Tbx2 and Tbx3 regulate the dynamics of cell proliferation during heart remodeling

PLoS ONE

Volumn 2, Issue 4, 2007, Pages

  Ribeiro, Inês ^a,c   Kawakami, Yasuhiko ^a   Büscher, Dirk ^a,d   Raya, Ángel ^a,e,f   Rodriguez León, Joaquín ^b,f   Morita, Masanobu ^a   Rodríguez Esteban, Concepción ^a   Izpisúa Belmonte, Juan Carlos ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d Cellerix SA   (Spain)

^e INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^f Centre de Medicina Regenerativa de Barcelona   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

T BOX TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TBX2; TRANSCRIPTION FACTOR TBX3; TRANSCRIPTION FACTOR TBX3A; TRANSCRIPTION FACTOR TBX3B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ATRIOVENTRICULAR CANAL; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; EMBRYO PATTERN FORMATION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; GENE REPRESSION; GENETIC ANALYSIS; GENETIC CONSERVATION; HEART DEVELOPMENT; HEART MUSCLE; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PHENOTYPE; ZEBRA FISH; ANIMAL; GENETICS; HEART; PHYSIOLOGY;

DANIO RERIO; MUS;

ANIMALS; CELL PROLIFERATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART; TRANSCRIPTION FACTORS; ZEBRAFISH;

EID: 43049091746     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000398     Document Type: Article

References (51)

