Effect of homocysteine on calcium mobilization and platelet function in type 2 diabetes mellitus

Journal of Cellular and Molecular Medicine

Volumn 12, Issue 5B, 2008, Pages 2015-2026

  Alexandru, N ^a   Jardin I ^b   Popov, D ^a   Simionescu, M ^a   Garcia Estan J ^c   Salido, G M ^b   Rosado, J A ^b  

^a INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

^b UNIVERSITY OF EXTREMADURA   (Spain)

^c UNIVERSITY OF MURCIA   (Spain)

Author keywords

Aggregation; Calcium signalling; Homocysteine; Platelets; ROS production; Thrombin

Indexed keywords

ADENOSINE DIPHOSPHATE; CALCIUM; HOMOCYSTEINE; REACTIVE OXYGEN METABOLITE; THAPSIGARGIN; THROMBIN;

AGED; ARTICLE; CALCIUM SIGNALING; CASE CONTROL STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSIOLOGY; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION;

ADENOSINE DIPHOSPHATE; AGED; BLOOD PLATELETS; CALCIUM; CALCIUM SIGNALING; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET AGGREGATION; REACTIVE OXYGEN SPECIES; THAPSIGARGIN; THROMBIN;

EID: 43049092323     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2008.00200.x     Document Type: Article

References (54)

