The effect of powder size on induction behaviour and binder distribution during high shear melt agglomeration of calcium carbonate

Powder Technology

Volumn 184, Issue 3, 2008, Pages 298-312

  Tu, Wei Da ^a   Hsiau, Shu San ^a   Ingram, Andy ^b   Seville, Jonathan ^b  

^a NATIONAL CENTRAL UNIVERSITY   (Taiwan)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Binder distribution; High shear melt agglomeration; Induction behaviour

Indexed keywords

AGGLOMERATION; CARBONATES; MIXERS (MACHINERY); POLYETHYLENE GLYCOLS; THERMAL EFFECTS;

BINDER DISTRIBUTION; HIGH SHEAR MELT AGGLOMERATION; INDUCTION BEHAVIOR;

CALCIUM COMPOUNDS;

CALCIUM CARBONATE;

AGGLOMERATION; CALCIUM COMPOUNDS; CARBONATES; MIXERS (MACHINERY); POLYETHYLENE GLYCOLS; THERMAL EFFECTS;

ARTICLE; BINDING AFFINITY; GROWTH RATE; PARTICLE SIZE; POWDER; SHEAR RATE;

EID: 43049142992     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2007.09.001     Document Type: Article

References (18)

1. Reynolds G.K., Le P.K., and Nilpawar A.M. In: Granulation, Salman A.D., Hounslow M., and Seville J.P.K. (Eds) (2007), Elsevier, Amsterdam 3-19
2. Hoornaert F., Wauters P.A.L., Meesters G.M.H., Pratsinis S.E., and Scarlett B. Agglomeration behavior of powders in a Lödige mixer granulator. Powder Technol. 96 (1998) 116-128
3. Iveson S.M., Litster J.D., Hapgood K., and Ennis B.J. Nucleation, growth and breakage phenomena in agitated wet granulation processes: a review. Powder Technol. 117 (2001) 3-39
4. Iveson S.M., and Litster J.D. Growth regime map for liquid-bound granules. AIChE. J. 44 (1998) 1510-1518
5. Fu J.S., Cheong Y.S., Reynolds G.K., Adams M.J., Salman A.D., and Hounslow M.J. An experimental study of the variability in the properties and quality of wet granules. Powder Technol. 140 (2004) 209-216
6. Scott A.C., Hounslow M.J., and Instone T. Direct evidence of heterogeneity during high-shear granulation. Powder Technol. 113 (2000) 205-213
7. Bock T.K., and Kraas U. Experience with the Diosna mini-granulator and assessment of process scalability. Eur. J. Pharm. Biopharm. 52 (2001) 297-303
8. Voinovich D., Moneghini M., Perissutti B., and Franceschinis E. Melt pelletization in high shear mixer using hydrophobic melt binder: influence of some apparatus and process variables. Eur. J. Pharm. Biopharm. 52 (2001) 305-313
9. Litster J.D. Scaleup of wet granulation processes: science not art. Powder Technol. 130 (2003) 35-40
10. Bardin M., Knight P.C., and Seville J.P.K. On control of particle size distribution in granulation using high-shear mixers. Powder Technol. 140 (2004) 169-175
11. Schæfer T. Growth mechanisms in melt agglomeration in high shear mixers. Powder Technol. 117 (2001) 68-82
12. Schæfer T., and Mathiesen C. Melt pellitization in a high shear mixer. VII. Effects of product temperature. Int. J. Pharm. 134 (1996) 105-117
13. Johansen A., and Schæfer T. Effects of interactions between powder particle size and binder viscosity on agglomerate growth mechanisms in a high shear mixer. Eur. J. Pharm. Sci. 12 (2001) 297-309
14. Schæfer T., Holm P., and Kristensen H.G. Melt granulation in a laboratory scale high shear mixer. Drug Dev. Ind. Pharm. 16 (1990) 1249-1277
15. Knight P.C., Instone T., Pearson J.M.K., and Hounslow M.J. An investigation into the kinetics of liquid distribution and growth in high shear mixer agglomeration. Powder Technol. 97 (1998) 246-257
16. Wauters P.A.L., van de Water R., Litster J.D., Meesters G.M.H., and Scarlett B. Growth and compaction behavior of copper concentrate granules in a rotating drum. Powder Technol. 124 (2002) 230-237
17. Mackaplow M.B., Rosen L.A., and Michaels J.N. Effect of primary particle size on granule growth and endpoint determination in high-shear wet granulation. Powder Technol. 108 (2000) 32-45
18. Wauters P.A.L., Jakobsen R.B., Litster J.D., Meesters G.M.H., and Scarlett B. Liquid distribution as a means to describing the granule growth mechanism. Powder Technol. 123 (2002) 166-177