p38 kinase/cytosolic phospholipase A2/cyclooxygenase-2 pathway: A new signaling cascade for lipopolysaccharide-induced interleukin-1β and interleukin-6 release in differentiated U937 cells

Prostaglandins and Other Lipid Mediators

Volumn 86, Issue 1-4, 2008, Pages 61-67

  Wang, Xiaohui ^a   Xue, Hui ^a   Xu, Quangang ^a   Zhang, Kai ^a   Hao, Xiuhua ^a   Wang, Luhuan ^a   Yan, Guangtao ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

COX 2; cPLA2; Interleukin; Lipopolysaccharide; p38 MAPK; Signal transduction

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTISENSE OLIGONUCLEOTIDE; ARACHIDONYL TRIFLUOROMETHYL KETONE; CYCLOOXYGENASE 2; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PHOSPHOLIPASE A2;

ARTICLE; CELL DIFFERENTIATION; CELL STRAIN U937; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BLOTTING, WESTERN; CELL DIFFERENTIATION; CYCLOOXYGENASE 2; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASES A2, CYTOSOLIC; PHOSPHORYLATION; PYRIDINES; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; U937 CELLS;

EID: 43049168782     PISSN: 10988823     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.prostaglandins.2008.03.002     Document Type: Article

References (32)