1. Naiche LA, Harrelson Z, Kelly RG, Papaioannou VE (2005) T-box Genes in Vertebrate Development. Annu Genet Rev 39: 219-239.
2. Li QY, Newbury-Ecob RA, Terrett JA, Wilson DI, Curtis ARJ, et al. (1997) Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachrug (T) gene family. Nat Genet 15: 21-29.
3. Merscher S, Funke B, Epstein JA, Heyer J, Puech A, et al. (2001) TBX1 is responsible for cardiovascular defects in velo-cardio-facial/ DiGeroge syndrome. Cell 104: 619-629.
4. Christoffels VM, Burch JBE, Moorman AFM (2004) Architectural Plan for the Heart: Early Patterning and Delineation of the Chambers and the Nodes. Trends in Cardiovascular Medicine TCM 14: 301-307.
5. Christriffels VM, Habets PE, Franco D, Campione M, de Jong F, et al. (2000) Chamber Formation and Morphogenesis in the Developing Mammalian Heart. Dev Biol 223: 266-278.
6. Neuhaus H, Rosen V, Thies RS (1999) Heart specific expression of mouse BMP-10 a novel member of the TGF-Beta superfamily. Mech Dev 80: 181-184.
7. Bartram U, Molin D, Wisse L, Mohamed A, Sanford P, et al. (2001) Double-Outlet Right Ventricle and Overriding Tricuspid Valve Reflect Disturbances of Looping, Myocardialization, Endocardial Cushion Differentiation, and Apoptosis in TGF-Beta2 -Knockout Mice. Circulation 103: 2745-2752.
8. Ma L, Lu M-F, Schwartz RJ, Martin JF (2005) Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development 132: 5601-5611.
9. Hiroi Y, Kudoh S, Monzen K, Ikeda Y, Yazaki Y, et al. (2001) Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet 28: 276-280.
10. Hoogars WMH, Tessari A, Moorman AFM, de Boer PAJ, Hagoort J, et al. (2004) The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. Cardiovacular Research 62: 489-499.
11. Habets PEMH, Moorman AFM, Clout DEW, van Roon MA, et al. (2002) Cooperative action of Tbx2 and Nkx2.5 inhibits ANF expression in the atrioventricular canal: implications for cardiac chamber formation. Genes & Development 16: 1234-1246.
12. Christoffels VM, Hoogars WMH, Tessari A, Clout DEW, Moorman AFM, et al. (2004) T-box Transcription Factor Tbx2 Repressed Differentiation and Formation of the Cardiac Chambers. Dev Dyn 229: 763-770.
13. John SW, Krege JH, Oliver PM, Hagaman JR, Hodgin JB, et al. (1995) Genetic Decreases in Atrial Natriuretic Peptide and Salt-Sensitive Hypertension. Science 267: 679-681.
14. Kirchhoff S, Nelles E, Hagendorff A, Kruger O, Traub O, et al. (1998) Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol 8: 299-302.
15. Palmer S, Groves N, Schindeler A, Yeoh T, Biben C, et al. (2001) The Small Muscle-specific Protein Csl Modifies Cell Shape and Promotes Myocyte Fusion in an Insulin-like Growth Factor 1-dependent Manner. JCB 153: 985-997.
16. Simon AM, Goodenough DA, Paul DL (1998) Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biology 8: 295-298.
17. Stennard FA, Costa MW, Lai D, Biben C, Furtado MB, et al. (2005) Murine T-box transcription factor Tbx20 acts as a repressor during heart development, and is essential for adult heart integrity, function and adaptation. Development 132: 2451-2462.
18. Takeuchi JK, Mileikovskaia M, Koshiba-Takeuchi K, Heidt AB, Mori AD, et al. (2005) Tbx20 dose-dependently regulates transcription factor networks required for mouse heart and motoneuron development. Development 132: 2463-2474.
19. Singh MK, Christffels VM, Dias JM, Trowe M-O, Petry M, et al. (2005) Tbx20 is essential for cardiac chamber differentiation and repression of Thx2. Development 132: 2697-2707.
20. Sawai S, Shimono A, Wakamatsu Y, Palmes C, Hanaoka K, et al. (1993) Defects of embryonic organogenesis resulting from targeted disruption of the N-myc gene in the mouse. Development 117: 1445-1455.
21. Moens CB, Stanton BR, Parada LF, Rossant J (1993) Defects in heart and lung development in compound heterozygotes for two different targeted mutations at the N-myc locus. Development 119: 485-499.
22. Harrelson Z, Kelly RG, Goldin SN, Gibson-Brown JJ, Bollag RJ, et al. (2004) Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development. Development 131: 5041-5052.
23. Bamshad M, Lin RC, Law DJ, Watkins WS, Krakowiak PA, et al. (1997) Mutations in human TBX3 alter limb, apocrine and genital development in ulnar-mammary syndrome. Nat Genet 16: 311-315.
24. Bamshad M, Le T, Watkins WS, Dixon ME, Kramer BE, et al. (1999) The spectrum of mutations in TBX3: genotype/phenotype relationship in ulnar-mammary syndrome. Am J Hum Genet 64: 1550-1562.
25. Meneghini V, Odent S, Platonova N, Egeo A, Merlo GR (2006) Novel TBX3 mutation data in families with Ulnar-Mammary syndrome indicate a genotype-phenotype relationship: mutations that do not disrupt the T-domain are associated with less severe limb defects. Eur J Med Genet 49: 151-158.
