A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor γ-chain complex

Journal of Clinical Investigation

Volumn 118, Issue 5, 2008, Pages 1785-1795

  Takayama, Hiroshi ^a,b   Hosaka, Yoshitaka ^c   Nakayama, Kazuyuki ^c   Shirakawa, Kamon ^c   Naitoh, Katsuki ^c   Matsusue, Tomokazu ^c   Shinozaki, Mikihiko ^c   Honda, Motoyasu ^c   Yatagai, Yukiko ^c   Kawahara, Tetsushi ^c   Hirose, Jiro ^c   Yokoyama, Tooru ^c   Kurihara, Michiru ^a   Furusako, Shoji ^c  

^a UNIVERSITY OF SHIGA PREFECTURE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; COLLAGEN; CYCLIC AMP; FC RECEPTOR; FLUORESCENT DYE; GLYCOPROTEIN VI; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CF1232; MONOCLONAL ANTIBODY MF1201; MONOCLONAL ANTIBODY MF1232; YA AUTOANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG INHIBITION; ENDOCYTOSIS; FEMALE; HUMAN; HUMAN CELL; MONKEY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE DRUG DOSE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTOPENIA;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; BLOOD PLATELETS; CYCLIC AMP; ENDOCYTOSIS; FEMALE; HUMANS; MACACA FASCICULARIS; MALE; MICE; MOLECULAR SEQUENCE DATA; PLATELET ADHESIVENESS; PLATELET AGGREGATION INHIBITORS; PLATELET MEMBRANE GLYCOPROTEINS; RECEPTORS, IGG; RECOMBINANT FUSION PROTEINS;

EID: 43049116482     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI32513     Document Type: Article

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