A constitutive mutation of ALK5 disrupts cardiac looping and morphogenesis in mice

Developmental Biology

Volumn 199, Issue 1, 1998, Pages 72-79

  Charng, Min Ji ^a   Frenkel, Peter A ^a   Lin, Qing ^b   Yumada, Miho ^a   Schwartz, Robert J ^a   Olson, Eric N ^b   Overbeek, Paul ^a   Schneider, Michael D ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

ALK5; Cardiac development; Looping; P21; TGF

Indexed keywords

ARTICLE; DEVELOPMENTAL GENETICS; EMBRYO; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HEART DEVELOPMENT; IN SITU HYBRIDIZATION; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

MUS MUSCULUS; VERTEBRATA;

EID: 0032126748     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1998.8905     Document Type: Article

References (48)

1. Bodmer R. The gene tinman is required for specification of the heart and visceral muscles inDrosophila. Development. 118:1993;719-729.
2. Carcamo J., Weis F. M., Ventura F., Wieser R., Wrana J. L., Attisano L., Massague J. Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin. Mol. Cell. Biol. 14:1994;3810-3821.
3. Charng M.-J., Kinnunen P., Hawker J., Brand T., Schneider M. D. FKBP-12 recognition is dispensable for signal generation by type I TGFβ receptors. J. Biol. Chem. 271:1996;22941-22944.
4. Chen J.-N., van Eeden F. J. M., Warren K. S., Chin A., Nüsslein-Vollard C., Haffter P., Fishman M. C. Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish. Development. 124:1997a;4373-4382.
5. Chen J. N., Fishman M. C. Zebrafish tinman homolog demarcates the heart field and initiates myocardial differentiation. Development. 122:1996;3809-3816.
6. Chen Y. G., Liu F., Massagué J. Mechanism of TGF beta receptor inhibition by FKBP12. EMBO J. 16:1997b;3866-3876.
7. Chen Z., Friedrich G. A., Soriano P. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 8:1994;2293-2301.
8. Dickson M. C., Martin J. S., Cousins F. M., Kulkarni A. B., Karlsson S., Akhurst R. J. Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knockout mice. Development. 121:1995;1845-1854.
9. Diebold R. J., Eis M. J., Yin M., Ormsby I., Boivin G. P., Darrow B. J., Saffitz J. E., Doetschman T. Early-onset multifocal inflammation in the transforming growth factor β1-null mouse is lymphocyte mediated. Proc. Natl. Acad. Sci. USA. 92:1995;12215-12219.
10. Fisher S. A., Siwik E., Branellec D., Walsh K., Watanabe M. Forced expression of the homeodomain protein Gax inhibits cardiomyocyte proliferation and perturbs heart morphogenesis. Development. 124:1997;4405-4413.
11. Fishman M. C., Chien K. R. Fashioning the vertebrate heart: Earliest embryonic decisions. Development. 124:1997;2099-2117.
12. Frasch M. Induction of visceral and cardiac mesoderm by ectodermal dpp in the earlyDrosophila. Nature. 374:1995;464-467.
13. Gebbia M., Bassi M. T., Ferrero G. B., Kosaki K., Casey B. Clinical and molecular genetics of human left-right axis disorders. Mol. Biol. Cell. 8:1997;7a.
14. Hammerschmidt M., Serbedzija G. N., McMahon A. P. Genetic analysis of dorsoventral pattern formation in the zebrafish: Requirement of a BMP-like ventralizing activity and its dorsal repressor. Genes Dev. 10:1996;2452-2461.
15. Hogan B. L. M. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev. 10:1996;1580-1594.
16. Hyatt B. A., Lohr J. L., Yost H. J. Initiation of vertebrate left-right axis formation by maternal Vg1. Nature. 384:1996;62-65.
17. Jaber M., Koch W. J., Rockman H., Smith B., Bond R. A., Sulik K. K., Ross J., Lefkowitz R. J., Caron M. G., Giros B. Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. Proc. Natl. Acad. Sci. USA. 93:1996;12974-12979.
18. Kirshenbaum L. A., Abdellatif M., Chakraborty S., Schneider M. D. Human E2F-1 reactivates cell cycle progression in ventricular myocytes and represses cardiac gene transcription. Dev. Biol. 179:1996;402-411.
19. Letterio J. J., Geiser A. G., Kulkarni A. B., Roche N. S., Sporn M. B., Roberts A. B. Maternal rescue of transforming growth factor-beta 1 null mice. Science. 264:1994;1936-1938.
20. Levin M., Johnson R. L., Stern C. D., Kuehn M., Tabin C. A molecular pathway determining left-right asymmetry in chick embryogenesis. Cell. 82:1995;803-814.
21. Li J. M., Hu P. P. C., Shen X., Yu Y., Wang X. F. E2F4-RB and E2F4-p107 complexes suppress gene expression by transforming growth factor beta through E2F binding sites. Proc. Natl. Acad. Sci. USA. 94:1997;4948-4953.
22. Lilly B., Galewsky S., Firulli A. B., Schulz R. A., Olson E. N. D-MEF2: A MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages duringDrosophila. Proc. Natl. Acad. Sci. USA. 91:1994;5662-5666.
