Hypoglycemic effect of a novel dialysed fenugreek seeds extract is sustainable and is mediated, in part, by the activation of hepatic enzymes

Phytotherapy Research

Volumn 22, Issue 4, 2008, Pages 500-505

  Vijayakumar, Maleppillil Vavachan ^a   Bhat, Manoj Kumar ^a  

^a NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Dialysed fenugreek seeds extract; Experimental diabetes; Glucokinase; Hexokinase; Human equivalent dose; Hypoglycemic

Indexed keywords

ALLOXAN; ANTIDIABETIC AGENT; FENUGREEK SEED EXTRACT; GLUCOKINASE; GLUCOSE; HEXOKINASE; INSULIN; LIVER ENZYME; PLANT EXTRACT; STREPTOZOCIN;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROL GROUP; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ACTIVITY; EXPERIMENTAL DIABETES MELLITUS; FENUGREEK; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN BLOOD LEVEL; MALE; METABOLISM; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; STATISTICAL SIGNIFICANCE; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; ENZYME ACTIVATION; GLUCOKINASE; GLUCOSE TOLERANCE TEST; HEXOKINASE; HYPOGLYCEMIC AGENTS; INJECTIONS, INTRAPERITONEAL; LIVER; MALE; MICE; MICE, INBRED BALB C; PLANT EXTRACTS; SEEDS; TRIGONELLA;

MUS; TRIGONELLA FOENUM-GRAECUM;

EID: 42949108213     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2351     Document Type: Article

References (31)

1. Alarcon-Aguilar FJ, Calzada-Bermejo F, Hernandez-Galicia E, Ruiz-Angeles C, Roman-Ramos R. 2005. Acute and chronic hypoglycemic effect of Ibervillea sonorae root extracts. II. J Ethnopharmacol 97: 447-452.
2. Al-Habori, Raman A. 2002. Pharmacological properties. In Fenugreek the Genus Trigonella. Taylor and Francis: New York, 163-182.
3. American Diabetes Association. 2002. Implications of the United Kingdom Prospective Diabetes Study. Diabetes Care 25: S28-S32.
4. Attele AS, Zhou YP, Xie JT et al. 2002. Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes 51: 1851-1858.
5. Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. 2003. Therapeutic applications of fenugreek. Altern Med Rev 8: 20-27.
6. Bradley R, Oberg EB, Calabrese C, Standish LJ. 2007. Algorithm for complementary and alternative medicine practice and research in type-2 diabetes. J Altern Complement Med 13: 159-175.
7. Collier JJ, Scott DK. 2004. Sweet changes: glucose homeostasis can be altered by manipulating genes controlling hepatic glucose metabolism. Mol Endocrinol 18: 1051-1063.
8. Day C. 1998. Traditional plant treatments for diabetes mellitus: pharmaceutical foods. Br J Nutr 80: 5-6.
9. Fabricant DS, Farnsworth NR. 2001. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 109: 69-75.
10. Ferre T, Pujol A, Riu E, Bosch F, Valera A. 1996. Correction of diabetic alterations by glucokinase. Proc Natl Acad Sci USA 93: 7225-7230.
11. Glad MZ, El-Salhi MM, Ismail MF, El-Tanbouly ND. 2006. Biochemical study of the anti-diabetic action of the Egyptian plants Fenugreek and Balanites. Mol Cell Biochem 281: 173-183.
12. Grimsby J, Sarabu R, Corbett WL et al. 2003. Allosteric activators of glucokinase: potential role in diabetes therapy. Science 301: 370-373.
13. Gupta A, Gupta R, Lal B. 2001. Effect of Trigonella foenum-graecum (fenugreek) seeds on glycaemic control and insulin resistance in type 2 diabetes mellitus: a double blind placebo controlled study. J Assoc Physicians India 49: 1055-1056.
14. Iynedjian PB, Marie S, Gjinovci A et al. 1995. Glucokinase and cytosolic phosphoenolpyruvate carboxykinase (GTP) in the human liver. Regulation of gene expression in cultured hepatocytes. J Clin Invest 95: 1966-1973.
15. Kusano S, Abe H, Tamura H. 2001. Isolation of antidiabetic components from white-skinned sweet potato (Ipomoea batatas L.). BioSci Biotechnol Biochem 65: 109-114.
16. Li Y, Wen S, Kota BP et al. 2005. Punica granatum flower extract, a potent alpha-glucosidase inhibitor improves postprandial hyperglycemia in Zucker diabetic fatty rats. J Ethnopharmacol 99: 239-244.
17. Murphy ED, Anderson JW. 1974. Tissue glycolytic and gluconeogenic enzyme activities in mildly and moderately diabetic rats. Influence of tolbutamide administration. Endocrinology 94: 27-34.
18. Oubre AY, Carlson TJ, King SR, Reaven GM. 1997. From plant to patient: an ethnomedical approach to the identification of new drugs for the treatment of NIDDM. Diabetologia 40: 614-617.
19. Petit PR, Sauvaire YD, Hillaire-Buys DM et al. 1995. Steroid saponins from fenugreek seeds: extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol. Steroids 60: 674-680.
20. Printz RL, Magnuson MA, Granner DK. 1993. Mammalian glucokinase. Annu Rev Nutr 13: 463-496.
21. Puri D, Prabhu KM, Murthy PS. 2002. Mechanism of action of a hypoglycemic principle isolated from fenugreek seeds. Indian J Physiol Pharmacol 46: 457-462.
22. Qureshi SA, Ding V, Li Z et al. 2000. Activation of insulin signal transduction pathway and anti-diabetic activity of small molecule insulin receptor activators. J Biol Chem 275: 36590-36595.
23. Raju J, Gupta D, Rao AR, Yadava PK, Baquer NZ. 2001. Trigonellafoenum graecum (fenugreek) seed powder improves glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic and lipogenic enzymes. Mol Cell Biochem 224: 45-51.
24. Raskin I, Ribnicky DM, Komarnytsky S et al. 2002. Plants and human health in the twenty-first century. Trend Biotechnol 20: 522-531.
25. Sauvaire Y, Petit P, Broca C et al. 1998. 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin secretion. Diabetes 47: 206-210.
26. Spence JT. 1983. Levels of translatable mRNA coding for rat liver glucokinase. J Biol Chem 258: 9143-9146.
27. Vats, V, Yadav SP, Grover JK. 2003. Effect of T. foenumgraecum on glycogen content of tissues and the key enzymes of carbohydrate metabolism. J Ethnopharmacol 85: 237-242.
28. Vijayakumar MV, Singh S, Chhipa RR, Bhat MK. 2005. The hypoglycaemic activity of fenugreek seeds extract is mediated through the stimulation of an insulin signalling pathway. Br J Pharmacol 146: 41-48.
29. Weber G, Lea MA, Fisher EA, Stamm NB. 1966. Regulatory pattern of liver carbohydrate metabolizing enzymes: insulin as inducer of key glycolytic enzymes. Enzymol Biol Clin (Basel) 7: 11-24.
30. Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. 2003. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 26: 1277-1294.
31. Yki-JäRvinen H. 2001. Combination therapies with insulin in type 2 diabetes. Diabetes Care 24: 758-767.