High-dose ultraviolet light exposure reduces scar hypertrophy in a rabbit ear model

Plastic and Reconstructive Surgery

Volumn 121, Issue 4, 2008, Pages 1165-1172

  Brown, Richard J ^a   Lee, Michael J ^a   Sisco, Mark ^a   Kim, John Y S ^a   Roy, Nakshatra ^a   Mustoe, Thomas A ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 1ALPHA2; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; EAR; EXPERIMENTAL MODEL; FEMALE; HISTOPATHOLOGY; HYPERTROPHIC SCAR; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; RADIATION DOSE; RADIATION EXPOSURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHORT COURSE THERAPY; SKIN INJURY; SKIN SCAR; SKIN ULCER; TREATMENT OUTCOME; ULTRAVIOLET B RADIATION; ANIMAL; DISEASE MODEL; METHODOLOGY; PHOTOTHERAPY;

ANIMALS; CICATRIX, HYPERTROPHIC; DISEASE MODELS, ANIMAL; EAR; RABBITS; ULTRAVIOLET THERAPY;

EID: 42949101313     PISSN: 00321052     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.prs.0000302512.17904.2a     Document Type: Article

References (40)

1. Ferguson, M. W., Whitby, D. J., Shah, M., et al. Scar formation: The spectral nature of fetal and adult wound repair. Plast. Reconstr. Surg. 97: 854, 1996.
2. McGrath, H., Martinez-Osuna, P., and Lee, F. A. Ultraviolet-A1 (340-400 nm) irradiation therapy in systemic lupus erythematosus. Lupus 5: 269, 1996.
3. Parrish, J. A., and Jaenicke, K. F. Action spectrum for phototherapy of psoriasis. J. Invest. Dermatol. 76: 359, 1981.
4. Krutmann, J. Phototherapy for atopic dermatitis. Clin. Exp. Dermatol. 25: 552, 2000.
5. Kerscher, M., Volkenandt, M., Gruss, C., et al. Low-dose UVA phototherapy for treatment of localized scleroderma. J. Am. Acad. Dermatol. 38: 21, 1998.
6. Stege, H., Berneburg, M., Humke, S., et al. High-dose UVA1 radiation therapy for localized scleroderma. J. Am. Acad. Dermatol. 36: 938, 1997.
7. Scherschun, L., Kim, J. J., and Lim, H. W. Narrow-band ultraviolet B is a useful and well-tolerated treatment for vitiligo. J. Am. Acad. Dermatol. 44: 999, 2001.
8. Petersen, M. J., Hansen, C., and Craig, S. Ultraviolet A irradiation stimulates collagenase production in cultured human fibroblasts. J. Invest. Dermatol. 99: 440, 1992.
9. Scharfetter, K., Wlaschek, M., and Hogg, A. UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo. Arch. Dermatol. Res. 283: 506, 1991.
10. Godar, D. E. Light and death: Photons and apoptosis. J. Investig. Dermatol. Symp. Proc. 4: 17, 1999.
11. Kloeters, O., Tandara, A., and Mustoe, T. A. Hypertrophic scar model in the rabbit ear: A reproducible scar model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction. Wound Repair Regen. 15: S40, 2007.
12. Reid, R., Roy, N., Mongford, J. E., et al. Reduction of hypertrophic scar via retroviral delivery of a dominant negative TGF-beta receptor II. J. Plast. Reconstr. Aesthet. Surg. 60: 64, 2007.
13. Kim, I., Mogford, J. E., Witschi, C., et al. Inhibition of prolyl 4-hydroxylase reduces scar hypertrophy in a rabbit model of cutaneous scarring. Wound Repair Regen. 11: 368, 2003.
14. Saulis, A. S., Chao, J. D., Telser, A., et al. Silicone occlusive treatment of hypertrophic scar in the rabbit model. Aesthetic Surg. J. 22: 147, 2002.
15. Saulis, A. S., Mogford, J. H., and Mustoe, T. A. Effect of Mederma on hypertrophic scarring in the rabbit ear model. Plast. Reconstr. Surg. 110: 177, 2002.
16. Morris, D. E., Wu, L., Zhao, L. L., et al. Acute and chronic animal models for excessive dermal scarring: Quantitative studies. Plast. Reconstr. Surg. 100: 674, 1997.
