Sarcoplasmic reticulum Ca2+ release channel ryanodine receptor (RyR2) plays a crucial role in aconitine-induced arrhythmias

Biochemical Pharmacology

Volumn 75, Issue 11, 2008, Pages 2147-2156

  Fu, Min ^a,b   Li, Ru Xin ^a   Fan, Li ^c   He, Guo Wei ^c   Thornburg, Kent L ^d   Wang, Zhao ^a  

^a Tsinghua University   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^c PROVIDENCE ST VINCENT MEDICAL CENTER   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Aconitine; Arrhythmia; Excitation contraction coupling; Knockdown; RyR2

Indexed keywords

ACONITINE; CALCIUM CHANNEL L TYPE; RYANODINE RECEPTOR 2; SMALL INTERFERING RNA; CAFFEINE; MESSENGER RNA; RYANODINE RECEPTOR;

ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; HEART ARRHYTHMIA; HEART MUSCLE CELL; IMMUNOFLUORESCENCE TEST; NEWBORN; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SARCOPLASMIC RETICULUM; SPRAGUE DAWLEY RAT; WESTERN BLOTTING; ANIMAL; CALCIUM SIGNALING; CELL CULTURE; CELL MEMBRANE POTENTIAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHYSIOLOGY;

ACONITINE; ANIMALS; ARRHYTHMIAS, CARDIAC; CAFFEINE; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CELLS, CULTURED; GENE EXPRESSION; GENE SILENCING; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; RNA, SMALL INTERFERING; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; TRANSFECTION;

EID: 43049179839     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.02.027     Document Type: Article

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