23. Lin Q., Schwarz J., Bucana C., Olson E. N. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C. Science. 276:1997;1404-1407.
24. Lowe L. A., Supp D. M., Sampath K., Yokoyama T., Wright C. V., Potter S. S., Overbeek P., Kuehn M. R. Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus. Nature. 381:1996;158-161.
25. Lyons G. E., Schiaffino S., Sassoon S., Barton P., Buckingham M. Developmental regulation of myosin gene expression in normal mouse cardiac muscle. J. Cell. Biol. 111:1990;2427-2436.
26. Lyons I., Parsons L. M., Hartley L., Li R., Andrews J. E., Robb L., Harvey R. P. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 9:1995;1654-1666.
27. Marchionni M. A. Cell-cell signalling: neu tack on neuregulin. Nature. 378:1995;334-335.
28. Massagué J. TGFβ signaling: Receptors, transducers, and Mad proteins. Cell. 85:1996;947-950.
29. Matzuk M. M., Kumar T. R., Bradley A. Different phenotypes for mice deficient in either activins or activin receptor type II. Nature. 374:1995;356-360.
30. Meno C., Saijoh Y., Fujii H., Ikeda M., Yokoyama T., Yokoyama M., Toyoda Y., Hamada H. Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. Nature. 381:1996;151-155.
31. O'Brien T. X., Lee K. J., Chien K. R. Positional specification of ventricular myosin light chain-2 expression in the primitive murine heart tube. Proc. Natl. Acad. Sci. USA. 90:1993;5157-5161.
32. Oh S. P., Li E. The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 11:1997;1812-1826.
33. Olson E. N., Srivastava D. Molecular pathways controlling heart development. Science. 272:1996;671-676.
34. Parker S. B., Eichele G., Zhang P. M., Rawls A., Sands A. T., Bradley A., Olson E. N., Harper J. W., Elledge S. J. p53-independent expression of p21(Cip)1 in muscle and other terminally differentiating cells. Science. 267:1995;1024-1027.
35. Radice G. L., Rayburn H., Matsunami H., Knudsen K. A., Takeichi M., Hynes R. O. Developmental defects in mouse embryos lacking N-cadherin. Dev. Biol. 181:1997;64-78.
36. Reynisdottir I., Polyak K., Iavarone A., Massagué J. Kip/Cip and INK4 cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta. Genes Dev. 9:1995;1831-1845.
37. Sanford L. P., Ormsby I., Gittenberger de Groot A. C., Sariola H., Friedman R., Boivin G. P., Cardell E. L., Doetschman T. TGF beta 2 knockout mice have multiple developmental defects that are nonoverlapping with other TGF beta knockout phenotypes. Development. 124:1997;2659-2670.
38. Schultheiss T. M., Burch J. B. E., Lassar A. B. A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev. 11:1997;451-462.
39. Show, W. Aghdasi, B. Armstrong, D. L. Guo, Q. Bao, S. Charng, M.-J. Mathews, L. M. Schneider, M. D. Hamilton, S. L. Matzuk, M. M. FKBP-12-deficient mice display cardiac defects and altered ryanodine receptor function, Nature.
40. Srivastava D., Thomas T., Lin Q., Kirby M. L., Brown D., Olson E. N. Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND. Nature Genet. 16:1997;154-160.
41. Subramaniam A., Jones W. K., Gulick J., Wert S., Neumann J., Robbins J. Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J. Biol. Chem. 266:1991;24613-24620.
42. Sucov H. M., Dyson E., Gumeringer C. L., Price J., Chien K. R., Evans R. M. RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 8:1994;1007-1018.
43. Supp D. M., Witte D. P., Potter S. S., Brueckner M. Mutation of an axonemal dynein affects left-right asymmetry ininversus viscerum. Nature. 389:1997;963-966.
44. Taketo M., Schroeder A. C., Mobraaten L. E., Gunning K. B., Hanten G., Fox R. R., Roderick T. H., Stewart C. L., Lilly F., Hansen C. T., Overbeek P. A. FVB/N: An inbred mouse strain preferable for transgenic analyses. Proc. Natl. Acad. Sci. USA. 88:1991;2065-2069.
45. Wang T. W., Li B. Y., Danielson P. D., Shah P. C., Rockwell S., Lechleider R. J., Martin J., Manganaro T., Donahoe P. K. The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors. Cell. 86:1996;435-444.
46. Wieser R., Wrana J. L., Massagué J. GS domain mutations that constitutively activate TβR-I, the downstream signaling component in the TGF-beta receptor complex. EMBO J. 14:1995;2199-2208.
47. Yokoyama T., Copeland N. G., Jenkins N. A., Montgomery C. A., Elder F. F., Overbeek P. A. Reversal of left-right asymmetry: A situs inversus mutation. Science. 260:1993;679-682.
48. Zhang H. B., Bradley A. Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development. Development. 122:1996;2977-2986.