17. Marcus, J. R., Tyrone, J. W., Bonomo, S., et al. Cellular mechanisms for diminished scarring with aging. Plast. Reconstr. Surg. 105: 1591, 2000.
18. Caswell, M. The kinetics of the tanning response to tanning bed exposures. Photodermatol. Photoimmunol. Photomed. 16: 10, 2000.
19. Walker, S. W., Hawk, J. L. M., and Young, A. R. Acute and Chronic Effects of Ultraviolet Radiation on Skin, 6th Ed, Vol. 1. New York: McGraw-Hill, 2003.
20. Giulietti, A., Overbergh, L., Valckx, D., et al. An overview of real-time quantitative PCR: Applications to quantify cytokine gene expression. Methods 25: 386, 2001.
21. Lu, L., Saulis, A. S., Liu, W. R., et al. The temporal effects of anti-TGF-beta1, 2, and 3 monoclonal antibody on wound healing and hypertrophic scar formation. J. Am. Coll. Surg. 201: 391, 2005.
22. Leask, A., and Abraham, D. J. TGF-beta signaling and the fibrotic response. F.A.S.E.B. J. 18: 816, 2004.
23. Ahn, S. T., Monafo, W. W., and Mustoe, T. A. Topical silicone gel: A new treatment for hypertrophic scars. Surgery 106: 781, 1989.
24. Ahn, S. T., Monafo, W. W., and Mustoe, T. A. Topical silicone gel for the prevention and treatment of hypertrophic scar. Arch. Surg. 126: 499, 1991.
25. Gilchrest, B. A., Park, H. Y., Eller, M. S., and Yaar, M. Mechanisms of ultraviolet light-induced pigmentation. Photochem. Photobiol. 63: 1, 1996.
26. Soter, N. A. Acute effects of ultraviolet radiation on the skin. Semin. Dermatol. 9: 11, 1990.
27. Matsumura, Y., and Ananthaswamy, H. N. Toxic effects of ultraviolet radiation on the skin. Toxicol. Appl. Pharmacol. 195: 298, 2004.
28. Beissert, S., and Schwarz, T. Mechanisms involved in ultraviolet light-induced immunosuppression. J. Investig. Dermatol. Symp. Proc. 4: 61, 1999.
29. Mustoe, T. A. Scars and keloids. B.M.J. 328: 1329, 2004.
30. Mustoe, T. A., Cooter, R. D., Gold, M. H., et al. International clinical recommendations on scar management. Plast. Reconstr. Surg. 110: 560, 2002.
31. Robson, M. C. Proliferative scarring. Surg. Clin. North Am. 83: 557, 2003.
32. Krutmann, J., and Morita, A. Mechanisms of ultraviolet (UV) B and UVA phototherapy. J. Investig. Dermatol. Symp. Proc. 4: 70, 1999.
33. Fisher, G. J., Datta, S., Wang, Z., et al. c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoic acid. J. Clin. Invest. 106: 663, 2000.
34. Quan, T., He, T., Kang, S., et al. Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivo. J. Invest. Dermatol. 119: 499, 2002.
35. Quan, T., He, T., Kang, S., et al. Solar ultraviolet irradiation reduces collagen in photoaged human skin by blocking transforming growth factor-beta type II receptor/Smad signaling. Am. J. Pathol. 165: 741, 2004.
36. Fisher, G. J., Choi, H. C., Bata-Csorgo, Z., et al. Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo. J. Invest. Dermatol. 117: 219, 2001.
37. Brenneisen, P., Sies, H., and Scharffetter-Kochanek, K. Ultraviolet-B irradiation and matrix metalloproteinases: From induction via signaling to initial events. Ann. N. Y. Acad. Sci. 973: 31, 2002.
38. Fisher, G. J., Datta, S. C., Talwar, H. S., et al. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379: 335, 1996.
39. Fisher, G. J., Wang, Z. Q., Datta, S. C., et al. Pathophysiology of premature skin aging induced by ultraviolet light. N. Engl. J. Med. 337: 1419, 1997.
40. Asawanonda, P., Khoo, L. S., Fitzpatrick, T. B., and Taylor, C. R. UV-A1 for keloid. Arch. Dermatol. 135: 348, 1999.