Non-specific anti-proliferative effect of FTY720, a derivative of fungal metabolite from Iscaria sinclarii

Archives of Pharmacal Research

Volumn 31, Issue 2, 2008, Pages 160-166

  Cho, Jae Youl ^a  

^a Kangwon National University   (South Korea)

Author keywords

Alloreactive T cell; FTY720; LPS activated macrophages; NO production; Non specific cell proliferation; TNF

Indexed keywords

ANILINE DERIVATIVE; ANTINEOPLASTIC ANTIBIOTIC; CYCLOSPORIN; DRUG DERIVATIVE; FINGOLIMOD; HYDROXYBUTYRIC ACID; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROPANEDIOL DERIVATIVE; SPHINGOSINE; TERIFLUNOMIDE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; CELL PROLIFERATION; CELLULAR IMMUNITY; CHEMISTRY; DRUG EFFECT; FUNGUS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MACROPHAGE; MALE; METABOLISM; MOUSE; PHYSIOLOGY; T LYMPHOCYTE;

ANILINE COMPOUNDS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; CELL PROLIFERATION; CYCLOSPORINE; FUNGI; HYDROXYBUTYRATES; IMMUNITY, CELLULAR; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-2; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NITRIC OXIDE; PROPYLENE GLYCOLS; SPHINGOSINE; T-LYMPHOCYTES; TETRAZOLIUM SALTS; THIAZOLES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 42949173598     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-1135-0     Document Type: Article

References (29)

