Lack of association between the amiloride-sensitive cation channel 2 (ACCN2) gene and anxiety spectrum disorders

Psychiatric Genetics

Volumn 18, Issue 2, 2008, Pages 73-79

  Hettema, John M ^a   An, Seon Sook ^a   Neale, Michael C ^a   Van Den Oord, Edwin J C G ^a   Kendler, Kenneth S ^a   Chen, Xiangning ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Amiloride sensitive cation channel; Anxiety; Association study; Depression; Genetics; Neuroticism

Indexed keywords

ACID SENSING ION CHANNEL; AMILORIDE SENSITIVE CATION CHANNEL 2; CATION CHANNEL; ACCN2 PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN; SODIUM CHANNEL;

AGORAPHOBIA; ALLELE; ANXIETY DISORDER; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DNA DETERMINATION; DNA REPLICATION; FEMALE; GENERALIZED ANXIETY DISORDER; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MULTIVARIATE ANALYSIS; NEUROSIS; PANIC; PHENOTYPE; POPULATION RESEARCH; POST HOC ANALYSIS; PRIORITY JOURNAL; SAMPLE (STATISTICS); SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL PHOBIA; THEORETICAL MODEL; ADULT; COMORBIDITY; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; HOSPITALIZATION; PERSONALITY TEST; TWINS;

RODENTIA;

ADULT; ANXIETY DISORDERS; CASE-CONTROL STUDIES; COMORBIDITY; DEPRESSIVE DISORDER, MAJOR; DISEASES IN TWINS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MEMBRANE PROTEINS; NERVE TISSUE PROTEINS; PERSONALITY INVENTORY; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SEVERITY OF ILLNESS INDEX; SODIUM CHANNELS;

EID: 42949164542     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/YPG.0b013e3282f08a2a     Document Type: Article

References (35)

1. SAS (1999). SAS Institute. SAS/STAT Software: Version 8. SAS Institute Inc. Cary, North Carolina.
2. The International HapMap Consortium (2003). The International HapMap Project. Nature 426:789-796.
3. Alvarez DLR, Zhang P, Shao D, White F, Canessa CM (2002). Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system. Proc Natl Acad Sci U S A 99:2326-2331.
4. American Psychiatric Association (1980). Diagnostic and statistical manual of mental disorders. 3rd ed. Washington, DC: American Psychiatric Association.
5. American Psychiatric Association (1987). Diagnostic and statistical manual of mental disorders. Revised 3rd ed. Washington, DC: American Psychiatric Association.
6. Barrett JC, Fry B, Maller J, Daly MJ (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
7. Dudbridge F (2003). Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 25:115-121.
8. Excoffier L, Slatkin M (1995). Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol Biol Evol 12:921-927.
9. Eysenck HJ, Eysenck SBG (1975). Manual of the Eysenck personality questionnaire. London: Hodder and Stoughton.
10. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J, Blumenstiel B, et al. (2002). The structure of haplotype blocks in the human genome. Science 296:2225-2229.
11. Gargus JJ (2006). Ion channel functional candidate genes in multigenic neuropsychiatric disease. Biol Psychiatry 60:177-185.
12. Hamosh A, Scott AF, Amberger J, Bocchini C, Valle D, McKusick VA (2002). Online Mendelian Inheritance in Man (OMIM), a knowledge base of human genes and genetic disorders. Nucleic Acids Res 30:52-55.
13. Hettema JM, Prescott CA, Kendler KS (2001). A population-based twin study of generalized anxiety disorder in men and women. J Nerv Ment Dis 189:413-420.
14. Hettema JM, An SS, Neale MC, Bukszar J, van den Oord EJ, Kendler KS, Chen X (2006a). Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism. Mol Psychiatry 11:752-762.
15. Hettema JM, Neale MC, Myers JM, Prescott CA, Kendler KS (2006b). A population-based twin study of the relationship between neuroticism and internalizing disorders. Am J Psychiatry 163:857-864.
16. Jardine R, Martin NG, Henderson AS (1984). Genetic covariation between neuroticism and the symptoms of anxiety and depression. Genet Epidemiol 1:89-107.
17. Kendler KS, Prescott CA (1999). A population-based twin study of lifetime major depression in men and women. Arch Gen Psychiatry 56:39-44.
18. Kendler KS, Gardner CO, Prescott CA (2001a). Panic syndromes in a population-based sample of male and female twins. Psychol Med 31:989-1000.
19. Kendler KS, Myers J, Prescott CA, Neale MC (2001b). The genetic epidemiology of irrational fears and phobias in men. Arch Gen Psychiatry 58:257-265.
20. Livak KJ (1999). Allelic discrimination using fluorogenic probes and the 50 nuclease assay. Genet Anal 14:143-149.
21. Middeldorp CM, Cath DC, Van Dyck R, Boomsma DI (2005). The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies. Psychol Med 35:611-624.
22. Robles JR, van den Oord EJ (2004). lga972: a cross-platform application for optimizing LD studies using a genetic algorithm. Bioinformatics 20:3244-3245.
23. Scherrer JF, True WR, Xian H, Lyons MJ, Eisen SA, Goldberg J, et al. (2000). Evidence for genetic influences common and specific to symptoms of generalized anxiety and panic. J Affect Disord 57:25-35.
24. Schork NJ, Nath SK, Fallin D, Chakravarti A (2000). Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects. Am J Hum Genet 67:1208-1218.
25. Smoller JW, Acierno JS Jr, Rosenbaum JF, Biederman J, Pollack MH, Meminger S, et al. (2001). Targeted genome screen of panic disorder and anxiety disorder proneness using homology to murine QTL regions. Am J Med Genet 105:195-206.
26. Spitzer RL, Williams JBW (1985). Structured clinical interview for DSM-III-R (SCID). New York: Biometrics Research Department, New York State Psychiatric Institute.
27. Storey J, Tibshirani R (2003). Statistical significance for genome-wide studies. Proc Natl Acad Sci 100:9440-9445.
28. Straub RE, Sullivan PF, Ma Y, Myakishev MV, Harris-Kerr C, Wormley B, et al. (1999). Susceptibility genes for nicotine dependence: a genome scan and follow-up in an independent sample suggest that regions on chromosomes 2, 4, 10, 16, 17 and 18 merit further study. Mol Psychiatry 4:129-144.
29. Van den Oord EJ, Sullivan PF (2003). A framework for controlling false discovery rates and minimizing the amount of genotyping in the search for disease mutations. Hum Hered 56:188-199.
30. Van den Oord EJCG (1999). A comparison between different designs and tests to detect QTLs in association studies. Behav Genet 29:245-256.
31. Van Gestel S, Houwing-Duistermaat JJ, Adolfsson R, van Duijn CM, Van Broeckhoven C (2000). Power of selective genotyping in genetic association analyses of quantitative traits. Behav Genet 30:141-146.
32. Waldmann R (2001). Proton-gated cation channels: neuronal acid sensors in the central and peripheral nervous system. Adv Exp Med Biol 502:293-304.
33. Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, et al. (2002). The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron 34:463-477.
34. Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH Jr, Welsh MJ (2003). Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci 23:5496-5502.
35. Wemmie JA, Coryell MW, Askwith CC, Lamani E, Leonard AS, Sigmund CD, Welsh MJ (2004). Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behavior. Proc Natl Acad Sci U S A 101:3621-3626.