1. Rietschel E.T., Kirikae T., Schade F.U., et al. Bacterial endotoxin: molecular relationships of structure to activity and function. FASEB J 8 2 (1994) 217-225
2. Lee J.C., Laydon J.T., McDonnell P.C., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372 (1994) 739-746
3. Roos-Engstrand E., Wallin A., Bucht A., Pourazar J., Sandstrom T., and Blomberg A. Increased expression of p38 MAPK in human bronchial epithelium after lipopolysaccharide exposure. Eur Respir J 25 5 (2005) 797-803
4. Basak C., Pathak S.K., Bhattacharyya A., Mandal D., Pathak S., and Kundu M. NF-kappaB- and C/EBPbeta-driven interleukin-1beta gene expression and PAK1-mediated caspase-1 activation play essential roles in interleukin-1beta release from Helicobacter pylori lipopolysaccharide-stimulated macrophages. J Biol Chem 280 6 (2005) 4279-4288
5. Campbell J., Ciesielski C.J., Hunt A.E., et al. A novel mechanism for TNF-alpha regulation by p38 MAPK: involvement of NF-kappa B with implications for therapy in rheumatoid arthritis. J Immunol 173 11 (2004) 6928-6937
6. Kotlyarov A., Neininger A., Schubert C., et al. MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nat Cell Biol 1 2 (1999) 94-97
7. Ambrosino C., Mace G., Galban S., et al. Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase. Mol Cell Biol 23 1 (2003) 370-381
8. Kumar S., Boehm J., and Lee J.C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2 9 (2003) 717-726
9. Yan G.T., Hao X.H., Xue H., Wang L.H., Li Y.L., and Shi L.P. Interleukin-1βexpression and phospholipase A2 activation after intestinal ischemia/reperfusion injury. Acta Phsiol Sin 4 1 (2002) 28-32
10. Wang X.H., Yan G.T., Wang L.H., Hao X.H., Zhang K., and Xue H. The mediating role of cPLA2 in IL-1 beta and IL-6 release in LPS-induced HeLa cells. Cell Biochem Funct 22 (2004) 41-44
11. Kramer R.M., Roberts E.F., Um S.L., et al. p38 Mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2. J Biol Chem 271 44 (1996) 27723-27729
12. Clark J.D., Lin L.L., Kriz R.W., et al. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Cell 65 6 (1991) 1043-1051
13. da Silva Correia J., Soldau K., Christen U., Christen U., Tobias P.S., and Ulevitch R.J. Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. Transfer from CD14 to TLR4 and MD-2. J Biol Chem 276 24 (2001) 21129-21135
14. Bjorkbacka H., Fitzgerald K.A., Huet F., et al. The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol Genomics Physiol Genomics 19 3 (2004) 319-330
15. Huang Q., Yang J., Lin Y., et al. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nat Immunol 5 1 (2004) 98-103
16. Wang X.H., Yan G.T., Zhang K., Xue H., Hao X.H., and Wang L.H. p38MAPK/cPLA2 pathway mediates interleukins release in inflammatory cell model. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 19 1 (2007) 31-35
17. Frevel M.A., Bakheet T., Silva A.M., Hissong J.G., Khabar K.S., and Williams B.R. p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts. Mol Cell Biol 23 2 (2003) 425-436
18. Williams J.A.E. Regulation of macrophage cytokine production by prostaglandin E2. Distinct roles of cyclooxygenase-1 and -2. J Biol Chem 272 41 (1997) 25693-25699
19. Chung K.W., Ando M., and Adashi E.Y. Periovulatory and interleukin (IL)-1-dependent regulation of IL-6 in the immature rat ovary: a specific IL-1 receptor mediated eicosanoid-dependent effect. J Soc Gynecol Investig 7 5 (2000) 301-308
20. Anderson G.D., Hauser S.D., McGarity K.L., Bremer M.E., Isakson P.C., and Gregory S.A. Selective inhibition of cyclooxygenase (COX-2) reverses inflammation and expression of COX-2 and interleukin-6 in rat adjuvant arthritis. J Clin Invest 97 11 (1996) 2672-2679
21. Walch L., and Morris P.L. Cyclooxygenase 2 pathway mediates IL-1beta regulation of IL-1alpha, -1beta, and IL-6 mRNA levels in Leydig cell progenitors. Endocrinology 143 9 (2002) 3276-3283
22. Mack Strong V.E., Mackrell P.J., Concannon E.M., et al. NS-398 treatment after trauma modifies NF-kapaB activation and improves survival. J Surg Res 98 1 (2001) 40-46
23. Kimura T., Iwase M., Kondo G., et al. Suppressive effect of selective cyclooxygenase-2 inhibitor on cytokine release in human neutrophils. Int Immunopharmacol 3 10-11 (2003) 1519-1528
24. Maihofner C., Charalambous M.P., Bhambra U., Lightfoot T., Geisslinger G., and Gooderham N.J. Colorectal Cancer Group. Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer. Carcinogenesis 24 4 (2003) 665-671
25. Penglis P.S., Cleland L.G., Demasi M., Caughey G.E., and James M.J. Differential regulation of prostaglandin E2 and thromboxane A2 production in human monocytes: implications for the use of cyclooxygenase inhibitors. J Immunol 165 (2000) 1605-1611
26. Yamane H., Sugimoto Y., Tanaka S., and Ichikawa A. Prostaglandin E2 receptors, EP2 and EP4, differentially modulate TNF-α and IL-6 production induced by lipopolysaccharide in mouse peritoneal neutrophils. Biochem Biophys Res Commun 278 1 (2000) 224-228
27. Caughey G.E., Pouliot M., Cleland L.G., and James M.J. Regulation of tumor necrosis factor-alpha and IL-1 beta synthesis by thromboxane A2 in nonadherent human monocytes. J Immunol 158 1 (1997) 351-358
28. Wu T., Han C., Lunz J.G., Michalopoulos G., Shelhamer J.H., and Demetris A.J. Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells. Hepatology 36 2 (2002) 363-373
29. Huang Z.F., Massey J.B., and Via D.P. Differential regulation of cyclooxygenase-2 (COX-2) mRNA stability by interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) in human in vitro differentiated macrophages. Biochem Pharmacol 59 2 (2000) 187-194
30. Kahlke V., Seidel M., Stapela S., Brotzmann K., Schafmayer C., and Schroder J. Inhibition of cyclooxygenase-2 by NS-398 following hemorrhage and subsequent sepsis: no beneficial effects in either gender. Surg Infect (Larchmt) 5 1 (2004) 29-37
31. Hartel C., von Puttkamer J., Gallner F., Strunk T., and Schultz C. Dose-dependent immunomodulatory effects of acetylsalicylic acid and indomethacin in human whole blood: potential role of cyclooxygenase-2 inhibition. Scand J Immunol 60 4 (2004) 412-420
32. Akaogi J., Yamada H., Kuroda Y., Nacionales D.C., Reeves W.H., and Satoh M. Prostaglandin E2 receptors EP2 and EP4 are up-regulated in peritoneal macrophages and joints of pristane-treated mice and modulate TNF-alpha and IL-6 production. J Leukoc Biol 76 1 (2004) 227-236