Dynlacht B.D. E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. Genes Dev. 16 (2002) 933-947
18. Lu Z., Luo R.Z., Peng H., Huang M., Nishmoto A., Hunt K.K., Helin K., Liao W.S., and Yu Y. E2F-HDAC complexes negatively regulate the tumor suppressor gene ARH1 in breast cancer. Oncogene 25 (2005) 230-239
19. Niwa H., Yamamura K., and Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108 (1991) 193-199
20. Blake M.C., Jambou R.C., Swick A.G., Kahn J.W., and Azizkhan J.C. Transcriptional initiation is controlled by upstream GC-box interactions in a TATAA-less promoter. Mol. Cell. Biol. 10 (1990) 6632-6641
21. Brooks A.R., Shiffman D., Chan C.S., Brooks E.E., and Milner P.G. Functional analysis of the human cyclin D2 and cyclin D3 promoters. J. Biol. Chem. 271 (1996) 9090-9099
22. WAF1/CIP1 and cyclin D1 genes in PC12 cells by activating the Sp1 transcription factor. Neurosci. 17 (1997) 6122-6132
23. Blais A., and Dynlacht B.D. Hitting their targets: an emerging picture of E2F and cell cycle control. Curr. Opin. Genet. Dev. 14 (2004) 527-532
24. Attwooll C., Denchi E.L., and Helin K. The E2F family: specific functions and overlapping interests. EMBO J. 23 (2004) 4709-4716
25. Jun D.Y., Rue S.W., Kim B.W., and Kim Y.H. Detection of mitotic centromere-associated kinesin (MCAK) during cell cycle progression of human Jurkat T cells using polyclonal antibody raised against its N-terminal region overexpressed in E. coli. J. Microbiol. Biotechnol. 13 (2003) 912-918