Effective Tumor Treatment Using Optimized Ultrasound-Mediated Delivery of Bleomycin

Ultrasound in Medicine and Biology

Volumn 34, Issue 3, 2008, Pages 406-413

  Larkin, John O ^a   Casey, Garrett D ^a   Tangney, Mark ^a   Cashman, James ^a   Collins, Chris G ^a   Soden, Declan M ^a   O'Sullivan, Gerald C ^a,b  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b MERCY UNIVERSITY HOSPITAL   (Ireland)

Author keywords

Bleomycin; Cancer; Chemotherapy; Tumor; Ultrasound

Indexed keywords

CHEMOTHERAPY; CYTOTOXICITY; DRUG DELIVERY; MACROMOLECULES; OPTIMIZATION; TUMORS; ULTRASONICS;

ANTICANCER TREATMENT; BLEOMYCIN;

ONCOLOGY;

BLEOMYCIN; BLEOMYCIN SULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ECHOGRAPHY; ELECTROCHEMOTHERAPY; ELECTROPORATION; ENDOSCOPIC ECHOGRAPHY; FEMALE; IN VIVO STUDY; LOW ENERGY RADIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOLID TUMOR; TEMPERATURE SENSITIVITY; TUMOR; ULTRASOUND THERAPY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLEOMYCIN; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, ANIMAL; NEOPLASMS; PHONOPHORESIS; STAINING AND LABELING;

EID: 43049092674     PISSN: 03015629     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2007.09.005     Document Type: Article

References (25)

1. Belehradek M., Domenge C., Luboinski B., Orlowski S., Belehradek Jr. J., and Mir L.M. Electrochemotherapy, a new antitumor treatment. First clinical phase I-II trial. Cancer 72 (1993) 3694-3700
2. Coleman A.J., and Saunders J.E. A review of the physical properties and biological effects of the high amplitude acoustic field used in extracorporeal lithotripsy. Ultrasonics 31 (1993) 75-89
3. Gehl J., Skovsgaard T., and Mir L.M. Enhancement of cytotoxicity by electropermeabilization: An improved method for screening drugs. Anticancer Drugs 9 (1998) 319-325
4. Gehl J., and Geertsen P.F. Efficient palliation of haemorrhaging malignant melanoma skin metastases by electrochemotherapy. Melanoma Res 10 (2000) 585-589
5. Gothelf A., Mir L.M., and Gehl J. Electrochemotherapy: Results of cancer treatment using enhanced delivery of bleomycin by electroporation. Cancer Treat Rev 29 (2003) 371-387
6. Heller R., Jaroszeski M.J., Reintgen D.S., Puleo C.A., DeConti R.C., Gilbert R.A., and Glass L.F. Treatment of cutaneous and subcutaneous tumors with electrochemotherapy using intralesional bleomycin. Cancer 83 (1998) 148-157
7. Ingram M., and Arregui M.E. Endoscopic ultrasonography. Surg Clin North Am 84 (2004) 1035-1059
8. Langer R. New methods of drug delivery. Science 249 (1990) 1527-1533
9. Larkin J.O., Collins C.G., Aarons S., Tangney M., Whelan M., O'Reily S., Breathnach O., Soden D.M., and O'Sullivan G.C. Electrochemotherapy: Aspects of preclinical development and early clinical experience. Ann Surg 245 (2007) 469-479
10. Jaroszeski M.J., Dang V., Pottinger C., Hickey J., Gilbert R., and Heller R. Toxicity of anticancer agents mediated by electroporation in vitro. Anticancer Drugs 11 (2000) 201-208
11. Mir L.M., Banoun H., and Paoletti C. Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: Direct access to the cytosol. Exp Cell Res 175 (1988) 15-25
12. Mir L.M., Orlowski S., Belehradek Jr. J., and Paoletti C. Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses. Eur J Cancer 27 (1991) 68-72
13. Mir L.M., Tounekti O., and Orlowski S. Bleomycin: Revival of an old drug. Gen Pharmacol 27 (1996) 745-748
14. Mir L.M., and Orlowski S. Mechanisms of electrochemotherapy. Adv Drug Deliv Rev 35 (1999) 107-118
15. Mir L.M. Electrochemotherapy. Eur J Cancer Suppl 4 (2006) 1-60
16. Sersa G., Cemazar M., and Miklavcic D. Antitumour effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice. Cancer Res 55 (1995) 3450-3455
17. Soden D.M., Larkin J.O., Collins C.G., Tangney M., Aarons S., Piggott J., Morrissey A., Dunne C., and O'Sullivan G.C. Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumours. Cancer Lett 232 (2006) 300-310
18. Tachibana K., Uchida T., Ogawa K., Yamashita N., and Tamura K. Induction of cell-membrane porosity by ultrasound. Lancet 353 (1999) 1409
19. Tachibana K., Uchida T., Tamura K., Eguchi H., Yamashita N., and Ogawa K. Enhanced cytotoxic effect of Ara-C by low intensity ultrasound to HL-60 cells. Cancer Lett 149 (2000) 189-194
20. Tomizawa M., Ebara M., Saisho H., Sakiyama S., and Tagawa M. Irradiation with ultrasound of low output intensity increased chemosensitivity of subcutaneous solid tumors to an anti-cancer agent. Cancer Lett 173 (2001) 31-35
21. Uchida T., Sanghvi N.T., Gardner T.A., Koch M.O., Ishii D., Minei S., Satoh T., Hyodo T., Irie A., and Baba S. Transrectal high-intensity focused ultrasound for treatment of patients with stage T1b-2n0m0 localized prostate cancer: A preliminary report. Urology 59 (2002) 394-398 discussion 398-399
22. Wu F., Wang Z.B., Chen W.Z., Wang W., Gui Y., Zhang M., Zheng G., Zhou Y., Xu G., Li M., Zhang C., Ye H., and Feng R. Extracorporeal high intensity focused ultrasound ablation in the treatment of 1038 patients with solid carcinomas in China: An overview. Ultrason Sonochem 11 (2004) 149-154
23. Wu F., Wang Z.B., Chen W.Z., Zhu H., Bai J., Zou J.Z., Li K.Q., Jin C.B., Xie F.L., and Su H.B. Extracorporeal high intensity focused ultrasound ablation in the treatment of patients with large hepatocellular carcinoma. Ann Surg Oncol 11 (2004) 1061-1069
24. Wu F., Wang Z.B., Chen W.Z., Zou J.Z., Bai J., Zhu H., Li K.Q., Xie F.L., Jin C.B., Su H.B., and Gao G.W. Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: Early Chinese clinical experience. Ultrasound Med Biol 30 (2004) 245-260
25. Yu T., Wang Z., and Jiang S. Potentiation of cytotoxicity of adriamycin on human ovarian carcinoma cell line 3AO by low-level ultrasound. Ultrasonics 39 (2001) 307-309