1. Undas A, Brozek J, Szczeklik A. Homocysteine and thrombosis: from basic science to clinical evidence. Thromb Haemost. 2005 94 : 907 15.
2. Frantzen F, Faaren AL, Alfheim I, Nordhei AK. Enzyme conversion immunoassay for determining total homocysteine in plasma or serum. Clin Chem. 1998 44 : 311 16.
3. Selhub J. Homocysteine metabolism. Ann Rev Nutr. 1999 19 : 217 46.
4. Wierzbicki AS. Homocysteine and cardiovascular disease: a review of the evidence. Diab Vasc Dis Res. 2007 4 : 143 50.
5. Cattaneo M. Heperhomocysteinemia, atherosclerosis and thrombosis. Thromb. Haemost. 1999 81 : 165 76.
6. Kanani PM, Sinkey CA, Browning RL, Allaman M, Knapp HR, Haynes WG. Role of oxidant stress in endothelial dysfunction produced by experimental hyper-homocysteinemia in humans. Circulation. 1999 100 : 1161 8.
7. Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, Loscalzo J. Adverse vascular effects of homocysteine are modulated by endothe-lium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993 91 : 308 18.
8. Lentz SR. Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost. 2005 3 : 1646 54.
9. Coppola A, Davi G, De Stefano V, Mancini FP, Cerbone AM, Di Minno G. Homocysteine, coagulation, platelet function, and thrombosis. Semin Thromb Hemost. 2000 26 : 243 54.
10. Leoncini G, Pascale R, Signorello MG. Effects of homocysteine on L-arginine transport and nitric oxide formation in human platelets. Eur J Clin Invest. 2003 33 : 713 9.
11. Durand P, Lussier-Cacan S, Blache D. Acute methionine load-induced hyper-homocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats. FASEB J. 1997 11 : 1157 68.
12. Upchurch GR Jr., Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF Jr., Loscalzo J. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997 272 : 17012 7.
13. Leoncini G, Bruzzese D, Signorello MG. Activation of p38 MAPKinase/cPLA2 pathway in homocysteine-treated platelets. J Thromb Haemost. 2006 4 : 209 16.
14. Leoncini G, Bruzzese D, Signorello MG. A role for PLCgamma2 in platelet activation by homocysteine. J Cell Biochem. 2007 100 : 1255 65.
15. 2+ mobilization and aggregation in platelets from type 2 diabetic patients. Biochem Biophys Res Commun. 2005 333 : 794 802.
16. Rudich A, Tirosh A, Potashnik R, Hemi R, Kanety H, Bashan N. Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Diabetes. 1998 47 : 1562 9.
17. Cooksey RC, Jouihan HA, Ajioka RS, Hazel MW, Jones DL, Kushner JP, McClain DA. Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis. Endocrinology. 2004 145 : 5305 12.
18. Cimminiello C, Milani M. Diabetes mellitus and peripheral vascular disease: is aspirin effective in preventing vascular events? Diabetologia. 1996 39 : 1402 4.
19. 2+ entry and tyrosine kinase pp60src hyperactivity are modulated by hyperglycemia in platelets from patients with non insulin-dependent diabetes mellitus. Arch Biochem Biophys. 2004 432 : 261 8.
20. 2+-ATPase function in platelets from patients with non-insulin-dependent diabetes mellitus. Haematologica. 2004 89 : 1142 4.
21. Signorello MG, Viviani GL, Armani U, Cerone R, Minniti G, Piana A, Leoncini G. Homocysteine, reactive oxygen species and nitric oxide in type 2 diabetes mellitus. Thromb Res. 2007 120 : 607 13.
22. 2+ indicators with greatly improved fluorescence properties. J Biol Chem. 1985 260 : 3440 50.
23. 2+ entry in human platelets: evidence for involvement of small GTP-binding proteins and actin cytoskeleton. Biochem J. 2000 347 : 183 92.
24. Redondo PC, Salido GM, Pariente JA, Rosado JA. Dual effect of hydrogen peroxide on store-mediated calcium entry in human platelets. Biochem Pharmacol. 2004 67 : 1065 76.
25. Tintinger GR, Theron AJ, Potjo M, Anderson R. Reactive oxidants regulate membrane repolarization and store-operated uptake of calcium by formyl peptide-activated human neutrophils. Free Radic Biol Med. 2007 42 : 1851 7.
26. 2+ ATPase system in human platelets. Br J Haematol. 1997 97 : 192 203.
27. 2+ ATPase 3 protein. J Biol Chem. 1994 269 : 1417 24.
28. Enyedi A, Paszty K, Kovacs T, Sarkadi B, Gardos G, Magnier C, Wuytack F, Enouf J. Simultaneous presence of two distinct endoplasmic-reticulum-type calcium-pump isoforms in human cells. Characterization by radio-immunoblotting and inhibition by 2,5-di-(t-butyl)-1,4-ben-zohydroquinone. Biochem J. 1992 288 : 297 302.
29. 2+- and vacuolar H+-ATPases in human platelets. Biochem J. 2005 390 : 243 52.
30. 2+ compartments show differential sensitivity to thrombin, ADP and vasopressin in human platelets. Cell Signal. 2006 18 : 373 81.
31. Jardin I, Redondo PC, Salido GM, Rosado JA. Phosphatidylinositol 4,5-bisphosphate enhances store-operated calcium entry through hTRPC6 channel in human platelets. Biochim Biophys Acta. 2008 1783 : 84 97.
32. 2+ ATPase expression in diabetes: a novel signature of abnormal megakary-ocytopoiesis. J Thromb Haemost. 2007 5 : 2127 35.
33. 2+-ATPase in hypertension. Hypertension. 2000 35 : 103 7.
34. Avram S, Lupu A, Angelescu S, Olteanu N, Mut-Popescu D. Abnormalities of platelet aggregation in chronic myelopro-liferative disorders. J Cell Mol Med. 2001 5 : 79 87.
35. Jardin I, Redondo PC, Salido GM, Pariente JA, Rosado JA. Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitus. Platelets. 2006 17 : 283 8.
36. Leoncini G, Signorello MG, Piana A, Carrubba M, Armani U. Hyperactivity and increased hydrogen peroxide formation in platelets of NIDDM patients. Thromb Res. 1997 86 : 153 60.
37. 2+ signalling in diabetic patients is due to increased formation of superoxide anions and reduced nitric oxide production. Diabetologia. 1999 42 : 167 76.
38. 2+ homeostasis and platelet hyperaggregability in type 2 diabetes mellitus patients. Arch Biochem Biophys. 2007 457 : 235 42.
39. 2+ release from two different intracellular stores in human platelets. Biochem J. 2007 401 : 167 74.
40. Zhang HS, Xiao JH, Cao EH, Qin JF. Homocysteine inhibits store-mediated calcium entry in human endothelial cells: evidence for involvement of membrane potential and actin cytoskeleton. Mol Cell Biochem. 2005 269 : 37 47.
41. Rosado JA, González A, Salido GM, Pariente JA. Effects of reactive oxygen species on actin filament polymerisation and amylase secretion in mouse pancreatic acinar cells. Cell Signal. 2002 14 : 547 56.
42. Zhu D, Tan KS, Zhang X, Sun AY, Sun GY, Lee JC. Hydrogen peroxide alters membrane and cytoskeleton properties and increases intercellular connections in astrocytes. J Cell Sci. 2005 118 : 3695 703.
43. Rosado JA, Salido GM, Jensen RT, Garcia LJ. Are tyrosine phosphorylation of p125(FAK) and paxillin or the small GTP binding protein, rho, needed for CCK-stimulated pancreatic amylase secretion? Biochim Biophys Acta. 1998 1404 : 412 26.
44. 2+ entry: evidence for a secretion-like coupling model. Cell. 1999 98 : 487 99.
45. Rosado JA, Sage SO. A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Trends Cardiovasc Med. 2000 10 : 327 32.
46. Bouaziz A, Amor NB, Woodard GE, Zibidi H, Lopez JJ, Bartegi A, Salido GM, Rosado JA. Tyrosine phosphorylation / dephosphorylation balance is involved in thrombin-evoked microtubular reorganisation in human platelets. Thromb Haemost. 2007 98 : 375 84.
47. 2+ entry: Dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane. J Physiol. 2003 547 : 333 48.
48. Putney JW Jr. Store-operated calcium channels: How do we measure them, and why do we care? Sci STKE. 2004 243 : 1 3.
49. 2+ entry: vesicle fusion or reversible trafficking and de novo conformational coupling? J Cell Physiol. 2005 205 : 262 9.
50. Ho PI, Collins SC, Dhitavat S, Ortiz D, Ashline D, Rogers E, Shea TB. Homocysteine potentiates beta-amyloid neurotoxicity: role of oxidative stress. J Neurochem. 2001 78 : 249 53.
51. 2+ mobilisation in human platelets through sulphydryl oxidation dependent and independent mechanisms. Biochem Pharmacol. 2004 67 : 491 502.
52. 2+ flux in pulmonary vascular endothelial cells. Am J Physiol. 1991 260 : H549 56.
53. Koubaa N, Nakbi A, Smaoui M, Abid N, Chaaba R, Abid M, Hammami M. Hyperhomocysteinemia and elevated ox-LDL in Tunisian type 2 diabetic patients: Role of genetic and dietary factors. Clin Biochem. 2007 40 : 1007 14.
54. Rasouli ML, Nasir K, Blumenthal RS, Park R, Aziz DC, Budoff MJ. Plasma homocysteine predicts progression of atherosclerosis. Atherosclerosis. 2005 181 : 159 65.