26. Davenport TG, Jerome-Majewska LA, Papaioannou V (2003) Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. development 130: 2263-2273.
27. Garrity DM, Childs S, Fishman MC (2002) The heartstrings mutation in zebrafish causes heart/fin Tbx5 defficiency syndrome. Development 129: 4635-4645.
28. Walsh EC, Stainier DY (2001) UDP-glucose dehydrogenase required for cardiac valve formation in zebrafish. Science 293: 1670-1673.
29. Berdougo E, Coleman H, Lee DH, Stainier DY, Yelon D (2003) Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish. Development 130: 6121-6129.
30. Huang CJ, Tu CT, Hsiao CD, Hsieh FJ, Tsai HJ (2003) Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish. Dev Dyn 228: 30-40.
31. Hurlstone AF, Haramis AT, Wienholds E, Begthel H, Korving J, et al. (2003) The Wnt/β-catenin pathway regulated cardiac valve formation. Nature 425: 633-637.
32. Sanford LP, Ormsby I, Gittenberger-de Groot AC, Sarlola H, Friedman R, et al. (1997) TGFbeta2 knockout mice have multiple developmental defects that are not overlapping with other TGFbeta knockout phenotypes. Developmnt 124: 2659-2670.
33. Galvin KM, Donovan MJ, Lynch CA, Meyer RI, Paul RJ, et al. (2000) A role for Smad6 in development and homeristasis of the cardiovascular system. Nature Genetics 24: 171-174.
34. Bruneau BG, Nemer G, Schmitt JP, Charron F, Robitaille L, et al. (2001) A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell 106: 709-721.
35. Sedmera D, Reckova M, deAlmeida A, Coppen SR, Kubalak SW, et al. (2003) Spatiotemporal Pattern of Commitment to Slowed Proliferation in the Embryonic Mouse Heart Indicates Progressive Differentiation of the Cardiac Conduction System. The Anatomical Record 274A: 773-777.
36. Thompson RP, Lindroth JR, Wong YMM (1990) Regional Differences in DNA-Synthetic Activity in the Preseptation Myricardium of the Chick. in Developmental Cardiology: Morphogenesis and Function, Clark EB, Takao A, eds. Mount Kisco, NY; Futura chapt. 17: 219-234.
37. Taber LA (2006) Biophysical mechanisms of cardiac looping. Int J Dev Biol 50: 323-332.
38. Szeto DP, Griffin KJP, Kimelman D (2002) hrT is required for cardiovascular development in zebrafish. Development 129: 5093-5101.
39. Walton RZ, Bruce AEE, Olivery HE, Najib K, Johnson V, et al. (2006) Fogl is required for cardiac looping in zebrafish. Developmental Biology 289.
40. Yamamoto A, Amacher SL, Kim SH, Geissert D, Kimmel CB, et al. (1998) Zebrafish paraxial protocadherin is a downstream target of spadetail involved in morphogenesis of gastrula mesoderm. Development 125: 3389-3397.
41. Rasskin-Gutman D, Izpisua-Belmonte JC (2004) Theoretical morphology of developmental asymmetries. Bioessays 26: 405-412.
42. Chen H, Shi S, Acosta L, Li W, Lu J, Bao S, et al. (2004) BMP10 is essential for maintaining cardiac growth during routine cardiogenesis. Development 131: 2219-2231.
43. Cai C-L, Zhou W, Yang L, Bu L, Qyang Y, Zhang X, et al. (2005) T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development 132: 2475-2487.
44. Bussen M, Petry M, Schuster-Gossler K, Leitges M, Gossler A, et al. (2004) The T-box transcription factor Tbx18 maintains the separation of anterior and posterior somite compartments. Genes & Development 18: 1209-1221.
45. Singh MK, Petry M, Haenig B, Lescher B, Leitges M, et al. (2005) The T-box transcription factor Tbx15 is required for skeletal development. Mech Dev 122: 131-144.
46. Moustakas A, Pardali K, Gaal A, Heldin CH (2002) Mechanisms of TGF-beta signaling in regulation of cell growth and differentiation. Immunol Lett 82: 85-91.
47. Charng A, Frenkel P, Lin Q, Yumada M, Schwartz R, et al. (1998) A Constitutive Mutation of ALK5 Disrupts Cardiac Looping and Morphogenesis in Mice. Dev Biol 199: 72-79.
48. Paxton C, Zhao H, Chin Y, Langner K, Reecy J (2002) Murine Tbx2 contains domains that activate and repress gene transcription. Gene 283: 117-124.
49. NgJK, Kawakami Y, Büscber D, Raya A, Itob T, et al. (2002) The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Developement 129: 5161-5170.
50. Matsui T, Raya A, Kawakami Y, Callol-Massot C, Capdevila J, et al. (2005) Noncanonical Wnt signaling regulates midline convergence of organ primordia during zebrarish development. Genes & Development 19: 164-175.
51. Kang JS, Oohashi T, Kawakami Y, Bekku Y, Izpisua Belmonte JC, et al. (2004) Characterization of dermacan, a novel zebrafish lectican gene, expressed in dermal bones. Mech Dev 121: 301-312.