Targeting the MEK1 cascade in lung epithelium inhibits proliferation and fibrogenesis by asbestos

American Journal of Respiratory Cell and Molecular Biology

Volumn 38, Issue 5, 2008, Pages 618-626

  Manning, Christopher B ^a   Sabo Attwood, Tara ^a   Robledo, Raymond F ^a   MacPherson, Maximilian B ^a   Rincón, Mercedes ^b   Vacek, Pamela ^b   Hemenway, David ^c   Taatjes, Douglas J ^a   Lee, Patty J ^d   Mossman, Brooke T ^a,b  

^a UNIVERSITY OF VERMONT   (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c University of Vermont   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Asbestosis; Cell signaling; Clara cell; Fibrosis; Mitogen activated protein kinases

Indexed keywords

ASBESTOS; CLARA CELL PROTEIN; HISTONE H3; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROCOLLAGEN; PROTEIN C FOS; CROCIDOLITE; MAP2K1 PROTEIN, MOUSE; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FIBROGENESIS; LASER MICRODISSECTION; LUNG ALVEOLUS EPITHELIUM; LUNG FLUID; LUNG INJURY; LUNG LAVAGE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; TRANSGENE; ANIMAL; ASBESTOSIS; C57BL MOUSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; LUNG; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

MUS; MUS MUSCULUS;

ANIMALS; ASBESTOS, CROCIDOLITE; ASBESTOSIS; CELL PROLIFERATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; LUNG; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PHOSPHORYLATION; RESPIRATORY MUCOSA;

EID: 42949162548     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2007-0382OC     Document Type: Article

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