Overexpression of protein kinase Cα mRNA may be an independent prognostic marker for gastric carcinoma

Journal of Surgical Oncology

Volumn 97, Issue 6, 2008, Pages 538-543

  Lin, Kai Yuan ^a,b   Fang, Chia Lang ^b,c   Uen, Yih Huei ^d,e   Chang, Chun Chao ^a,b   Lou, Horng Yuan ^a,b   Hsieh, Ching Ruey ^a,b   Tiong, Cheng ^a,b   Pan, Shiann ^a,b   Chen, Sheng Hsuan ^a,b  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d CHI MEI MEDICAL CENTER   (Taiwan)

^e SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

Author keywords

Distant metastasis; Gastric carcinoma; Prognosis; Protein kinase C

Indexed keywords

MESSENGER RNA; PROTEIN KINASE C ALPHA;

AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REGRESSION ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH; STOMACH CARCINOMA;

EID: 43049120627     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.20997     Document Type: Article

References (30)

1. 1 Parkin DM, Pisani P, Ferlay J: Global cancer statistics. CA‐Cancer J Clin 1999 ; 49: 33–64.
2. 2 Wu MS, Lin JT, Lee WJ, et al.: Gastric cancer in Taiwan. J Formos Med Assoc 1994 ; 93 Suppl2: S77–89.
3. 3 Fuchs CS, Mayer RJ: Gastric carcinoma. N Engl J Med 1995 ; 333: 32–41.
4. 4 Dicken BJ, Saunders LD, Jhangri GS, et al.: Gastric cancer: Establishing predictors of biological behavior with use of population‐based data. Ann Surg Oncol 2004 ; 11: 629–635.
5. 5 Basu A: The potential of protein kinase C as a target for anticancer research. Pharmacol Ther 1993 ; 59: 257–280.
6. 6 Nishizuka Y: The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature 1988 ; 334: 661–665.
7. 7 Martelli AM, Sang N, Borgatti P, et al.: Multiple biological responses activated by nuclear protein kinase C. J Cell Biochem 1999 ; 74: 499–521.
8. 8 Michie AM, Nakagawa R: The link between PKCalpha regulation and cellular transformation. Immunol Lett 2005 ; 96: 155–162.
9. 9 Ways DK, Kukoly CA, deVente J, et al.: MCF‐7 breast cancer cells transfected with protein kinase C‐α exhibit altered expression of other protein kinase C isoforms and display a more aggressive neoplastic phenotype. J Clin Invest 1995 ; 95: 1906–1915.
10. 10 Mandil R, Ashkenazi E, Blass M, et al.: Protein kinase Cα and protein kinase Cδ play opposite roles in the proliferation and apoptosis of glioma cells. Cancer Res 2001 ; 61: 4612–4619.
11. 11 Li H, Zhao L, Yang Z, et al.: Telomerase is controlled by protein kinase Calpha in human breast cancer cells. J Biol Chem 1998 ; 273: 33436–33442.
12. 12 Okuda H, Adachi M, Miyazawa M, et al.: Protein kinase Cα promotes apoptotic cell death in gastric cancer cells depending upon loss of anchorage. Oncogene 1999 ; 18: 5604–5609.
13. 13 Jiang XH, Tu SP, Cui JT, et al.: Antisense targeting protein kinase C α and β 1 inhibits gastric carcinogenesis. Cancer Res 2004 ; 64: 5787–5794.
14. 14 Atten MJ, Attar BM, Milson T, et al.: Resveratrol‐induced inactivation of human gastric adenocarcinoma cells through a protein kinase C‐mediated mechanism. Biochem Pharmacol 2001 ; 62: 1423–1432.
15. 15 Hans CP, Weisenburger DD, Greiner TC, et al.: Expression of PKC‐beta or cyclin D2 predicts for inferior survival in diffuse large B‐cell lymphoma. Mod Pathol 2005 ; 18: 1377–1384.
16. 16 Pan Q, Bao LW, Kleer CG, et al.: Protein kinase Cε is a predictive biomarker of aggressive breast cancer and a validated target for RNA interference anticancer therapy. Cancer Res 2005 ; 65: 8366–8371.
17. 17 Zhu GH, Wong BC, Slosberg ED, et al.: Overexpression of protein kinase C‐beta1 isoenzyme suppresses indomethacin‐induced apoptosis in gastric epithelial cells. Gastroenterology 2000 ; 118: 507–514.
18. 18 Schonwasser DC, Marais RM, Marshall CJ, et al.: Activation of the mitogen‐activated protein kinase/extracellular signal‐regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol Cell Biol 1998 ; 18: 790–798.
19. 19 Soh JW, Weinstein IB: Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J Biol Chem 2003 ; 278: 34709–34716.
20. 20 Benimetskaya L, Miller P, Benimetsky S, et al.: Inhibition of potentially anti‐apoptotic proteins by antisense protein kinase C‐alpha (Isis 3521) and antisense bcl‐2 (G3139): Phosphorothioate oligodeoxynucleotides: Relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells. Mol Pharmacol 2001 ; 60: 1296–1307.
21. 21 Jiang Y, Berk M, Singh LS, et al.: KiSS1 suppresses metastasis in human ovarian cancer via inhibition of protein kinase C alpha. Clin Exp Metastasis 2005 ; 22: 369–376.
22. 22 Masur K, Lang K, Niggemann B, et al.: High PKCα and low E‐cadherin expression contribute to high migratory activity of colon carcinoma cells. Mol Biol Cell 2001 ; 12: 1973–1982.
23. 23 Schwartz GK, Jiang J, Kelsen D, et al.: Protein kinase C: A novel target for inhibiting gastric cancer cell invasion. J Natl Cancer Inst 1993 ; 85: 402–407.
24. 24 Teicher BA, Menon K, Alvarez E, et al.: Antiangiogenic and antitumor effects of a protein kinase C beta inhibitor in human hepatocellular and gastric cancer xenografts. In Vivo 2001 ; 15: 185–193.
25. 25 Harrington EO, Löffler J, Nelson PR, et al.: Enhancement of migration by protein kinase Cα and inhibition of proliferation and cell cycle progression by protein kinase Cδ in capillary endothelial cells. J Biol Chem 1997 ; 272: 7390–7397.
26. 26 Wong C, Jin ZG: Protein kinase C‐dependent protein kinase D activation modulates ERK signal pathway and endothelial cell proliferation by vascular endothelial growth factor. J Biol Chem 2005 ; 280: 33262–33269.
27. 27 Wang A, Nomura M, Patan S, et al.: Inhibition of protein kinase Cα prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo. Circ Res 2002 ; 90: 609–616.
28. 28 Wellner M, Maasch C, Kupprion C, et al.: The proliferative effect of vascular endothelial growth factor requires protein kinase C‐α and protein kinase C‐ζ. Arterioscler Thromb Vasc Biol 1999 ; 19: 178–185.
29. 29 Shih SC, Mullen A, Abrams K, et al.: Role of protein kinase C isoforms in phorbol ester‐induced vascular endothelial growth factor expression in human glioblastoma cells. J Biol Chem 1999 ; 274: 15407–15414.
30. 30 Yasui W, Oue N, Aung PP, et al.: Molecular‐pathological prognostic factors of gastric cancer: A review. Gastric Cancer 2005 ; 8: 86–94.