The release and analgesic activities of morphine and its ester prodrug, morphine propionate, formulated by water-in-oil nanoemulsions

Journal of Drug Targeting

Volumn 16, Issue 4, 2008, Pages 294-301

  Wang, Jhi Joung ^a   Hung, Chi Feng ^b   Yeh, Chi Hui ^c   Fang, Jia You ^c  

^a CHI MEI MEDICAL CENTER   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Controlled release; Morphine; Nanoemulsion; Prodrug; Subcutaneous injection

Indexed keywords

MORPHINE; MORPHINE DERIVATIVE; MORPHINE PROPIONATE; POLYOXYETHYLENE OLEYL ETHER; POLYSORBATE 80; PRODRUG; SESAME SEED OIL; SORBITAN OLEATE; SOYBEAN OIL EMULSION; WATER; WATER OIL CREAM;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTINOCICEPTION; AQUEOUS SOLUTION; AREA UNDER THE CURVE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSAGE FORM COMPARISON; DRUG EFFECT; DRUG RELEASE; DRUG TARGETING; EMULSION; FEASIBILITY STUDY; MALE; NANOPHARMACEUTICS; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SUSTAINED RELEASE FORMULATION; VISCOSITY; ZETA POTENTIAL;

ANALGESICS, OPIOID; ANIMALS; AREA UNDER CURVE; CHEMISTRY, PHARMACEUTICAL; CHEMISTRY, PHYSICAL; EMULSIONS; MALE; MORPHINE DERIVATIVES; NANOSPHERES; OILS; PAIN MEASUREMENT; PARTICLE SIZE; PRODRUGS; PROPIONATES; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; VEHICLES; VISCOSITY; WATER;

EID: 43049097519     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860801900090     Document Type: Article

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