1. Aki, F. T. and Kahan, B. D., FTY720: A new kid on the block for transplant immunosuppression. Expert. Opin. Biol. Ther., 3, 665-681 (2003).
2. Albi, E., Cataldi, S., Bartoccini, E., Magni, M. V., Marini, F., Mazzonl, R, Rainaldi, G., Evangelista, M., and Garcia-Gil, M., Nuclear sphingomyelin pathway in serum deprivation-induced apoptosis of embryonic hippocampal cells. J. Cell Physiol., 206, 189-195 (2006).
3. Brogdon, J. L., Xu, Y., Szabo, S. J., An, S., Buxton, F., Cohen, D., and Huang, Q., Histone deacetylase activities are required for innate immune cell control of Th1 but not Th2 effector cell function. Blood, 109, 1123-1130 (2007).
4. Bryant, P. and Ploegh, H., Class II MHC peptide loading by the professionals. Curr. Opin. Immunol., 16, 96-102 (2004).
5. Budde, K., Schutz, M., Glander, P., Peters, H., Waiser, J., Liefeldt, L., Neumayer, H. H., and Bohler, T., FTY720 (fingolimod) in renal transplantation. Clin. Transplant., 20Suppl 17, 17-24 (2006).
6. Cho, J. Y., Baik, K. U., Jung, J. H., and Park, M. H., In vitro anti-inflammatory effects of cynaropicrin, a sesquiterpene lactone, from Saussurea lappa. Eur. J. Pharmacol., 398, 399-407 (2000).
7. Downes, S., Chen, Y. J., Kyles, A., and Gregory, C., Oral pharmacokinetic and pharmacodynamic effects of FTY720 in cats. J. Vet. Pharmacol. Ther., 30, 55-61 (2007).
8. Fujino, M., Funeshima, N., Kitazawa, Y., Kimura, H., Amemiya, H., Suzuki, S., and Li, X. K., Amelioration of experimental autoimmune encephalomyelitis in Lewis rats by FTY720 treatment. J. Pharmacol. Exp. Ther., 305, 70-77 (2003).
9. Honig, S. M., Fu, S., Mao, X., Yopp, A., Gunn, M. D., Randolph, G. J., and Bromberg, J. S., FTY720 stimulates multidrug transporter-and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. J. Clin. Invest., 111, 627-637 (2003).
10. Im, D. S., Linking Chinese medicine and G-protein-coupled receptors. Trends Pharmacol. Sci., 24, 2-4 (2003).
11. LaMontagne, K., Littlewood-Evans, A., Schnell, C., O'Reilly, T., Wyder, L., Sanchez, T., Probst, B., Butler, J., Wood, A., Liau, G., Billy, E., Theuer, A., Hla, T., and Wood, J., Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization. Cancer Res., 66, 221-231 (2006).
12. Lan, Y. Y., De Creus, A., Colvin, B. L., Abe, M., Brinkmann, V., Coates, P. T., and Thomson, A. W., The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. Am. J. Transplant., 5, 2649-2659 (2005).
13. Lee, T. K., Man, K., Ho, J. W., Sun, C. K., Ng, K. T., Wang, X. H., Wong, Y. C., Ng, I. O., Xu, R., and Fan, S. T., FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis, 25, 2397-2405 (2004).
14. Lemos, M. P., Fan, L., Lo, D., and Laufer, T. M., CD8alpha+ and CD11b+ dendritic cell-restricted MHC class II controls Th1 CD4+ T cell immunity. J. Immunol., 171, 5077-5084 (2003).
15. Leshem, B. and Kedar, E., Cytotoxic T lymphocytes reactive against a syngeneic murine tumor and their specific suppressor T cells are both elicited by in vitro allosensitization. J. Exp. Med., 171, 1057-1071 (1990).
16. Li, X. K., Enosawa, S., Kakefuda, T., Amemiya, H., and Suzuki, S., FTY720, a novel immunosuppressive agent, enhances upregulation of the cell adhesion molecular ICAM-1 in TNF-alpha treated human umbilical vein endothelial cells. Transplant. Proc., 29, 1265-1266 (1997).
17. Miyake, Y., Kozutsumi, Y., Nakamura, S., Fujita, T., and Kawasaki, T., Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun., 211, 396-403 (1995).
18. Morris, M. A., Gibb, D. R., Picard, F., Brinkmann, V., Straume, M., and Ley, K., Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720. Eur. J. Immunol., 35, 3570-3580 (2005).
19. Napoli, K. L., The FTY720 story. Ther. Drug Monit., 22, 47-51 (2000).
20. Pabst, O., Herbrand, H., Willenzon, S., Worbs, T., Schippers, A., Muller, W., Bernhardt, G., and Forster, R., Enhanced FTY720-mediated lymphocyte homing requires G alpha i signaling and depends on beta 2 and beta 7 integrin. J. Immunol., 176, 1474-1480 (2006).
21. Schmid, G., Guba, M., Papyan, A., Ischenko, I., Bruckel, M., Bruns, C. J., Jauch, K. W., and Graeb, C., FTY720 inhibits tumor growth and angiogenesis. Transplant. Proc., 37, 110-111 (2005).
22. Shen, Y., Cai, M., Xia, W., Liu, J., Zhang, Q., Xie, H., Wang, C., Wang, X., and Zheng, S., FTY720, a synthetic compound from Isaria sinclairii, inhibits proliferation and induces apoptosis in pancreatic cancer cells. Cancer Lett., (2007).
23. Skapenko, A., Leipe, J., Lipsky, P. E., and Schulze-Koops, H., The role of the T cell in autoimmune inflammation. Arthritis Res. Ther., 7Suppl 2, S4-14 (2005).
24. Song, J., Ito, T., Matsuda, C., Miao, G., Tanemura, M., Nishida, T., Nozawa, M., Matsuda, H., and Sawa, Y., Inhibition of donor-derived T cells trafficking into target organs by FTY720 during acute graft-versus-host disease in small bowel transplantation. Clin. Exp. Immunol., 146, 85-92 (2006).
25. Spiegel, S., Cuvillier, O., Edsall, L. C., Kohama, T., Menzeleev, R., Olah, Z., Olivera, A., Pirianov, G., Thomas, D. M., Tu, Z., Van Brocklyn, J. R., and Wang, F., Sphingosine-1-phosphate in cell growth and cell death. Ann. N. Y. Acad. Sci., 845, 11-18 (1998).
26. Stankovic, S., Zhan, Y., and Harrison, L. C., Homeostatic proliferation of intestinal intraepithelial lymphocytes precedes their migration to extra-intestinal sites. Eur. J. Immunol., (2007).
27. Yang, Z., Chen, M., Fialkow, L. B., Ellett, J. D., Wu, R., Brinkmann, V., Nadler, J. L., and Lynch, K. R., The immune modulator FYT720 prevents autoimmune diabetes in nonobese diabetic mice small star, filled. Clin. Immunol., 107, 30-35 (2003).
28. Yu, M. U., Yoo, J. M., Lee, Y. S., Lee, Y. M., Hong, J. T., Oh, K. W., Song, S., Yun, Y. P., Yoo, H. S., and Oh, S., Altered de novo sphingolipid biosynthesis is involved in the serum deprivation-induced cell death in LLC-PK1 cells. J. Toxicol. Environ. Health. A., 67, 2085-2094 (2004).
29. Zhang, Q., Chen, Y., Fairchild, R. L., Heeger, P. S., and Valujskikh, A., Lymphoid sequestration of alloreactive memory CD4 T cells promotes cardiac allograft survival. J. Immunol., 176, 770-777 (2006).